Open Access

miR‑365b regulates the development of non‑small cell lung cancer via GALNT4

  • Authors:
    • Lei Xing
    • Xiaodong Hong
    • Liang Chang
    • Ping Ren
    • Hong Zhang
  • View Affiliations

  • Published online on: June 10, 2020     https://doi.org/10.3892/etm.2020.8857
  • Pages: 1637-1643
  • Copyright: © Xing et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Non-small cell lung cancer (NSCLC) is a type of cancer that is associated with high prevalence and high mortality rates in China. Therefore, it is of importance to identify the mechanisms underlying NSCLC progression. In the present study, reverse transcription‑quantitative PCR was performed to measure the expression of microRNA (miR)‑365b in NSCLC cell lines. In addition, the biological roles of miR‑365b and N‑acetylgalactosaminyltransferase 4 (GALNT4) were investigated by manipulating the expression levels of miR‑365b and GALNT4 in NSCLC cells. It was found that miR‑365b expression was reduced in NSCLC tissues and cells. Overexpression of miR‑365b inhibited NSCLC cell proliferation whilst promoting apoptosis, but miR‑365b knockdown promoted NSCLC cell proliferation. In addition, it was demonstrated that miR‑365b regulated the proliferation and apoptosis of NSCLC cells by targeting GALNT4 expression. Collectively, the present study identified a miR‑365b/GALNT4 regulatory axis in NSCLC, suggesting that miR‑365b may serve as a therapeutic target for NSCLC.

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August-2020
Volume 20 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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APA
Xing, L., Hong, X., Chang, L., Ren, P., & Zhang, H. (2020). miR‑365b regulates the development of non‑small cell lung cancer via GALNT4. Experimental and Therapeutic Medicine, 20, 1637-1643. https://doi.org/10.3892/etm.2020.8857
MLA
Xing, L., Hong, X., Chang, L., Ren, P., Zhang, H."miR‑365b regulates the development of non‑small cell lung cancer via GALNT4". Experimental and Therapeutic Medicine 20.2 (2020): 1637-1643.
Chicago
Xing, L., Hong, X., Chang, L., Ren, P., Zhang, H."miR‑365b regulates the development of non‑small cell lung cancer via GALNT4". Experimental and Therapeutic Medicine 20, no. 2 (2020): 1637-1643. https://doi.org/10.3892/etm.2020.8857