Open Access

Initial dosage optimization of ciclosporin in pediatric Chinese patients who underwent bone marrow transplants based on population pharmacokinetics

  • Authors:
    • Xiao Chen
    • Xin Yu
    • Dong‑Dong Wang
    • Hong Xu
    • Zhiping Li
  • View Affiliations

  • Published online on: May 8, 2020     https://doi.org/10.3892/etm.2020.8732
  • Pages: 401-408
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Bone marrow transplants (BMT) are an established therapeutic strategy for patients with severe aplastic anemia, acute lymphoblastic leukemia, acute myeloid leukemia or chronic myeloid leukemia. However, the successful application of BMT is limited by graft‑vs.‑host disease (GVHD). Ciclosporin has been widely used for treating GVHD in pediatric patients who underwent BMT. The present study aimed to optimize the dosage of ciclosporin for safety and effectiveness based on population pharmacokinetics. A non‑linear mixed‑effects model was used to analyze the clinical data of pediatric patients who underwent BMT between September 2016 and September 2019 at the Children's Hospital of Fudan University. Monte Carlo simulations were used to identify the optimal dose of ciclosporin. The final population pharmacokinetic model indicated that body weight and days post‑transplant influenced the clearance of ciclosporin in pediatric patients who underwent BMT. The present study indicated that the optimal initial dose of ciclosporin for pediatric patients weighing 5‑30 kg who underwent BMT was 6 mg/kg/day split into 2 doses.
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July-2020
Volume 20 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Chen X, Yu X, Wang DD, Xu H and Li Z: Initial dosage optimization of ciclosporin in pediatric Chinese patients who underwent bone marrow transplants based on population pharmacokinetics. Exp Ther Med 20: 401-408, 2020
APA
Chen, X., Yu, X., Wang, D., Xu, H., & Li, Z. (2020). Initial dosage optimization of ciclosporin in pediatric Chinese patients who underwent bone marrow transplants based on population pharmacokinetics. Experimental and Therapeutic Medicine, 20, 401-408. https://doi.org/10.3892/etm.2020.8732
MLA
Chen, X., Yu, X., Wang, D., Xu, H., Li, Z."Initial dosage optimization of ciclosporin in pediatric Chinese patients who underwent bone marrow transplants based on population pharmacokinetics". Experimental and Therapeutic Medicine 20.1 (2020): 401-408.
Chicago
Chen, X., Yu, X., Wang, D., Xu, H., Li, Z."Initial dosage optimization of ciclosporin in pediatric Chinese patients who underwent bone marrow transplants based on population pharmacokinetics". Experimental and Therapeutic Medicine 20, no. 1 (2020): 401-408. https://doi.org/10.3892/etm.2020.8732