Maternal inherited thrombophilia and pregnancy outcomes

  • Authors:
    • Diana Ioana Voicu
    • Octavian Munteanu
    • Florentina Gherghiceanu
    • Luciana Valentina Arsene
    • Roxana Elena Bohiltea
    • Delia Maria Gradinaru
    • Monica Mihaela Cirstoiu
  • View Affiliations

  • Published online on: May 13, 2020     https://doi.org/10.3892/etm.2020.8747
  • Pages: 2411-2414
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Abstract

Thrombophilia is a group of genetical disorders that cause blood to clot abnormally. Thrombophilia is linked to recurrent pregnancy loss, foetal growth restriction, late miscarriages, stillbirth and preeclampsia. Clinicians usually apply the term thrombophilia only to patients with atypical thrombosis. A successful outcome of pregnancy requires an efficient uteroplacental circulation. Since this system may be compromised by disorders associated with a prothrombotic state, it was postulated that maternal thrombophilia might be a risk factor for preeclampsia and intrauterine growth retardation. The study included 459 pregnant women with gestational ages ranging from 14 weeks to 28 weeks and the patients in the study were tested for hereditary thrombophilia. The type of thrombophilic mutation most common found was the MTHFR mutation (25.7%), followed by the prothrombin gene mutation (20.9%) and the Leiden factor V mutation (15.7%). Also 15.03% patients had been diagnosed with preeclampsia and 6.75% of the pregnant women had IUGR fetuses.

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September-2020
Volume 20 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Voicu DI, Munteanu O, Gherghiceanu F, Arsene LV, Bohiltea RE, Gradinaru DM and Cirstoiu MM: Maternal inherited thrombophilia and pregnancy outcomes. Exp Ther Med 20: 2411-2414, 2020
APA
Voicu, D.I., Munteanu, O., Gherghiceanu, F., Arsene, L.V., Bohiltea, R.E., Gradinaru, D.M., & Cirstoiu, M.M. (2020). Maternal inherited thrombophilia and pregnancy outcomes. Experimental and Therapeutic Medicine, 20, 2411-2414. https://doi.org/10.3892/etm.2020.8747
MLA
Voicu, D. I., Munteanu, O., Gherghiceanu, F., Arsene, L. V., Bohiltea, R. E., Gradinaru, D. M., Cirstoiu, M. M."Maternal inherited thrombophilia and pregnancy outcomes". Experimental and Therapeutic Medicine 20.3 (2020): 2411-2414.
Chicago
Voicu, D. I., Munteanu, O., Gherghiceanu, F., Arsene, L. V., Bohiltea, R. E., Gradinaru, D. M., Cirstoiu, M. M."Maternal inherited thrombophilia and pregnancy outcomes". Experimental and Therapeutic Medicine 20, no. 3 (2020): 2411-2414. https://doi.org/10.3892/etm.2020.8747