Prognosis of autoimmune thyroid disease associated with hereditary thrombophilia during pregnancy

Păuleț,Florina‑Paula; Țurcan,Natalia; Gherghiceanu,Florentina; Bohîlțea,Roxana Elena; Nemescu,Dragos; Cîrstoiu,Monica Mihaela

doi:10.3892/etm.2020.8785

Prognosis of autoimmune thyroid disease associated with hereditary thrombophilia during pregnancy

Authors:
- Florina‑Paula Păuleț
- Natalia Țurcan
- Florentina Gherghiceanu
- Roxana Elena Bohîlțea
- Dragos Nemescu
- Monica Mihaela Cîrstoiu
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Affiliations: Department of Obstetrics Gynecology, ‘Carol Davila’ University of Medicine and Pharmacy Doctoral School, University Emergency Hospital Bucharest, 050098 Bucharest, Romania, Department of Marketing and Medical Technology, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania, Department of Obstetrics Gynecology, ‘Carol Davila’ University of Medicine and Pharmacy, University Emergency Hospital Bucharest, 050098 Bucharest, Romania, Department of Obstetrics Gynecology, University of Medicine and Pharmacy ‘Grigore T. Popa’, 700115 Iasi, Romania
Published online on: May 22, 2020 https://doi.org/10.3892/etm.2020.8785
Pages: 2429-2433
Copyright: © Păuleț et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Autoimmune thyroid pathology has been connected with several systemic autoimmune disorders, namely hereditary thrombophilia and antiphospholipid syndrome. In an iodine‑replete country, these diseases need to be evaluated simultaneously. This study was conducted to assess the connection between acute and chronic thyroiditis and inherited thrombophilia and their potential implications in pregnancy. In the analysis of the cases admitted to the Department of Obstetrics Gynecology of the University Emergency Hospital Bucharest from January 2015 up to September 2019, we identified pregnancies marked by autoimmune hypothyroidism and hyperthyroidism associated with hereditary thrombophilia, by standard statistical methods. In this investigation, we determined the prevalence of immunological markers specific for thrombophilia and against thyroid antigens in pregnant women, and explored whether they associate with distinct clinical phenotypes. Besides the well‑accounted impact of hereditary thrombophilia during pregnancy ‑ which is emphasized in our study by the incidence of moderate preeclampsia ‑ we also account for a direct and statistically significant relationship between thrombophilia and moderate intensity autoimmune diseases (including autoimmune thyroiditis). Moreover, if these two pathologies are combined there is an increased risk of the presence of another autoimmune disease.

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