Maternal inherited thrombophilia and pregnancy outcomes

Voicu,Diana   Ioana; Munteanu,Octavian; Gherghiceanu,Florentina; Arsene,Luciana   Valentina; Bohiltea,Roxana   Elena; Gradinaru,Delia  Maria; Cirstoiu,Monica   Mihaela

doi:10.3892/etm.2020.8747

September-2020 Volume 20 Issue 3

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September-2020 Volume 20 Issue 3

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Article

Maternal inherited thrombophilia and pregnancy outcomes

Authors:
- Diana Ioana Voicu
- Octavian Munteanu
- Florentina Gherghiceanu
- Luciana Valentina Arsene
- Roxana Elena Bohiltea
- Delia Maria Gradinaru
- Monica Mihaela Cirstoiu
View Affiliations / Copyright

Affiliations: Department of Obstetrics and Gynecology, University Emergency Hospital of Bucharest, 050098 Bucharest, Romania, Department of Marketing and Medical Technology, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania
Pages: 2411-2414
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Published online on: May 13, 2020

https://doi.org/10.3892/etm.2020.8747
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Abstract

Thrombophilia is a group of genetical disorders that cause blood to clot abnormally. Thrombophilia is linked to recurrent pregnancy loss, foetal growth restriction, late miscarriages, stillbirth and preeclampsia. Clinicians usually apply the term thrombophilia only to patients with atypical thrombosis. A successful outcome of pregnancy requires an efficient uteroplacental circulation. Since this system may be compromised by disorders associated with a prothrombotic state, it was postulated that maternal thrombophilia might be a risk factor for preeclampsia and intrauterine growth retardation. The study included 459 pregnant women with gestational ages ranging from 14 weeks to 28 weeks and the patients in the study were tested for hereditary thrombophilia. The type of thrombophilic mutation most common found was the MTHFR mutation (25.7%), followed by the prothrombin gene mutation (20.9%) and the Leiden factor V mutation (15.7%). Also 15.03% patients had been diagnosed with preeclampsia and 6.75% of the pregnant women had IUGR fetuses.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Maternal inherited thrombophilia and pregnancy outcomes

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