Open Access

Interleukin‑1α and ‑1β assessment in the gingival crevicular fluid of periodontal patients with chronic hepatitis C

  • Authors:
    • Petra Surlin
    • Dorin Nicolae Gheorghe
    • Dora Maria Popescu
    • Alexandra Maria Martu
    • Sorina Solomon
    • Alexandra Roman
    • Luminita Lazar
    • Stefan Ioan Stratul
    • Darian Rusu
    • Liliana Foia
    • Mihail Virgil Boldeanu
    • Lidia Boldeanu
    • Monica Danilescu
    • Ion Rogoveanu
  • View Affiliations

  • Published online on: June 18, 2020     https://doi.org/10.3892/etm.2020.8906
  • Pages: 2381-2386
  • Copyright: © Surlin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The study assessed whether the increased production of interleukin‑1α (IL‑1α) and interleukin‑1β (IL‑1β), as a result of chronic hepatic inflammation, could be the expression of the negative impact on periodontal disease. The study included chronic periodontitis patients who were systemically healthy, chronic periodontitis patients suffering from chronic hepatitis C, as well as control patients, being systemically and periodontally healthy. After periodontal examination and the assessment of certain periodontal parameters, gingival crevicular fluid was collected from all participating patients. By using the enzyme‑linked immunosorbent assay method, a quantitative assessment of IL‑1α and IL‑1β levels was possible. The immunologic results were correlated to the clinical periodontal data. The gingival fluid levels of cytokines were higher for periodontitis patients with chronic hepatitis C than for the systemically healthy periodontitis patients (1.8‑fold higher for IL‑1α and 2.1‑fold higher for IL‑1β). In addition, the gingival fluid cytokine levels were significantly higher for the periodontal patients (with/without chronic hepatitis C) than for the control group. Positive correlations were found between gingival fluid IL‑1α and IL‑1β levels and certain clinical periodontal parameters or the age of the viral hepatitis C diagnosis, in periodontitis patients with chronic hepatitis C. The chronic hepatic inflammation may have an important additional negative impact on the periodontal status, as both inflammatory reactions seem to be promoted by common pro‑inflammatory cytokines.

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September-2020
Volume 20 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Surlin P, Gheorghe DN, Popescu DM, Martu AM, Solomon S, Roman A, Lazar L, Stratul SI, Rusu D, Foia L, Foia L, et al: Interleukin‑1α and ‑1β assessment in the gingival crevicular fluid of periodontal patients with chronic hepatitis C. Exp Ther Med 20: 2381-2386, 2020
APA
Surlin, P., Gheorghe, D.N., Popescu, D.M., Martu, A.M., Solomon, S., Roman, A. ... Rogoveanu, I. (2020). Interleukin‑1α and ‑1β assessment in the gingival crevicular fluid of periodontal patients with chronic hepatitis C. Experimental and Therapeutic Medicine, 20, 2381-2386. https://doi.org/10.3892/etm.2020.8906
MLA
Surlin, P., Gheorghe, D. N., Popescu, D. M., Martu, A. M., Solomon, S., Roman, A., Lazar, L., Stratul, S. I., Rusu, D., Foia, L., Boldeanu, M. V., Boldeanu, L., Danilescu, M., Rogoveanu, I."Interleukin‑1α and ‑1β assessment in the gingival crevicular fluid of periodontal patients with chronic hepatitis C". Experimental and Therapeutic Medicine 20.3 (2020): 2381-2386.
Chicago
Surlin, P., Gheorghe, D. N., Popescu, D. M., Martu, A. M., Solomon, S., Roman, A., Lazar, L., Stratul, S. I., Rusu, D., Foia, L., Boldeanu, M. V., Boldeanu, L., Danilescu, M., Rogoveanu, I."Interleukin‑1α and ‑1β assessment in the gingival crevicular fluid of periodontal patients with chronic hepatitis C". Experimental and Therapeutic Medicine 20, no. 3 (2020): 2381-2386. https://doi.org/10.3892/etm.2020.8906