Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
October-2020 Volume 20 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2020 Volume 20 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review

Glucagonoma: From skin lesions to the neuroendocrine component (Review)

  • Authors:
    • Florica Sandru
    • Mara Carsote
    • Simona Elena Albu
    • Ana Valea
    • Aida Petca
    • Mihai Cristian Dumitrascu
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, ‘Elias’ Emergency University Hospital, 125100 Bucharest, Romania, Department of Endocrinology,‘C.I. Parhon’ National Institute of Endocrinology, 011863 Bucharest, Romania, Department of Gynecology, Emergency University Hospital, 050098 Bucharest, Romania, Department of Endocrinology, Clinical County Hospital, 400000 Cluj-Napoca, Romania
  • Pages: 3389-3393
    |
    Published online on: July 3, 2020
       https://doi.org/10.3892/etm.2020.8966
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Glucagonoma is a hormonally active rare pancreatic neuroendocrine tumour causing an excess of glucagon. This is a narrative review based on a multidisciplinary approach of the tumour. Typically associated dermatosis is necrolytic migratory erythema (NME) which is most frequently seen at disease onset. Insulin‑dependent diabetes mellitus, depression, diarrhoea, deep vein thrombosis are also identified, as parts of so‑called ‘D’ syndrome. Early diagnosis is life saving due to potential aggressive profile and high risk of liver metastasis. NME as paraneoplastic syndrome may be present for months and even years until adequate recognition and therapy; it is remitted after successful pancreatic surgery. Thus the level of practitioners' awareness is essential. If surgery is not curative, debulking techniques may improve the clinical aspects and even the outcome in association with other procedures such as embolization of hepatic metastasis; ablation of radiofrequency type; medical therapy including chemotherapy, targeted therapy with mTOR inhibitors such as everolimus, PRRT (peptide receptor radiotherapy), and somatostatin analogues (including combinations of medical treatments). Increased awareness of the condition involves multidisciplinary practitioners.
View Figures
View References

1 

John AM and Schwartz RA: Glucagonoma syndrome: A review and update on treatment. J Eur Acad Dermatol Venereol. 30:2016–2022. 2016.PubMed/NCBI View Article : Google Scholar

2 

Mountjoy L and Kollmorgen D: Glucagonoma-associated rash. N Engl J Med. 376(e18)2017.PubMed/NCBI View Article : Google Scholar

3 

Cunha-Silva M, da Costa JG, Faria GA, Massuda JY, Cintra ML, da Costa LB, Assad VM, de Ataíde EC, Mazo DF and Sevá-Pereira T: Diarrhea: A missed D in the 4D glucagonoma syndrome. Autops Case Rep. 9(e2019129)2019.PubMed/NCBI View Article : Google Scholar

4 

Bosch-Amate X, Riera-Monroig J and Iranzo Fernández P: Glucagonoma-related necrolytic migratory erythema. Med Clin (Barc): Sep 9, 2019 (Epub ahead of print). doi: 10.1016/j.medcli.2019.06.027.

5 

Maurelli M, Gisondi P and Girolomoni G: Visual Vignette. Endocr Pract. 26(253)2020.PubMed/NCBI View Article : Google Scholar

6 

Guilbaud T, Berbis P and Birnbaum DJ: Glucagonoma with paraneoplasic dermatitis: Diagnosis and management. J Gastrointest Surg. 24:701–703. 2019.PubMed/NCBI View Article : Google Scholar

7 

Wei J, Song X, Liu X, Ji Z, Ranasinha N, Wu J and Miao Y: Glucagonoma and glucagonoma syndrome: One center's experience of six cases. J Pancreat Cancer. 4:11–16. 2018.PubMed/NCBI View Article : Google Scholar

8 

V'lckova-Laskoska M, Balabanova-Stefanova M, Arsovska-Bezhoska I, Caca-Biljanovska N and Laskoski D: Necrolytic migratory erythema: Complete healing after surgical removal of pancreatic carcinoma. Acta Dermatovenerol Croat. 26:329–332. 2018.PubMed/NCBI

9 

Al-Faouri A, Ajarma K, Alghazawi S, Al-Rawabdeh S and Zayadeen A: Glucagonoma and glucagonoma syndrome: A case report with review of recent advances in management. Case Rep Surg. 2016(1484089)2016.PubMed/NCBI View Article : Google Scholar

10 

Wewer Albrechtsen NJ, Kuhre RE, Pedersen J, Knop FK and Holst JJ: The biology of glucagon and the consequences of hyperglucagonemia. Biomarkers Med. 10:1141–1151. 2016.PubMed/NCBI View Article : Google Scholar

11 

Adeva-Andany MM, Funcasta-Calderón R, Fernández-Fernández C, Castro-Quintela E and Carneiro-Freire N: Metabolic effects of glucagon in humans. J Clin Transl Endocrinol. 15:45–53. 2018.PubMed/NCBI View Article : Google Scholar

12 

Müller TD, Finan B, Clemmensen C, DiMarchi RD and Tschöp MH: The new biology and pharmacology of glucagon. Physiol Rev. 97:721–766. 2017.PubMed/NCBI View Article : Google Scholar

13 

Dumitrascu MC, Stanescu AMA, Bejan C, Sandru F, Toader DO, Radavoi DG, Cotirlet A, Pusta CTJ and Diaconu CC: Obesity and its implications on stress urinary incontinence. Rev Chim Bucharerst. 70:3660–3662. 2019.

14 

Silaghi AC, Poantă L, Valea A, Pais R and Silaghi H: Is epicardial adipose tissue, assessed by echocardiography, a reliable method for visceral adipose tissue prediction? Med Ultrason. 13:15–20. 2011.PubMed/NCBI

15 

Ahrén B: Glucagon - Early breakthroughs and recent discoveries. Peptides. 67:74–81. 2015.PubMed/NCBI View Article : Google Scholar

16 

Stensen S, Gasbjerg LS, Helsted MM, Hartmann B, Christensen MB and Knop FK: GIP and the gut-bone axis - Physiological, pathophysiological and potential therapeutic implications. Peptides. 170197(2019)2019.PubMed/NCBI View Article : Google Scholar

17 

Holst JJ: Incretin therapy for diabetes mellitus type 2. Curr Opin Endocrinol Diabetes Obes. 27:2–10. 2019.PubMed/NCBI View Article : Google Scholar

18 

Müller TD, Finan B, Bloom SR, D'Alessio D, Drucker DJ, Flatt PR, Fritsche A, Gribble F, Grill HJ, Habener JF, et al: Glucagon-like peptide 1 (GLP-1). Mol Metab. 30:72–130. 2019.PubMed/NCBI View Article : Google Scholar

19 

Albulescu DM, Carsote M, Ionovici N, Ghemigian A, Popescu M, Tuculina MJ, Dascalu IT, Preda SA, Tirca T, Petrescu MS, et al: 5-Hydroxytriptamine and skeleton influence Clinical study. Rev Chim Buchar. 69:2438–2442. 2018.

20 

Öberg K: Management of functional neuroendocrine tumors of the pancreas. Gland Surg. 7:20–27. 2018.PubMed/NCBI View Article : Google Scholar

21 

Poiană C, Neamţu MC, Avramescu ET, Carşote M, Trifănescu R, Terzea D, Neamţu OM, Ferechide D and Dănciulescu Miulescu R: The poor prognosis factors in G2 neuroendocrine tumor. Rom J Morphol Embryol. 54 (Suppl 3):717–720. 2013.PubMed/NCBI

22 

Carşote M, Păun S, Neamţu MC, Avramescu ET, Iosif C, Terzea D, Constantinoiu S, Dănciulescu Miulescu R, Neamţu OM and Poiană C: The immunohistochemistry aspects in two cases of neurofibromatosis-associated abdominal tumors. Rom J Morphol Embryol. 53:401–405. 2012.PubMed/NCBI

23 

Lv WF, Han JK, Liu X, Wang SC, Pan BO and Xu AO: Imaging features of glucagonoma syndrome: A case report and review of the literature. Oncol Lett. 9:1579–1582. 2015.PubMed/NCBI View Article : Google Scholar

24 

Kawsar HI, Habib A and Saeed A and Saeed A: Unremitting chronic skin lesions: A case of delayed diagnosis of glucagonoma. J Community Hosp Intern Med Perspect. 9:425–429. 2019.PubMed/NCBI View Article : Google Scholar

25 

Cao X, Wang X, Lu Y, Zhao B, Shi J, Guan Q and Zhang X: Spleen-preserving distal pancreatectomy and lymphadenectomy for glucagonoma syndrome: A case report. Medicine (Baltimore). 98(e17037)2019.PubMed/NCBI View Article : Google Scholar

26 

Wang ZX, Wang F and Zhao JG: Glucagonoma syndrome with severe erythematous rash: A rare case report. Medicine (Baltimore). 98(e17158)2019.PubMed/NCBI View Article : Google Scholar

27 

Song X, Zheng S, Yang G, Xiong G, Cao Z, Feng M, Zhang T and Zhao Y: Glucagonoma and the glucagonoma syndrome. Oncol Lett. 15:2749–2755. 2018.PubMed/NCBI View Article : Google Scholar

28 

Anderson CW and Bennett JJ: Clinical presentation and diagnosis of pancreatic neuroendocrine tumors. Surg Oncol Clin N Am. 25:363–374. 2016.PubMed/NCBI View Article : Google Scholar

29 

Toberer F, Hartschuh W and Wiedemeyer K: Glucagonoma-associated necrolytic migratory erythema: The broad spectrum of the clinical and histopathological findings and clues to the diagnosis. Am J Dermatopathol. 41:e29–e32. 2019.PubMed/NCBI View Article : Google Scholar

30 

Tolliver S, Graham J and Kaffenberger BH: A review of cutaneous manifestations within glucagonoma syndrome: Necrolytic migratory erythema. Int J Dermatol. 57:642–645. 2018.PubMed/NCBI View Article : Google Scholar

31 

Ochi N, Kawahara T, Yamane H and Takigawa N: Erythema as a visual surrogate marker of glucagonoma. Intern Med. 57:2283–2284. 2018.PubMed/NCBI View Article : Google Scholar

32 

He S, Zeng W, Geng S and Jia J: Glucagonoma syndrome with atypical necrolytic migratory erythema. Indian J Dermatol Venereol Leprol: Aug 1, 2019 (Epub ahead of print). doi: 10.4103/ijdvl.IJDVL_588_18.

33 

Martínez Manzano Á, Balsalobre Salmerón MD, García López MA, Soto García S and Vázquez Rojas JL: Psoriasiform lesions: Uncommon presentation of glucagonoma. Gastroenterol Hepatol. 41:500–502. 2018.PubMed/NCBI View Article : Google Scholar

34 

Tremblay C and Marcil I: Necrolytic migratory erythema: A forgotten paraneoplastic condition. J Cutan Med Surg. 21:559–561. 2017.PubMed/NCBI View Article : Google Scholar

35 

Jiménez-Gallo D, Ossorio-García L, de la Varga-Martínez R, Arjona-Aguilera C and Linares-Barrios M: Necrolytic migratory erythema associated with glucagonoma treated successfully with cyclosporine. Dermatol Ther (Heidelb). 30(e12498)2017.PubMed/NCBI View Article : Google Scholar

36 

Parbhu SK and Adler DG: Pancreatic neuroendocrine tumors: contemporary diagnosis and management. Hosp Pract (1995). 44:109–119. 2016.PubMed/NCBI View Article : Google Scholar

37 

Rosenbaum JN and Lloyd RV: Pancreatic neuroendocrine neoplasms. Surg Pathol Clin. 7:559–575. 2014.PubMed/NCBI View Article : Google Scholar

38 

Granberg D: Biochemical testing in patients with neuroendocrine tumors. Front Horm Res. 44:24–39. 2015.PubMed/NCBI View Article : Google Scholar

39 

Rodríguez G, Vargas E, Abaúnza C and Cáceres S: Necrolytic migratory erythema and pancreatic glucagonoma. Biomedica. 36:176–181. 2016.PubMed/NCBI View Article : Google Scholar

40 

Zhang P, Li YL, Qiu XD, Luo J, Shi YF, Sun YL, Su F, Qi ZR and Tan HY: Clinicopathological characteristics and risk factors for recurrence of well-differentiated pancreatic neuroendocrine tumors after radical surgery: A case-control study. World J Surg Oncol. 17(66)2019.PubMed/NCBI View Article : Google Scholar

41 

Barabas M, Huang-Doran I, Pitfield D, Philips H, Goonewardene M, Casey RT and Challis BG: Glucagonoma-associated dilated cardiomyopathy refractory to somatostatin analogue therapy. Endocrinol Diabetes Metab Case Rep: Mar 5, 2019 (Epub ahead of print). doi: 10.1530/EDM-18-0157.

42 

Saavedra C, Lamarca A and Hubner RA: Resolution of necrolytic migratory erythema with somatostatin analogue in a patient diagnosed with pancreatic glucagonoma. BMJ Case Rep. 12(e229115)2019.PubMed/NCBI View Article : Google Scholar

43 

Halperin DM, Kulke MH and Yao JC: A tale of two tumors: Treating pancreatic and extrapancreatic neuroendocrine tumors. Annu Rev Med. 66:1–16. 2015.PubMed/NCBI View Article : Google Scholar

44 

Dimitriadis GK, Weickert MO, Randeva HS, Kaltsas G and Grossman A: Medical management of secretory syndromes related to gastroenteropancreatic neuroendocrine tumours. Endocr Relat Cancer. 23:R423–R436. 2016.PubMed/NCBI View Article : Google Scholar

45 

Jin XF, Spampatti MP, Spitzweg C and Auernhammer CJ: Supportive therapy in gastroenteropancreatic neuroendocrine tumors: Often forgotten but important. Rev Endocr Metab Disord. 19:145–158. 2018.PubMed/NCBI View Article : Google Scholar

46 

Gut P, Waligórska-Stachura J, Czarnywojtek A, Sawicka-Gutaj N, Bączyk M, Ziemnicka K, Fischbach J, Woliński K, Kaznowski J, Wrotkowska E, et al: Management of the hormonal syndrome of neuroendocrine tumors. Arch Med Sci. 13:515–524. 2017.PubMed/NCBI View Article : Google Scholar

47 

Wick MR and Patterson JW: Cutaneous paraneoplastic syndromes. Semin Diagn Pathol. 36:211–228. 2019.PubMed/NCBI View Article : Google Scholar

48 

Eldor R, Glaser B, Fraenkel M, Doviner V, Salmon A and Gross DJ: Glucagonoma and the glucagonoma syndrome-cumulative experience with an elusive endocrine tumour. Clin Endocrinol (Oxf). 74:593–598. 2011.PubMed/NCBI View Article : Google Scholar

49 

Guilmette J and Nosé V: Paraneoplastic syndromes and other systemic disorders associated with neuroendocrine neoplasms. Semin Diagn Pathol. 36:229–239. 2019.PubMed/NCBI View Article : Google Scholar

50 

Ahmad Z, Shastry S, Vuitch F and Garg A: Cirrhosis-induced pseudoglucagonoma syndrome in a patient with type 2 diabetes: An autopsy study. Clin Endocrinol (Oxf). 74:658–660. 2011.PubMed/NCBI View Article : Google Scholar

51 

Liu JW, Qian YT and Ma DL: Necrolytic migratory erythema. JAMA Dermatol: Jul 24, 2019 (Epub ahead of print). doi: 10.1001/jamadermatol.2019.1658.

52 

Virani S, Prajapati V, Devani A, Mahmood MN and Elliott JF: Octreotide-responsive necrolytic migratory erythema in a patient with pseudoglucagonoma syndrome. J Am Acad Dermatol. 68:e44–e46. 2013.PubMed/NCBI View Article : Google Scholar

53 

Zhang M, Tang X, Zhou H, Liao Q and Han J: Case of autoimmune progesterone dermatitis presenting as necrotic migratory erythema successfully controlled by danazol. J Dermatol. 47:178–180. 2020.PubMed/NCBI View Article : Google Scholar

54 

Taskin OC and Adsay V: Lipase hypersecretion syndrome: A distinct form of paraneoplastic syndrome specific to pancreatic acinar carcinomas. Semin Diagn Pathol. 36:240–245. 2019.PubMed/NCBI View Article : Google Scholar

55 

Cornacchia C, Rutigliani M, Serventi A, Ciferri E, Angelini G and Filauro M: Pancreatic ductal adenocarcinoma derived from an intraductal papillary neoplasm with synchronous incidental glucagonoma: A case report and literature review. Pancreas. 48:e24–e26. 2019.PubMed/NCBI View Article : Google Scholar

56 

Gheorghisan-Galateanu AA, Carsote M and Valea A: Incidentaloma: From general practice to specific endocrine frame. J Pak Med Assoc. 67:917–922. 2017.PubMed/NCBI

57 

Solomon I, Voiculescu VM, Caruntu C, Lupu M, Popa A, Ilie MA, Albulescu R, Caruntu A, Tanase C, Constantin C, et al: Neuroendocrine factors and head and neck squamous cell carcinoma: An affair to remember. Dis Markers. 2018(9787831)2018.PubMed/NCBI View Article : Google Scholar

58 

Ion A, Popa IM, Papagheorghe LML, Lisievici C, Lupu M, Voiculescu V, Caruntu C and Boda D: Proteomic approaches to biomarker discovery in cutaneous T-cell lymphoma. Dis Markers. 2016(9602472)2016.PubMed/NCBI View Article : Google Scholar

59 

Boda D: Cellomics as integrative omics for cancer. Curr Proteomics. 10:237–245. 2013.

60 

Ilie MA, Caruntu C, Lupu M, Lixandru D, Tampa M, Georgescu SR, Bastian A, Constantin C, Neagu M, Zurac SA, et al: Current and future applications of confocal laser scanning microscopy imaging in skin oncology. Oncol Lett. 17:4102–4111. 2019.PubMed/NCBI View Article : Google Scholar

61 

Căruntu C, Boda D, Guţu DE and Căruntu A: In vivo reflectance confocal microscopy of basal cell carcinoma with cystic degeneration. Rom J Morphol Embryol. 55:1437–1441. 2014.PubMed/NCBI

62 

Georgiou GK, Gizas I, Katopodis KP and Katsios CS: Non-secreting benign glucagonoma diagnosed incidentally in a patient with refractory thrombocytopenic thrombotic purpura: Report of a case. Surg Today. 45:1317–1320. 2015.PubMed/NCBI View Article : Google Scholar

63 

Mai VQ, Jones RC, Dickert JM, Clyde PW and Shakir KM: Plasma glucagon levels suppressed by a glucose load in a man with incidental pancreatic glucagonoma. Endocr Pract. 13:780–784. 2007.PubMed/NCBI View Article : Google Scholar

64 

Wewer Albrechtsen NJ, Challis BG, Damjanov I and Holst JJ: Do glucagonomas always produce glucagon? Bosn J Basic Med Sci. 16:1–7. 2016.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Sandru F, Carsote M, Albu SE, Valea A, Petca A and Dumitrascu MC: Glucagonoma: From skin lesions to the neuroendocrine component (Review). Exp Ther Med 20: 3389-3393, 2020.
APA
Sandru, F., Carsote, M., Albu, S.E., Valea, A., Petca, A., & Dumitrascu, M.C. (2020). Glucagonoma: From skin lesions to the neuroendocrine component (Review). Experimental and Therapeutic Medicine, 20, 3389-3393. https://doi.org/10.3892/etm.2020.8966
MLA
Sandru, F., Carsote, M., Albu, S. E., Valea, A., Petca, A., Dumitrascu, M. C."Glucagonoma: From skin lesions to the neuroendocrine component (Review)". Experimental and Therapeutic Medicine 20.4 (2020): 3389-3393.
Chicago
Sandru, F., Carsote, M., Albu, S. E., Valea, A., Petca, A., Dumitrascu, M. C."Glucagonoma: From skin lesions to the neuroendocrine component (Review)". Experimental and Therapeutic Medicine 20, no. 4 (2020): 3389-3393. https://doi.org/10.3892/etm.2020.8966
Copy and paste a formatted citation
x
Spandidos Publications style
Sandru F, Carsote M, Albu SE, Valea A, Petca A and Dumitrascu MC: Glucagonoma: From skin lesions to the neuroendocrine component (Review). Exp Ther Med 20: 3389-3393, 2020.
APA
Sandru, F., Carsote, M., Albu, S.E., Valea, A., Petca, A., & Dumitrascu, M.C. (2020). Glucagonoma: From skin lesions to the neuroendocrine component (Review). Experimental and Therapeutic Medicine, 20, 3389-3393. https://doi.org/10.3892/etm.2020.8966
MLA
Sandru, F., Carsote, M., Albu, S. E., Valea, A., Petca, A., Dumitrascu, M. C."Glucagonoma: From skin lesions to the neuroendocrine component (Review)". Experimental and Therapeutic Medicine 20.4 (2020): 3389-3393.
Chicago
Sandru, F., Carsote, M., Albu, S. E., Valea, A., Petca, A., Dumitrascu, M. C."Glucagonoma: From skin lesions to the neuroendocrine component (Review)". Experimental and Therapeutic Medicine 20, no. 4 (2020): 3389-3393. https://doi.org/10.3892/etm.2020.8966
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team