Effects of lentinan on NF‑κB activity in the liver of burn rats with sepsis

  • Authors:
    • Qianwen Lv
    • Yunpeng Gu
    • Yue Qi
    • Zhenjun Liu
    • Gui‑E Ma
  • View Affiliations

  • Published online on: June 29, 2020     https://doi.org/10.3892/etm.2020.8955
  • Pages: 2279-2283
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Abstract

Effects of lentinan on nuclear factor-κB (NF-κB) activity in liver of burn rats with sepsis were investigated. To mimic the clinical sepsis after burn, rats were subjected to 30% full‑thickness scald injury, followed by intraperitoneal (i.p.) injection of lipopolysaccharide (LPS). Seventy‑two adult rats were randomly divided into six groups: the normal control group (n=12); the burn sepsis group (n=12); the burn sepsis with positive drugs; the burn sepsis with low‑dose lentinan treatment group (50.0 mg/kg, n=12); the burn sepsis with middle‑dose lentinan treatment group (100.0 mg/kg, n=12) and the burn sepsis with high‑dose lentinan treatment group (200.0 mg/kg, n=12). Expression of NF‑κB in the liver was measured with western blot analysis. The morphology of liver was evaluated with hematoxylin and eosin staining. The expression of NF‑κB significantly increased in the liver of burn rats with sepsis. Compared with the burn sepsis group, lentinan treatment obviously reduced the damage of hepatic cell morphology, and decreased the activity of NF‑κB significantly in the medium and high concentrations of lentinan treatment groups (P<0.05). Most importantly, treatment with lentinan was able to reverse the increased concentration of IL‑4, IL‑6, IL‑10 and TNF‑α in plasma which was induced by LPS. Lentinan treatment can significantly decrease the expression of NF‑κB in the liver of burn rats with sepsis.

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September-2020
Volume 20 Issue 3

Print ISSN: 1792-0981
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Spandidos Publications style
Lv Q, Gu Y, Qi Y, Liu Z and Ma GE: Effects of lentinan on NF‑κB activity in the liver of burn rats with sepsis. Exp Ther Med 20: 2279-2283, 2020
APA
Lv, Q., Gu, Y., Qi, Y., Liu, Z., & Ma, G. (2020). Effects of lentinan on NF‑κB activity in the liver of burn rats with sepsis. Experimental and Therapeutic Medicine, 20, 2279-2283. https://doi.org/10.3892/etm.2020.8955
MLA
Lv, Q., Gu, Y., Qi, Y., Liu, Z., Ma, G."Effects of lentinan on NF‑κB activity in the liver of burn rats with sepsis". Experimental and Therapeutic Medicine 20.3 (2020): 2279-2283.
Chicago
Lv, Q., Gu, Y., Qi, Y., Liu, Z., Ma, G."Effects of lentinan on NF‑κB activity in the liver of burn rats with sepsis". Experimental and Therapeutic Medicine 20, no. 3 (2020): 2279-2283. https://doi.org/10.3892/etm.2020.8955