Open Access

Antiproliferative effects of L‑asparaginase in acute myeloid leukemia

  • Authors:
    • Tingting Chen
    • Juan Zhang
    • Hui Zeng
    • Yue Zhang
    • Yong Zhang
    • Xiaohuan Zhou
    • Hebing Zhou
  • View Affiliations

  • Published online on: June 18, 2020     https://doi.org/10.3892/etm.2020.8904
  • Pages: 2070-2078
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The antitumor enzyme L‑asparaginase (L‑Asp) has commonly been used for the treatment of acute lymphoblastic leukemia. However, the effects of L‑Asp on acute myeloid leukemia (AML) and their underlying mechanisms have not been fully elucidated. In the present study, the effects of L‑Asp on cell proliferation and apoptosis were investigated using the AML cell lines U937, HL‑60 and KG‑1a. The effects of combining L‑Asp with mitoxantrone (MIT) and cytarabine (Ara‑c) were also analyzed. The combination of MIT and Ara‑C is known as MA therapy, and is a widely used therapeutic regimen for the treatment of elderly patients with refractory AML. When applied alone, L‑Asp inhibited cell proliferation and induced apoptosis in each of the cell lines tested. Furthermore, the combined use of L‑Asp with MA therapy further potentiated the inhibition of cell proliferation while increasing the induction of apoptosis. These findings provide evidence for the potential antitumor effect of L‑Asp in AML, and indicate that improved efficacy maybe achieved by combining L‑Asp with MIT and Ara‑c. This combination may provide a promising new therapeutic strategy for the treatment of AML.

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September-2020
Volume 20 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Chen T, Zhang J, Zeng H, Zhang Y, Zhang Y, Zhou X and Zhou H: Antiproliferative effects of L‑asparaginase in acute myeloid leukemia. Exp Ther Med 20: 2070-2078, 2020
APA
Chen, T., Zhang, J., Zeng, H., Zhang, Y., Zhang, Y., Zhou, X., & Zhou, H. (2020). Antiproliferative effects of L‑asparaginase in acute myeloid leukemia. Experimental and Therapeutic Medicine, 20, 2070-2078. https://doi.org/10.3892/etm.2020.8904
MLA
Chen, T., Zhang, J., Zeng, H., Zhang, Y., Zhang, Y., Zhou, X., Zhou, H."Antiproliferative effects of L‑asparaginase in acute myeloid leukemia". Experimental and Therapeutic Medicine 20.3 (2020): 2070-2078.
Chicago
Chen, T., Zhang, J., Zeng, H., Zhang, Y., Zhang, Y., Zhou, X., Zhou, H."Antiproliferative effects of L‑asparaginase in acute myeloid leukemia". Experimental and Therapeutic Medicine 20, no. 3 (2020): 2070-2078. https://doi.org/10.3892/etm.2020.8904