Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
September-2020 Volume 20 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2020 Volume 20 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report Open Access

Triamcinolone acetonide induces sterile endophthalmitis in patients with intermediate uveitis: A case report series

  • Authors:
    • Marius Cristian Șuță
    • Olimpiu Ladislau Karancsi
    • Ovidiu Mușat
    • Nicolae Balica
    • Iasmina Yasar
    • Cosmin Roșca
    • Simona Stanca
    • Diana‑Maria Dărăbuş
  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, ‘Victor Babeş’ University of Medicine and Pharmacy, 300041 Timișoara, Romania, Department of Oral Implantology and Prosthetic Restorations on Implants, ‘Victor Babeş’ University of Medicine and Pharmacy, 300041 Timișoara, Romania, Department of Ophthalmology, ‘Dr. Carol Davila’ Central Military Emergency University Hospital, 010825 Bucharest, Romania, Department of ENT, ‘Victor Babeş’ University of Medicine and Pharmacy, Timişoara County Emergency Clinical Hospital, 300041 Timişoara, Romania, Department of Ophthalmology, Timişoara County Emergency Clinical Hospital, 300041 Timişoara, Romania, Department of Ophthalmology, Oculens Clinic, 400501 Cluj‑Napoca, Romania, Department of Pediatrics, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania
    Copyright: © Șuță et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2524-2528
    |
    Published online on: June 12, 2020
       https://doi.org/10.3892/etm.2020.8883
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Due to their anti‑inflammatory, antiangiogenic and antiedematous properties, corticosteroids have been commonly used in the treatment of retinal diseases. Intra­vitreal administration of steroids offers the maximal drug efficacy and the lowest risk of systemic side effects. The authors report three cases of presumed sterile endophthalmitis induced by triamcinolone acetonide (TA) in three eyes with intermediate non‑infectious uveitis. Each patient received a single intravitreal injection of TA of 4 mg. Because of the intense vitreous inflammatory reaction, retina examination and the optical coherence tomography could not be performed, although vitreous opacities were observed on the ocular ultrasound. The dense vitreous opacity is a defining factor, the anterior segment inflammation is mild to moderate and a hypopyon is present, which may be a sterile inflammatory reaction or the triamcinolone material itself. In cases of sterile endophthalmitis, the visual acuity increases progressively as the intraocular inflammation diminishes. Local treatment with topical antibiotics, prednisolone acetate and cycloplegic eyedrops is recommended to control the inflammatory reaction.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Oh-i K, Keino H, Goto H, Yamakawa N, Murase K, Usui Y, Kezuka T, Sakai J, Takeuchi M and Usui M: Intravitreal injection of Tacrolimus (FK506) suppresses ongoing experimental autoimmune uveoretinitis in rats. Br J Ophthalmol. 91:237–242. 2007.PubMed/NCBI View Article : Google Scholar

2 

Stanca HT, Suvac E, Munteanu M, Jianu DC, Motoc AGM, Roşca GC and Boruga O: Giant cell arteritis with arteritic anterior ischemic optic neuropathy. Rom J Morphol Embryol. 58:281–285. 2017.PubMed/NCBI

3 

Nachod GR: ACTH and cortisone in ocular disease. J Am Med Womens Assoc. 6:453–455. 1951.PubMed/NCBI

4 

Sarao V, Veritti D, Boscia F and Lanzetta P: Intravitreal steroids for the treatment of retinal diseases. ScientificWorldJournal. 2014(989501)2014.PubMed/NCBI View Article : Google Scholar

5 

Umland SP, Nahrebne DK, Razac S, Beavis A, Pennline KJ, Egan RW and Billah MM: The inhibitory effects of topically active glucocorticoids on IL-4, IL-5, and interferon-γ production by cultured primary CD4+ T cells. J Allergy Clin Immunol. 100:511–519. 1997.PubMed/NCBI View Article : Google Scholar

6 

Floman N and Zor U: Mechanism of steroid action in ocular inflammation: Inhibition of prostaglandin production. Invest Ophthalmol Vis Sci. 16:69–73. 1977.PubMed/NCBI

7 

Machemer R, Sugita G and Tano Y: Treatment of intraocular proliferations with intravitreal steroids. Trans Am Ophthalmol Soc. 77:171–180. 1979.PubMed/NCBI

8 

Munteanu M, Giuri S, Roșca C, Boruga O and Creţu O: Multifocal choroidal metastases from thyroid carcinoma: A case report. Chirurgia (Bucur). 108:268–272. 2013.PubMed/NCBI

9 

Munteanu M, Munteanu G, Zolog I, Giuri S, Coviltir V, Stanca H and Cretu O: Ocular decompression retinopathy after combined deep sclerectomy and trabeculotomy. Klin Monbl Augenheilkd. 229:830–831. 2012.PubMed/NCBI View Article : Google Scholar : (In German).

10 

Grigore O, Mihailescu AI, Solomon I, Boda D and Caruntu C: Role of stress in modulation of skin neurogenic inflammation. Exp Ther Med. 17:997–1003. 2019.PubMed/NCBI View Article : Google Scholar

11 

Ilie MA, Caruntu C, Lixandru D, Tampa M, Georgescu SR, Constantin MM, Constantin C, Neagu M, Zurac SA and Boda D: In vivo confocal laser scanning microscopy imaging of skin inflammation: Clinical applications and research directions. Exp Ther Med. 17:1004–1011. 2019.PubMed/NCBI View Article : Google Scholar

12 

Ilie MA, Caruntu C, Tampa M, Georgescu SR, Matei C, Negrei C, Ion RM, Constantin C, Neagu M and Boda D: Capsaicin: Physicochemical properties, cutaneous reactions and potential applications in painful and inflammatory conditions. Exp Ther Med. 18:916–925. 2019.PubMed/NCBI View Article : Google Scholar

13 

Stanca S, Ulmeanu CE, Stanca HT and Iovanescu G: Clinical features in toxic coma in children. Exp Ther Med. 18:5082–5087. 2019.PubMed/NCBI View Article : Google Scholar

14 

Stanca HT, Munteanu M, Jianu DC, Motoc AGM, Tăbăcaru B, Stanca S, Ungureanu E, Boruga VM and Preda MA: New perspectives in the use of laser diode transscleral cyclophotocoagulation. A prospective single center observational cohort study. Rom J Morphol Embryol. 59:869–872. 2018.PubMed/NCBI

15 

Boruga O, Balasoiu AT, Giuri S, Munteanu M, Stanca HT, Iovanescu G and Preda MA: Caruncular late-onset junctional nevus: Apropos of an anatomo-clinical observation. Rom J Morphol Embryol. 58:1461–1464. 2017.PubMed/NCBI

16 

Stanca HT, Petrović Z and Munteanu M: Transluminal Nd: YAG laser embolysis -a reasonable method to reperfuse occluded branch retinal arteries. Vojnosanit Pregl. 71:1072–1077. 2014.PubMed/NCBI View Article : Google Scholar

17 

Ghiţă MA, Căruntu C, Rosca AE, Căruntu A, Moraru L, Constantin C, Neagu M and Boda D: Real-time investigation of skin blood flow changes induced by topical capsaicin. Acta Dermatovenerol Croat. 25:223–227. 2017.PubMed/NCBI

18 

Boda D, Negrei C, Nicolescu F and Badalau C: Assessment of some oxidative stress parameters in methotrexate treated psoriasis patients. Farmacia. 62:704–710. 2014.

19 

Sarao V, Veritti D and Lanzetta P: Triamcinolone Acetonide for the treatment of diabetic macular oedema. Eur Ophthalmic Rev. 6:28–33. 2012.PubMed/NCBI View Article : Google Scholar

20 

Beer PM, Bakri SJ, Singh RJ, Liu W, Peters GB III and Miller M: Intraocular concentration and pharmacokinetics of triamcinolone acetonide after a single intravitreal injection. Ophthalmology. 110:681–686. 2003.PubMed/NCBI View Article : Google Scholar

21 

Inoue M, Takeda K, Morita K, Yamada M, Tanigawara Y and Oguchi Y: Vitreous concentrations of triamcinolone acetonide in human eyes after intravitreal or subtenon injection. Am J Ophthalmol. 138:1046–1048. 2004.PubMed/NCBI View Article : Google Scholar

22 

Munteanu M and Rosca C: Repositioning and follow-up of intralenticular dexamethasone implant. J Cataract Refract Surg. 39:1271–1274. 2013.PubMed/NCBI View Article : Google Scholar

23 

Preda MA, Popa G, Karancsi OL, Musat O, Popescu SI, Munteanu M and Popa Z: Effectiveness of subconjunctival bevacizumab associated with a laser-based procedure in the treatment of neovascular glaucoma. Farmacia. 66:621–626. 2018.

24 

Preda MA, Karancsi OL, Munteanu M and Stanca HT: Clinical outcomes of micropulse transscleral cyclophotocoagulation in refractory glaucoma - 18 months follow-up. Lasers Med Sci: Jan 14, 2020 (Epub ahead of print).

25 

Zierhut M, Deuter C and Murray PI: Classification of uveitis - current guidelines. Eur Ophthalmic Rev: 77-78, 2011. http://doi.org/10.17925/EOR.2007.00.00.77.

26 

Jonisch J, Lai JC, Deramo VA, Flug AJ and Fastenberg DM: Increased incidence of sterile endophthalmitis following intravitreal preserved triamcinolone acetonide. Br J Ophthalmol. 92:1051–1054. 2008.PubMed/NCBI View Article : Google Scholar

27 

Roth DB, Chieh J, Spirn MJ, Green SN, Yarian DL and Chaudhry NA: Noninfectious endophthalmitis associated with intravitreal triamcinolone injection. Arch Ophthalmol. 121:1279–1282. 2003.PubMed/NCBI View Article : Google Scholar

28 

Yeung CK, Chan KP, Chan CKM, Pang CP and Lam DSC: Cytotoxicity of triamcinolone on cultured human retinal pigment epithelial cells: Comparison with dexamethasone and hydrocortisone. Jpn J Ophthalmol. 48:236–242. 2004.PubMed/NCBI View Article : Google Scholar

29 

Lam A, Garg SJ, Spirn MJ, Fineman MS and Sivalingam A: Sterile endophthalmitis following intravitreal injection of preservative-free triamcinolone acetonide. Retin Cases Brief Rep. 2:228–230. 2008.PubMed/NCBI View Article : Google Scholar

30 

Montoro J, Valero A, Elices A, Rubira N, Serra-Baldrich E, Amat P and Malet A: Anaphylactic shock after intra-articular injection of carboxymethylcellulose. Allergol Immunopathol (Madr). 28:332–333. 2000.PubMed/NCBI

31 

Scott IU and Flynn HW Jr: Reducing the risk of endophthalmitis following intravitreal injections. Retina. 27:10–12. 2007.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Șuță MC, Karancsi OL, Mușat O, Balica N, Yasar I, Roșca C, Stanca S and Dărăbuş DM: Triamcinolone acetonide induces sterile endophthalmitis in patients with intermediate uveitis: A case report series. Exp Ther Med 20: 2524-2528, 2020.
APA
Șuță, M.C., Karancsi, O.L., Mușat, O., Balica, N., Yasar, I., Roșca, C. ... Dărăbuş, D. (2020). Triamcinolone acetonide induces sterile endophthalmitis in patients with intermediate uveitis: A case report series. Experimental and Therapeutic Medicine, 20, 2524-2528. https://doi.org/10.3892/etm.2020.8883
MLA
Șuță, M. C., Karancsi, O. L., Mușat, O., Balica, N., Yasar, I., Roșca, C., Stanca, S., Dărăbuş, D."Triamcinolone acetonide induces sterile endophthalmitis in patients with intermediate uveitis: A case report series". Experimental and Therapeutic Medicine 20.3 (2020): 2524-2528.
Chicago
Șuță, M. C., Karancsi, O. L., Mușat, O., Balica, N., Yasar, I., Roșca, C., Stanca, S., Dărăbuş, D."Triamcinolone acetonide induces sterile endophthalmitis in patients with intermediate uveitis: A case report series". Experimental and Therapeutic Medicine 20, no. 3 (2020): 2524-2528. https://doi.org/10.3892/etm.2020.8883
Copy and paste a formatted citation
x
Spandidos Publications style
Șuță MC, Karancsi OL, Mușat O, Balica N, Yasar I, Roșca C, Stanca S and Dărăbuş DM: Triamcinolone acetonide induces sterile endophthalmitis in patients with intermediate uveitis: A case report series. Exp Ther Med 20: 2524-2528, 2020.
APA
Șuță, M.C., Karancsi, O.L., Mușat, O., Balica, N., Yasar, I., Roșca, C. ... Dărăbuş, D. (2020). Triamcinolone acetonide induces sterile endophthalmitis in patients with intermediate uveitis: A case report series. Experimental and Therapeutic Medicine, 20, 2524-2528. https://doi.org/10.3892/etm.2020.8883
MLA
Șuță, M. C., Karancsi, O. L., Mușat, O., Balica, N., Yasar, I., Roșca, C., Stanca, S., Dărăbuş, D."Triamcinolone acetonide induces sterile endophthalmitis in patients with intermediate uveitis: A case report series". Experimental and Therapeutic Medicine 20.3 (2020): 2524-2528.
Chicago
Șuță, M. C., Karancsi, O. L., Mușat, O., Balica, N., Yasar, I., Roșca, C., Stanca, S., Dărăbuş, D."Triamcinolone acetonide induces sterile endophthalmitis in patients with intermediate uveitis: A case report series". Experimental and Therapeutic Medicine 20, no. 3 (2020): 2524-2528. https://doi.org/10.3892/etm.2020.8883
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team