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CD271+ stem cell treatment of patients with chronic stroke: A retrospective case series report

Corrigendum in: /10.3892/etm.2023.12243
  • Authors:
    • Felician Stancioiu
    • Georgios Z. Papadakis
    • George Lazopoulos
    • Demetrios A. Spandidos
    • Aristidis Tsatsakis
    • Marius Floroiu
    • Corin Badiu
  • View Affiliations / Copyright

    Affiliations: Bio‑Forum Foundation, 030121 Bucharest, Romania, Department of Radiology, Medical School, University of Crete, 71003 Heraklion, Greece, Department of Cardiothoracic Surgery, University General Hospital of Heraklion, 71003 Heraklion, Greece, Laboratory of Clinical Virology, Medical School, University of Crete, 71003 Heraklion, Greece, Laboratory of Toxicology, Medical School, University of Crete, 71003 Heraklion, Greece, Cardiovascular Surgery Department, Angiomedica Hospital, 020657 Bucharest, Romania, CI Parhon Institute of Endocrinology, 011863 Bucharest, Romania
    Copyright: © Stancioiu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2055-2062
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    Published online on: June 26, 2020
       https://doi.org/10.3892/etm.2020.8948
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Abstract

Patients with chronic stroke have currently little hope for motor improvement towards regaining independent activities of daily living; stem cell treatments offer a new treatment option and needs to be developed. Patients with chronic stroke (more than 3 months prior to stem cell treatment, mean 21.2 months post‑stroke) were treated with CD271+ stem cells, 7 patients received autologous and 1 allogeneic cells from first degree relative; administration was intravenous in 1 and intrathecal in 7 patients. Each patient received a single treatment consisting of 2‑5x106 cells/kg and they were followed up for up to 12 months. There were significant improvements in expressive aphasia (2/3 patients) spasticity (5/5, of which 2 were transient), and small improvements in motor function (2/8 patients). Although motor improvements were minor in our chronic stroke patients, improvements in aphasia and spasticity were significant and in the context of good safety we are advocating further administration and clinical studies of CD271+ stem cells not only in chronic stroke patients, but also for spastic paresis/plegia; a different, yet unexplored application is pulmonary emphysema.
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Copy and paste a formatted citation
Spandidos Publications style
Stancioiu F, Papadakis GZ, Lazopoulos G, Spandidos DA, Tsatsakis A, Floroiu M and Badiu C: CD271+ stem cell treatment of patients with chronic stroke: A retrospective case series report Corrigendum in /10.3892/etm.2023.12243. Exp Ther Med 20: 2055-2062, 2020.
APA
Stancioiu, F., Papadakis, G.Z., Lazopoulos, G., Spandidos, D.A., Tsatsakis, A., Floroiu, M., & Badiu, C. (2020). CD271+ stem cell treatment of patients with chronic stroke: A retrospective case series report Corrigendum in /10.3892/etm.2023.12243. Experimental and Therapeutic Medicine, 20, 2055-2062. https://doi.org/10.3892/etm.2020.8948
MLA
Stancioiu, F., Papadakis, G. Z., Lazopoulos, G., Spandidos, D. A., Tsatsakis, A., Floroiu, M., Badiu, C."CD271+ stem cell treatment of patients with chronic stroke: A retrospective case series report Corrigendum in /10.3892/etm.2023.12243". Experimental and Therapeutic Medicine 20.3 (2020): 2055-2062.
Chicago
Stancioiu, F., Papadakis, G. Z., Lazopoulos, G., Spandidos, D. A., Tsatsakis, A., Floroiu, M., Badiu, C."CD271+ stem cell treatment of patients with chronic stroke: A retrospective case series report Corrigendum in /10.3892/etm.2023.12243". Experimental and Therapeutic Medicine 20, no. 3 (2020): 2055-2062. https://doi.org/10.3892/etm.2020.8948
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Spandidos Publications style
Stancioiu F, Papadakis GZ, Lazopoulos G, Spandidos DA, Tsatsakis A, Floroiu M and Badiu C: CD271+ stem cell treatment of patients with chronic stroke: A retrospective case series report Corrigendum in /10.3892/etm.2023.12243. Exp Ther Med 20: 2055-2062, 2020.
APA
Stancioiu, F., Papadakis, G.Z., Lazopoulos, G., Spandidos, D.A., Tsatsakis, A., Floroiu, M., & Badiu, C. (2020). CD271+ stem cell treatment of patients with chronic stroke: A retrospective case series report Corrigendum in /10.3892/etm.2023.12243. Experimental and Therapeutic Medicine, 20, 2055-2062. https://doi.org/10.3892/etm.2020.8948
MLA
Stancioiu, F., Papadakis, G. Z., Lazopoulos, G., Spandidos, D. A., Tsatsakis, A., Floroiu, M., Badiu, C."CD271+ stem cell treatment of patients with chronic stroke: A retrospective case series report Corrigendum in /10.3892/etm.2023.12243". Experimental and Therapeutic Medicine 20.3 (2020): 2055-2062.
Chicago
Stancioiu, F., Papadakis, G. Z., Lazopoulos, G., Spandidos, D. A., Tsatsakis, A., Floroiu, M., Badiu, C."CD271+ stem cell treatment of patients with chronic stroke: A retrospective case series report Corrigendum in /10.3892/etm.2023.12243". Experimental and Therapeutic Medicine 20, no. 3 (2020): 2055-2062. https://doi.org/10.3892/etm.2020.8948
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