Impact of obesity on the prognosis of hypertensive disorders in pregnancy
- Authors:
- Roxana Elena Bohiltea
- Corina‑Aurelia Zugravu
- Dragos Nemescu
- Natalia Turcan
- Florina‑Paula Paulet
- Florentina Gherghiceanu
- Ionita Ducu
- Monica Mihaela Cirstoiu
View Affiliations
Affiliations: Department of Obstetrics and Gynecology, ‘Carol Davila’ University of Medicine and Pharmacy, University Emergency Hospital of Bucharest, 050098 Bucharest, Romania, Department of Food Hygiene and Nutrition, ‘Carol Davila’ University of Medicine and Pharmacy, 050463 Bucharest, Romania, Department of Obstetrics and Gynecology, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania, Department of Obstetrics and Gynecology, ‘Carol Davila’ University of Medicine and Pharmacy Doctoral School, University Emergency Hospital of Bucharest, 050098 Bucharest, Romania, Department of Marketing and Medical Technology, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania
- Published online on: May 21, 2020 https://doi.org/10.3892/etm.2020.8783
-
Pages:
2423-2428
-
Copyright: © Bohiltea
et al. This is an open access article distributed under the
terms of Creative
Commons Attribution License.
Metrics: Total
Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
This article is mentioned in:
Abstract
The prevalence of pathologies due to placental dysfunction superimposed on pregnancy is constantly increasing. The prognosis of the cases complicated by gestational hypertension is usually good, significantly better compared with that of the cases associating preeclampsia. About half of the cases with gestational hypertension will progress to preeclampsia, the risk of decompensation being inversely proportional to the gestational age of the onset of gestational hypertension. The present study, analyzed the cases of pregnancy and postpartum complicated by pathologies related to placental dysfunction, during a period of 5 years. The risk factors analyzed were the presence of infections during pregnancy, diabetes, thrombophilia, pregnancy obtained by in vitro fertilization, abnormal adherence of the placenta, obesity, multiple pregnancy, the presence of an earlier hepatic, endocrine, renal, cardiac or autoimmune pathology, and the existence of an uterine malformation. Obesity appears with a significantly increased incidence in patients with gestational hypertension and middle preeclampsia. Intrauterine growth restriction appears with a significantly increased incidence in patients with mild preeclampsia. Complications such as prematurity, acute fetal distress and abruption of placentae had a significantly increased incidence in patients with severe preeclampsia. Thus, obese patients have a higher risk of moderate preeclampsia, following gestational hypertension and finally severe preeclampsia.
View References
|
1
|
No authors listed. Report of the National
High Blood Pressure Education Program Working Group on high blood
pressure in pregnancy. Am J Obstet Gynecol.
183(S1-S22)2000.PubMed/NCBI
|
|
2
|
Sibai BM and Stella CL: Diagnosis and
management of atypical preeclampsia-eclampsia. Am J Obstet Gynecol.
200(481.e1-481.e7)2009.PubMed/NCBI View Article : Google Scholar
|
|
3
|
Thornton CE, Makris A, Ogle RF, Tooher JM
and Hennessy A: Role of proteinuria in defining pre-eclampsia:
Clinical outcomes for women and babies. Clin Exp Pharmacol Physiol.
37:466–470. 2010.PubMed/NCBI View Article : Google Scholar
|
|
4
|
Homer CS, Brown MA, Mangos G and Davis GK:
Non-proteinuric pre-eclampsia: A novel risk indicator in women with
gestational hypertension. J Hypertens. 26:295–302. 2008.PubMed/NCBI View Article : Google Scholar
|
|
5
|
Barton JR and Sibai BM: Diagnosis and
management of hemolysis, elevated liver enzymes, and low platelets
syndrome. Clin Perinatol. 31807–833. (vii)2004.PubMed/NCBI View Article : Google Scholar
|
|
6
|
Osmanağaoğlu MA, Erdoğan I, Zengin U and
Bozkaya H: Comparison between HELLP syndrome, chronic hypertension,
and superimposed preeclampsia on chronic hypertension without HELLP
syndrome. J Perinat Med. 32:481–485. 2004.PubMed/NCBI View Article : Google Scholar
|
|
7
|
Murray D, O'Riordan M, Geary M, Phillips
R, Clarke T and McKenna P: The HELLP syndrome: Maternal and
perinatal outcome. Ir Med J. 94:16–18. 2001.PubMed/NCBI
|
|
8
|
Brown CE, Cunningham FG and Pritchard JA:
Convulsions in hypertensive, proteinuric primiparas more than 24
hours after delivery. Eclampsia or some other cause? J Reprod Med.
32:499–503. 1987.PubMed/NCBI
|
|
9
|
Zeeman GG: Neurologic complications of
pre-eclampsia. Semin Perinatol. 33:166–172. 2009.PubMed/NCBI View Article : Google Scholar
|
|
10
|
Belfort MA, Saade GR, Grunewald C, Dildy
GA, Abedejos P, Herd JA and Nisell H: Association of cerebral
perfusion pressure with headache in women with pre-eclampsia. Br J
Obstet Gynaecol. 106:814–821. 1999.PubMed/NCBI View Article : Google Scholar
|
|
11
|
Ghulmiyyah L and Sibai B: Maternal
mortality from pre-eclampsia/eclampsia. Semin Perinatol. 36:56–59.
2012.PubMed/NCBI View Article : Google Scholar
|
|
12
|
LeFevre ML: U.S. Preventive Services Task
Force. Low-dose aspirin use for the prevention of morbidity and
mortality from preeclampsia: U.S. Preventive Services Task Force
recommendation statement. Ann Intern Med. 161:819–826.
2014.PubMed/NCBI View
Article : Google Scholar
|
|
13
|
Wang Y, Beydoun MA, Liang L, Caballero B
and Kumanyika SK: Will all Americans become overweight or obese?
Estimating the progression and cost of the US obesity epidemic.
Obesity (Silver Spring). 16:2323–2330. 2008.PubMed/NCBI View Article : Google Scholar
|
|
14
|
Yogev Y and Catalano PM: Pregnancy and
obesity. Obstet Gynecol Clin North Am. 36285–300.
(viii)2009.PubMed/NCBI View Article : Google Scholar
|
|
15
|
Sierra-Laguado J, García RG, Celedón J,
Arenas-Mantilla M, Pradilla LP, Camacho PA and López-Jaramillo P:
Determination of insulin resistance using the homeostatic model
assessment (HOMA) and its relation with the risk of developing
pregnancy-induced hypertension. Am J Hypertens. 20:437–442.
2007.PubMed/NCBI View Article : Google Scholar
|
|
16
|
Lopez-Jaramillo P: The role of adiponectin
in cardiometabolic diseases: Effects of nutritional interventions.
J Nutr. 146(422S-426S)2016.PubMed/NCBI View Article : Google Scholar
|
|
17
|
Spradley FT, Palei AC and Granger JP:
Increased risk for the development of preeclampsia in obese
pregnancies: Weighing in on the mechanisms. Am J Physiol Regul
Integr Comp Physiol. 309(R1326-R1343)2015.PubMed/NCBI View Article : Google Scholar
|
