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Antiproliferative effects of L‑asparaginase in acute myeloid leukemia

  • Authors:
    • Tingting Chen
    • Juan Zhang
    • Hui Zeng
    • Yue Zhang
    • Yong Zhang
    • Xiaohuan Zhou
    • Hebing Zhou
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    Affiliations: Department of Hematology, Beijing Luhe Hospital, Capital Medical University, Beijing 101100, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2070-2078
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    Published online on: June 18, 2020
       https://doi.org/10.3892/etm.2020.8904
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Abstract

The antitumor enzyme L‑asparaginase (L‑Asp) has commonly been used for the treatment of acute lymphoblastic leukemia. However, the effects of L‑Asp on acute myeloid leukemia (AML) and their underlying mechanisms have not been fully elucidated. In the present study, the effects of L‑Asp on cell proliferation and apoptosis were investigated using the AML cell lines U937, HL‑60 and KG‑1a. The effects of combining L‑Asp with mitoxantrone (MIT) and cytarabine (Ara‑c) were also analyzed. The combination of MIT and Ara‑C is known as MA therapy, and is a widely used therapeutic regimen for the treatment of elderly patients with refractory AML. When applied alone, L‑Asp inhibited cell proliferation and induced apoptosis in each of the cell lines tested. Furthermore, the combined use of L‑Asp with MA therapy further potentiated the inhibition of cell proliferation while increasing the induction of apoptosis. These findings provide evidence for the potential antitumor effect of L‑Asp in AML, and indicate that improved efficacy maybe achieved by combining L‑Asp with MIT and Ara‑c. This combination may provide a promising new therapeutic strategy for the treatment of AML.
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1 

Saultz JN and Garzon R: Acute myeloid, leukemia: A concise review. J Clin Med. 5(pii: E33)2016.PubMed/NCBI View Article : Google Scholar

2 

Cartwright RA and Staines A: Acute leukaemias. Baillieres Clin Haematol. 5:1–26. 1992.PubMed/NCBI View Article : Google Scholar

3 

Dohner H, Estey EH, Amadori S, Appelbaum FR, Büchner T, Burnett AK, Dombret H, Fenaux P, Grimwade D, Larson RA, et al: Diagnosis and management of acute myeloid leukemia in adults: Recommendations from an international expert panel, on behalf of the European Leukemia Net. Blood. 115:453–474. 2010.PubMed/NCBI View Article : Google Scholar

4 

Dohner H, Weisdorf DJ and Bloomfield CD: Acute myeloid leukemia. N Engl J Med. 373:1136–1152. 2015.PubMed/NCBI View Article : Google Scholar

5 

Stein EM and Tallman MS: Emerging therapeutic drugs for AML. Blood. 127:71–78. 2016.PubMed/NCBI View Article : Google Scholar

6 

Xie Y, Davies SM, Xiang Y, Robison LL and Ross JA: Trends in leukemia incidence and survival in the United States (1973-1998). Cancer. 97:2229–2235. 2003.PubMed/NCBI View Article : Google Scholar

7 

Luke C, Nguyen AM, To B, Seshadri R, Hughes T, Bardy P, Colbeck M, Buranyi-Trevarton D, McMellon M and Roder D: Myeloid leukaemia treatment and survival-the South Australian experience, 1977 to 2002. Asian Pac J Cancer Prev. 7:227–233. 2006.PubMed/NCBI

8 

Norsworthy KJ, DeZern AE, Tsai HL, Hand WA, Varadhan R, Gore SD, Gojo I, Pratz K, Carraway HE, Showel M, et al: Timed sequential therapy for acute myelogenous leukemia: Results of a retrospective study of 301 patients and review of the literature. Leuk Res. 61:25–32. 2017.PubMed/NCBI View Article : Google Scholar

9 

Khaled S, Al-Malki M and Marcucci G: Acute myeloid leukemia: Biologic, prognostic, and therapeutic insights. Oncology (Williston Park). 30:318–329. 2016.PubMed/NCBI

10 

Tallman MS, Gilliland DG and Rowe JM: Drug therapy for acute myeloid leukemia. Blood. 106:1154–1163. 2005.PubMed/NCBI View Article : Google Scholar

11 

Zeidner JF, Foster MC, Blackford AL, Litzow MR, Morris LE, Strickland SA, Lancet JE, Bose P, Levy MY, Tibes R, et al: Final results of a randomized multicenter phase II study of alvocidib, cytarabine and mitoxantrone versus cytarabine and daunorubicin (7 + 3) in newly diagnosed high-risk acute myeloid leukemia (AML). Leuk Res. 72:92–95. 2018.PubMed/NCBI View Article : Google Scholar

12 

Saini NY, Cerny J, Furtado VF, Desmond A, Zhou Z, Raffel G, Puthawala I, Bednarik J, Shanahan L, Miron PM, et al: Elderly do benefit from induction chemotherapy: High dose mitoxantrone-based (‘5 + 1’) induction chemotherapy regimen in newly diagnosed acute myeloid leukemia. Am J Hematol. 94:209–215. 2018.PubMed/NCBI View Article : Google Scholar

13 

Pardee TS, Anderson RG, Pladna KM, Isom S, Ghiraldeli LP, Miller LD, Chou JW, Jin G, Zhang W, Ellis LR, et al: A Phase I study of CPI-613 in combination with high-dose cytarabine and mitoxantrone for relapsed or refractory acute myeloid leukemia. Clin Cancer Res. 24:2060–2073. 2018.PubMed/NCBI View Article : Google Scholar

14 

Ahmed T, Holwerda S, Klepin HD, Isom S, Ellis LR, Lyerly S, Manuel M, Dralle S, Berenzon D, Powell BL and Pardee TS: High dose cytarabine, mitoxantrone and l-asparaginase (HAMA) salvage for relapsed or refractory acute myeloid leukemia (AML) in the elderly. Leuk Res. 39:945–949. 2015.PubMed/NCBI View Article : Google Scholar

15 

Jia LT, Chen SY and Yang AG: Cancer gene therapy targeting cellular apoptosis machinery. Cancer Treat Rev. 38:868–876. 2012.PubMed/NCBI View Article : Google Scholar

16 

Dübbers A, Würthwein G, Müller HJ, Schulze-Westhoff P, Winkelhorst M, Kurzknabe E, Lanvers C, Pieters R, Kaspers GJ, Creutzig U, et al: Asparagine synthetase activity in paediatric acute leukaemias: AML-M5 subtype shows lowest activity. Br J Haematol. 109:427–429. 2000.PubMed/NCBI View Article : Google Scholar

17 

Baud V and Karin M: Signal transduction by tumor necrosis factor and its relatives. Trends Cell Biol. 11:372–377. 2001.PubMed/NCBI View Article : Google Scholar

18 

Shen HM and Pervaiz S: TNF receptor superfamily-induced cell death: Redox-dependent execution. FASEB J. 20:1589–1598. 2006.PubMed/NCBI View Article : Google Scholar

19 

Galluzzi L, Pietrocola F, Bravo-San Pedro JM, Amaravadi RK, Baehrecke EH, Cecconi F, Codogno P, Debnath J, Gewirtz DA, Karantza V, et al: Autophagy in malignant transformation and cancer progression. EMBO J. 34:856–880. 2015.PubMed/NCBI View Article : Google Scholar

20 

Puissant A, Robert G and Auberger P: Targeting autophagy to fight hematopoietic malignancies. Cell Cycle. 9:3470–3478. 2010.PubMed/NCBI View Article : Google Scholar

21 

Lin L and Baehrecke EH: Autophagy, cell death, and cancer. Mol Cell Oncol. 2(e985913)2015.PubMed/NCBI View Article : Google Scholar

22 

Tanida I, Sou YS, Minematsu-Ikeguchi N, Ueno T and Kominami E: Atg8L/Apg8L is the fourth mammalian modifier of mammalian Atg8 conjugation mediated by human Atg4B, Atg7 and Atg3. FEBS J. 273:2553–2562. 2006.PubMed/NCBI View Article : Google Scholar

23 

Mann SS and Hammarback JA: Molecular characterization of light chain 3. A microtubule binding subunit of MAP1A and MAP1B. J Biol Chem. 269:11492–11497. 1994.PubMed/NCBI

24 

Wu J, Dang Y, Su W, Liu C, Ma H, Shan Y, Pei Y, Wan B, Guo J and Yu L: Molecular cloning and characterization of rat LC3A and LC3B-two novel markers of autophagosome. Biochem Biophys Res Commun. 339:437–442. 2006.PubMed/NCBI View Article : Google Scholar

25 

Shpilka T, Weidberg H, Pietrokovski S and Elazar Z: Atg8: An autophagy-related ubiquitin-like protein family. Genome Biol. 12(226)2011.PubMed/NCBI View Article : Google Scholar

26 

He H, Dang Y, Dai F, Guo Z, Wu J, She X, Pei Y, Chen Y, Ling W, Wu C, et al: Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B. J Biol Chem. 278:29278–29287. 2003.PubMed/NCBI View Article : Google Scholar

27 

Sou YS, Tanida I, Komatsu M, Ueno T and Kominami E: Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16. J Biol Chem. 281:3017–3024. 2006.PubMed/NCBI View Article : Google Scholar

28 

Taguchi-Atarashi N, Hamasaki M, Matsunaga K, Omori H, Ktistakis NT, Yoshimori T and Noda T: Modulation of local PtdIns3P levels by the PI phosphatase MTMR3 regulates constitutive autophagy. Traffic. 11:468–478. 2010.PubMed/NCBI View Article : Google Scholar

29 

Tanida I: Autophagy basics. Microbiol Immunol. 55:1–11. 2011.PubMed/NCBI View Article : Google Scholar

30 

Song P, Ye L, Fan J, Li Y, Zeng X, Wang Z, Wang S, Zhang G, Yang P, Cao Z and Ju D: Asparaginase induces apoptosis and cytoprotective autophagy in chronic myeloid leukemia cells. Oncotarget. 6:3861–3873. 2015.PubMed/NCBI View Article : Google Scholar

31 

Yoshii SR and Mizushima N: Monitoring and measuring autophagy. Int J Mol Sci. 18(pii: E1865)2017.PubMed/NCBI View Article : Google Scholar

32 

Gollner S, Oellerich T, Agrawal-Singh S, Schenk T, Klein HU, Rohde C, Pabst C, Sauer T, Lerdrup M, Tavor S, et al: Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia. Nat Med. 23:69–78. 2017.PubMed/NCBI View Article : Google Scholar

33 

Hourigan CS, Gale RP, Gormley NJ, Ossenkoppele GJ and Walter RB: Measurable residual disease testing in acute myeloid leukaemia. Leukemia. 31:1482–1490. 2017.PubMed/NCBI View Article : Google Scholar

34 

Xu B, Zhao Y, Wang X, Gong P and Ge W: MZH29 is a novel potent inhibitor that overcomes drug resistance FLT3 mutations in acute myeloid leukemia. Leukemia. 31:913–921. 2017.PubMed/NCBI View Article : Google Scholar

35 

Pollyea DA and Jordan CT: Therapeutic targeting of acute myeloid leukemia stem cells. Blood. 129:1627–1635. 2017.PubMed/NCBI View Article : Google Scholar

36 

Estey EH: Treatment of acute myeloid leukemia. Haematologica. 94:10–16. 2009.PubMed/NCBI View Article : Google Scholar

37 

Subramanian S and Kartha RV: MicroRNA-mediated gene regulations in human sarcomas. Cell Mol Life Sci. 69:3571–3585. 2012.PubMed/NCBI View Article : Google Scholar

38 

Kabat AM, Pott J and Maloy KJ: The mucosal immune system and its regulation by autophagy. Front Immunol. 7(240)2016.PubMed/NCBI View Article : Google Scholar

39 

Ndoye A and Weeraratna AT: Autophagy-An emerging target for melanoma therapy. F1000Res. 5(pii: F1000)2016.PubMed/NCBI View Article : Google Scholar

40 

Li CJ, Liao WT, Wu MY and Chu PY: New insights into the role of autophagy in tumor immune microenvironment. Int J Mol Sci. 18(pii: E1566)2017.PubMed/NCBI View Article : Google Scholar

41 

Zhang WX, Zhou JC, Peng D, Hua F, Li K, Yu JJ, Lv XX, Cui B, Liu SS, Yu JM, et al: Disrupting the TRIB3-SQSTM1 interaction reduces liver fibrosis by restoring autophagy and suppressing exosome-mediated HSC activation. Autophagy. 1–15. 2019.PubMed/NCBI View Article : Google Scholar

42 

Karvela M, Baquero P, Kuntz EM, Mukhopadhyay A, Mitchell R, Allan EK, Chan E, Kranc KR, Calabretta B, Salomoni P, et al: ATG7 regulates energy metabolism, differentiation and survival of Philadelphia-chromosome-positive cells. Autophagy. 12:936–948. 2016.PubMed/NCBI View Article : Google Scholar

43 

Rothe K, Lin H, Lin KB, Leung A, Wang HM, Malekesmaeili M, Brinkman RR, Forrest DL, Gorski SM and Jiang X: The core autophagy protein ATG4B is a potential biomarker and therapeutic target in CML stem/progenitor cells. Blood. 123:3622–3634. 2014.PubMed/NCBI View Article : Google Scholar

44 

Yu Y, Zhang X, Tian H, Zhang Z and Tian Y: Knockdown of long non-coding RNA HOTAIR increases cisplatin sensitivity in ovarian cancer by inhibiting cisplatin-induced autophagy. J BUON. 23:1396–1401. 2018.PubMed/NCBI

45 

Song X, Liu L, Chang M, Geng X, Wang X, Wang W, Chen TC, Xie L and Song X: NEO212 induces mitochondrial apoptosis and impairs autophagy flux in ovarian cancer. J Exp Clin Cancer. 38(239)2019.PubMed/NCBI View Article : Google Scholar

46 

Gong C, Bauvy C, Tonelli G, Yue W, Deloménie C, Nicolas V, Zhu Y, Domergue V, Marin-Esteban V, Tharinger H, et al: Beclin 1 and autophagy are required for the tumorigenicity of breast cancer stem-like/progenitor cells. Oncogene. 322261–2672. (2272e.1-11)2013.PubMed/NCBI View Article : Google Scholar

47 

Mitter SK, Song C, Qi X, Mao H, Rao H, Akin D, Lewin A, Grant M, Dunn W Jr, Ding J, et al: Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD. Autophagy. 10:1989–2005. 2014.PubMed/NCBI View Article : Google Scholar

48 

Lu Z, Chen C, Wu Z, Miao Y, Muhammad I, Ding L, Tian E, Hu W, Ni H, Li R, et al: A dual role of P53 in regulating colistin-induced autophagy in PC-12 cells. Front Pharmacol. 8(768)2017.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Chen T, Zhang J, Zeng H, Zhang Y, Zhang Y, Zhou X and Zhou H: Antiproliferative effects of L‑asparaginase in acute myeloid leukemia. Exp Ther Med 20: 2070-2078, 2020.
APA
Chen, T., Zhang, J., Zeng, H., Zhang, Y., Zhang, Y., Zhou, X., & Zhou, H. (2020). Antiproliferative effects of L‑asparaginase in acute myeloid leukemia. Experimental and Therapeutic Medicine, 20, 2070-2078. https://doi.org/10.3892/etm.2020.8904
MLA
Chen, T., Zhang, J., Zeng, H., Zhang, Y., Zhang, Y., Zhou, X., Zhou, H."Antiproliferative effects of L‑asparaginase in acute myeloid leukemia". Experimental and Therapeutic Medicine 20.3 (2020): 2070-2078.
Chicago
Chen, T., Zhang, J., Zeng, H., Zhang, Y., Zhang, Y., Zhou, X., Zhou, H."Antiproliferative effects of L‑asparaginase in acute myeloid leukemia". Experimental and Therapeutic Medicine 20, no. 3 (2020): 2070-2078. https://doi.org/10.3892/etm.2020.8904
Copy and paste a formatted citation
x
Spandidos Publications style
Chen T, Zhang J, Zeng H, Zhang Y, Zhang Y, Zhou X and Zhou H: Antiproliferative effects of L‑asparaginase in acute myeloid leukemia. Exp Ther Med 20: 2070-2078, 2020.
APA
Chen, T., Zhang, J., Zeng, H., Zhang, Y., Zhang, Y., Zhou, X., & Zhou, H. (2020). Antiproliferative effects of L‑asparaginase in acute myeloid leukemia. Experimental and Therapeutic Medicine, 20, 2070-2078. https://doi.org/10.3892/etm.2020.8904
MLA
Chen, T., Zhang, J., Zeng, H., Zhang, Y., Zhang, Y., Zhou, X., Zhou, H."Antiproliferative effects of L‑asparaginase in acute myeloid leukemia". Experimental and Therapeutic Medicine 20.3 (2020): 2070-2078.
Chicago
Chen, T., Zhang, J., Zeng, H., Zhang, Y., Zhang, Y., Zhou, X., Zhou, H."Antiproliferative effects of L‑asparaginase in acute myeloid leukemia". Experimental and Therapeutic Medicine 20, no. 3 (2020): 2070-2078. https://doi.org/10.3892/etm.2020.8904
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