Treatment of acute pancreatitis with pancreatic duct decompression via ERCP: A case report series

Wang,Zouzheng; Wang,Qi; Song,Jianjun; Li,Ming; Wang,Feng; Chen,Bendong; Lu,Zhenhui; Chen,Hong; Wang,Na; Yong,Li; Yao,Weijie

doi:10.3892/etm.2020.8962

September-2020 Volume 20 Issue 3

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

September-2020 Volume 20 Issue 3

Full Size Image

Case Report Open Access

Treatment of acute pancreatitis with pancreatic duct decompression via ERCP: A case report series

Authors:
- Zouzheng Wang
- Qi Wang
- Jianjun Song
- Ming Li
- Feng Wang
- Bendong Chen
- Zhenhui Lu
- Hong Chen
- Na Wang
- Li Yong
- Weijie Yao
View Affiliations / Copyright

Affiliations: Department of Hepatobiliary Surgery, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, P.R. China

Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 2593-2598
|
Published online on: June 30, 2020

https://doi.org/10.3892/etm.2020.8962
Expand metrics +

Abstract

Acute pancreatitis is a common disorder in the gastrointestinal system, which is characterized by an increasing incidence and a high mortality. Currently, symptomatic treatment becomes the predominant option for the treatment of acute pancreatitis. To date, there is little knowledge on the treatment of acute pancreatitis through alleviation of pancreatic ductal hypertension and removal of pancreatic ductal obstruction. Endoscopic retrograde cholangiopancreatography (ERCP), an effective treatment for acute biliary pancreatitis, may alleviate the obstruction and edema in the common channel of the bile duct and pancreatic duct, to achieve the indirect treatment of acute pancreatitis, and may achieve the removal of intrapancreatic ductal obstruction and reduction in the intrapancreatic ductal pressure. Hereby, we report 3 cases with acute pancreatitis that were successfully treated by the pancreatic duct decompression via ERCP in one single center from China. Our data demonstrate that pancreatic duct decompression via ERCP is effective for the treatment of acute pancreatitis, which may shorten the course of acute pancreatitis through alleviating pain, shortening fasting duration and controlling the inflammatory reactions. It is recommended to use further prospective, randomized, controlled clinical trials to evaluate the efficacy and safety of pancreatic duct decompression via ERCP for acute pancreatitis.

View Figures

View References

1	Lankisch PG, Apte M and Banks PA: Acute pancreatitis. Lancet. 386:85–96. 2015.PubMed/NCBI View Article : Google Scholar
2	Yokoe M, Takada T, Mayumi T, Yoshida M, Isaji S, Wada K, Itoi T, Sata N, Gabata T, Igarashi H, et al: Japanese guidelines for the management of acute pancreatitis: Japanese Guidelines 2015. J Hepatobiliary Pancreat Sci. 22:405–432. 2015.PubMed/NCBI View Article : Google Scholar
3	Working Group IAP/APA Acute Pancreatitis Guidelines. IAP/APA evidence-based guidelines for the management of acute pancreatitis. Pancreatology. 13 (Suppl 2):e1–e15. 2013.PubMed/NCBI View Article : Google Scholar
4	Tenner S, Baillie J, DeWitt J and Vege SS: American College of Gastroenterology. American College of Gastroenterology Guideline: Management of acute pancreatitis. Am J Gastroenterol. 108:1400–15. 2013.PubMed/NCBI View Article : Google Scholar
5	Janisch NH and Gardner TB: Advances in management of acute pancreatitis. Gastroenterol Clin North Am. 45:1–8. 2016.PubMed/NCBI View Article : Google Scholar
6	Bhatia M, Wong FL, Cao Y, Lau HY, Huang J, Puneet P and Chevali L: Pathophysiology of acute pancreatitis. Pancreatology. 5:132–144. 2005.PubMed/NCBI View Article : Google Scholar
7	Kapetanos DJ: ERCP in acute biliary pancreatitis. World J Gastrointest Endosc. 2:25–28. 2010.PubMed/NCBI View Article : Google Scholar
8	Delhaye M, Matos C, Arvanitakis M and Deviere J: Pancreatic ductal system obstruction and acute recurrent pancreatitis. World J Gastroenterol. 14:1027–1033. 2008.PubMed/NCBI View Article : Google Scholar
9	Harvey MH, Wedgwood KR, Austin JA and Reber HA: Pancreatic duct pressure, duct permeability and acute pancreatitis. Br J Surg. 76:859–862. 1989.PubMed/NCBI View Article : Google Scholar
10	Arendt T, Nizze H, Mönig H, Kloehn S, Stüber E and Fölsch UR: Biliary pancreatic reflux-induced acute pancreatitis-myth or possibility? Eur J Gastroenterol Hepatol. 11:329–335. 1999.PubMed/NCBI View Article : Google Scholar
11	Siqin D, Wang C, Zhou Z and Li Y: The key event of acute pancreatitis: Pancreatic duct obstruction and bile reflux, not a single one can be omitted. Med Hypotheses. 72:589–591. 2009.PubMed/NCBI View Article : Google Scholar
12	Fujiwara H: Pressure measurement in pancreatic duct and biliary duct system in dogs with acute pancreatitis. Kobe J Med Sci. 37:47–55. 1991.PubMed/NCBI
13	Shi CX, Chen JW, Carati CJ, Schloithe AC, Toouli J and Saccone GT: Effects of acute pancreatic duct obstruction on pancreatic perfusion: Implication of acute pancreatic duct decompression. Scand J Gastroenterol. 37:1328–1333. 2002.PubMed/NCBI View Article : Google Scholar
14	Arendt T: Bile-induced acute pancreatitis in cats. Roles of bile, bacteria, and pancreatic duct pressure. Dig Dis Sci. 38:39–44. 1993.PubMed/NCBI View Article : Google Scholar
15	Fantini L, Tomassetti P and Pezzilli R: Management of acute pancreatitis: Current knowledge and future perspectives. World J Emerg Surg. 1(16)2006.PubMed/NCBI View Article : Google Scholar
16	Seicean A and Vultur S: Endoscopic therapy in chronic pancreatitis: Current perspectives. Clin Exp Gastroenterol. 8:1–11. 2014.PubMed/NCBI View Article : Google Scholar
17	Nadkarni NA, Kotwal V, Sarr MG and Swaroop Vege S: Disconnected pancreatic duct syndrome: Endoscopic stent or surgeon's knife? Pancreas. 44:16–22. 2015.PubMed/NCBI View Article : Google Scholar

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Treatment of acute pancreatitis with pancreatic duct decompression via ERCP: A case report series

This article is mentioned in:

Abstract

Figure 1

Figure 2

Figure 3

Related Articles