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Postanesthetic skin erythema due to succinylcholine versus atracurium

  • Authors:
    • Oana Roxana Ciobotaru
    • Gabriela Stoleriu
    • Octavian Catalin Ciobotaru
    • Alexandru Grigorovici
    • Doina Carina Voinescu
    • Madalina Nicoleta Matei
    • Roxana Gabriela Cobzaru
    • Nicuta Manolache
    • Mary‑Nicoleta Lupu
  • View Affiliations / Copyright

    Affiliations: Clinical Department, Faculty of Medicine and Pharmacy, ‘Dunărea de Jos’ University, 800008 Galati, Romania, Department of Surgery, Faculty of Medicine and Pharmacy, ‘Dunărea de Jos’ University, 800008 Galati, Romania, Department of Surgery, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania, Department of Dental Medicine, Faculty of Medicine and Pharmacy, ‘Dunărea de Jos’ University, 800008 Galati, Romania, Department of Preventive Medicine and Interdisciplinarity, Discipline Microbiology, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania, Department of Pharmaceutical Sciences, Faculty of Medicine and Pharmacy, ‘Dunărea de Jos’ University, 800008 Galati, Romania
    Copyright: © Ciobotaru et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2368-2372
    |
    Published online on: May 26, 2020
       https://doi.org/10.3892/etm.2020.8792
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Abstract

Intraoperative anaphylactic reactions may range from mild, erythema‑like to anaphylactic shock, with tension crash and bronchospasm. The substances considered to be most responsible for the occurrence of intraoperative allergic reactions are neuromuscular blocking agents, antibiotics and latex. Recent studies have identified a new receptor, Mas‑Related G‑Protein‑coupled Receptor X2 (MRGPRX2), considered as a target for some neuromuscular blockers such as atracurium, rocuronium or fluoroquinolone, resulting in pseudoallergic or anaphylactoid reactions. Induction of anesthesia can use both depolarizing myorelaxants, useful especially in emergency situations, in the patient with gastric plenitude or at high risk of intubation, and non‑depolarizing myorelaxants such as atracurium, cisatracurium and rocuronium. Succinylcholine has a short time of action and it is rapidly metabolized. Atracurium, although having a slightly longer time to action, has the benefit of a low risk of increased levels of potassium in blood, which is extremely important in patients with cardiac pathology or associated kidney diseases. The present study compared the side effects of systemic anesthesia with succinylcholine vs. atracurium.
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Copy and paste a formatted citation
Spandidos Publications style
Ciobotaru OR, Stoleriu G, Ciobotaru OC, Grigorovici A, Voinescu DC, Matei MN, Cobzaru RG, Manolache N and Lupu MN: Postanesthetic skin erythema due to succinylcholine versus atracurium. Exp Ther Med 20: 2368-2372, 2020.
APA
Ciobotaru, O.R., Stoleriu, G., Ciobotaru, O.C., Grigorovici, A., Voinescu, D.C., Matei, M.N. ... Lupu, M. (2020). Postanesthetic skin erythema due to succinylcholine versus atracurium. Experimental and Therapeutic Medicine, 20, 2368-2372. https://doi.org/10.3892/etm.2020.8792
MLA
Ciobotaru, O. R., Stoleriu, G., Ciobotaru, O. C., Grigorovici, A., Voinescu, D. C., Matei, M. N., Cobzaru, R. G., Manolache, N., Lupu, M."Postanesthetic skin erythema due to succinylcholine versus atracurium". Experimental and Therapeutic Medicine 20.3 (2020): 2368-2372.
Chicago
Ciobotaru, O. R., Stoleriu, G., Ciobotaru, O. C., Grigorovici, A., Voinescu, D. C., Matei, M. N., Cobzaru, R. G., Manolache, N., Lupu, M."Postanesthetic skin erythema due to succinylcholine versus atracurium". Experimental and Therapeutic Medicine 20, no. 3 (2020): 2368-2372. https://doi.org/10.3892/etm.2020.8792
Copy and paste a formatted citation
x
Spandidos Publications style
Ciobotaru OR, Stoleriu G, Ciobotaru OC, Grigorovici A, Voinescu DC, Matei MN, Cobzaru RG, Manolache N and Lupu MN: Postanesthetic skin erythema due to succinylcholine versus atracurium. Exp Ther Med 20: 2368-2372, 2020.
APA
Ciobotaru, O.R., Stoleriu, G., Ciobotaru, O.C., Grigorovici, A., Voinescu, D.C., Matei, M.N. ... Lupu, M. (2020). Postanesthetic skin erythema due to succinylcholine versus atracurium. Experimental and Therapeutic Medicine, 20, 2368-2372. https://doi.org/10.3892/etm.2020.8792
MLA
Ciobotaru, O. R., Stoleriu, G., Ciobotaru, O. C., Grigorovici, A., Voinescu, D. C., Matei, M. N., Cobzaru, R. G., Manolache, N., Lupu, M."Postanesthetic skin erythema due to succinylcholine versus atracurium". Experimental and Therapeutic Medicine 20.3 (2020): 2368-2372.
Chicago
Ciobotaru, O. R., Stoleriu, G., Ciobotaru, O. C., Grigorovici, A., Voinescu, D. C., Matei, M. N., Cobzaru, R. G., Manolache, N., Lupu, M."Postanesthetic skin erythema due to succinylcholine versus atracurium". Experimental and Therapeutic Medicine 20, no. 3 (2020): 2368-2372. https://doi.org/10.3892/etm.2020.8792
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