Open Access

Expression levels of CXCR4 and CXCL12 in patients with rheumatoid arthritis and its correlation with disease activity

  • Authors:
    • Liping Peng
    • Ning Zhu
    • Jing Mao
    • Li Huang
    • Yameng Yang
    • Zhengju Zhou
    • Li Wang
    • Bin Wu
  • View Affiliations

  • Published online on: June 26, 2020     https://doi.org/10.3892/etm.2020.8950
  • Pages: 1925-1934
  • Copyright: © Peng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study aimed to investigate the expression levels of C‑X‑C motif chemokine receptor 4 (CXCR4) and CXC ligand 12 (CXCL12) in patients with rheumatoid arthritis (RA) and the correlation with disease activity. In total, 60 patients with RA were selected as the study group, comprising of 28 patients in active‑stage and 32 patients in remission‑stage. In addition, 60 patients with osteoarthritis were selected as the control group. Western blotting and ELISA were used to detect the expression of CXCR4 and CXCL12, respectively. The Spearman's correlation test was used to analyze correlations between CXCR4 and CXCL12, and erythrocyte sedimentation rate (ESR), C‑reactive protein (CRP), disease activity score 28 (DAS28) scores and rheumatoid factor (RF). The present results suggested that CXCR4 and CXCL12 expression levels in the serum and joint synovial fluid of the study group were significantly higher compared with the control group (P<0.05). Moreover, CXCR4 and CXCL12 expression levels in the RA‑active group were higher compared with the remission (P<0.05) and control groups (P<0.01). The Pearson test results suggested that the expression levels of CXCR4 and CXCL12 in the serum and joint synovial fluid of patients with RA had a positive correlation with the ESR, CRP, RF and DAS28 scores (P<0.05). CXCL12 and CXCR4 were highly expressed in the serum and joint synovial fluid of patients with RA, and these expression levels were positively correlated with ESR, CRP, RF and DAS28 scores. Therefore, these clinical parameters may be used as indicators to evaluate the disease activity of patients with RA.

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September-2020
Volume 20 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Peng L, Zhu N, Mao J, Huang L, Yang Y, Zhou Z, Wang L and Wu B: Expression levels of CXCR4 and CXCL12 in patients with rheumatoid arthritis and its correlation with disease activity. Exp Ther Med 20: 1925-1934, 2020
APA
Peng, L., Zhu, N., Mao, J., Huang, L., Yang, Y., Zhou, Z. ... Wu, B. (2020). Expression levels of CXCR4 and CXCL12 in patients with rheumatoid arthritis and its correlation with disease activity. Experimental and Therapeutic Medicine, 20, 1925-1934. https://doi.org/10.3892/etm.2020.8950
MLA
Peng, L., Zhu, N., Mao, J., Huang, L., Yang, Y., Zhou, Z., Wang, L., Wu, B."Expression levels of CXCR4 and CXCL12 in patients with rheumatoid arthritis and its correlation with disease activity". Experimental and Therapeutic Medicine 20.3 (2020): 1925-1934.
Chicago
Peng, L., Zhu, N., Mao, J., Huang, L., Yang, Y., Zhou, Z., Wang, L., Wu, B."Expression levels of CXCR4 and CXCL12 in patients with rheumatoid arthritis and its correlation with disease activity". Experimental and Therapeutic Medicine 20, no. 3 (2020): 1925-1934. https://doi.org/10.3892/etm.2020.8950