Open Access

hsa‑microRNA‑411‑5p regulates proliferation, migration and invasion by targeting the hyaluronan mediated motility receptor in ovarian cancer

  • Authors:
    • Fang He
    • Dongyu Zu
    • Chong Lan
    • Jumin Niu
    • Xiaocui Nie
  • View Affiliations

  • Published online on: June 17, 2020     https://doi.org/10.3892/etm.2020.8899
  • Pages: 1899-1906
  • Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The mortality rate of ovarian cancer is the highest out of all gynecological malignancies worldwide. Therefore, it is important to understand the mechanisms of ovarian cancer, identify new biomarkers and develop targeted drugs. The role and molecular mechanisms of hsa‑microRNA (miR)‑411‑5p in ovarian cancer have not been fully elucidated. The present study investigated the ovarian cancer cell lines OVCAR‑8 and SKOV3. After transfection with miRNA mimics, cell proliferation was monitored by a proliferation assay. Furthermore, cell migration was measured by a cell wound healing assay and cell invasion was measured by Matrigel invasion assays. A miRNA luciferase reporter assay was used to analyze the relationship between miRNAs and the target gene HMMR, which was then further evaluated by gene differential analysis. In the current study, hsa‑mir‑411‑5p was identified as a miRNA regulator of the hyaluronan mediated motility receptor, which negatively regulated the activity of ERK1/2 and ultimately inhibited ovarian cancer cell proliferation and motility. Although hsa‑mir‑411‑5p may have different roles in other types of cancer, the present study suggested that miR‑411‑5p functions as a negative tumor regulator in ovarian cancer cells, displaying the potential of miR‑411‑5p as a biomarker for ovarian cancer.

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September-2020
Volume 20 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
He F, Zu D, Lan C, Niu J and Nie X: hsa‑microRNA‑411‑5p regulates proliferation, migration and invasion by targeting the hyaluronan mediated motility receptor in ovarian cancer. Exp Ther Med 20: 1899-1906, 2020
APA
He, F., Zu, D., Lan, C., Niu, J., & Nie, X. (2020). hsa‑microRNA‑411‑5p regulates proliferation, migration and invasion by targeting the hyaluronan mediated motility receptor in ovarian cancer. Experimental and Therapeutic Medicine, 20, 1899-1906. https://doi.org/10.3892/etm.2020.8899
MLA
He, F., Zu, D., Lan, C., Niu, J., Nie, X."hsa‑microRNA‑411‑5p regulates proliferation, migration and invasion by targeting the hyaluronan mediated motility receptor in ovarian cancer". Experimental and Therapeutic Medicine 20.3 (2020): 1899-1906.
Chicago
He, F., Zu, D., Lan, C., Niu, J., Nie, X."hsa‑microRNA‑411‑5p regulates proliferation, migration and invasion by targeting the hyaluronan mediated motility receptor in ovarian cancer". Experimental and Therapeutic Medicine 20, no. 3 (2020): 1899-1906. https://doi.org/10.3892/etm.2020.8899