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Review

Metabolic and cardiovascular benefits of GLP‑1 agonists, besides the hypoglycemic effect (Review)

  • Authors:
    • Roua Anamaria Iorga
    • Nicolae Bacalbasa
    • Mara Carsote
    • Ovidiu Gabriel Bratu
    • Ana Maria Alexandra Stanescu
    • Simona Bungau
    • Carmen Pantis
    • Camelia Cristina Diaconu
  • View Affiliations

    Affiliations: Internal Medicine Department, Clinical Emergency Hospital of Bucharest, 014461 Bucharest, Romania, Department 13 Obstetrics‑Gynecology, ‘Ion Cantacuzino’ Clinical Hospital, ‘Carol Davila’ University of Medicine and Pharmacy, 030167 Bucharest, Romania, Department 2 Endocrinology, National Institute of Endocrinology ‘C.I. Parhon’, ‘Carol Davila’ University of Medicine and Pharmacy, 011863 Bucharest, Romania, Urology Department, Emergency University Central Military Hospital, ‘Carol Davila’ University of Medicine and Pharmacy, 010825 Bucharest, Romania, Family Medicine Department, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania, Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 410028 Oradea, Romania, Department of Surgical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410087 Oradea, Romania, Internal Medicine Department, Clinical Emergency Hospital of Bucharest, ‘Carol Davila’ University of Medicine and Pharmacy, 014461 Bucharest, Romania
  • Published online on: May 5, 2020     https://doi.org/10.3892/etm.2020.8714
  • Pages: 2396-2400
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Abstract

Patients with type 2 diabetes exhibit higher cardiovascular risk than normal individuals. Optimal blood glucose levels are rarely achieved in diabetic patients. Glucagon‑like peptide‑1 receptor agonists (GLP‑1 RAs) have emerged as a new antidiabetic drug class with multiple metabolic effects. Some trials have evaluated their safety, but it has been recently demonstrated that this new class has cardiovascular benefits, through other mechanisms than glycemic control. The use of GLP‑1RAs was associated with a significant reduction of cardiovascular and all‑cause mortality, with a safe profile related to pancreatitis or thyroid cancer, as compared with placebo. This review presents the cardiovascular and metabolic benefits of GLP‑1 RAs versus placebo, in patients with type 2 diabetes. Semaglutide and liraglutide demonstrated a reduction in cardiovascular events, with similar rates on cardiovascular mortality. Ongoing trials assess the cardiovascular benefits and side effects of dulaglutide treatment. Exenatide and liraglutide demonstrated the decrease of blood pressure values, weight reduction and improvement of dyslipidemia. Liraglutide induced, both in vivo and in vitro, an improvement of blood circulation, increasing the nitric oxide level and inhibiting the adhesion and procoagulant factors. Also, liraglutide demonstrated beneficial effects on cardiac remodeling after myocardial infarction, but more large trials are required. However, the international guidelines recommend using GLP‑1 RAs as first‑line therapy in type 2 diabetes patients with high cardiovascular risk or as first‑line agents in patients intolerant to metformin.
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1 

No authors listed. New WHO statistics highlight increases in blood pressure and diabetes, other noncommunicable risk factors. Cent Eur J Public Health. 20:134–149, 149. 2012.PubMed/NCBI

2 

Leon BM and Maddox TM: Diabetes and cardiovascular disease: Epidemiology, biological mechanisms, treatment recommendations and future research. World J Diabetes. 6:1246–1258. 2015.PubMed/NCBI View Article : Google Scholar

3 

Kovacic JC, Castellano JM, Farkouh ME and Fuster V: The relationships between cardiovascular disease and diabetes: Focus on pathogenesis. Endocrinol Metab Clin North Am. 43:41–57. 2014.PubMed/NCBI View Article : Google Scholar

4 

Dupré J, Behme MT and McDonald TJ: Exendin-4 normalized postcibal glycemic excursions in type 1 diabetes. J Clin Endocrinol Metab. 89:3469–3473. 2004.PubMed/NCBI View Article : Google Scholar

5 

Sposito AC, Berwanger O, de Carvalho LSF and Saraiva JFK: GLP-1RAs in type 2 diabetes: Mechanisms that underlie cardiovascular effects and overview of cardiovascular outcome data. Cardiovasc Diabetol. 17(157)2018.PubMed/NCBI View Article : Google Scholar

6 

Xia C, Goud A, D'Souza J, Dahagam C, Rao X, Rajagopalan S and Zhong J: DPP4 inhibitors and cardiovascular outcomes: Safety on heart failure. Heart Fail Rev. 22:299–304. 2017.PubMed/NCBI View Article : Google Scholar

7 

Lee YS and Jun HS: Anti-diabetic actions of glucagon-like peptide-1 on pancreatic beta-cells. Metabolism. 63:9–19. 2014.PubMed/NCBI View Article : Google Scholar

8 

Fava S: Glucagon-like peptide 1 and the cardiovascular system. Curr Diabetes Rev. 10:302–310. 2014.PubMed/NCBI View Article : Google Scholar

9 

Knop FK, Brønden A and Vilsbøll T: Exenatide: Pharmacokinetics, clinical use, and future directions. Expert Opin Pharmacother. 18:555–571. 2017.PubMed/NCBI View Article : Google Scholar

10 

Jacobsen LV, Flint A, Olsen AK and Ingwersen SH: Liraglutide in type 2 diabetes mellitus: Clinical pharmacokinetics and pharmacodynamics. Clin Pharmacokinet. 55:657–672. 2016.PubMed/NCBI View Article : Google Scholar

11 

Brønden A, Knop FK and Christensen MB: Clinical pharmacokinetics and pharmacodynamics of albiglutide. Clin Pharmacokinet. 56:719–731. 2017.PubMed/NCBI View Article : Google Scholar

12 

Scheen AJ: Dulaglutide for the treatment of type 2 diabetes. Expert Opin Biol Ther. 17:485–496. 2017.PubMed/NCBI View Article : Google Scholar

13 

McCarty D, Coleman M and Boland CL: Lixisenatide: A new daily GLP-1 agonist for type 2 diabetes management. Ann Pharmacother. 51:401–409. 2017.PubMed/NCBI View Article : Google Scholar

14 

Tan X, Cao X, Zhou M, Zou P and Hu J: Efficacy and safety of once-weekly semaglutide for the treatment of type 2 diabetes. Expert Opin Investig Drugs. 26:1083–1089. 2017.PubMed/NCBI View Article : Google Scholar

15 

Davies M, Pieber TR, Hartoft-Nielsen ML, Hansen OKH, Jabbour S and Rosenstock J: Effect of oral semaglutide compared with placebo and subcutaneous semaglutide on glycemic control in patients with type 2 diabetes: A randomized clinical trial. JAMA. 318:1460–1470. 2017.PubMed/NCBI View Article : Google Scholar

16 

Shyangdan DS, Royle P, Clar C, Sharma P, Waugh N and Snaith A: Glucagon-like peptide analogues for type 2 diabetes mellitus. Cochrane Database Syst Rev. 10(CD006423)2011.PubMed/NCBI View Article : Google Scholar

17 

Ying Y, Zhu H, Liang Z, Ma X and Li S: GLP1 protects cardiomyocytes from palmitate-induced apoptosis via Akt/GSK3β/β-catenin pathway. J Mol Endocrinol. 55:245–262. 2015.PubMed/NCBI View Article : Google Scholar

18 

Marso SP, Bain SC, Consoli A, Eliaschewitz FG, Jódar E, Leiter LA, Lingvay I, Rosenstock J, Seufert J, Warren ML, et al: SUSTAIN-6 Investigators. Semaglutide and cardiovascular outcomes in patients with type 2 diabetes. N Engl J Med. 375:1834–1844. 2016. View Article : Google Scholar

19 

Hunter K and Hölscher C: Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis. BMC Neurosci. 13(33)2012.PubMed/NCBI View Article : Google Scholar

20 

Marso SP, Daniels GH, Brown-Frandsen K, Kristensen P, Mann JFE, Nauck MA, Nissen SE, Pocock S, Poulter NR, Ravn LS, et al: LEADER Steering Committee. LEADER Trial Investigators: Liraglutide and cardiovascular outcomes in type 2 diabetes. N Engl J Med. 375:311–322. 2016.PubMed/NCBI View Article : Google Scholar

21 

Margulies KB, Hernandez AF, Redfield MM, Givertz MM, Oliveira GH, Cole R, Mann DL, Whellan DJ, Kiernan MS, Felker GM, et al: NHLBI Heart Failure Clinical Research Network. Effects of liraglutide on clinical stability among patients with advanced heart failure and reduced ejection fraction: A randomized clinical trial. JAMA. 316:500–508. 2016.PubMed/NCBI View Article : Google Scholar

22 

Gerstein HC, Colhoun HM, Dagenais GR, Diaz R, Lakshmanan M, Pais P, Probstfield J, Riddle MC, Rydén L, Xavier D, et al: REWIND Trial Investigators. Design and baseline characteristics of participants in the Researching cardiovascular Events with a Weekly INcretin in Diabetes (REWIND) trial on the cardiovascular effects of dulaglutide. Diabetes Obes Metab. 20:42–49. 2018.PubMed/NCBI View Article : Google Scholar

23 

Holman RR, Bethel MA, Mentz RJ, Thompson VP, Lokhnygina Y, Buse JB, Chan JC, Choi J, Gustavson SM, Iqbal N, et al: EXSCEL Study Group. Effects of once-weekly exenatide on cardiovascular outcomes in type 2 diabetes. N Engl J Med. 377:1228–1239. 2017.PubMed/NCBI View Article : Google Scholar

24 

Korzh O, Krasnokutskiy S and Pankova O: Improving the drug compliance of hypertensive patients in primary care: importance of health education and self-management. Arch Balk Med Union. 54:497–502. 2019. View Article : Google Scholar

25 

Valkova MP, Veleva II, Guergueltcheva VN and Burgov PS: Impact of vascular risk factors on cognitive decline associated with diabetes mellitus. Arch Balk Med Union. 54:492–496. 2019. View Article : Google Scholar

26 

Munteanu MA, Gheorghe G, Stanescu AMA, Bratu OG and Diaconu C: What is new regarding the treatment of dyslipidemia in the 2019 European Society of Cardiology Guidelines? Arch Balk Med Union. 53:749–752. 2019. View Article : Google Scholar

27 

Del Olmo-Garcia MI and Merino-Torres JF: GLP-1 receptor agonists and cardiovascular disease in patients with type 2 diabetes. J Diabetes Res. 2018(4020492)2018.PubMed/NCBI View Article : Google Scholar

28 

Patel A, MacMahon S, Chalmers J, Neal B, Billot L, Woodward M, Marre M, Cooper M, Glasziou P, Grobbee D, et al: ADVANCE Collaborative Group. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med. 358:2560–2572. 2008.PubMed/NCBI View Article : Google Scholar

29 

UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonyl ureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet. 352:837–853. 1998.PubMed/NCBI

30 

Abdel-Daim MM, El-Tawil OS, Bungau SG and Atanasov AG: Applications of antioxidants in metabolic disorders and degenerative diseases: mechanistic approach. Oxidative Med Cell Longev 2019: ID 4179676. 2019.

31 

Saraiva FK and Sposito AC: Cardiovascular effects of glucagon-like peptide 1 (GLP-1) receptor agonists. Cardiovasc Diabetol. 13(142)2014.PubMed/NCBI View Article : Google Scholar

32 

Sharma A, Ambrosy AP, DeVore AD, Margulies KB, McNulty SE, Mentz RJ, Hernandez AF, Michael Felker G, Cooper LB, Lala A, et al: Liraglutide and weight loss among patients with advanced heart failure and a reduced ejection fraction: Insights from the FIGHT trial. ESC Heart Fail. 5:1035–1043. 2018.PubMed/NCBI View Article : Google Scholar

33 

Stoicescu M, Csepento C, Mutiu G and Bungau S: The role of increased plasmatic renin level in the pathogenesis of arterial hypertension in young adults. Rom J Morphol Embryol. 52 (Suppl. 1):419–423. 2011.PubMed/NCBI

34 

Scheen AJ: GLP-1 receptor agonists and heart failure in diabetes. Diabetes Metab. 43 (Suppl. 1)(2S13-2S19)2017.PubMed/NCBI View Article : Google Scholar

35 

Bahtiyar G, Pujals-Kury J and Sacerdote A: Cardiovascular effects of different GLP-1 receptor agonists in patients with type 2 diabetes. Curr Diab Rep. 18(92)2018.PubMed/NCBI View Article : Google Scholar

36 

Giugliano D, Meier JJ and Esposito K: Heart failure and type 2 diabetes: From cardiovascular outcome trials, with hope. Diabetes Obes Metab. 21:1081–1087. 2019.PubMed/NCBI View Article : Google Scholar

37 

Gaman MA, Dobrica EC, Pascu EG, Cozma MA, Epingeac ME, Gaman AM, Pantea Stoian A, Bratu OG and Diaconu CC: Cardiometabolic risk factors for atrial fibrillation in type 2 diabetes mellitus: Focus on hypertension, metabolic syndrome and obesity. J Mind Med Sci. 6:157–161. 2019.

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Copy and paste a formatted citation
Spandidos Publications style
Iorga RA, Bacalbasa N, Carsote M, Bratu OG, Stanescu AA, Bungau S, Pantis C and Diaconu CC: Metabolic and cardiovascular benefits of GLP‑1 agonists, besides the hypoglycemic effect (Review). Exp Ther Med 20: 2396-2400, 2020.
APA
Iorga, R.A., Bacalbasa, N., Carsote, M., Bratu, O.G., Stanescu, A.A., Bungau, S. ... Diaconu, C.C. (2020). Metabolic and cardiovascular benefits of GLP‑1 agonists, besides the hypoglycemic effect (Review). Experimental and Therapeutic Medicine, 20, 2396-2400. https://doi.org/10.3892/etm.2020.8714
MLA
Iorga, R. A., Bacalbasa, N., Carsote, M., Bratu, O. G., Stanescu, A. A., Bungau, S., Pantis, C., Diaconu, C. C."Metabolic and cardiovascular benefits of GLP‑1 agonists, besides the hypoglycemic effect (Review)". Experimental and Therapeutic Medicine 20.3 (2020): 2396-2400.
Chicago
Iorga, R. A., Bacalbasa, N., Carsote, M., Bratu, O. G., Stanescu, A. A., Bungau, S., Pantis, C., Diaconu, C. C."Metabolic and cardiovascular benefits of GLP‑1 agonists, besides the hypoglycemic effect (Review)". Experimental and Therapeutic Medicine 20, no. 3 (2020): 2396-2400. https://doi.org/10.3892/etm.2020.8714
Copy and paste a formatted citation
x
Spandidos Publications style
Iorga RA, Bacalbasa N, Carsote M, Bratu OG, Stanescu AA, Bungau S, Pantis C and Diaconu CC: Metabolic and cardiovascular benefits of GLP‑1 agonists, besides the hypoglycemic effect (Review). Exp Ther Med 20: 2396-2400, 2020.
APA
Iorga, R.A., Bacalbasa, N., Carsote, M., Bratu, O.G., Stanescu, A.A., Bungau, S. ... Diaconu, C.C. (2020). Metabolic and cardiovascular benefits of GLP‑1 agonists, besides the hypoglycemic effect (Review). Experimental and Therapeutic Medicine, 20, 2396-2400. https://doi.org/10.3892/etm.2020.8714
MLA
Iorga, R. A., Bacalbasa, N., Carsote, M., Bratu, O. G., Stanescu, A. A., Bungau, S., Pantis, C., Diaconu, C. C."Metabolic and cardiovascular benefits of GLP‑1 agonists, besides the hypoglycemic effect (Review)". Experimental and Therapeutic Medicine 20.3 (2020): 2396-2400.
Chicago
Iorga, R. A., Bacalbasa, N., Carsote, M., Bratu, O. G., Stanescu, A. A., Bungau, S., Pantis, C., Diaconu, C. C."Metabolic and cardiovascular benefits of GLP‑1 agonists, besides the hypoglycemic effect (Review)". Experimental and Therapeutic Medicine 20, no. 3 (2020): 2396-2400. https://doi.org/10.3892/etm.2020.8714
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