|
1
|
Elam M and Wallin BG: Skin blood flow
responses to mental stress in man depend on body temperature. Acta
Physiol Scand. 129:429–431. 1987.PubMed/NCBI View Article : Google Scholar
|
|
2
|
Liu C, Yavar Z and Sun Q: Cardiovascular
response to thermoregulatory challenges. Am J Physiol Heart Circ
Physiol. 309:H1793–H1812. 2015.PubMed/NCBI View Article : Google Scholar
|
|
3
|
LeRoy EC and Medsger TA Jr: Raynaud's
phenomenon: A proposal for classification. Clin Exp Rheumatol.
10:485–488. 1992.PubMed/NCBI
|
|
4
|
Lis-Święty A: Recent advances in the
workup and management of Raynaud phenomenon. Pol Arch Intern Med.
129:798–808. 2019.PubMed/NCBI View Article : Google Scholar
|
|
5
|
United States Pharmacopeial Convention I.
United States Pharmacopoeia 38 Garlic Fluid Extract USP 28-NF 33.
United States Pharmacopeial Convention, Rockville MD, pp6052-6055,
2015.
|
|
6
|
Colín-González AL, Santana RA, Silva-Islas
CA, Chánez-Cárdenas ME, Santamaría A and Maldonado PD: The
antioxidant mechanisms underlying the aged garlic extract- and
S-allylcysteine-induced protection. Oxid Med Cell Longev.
2012(907162)2012.PubMed/NCBI View Article : Google Scholar
|
|
7
|
Matsutomo T and Kodera Y: Development of
an analytic method for sulfur compounds in aged garlic extract with
the use of a postcolumn high performance liquid chromatography
method with sulfur-specific detection. J Nutr. 146:450S–455S.
2016.PubMed/NCBI View Article : Google Scholar
|
|
8
|
Ried K, Frank OR and Stocks NP: Aged
garlic extract lowers blood pressure in patients with treated but
uncontrolled hypertension: A randomised controlled trial.
Maturitas. 67:144–150. 2010.PubMed/NCBI View Article : Google Scholar
|
|
9
|
Ried K, Frank OR and Stocks NP: Aged
garlic extract reduces blood pressure in hypertensives: A
dose-response trial. Eur J Clin Nutr. 67:64–70. 2013.PubMed/NCBI View Article : Google Scholar
|
|
10
|
Ried K, Travica N and Sali A: The effect
of aged garlic extract on blood pressure and other cardiovascular
risk factors in uncontrolled hypertensives: The AGE at Heart trial.
Integr Blood Press Control. 9:9–21. 2016.PubMed/NCBI View Article : Google Scholar
|
|
11
|
Ried K, Travica N and Sali A: The effect
of kyolic aged garlic extract on gut microbiota, inflammation, and
cardiovascular markers in hypertensives: The GarGIC Trial. Front
Nutr. 5(122)2018.PubMed/NCBI View Article : Google Scholar
|
|
12
|
Ried K: Garlic lowers blood pressure in
hypertensive subjects, improves arterial stiffness and gut
microbiota: A review and meta-analysis. Exp Ther Med. 19:1472–1478.
2020.PubMed/NCBI View Article : Google Scholar
|
|
13
|
Budoff MJ, Ahmadi N, Gul KM, Liu ST,
Flores FR, Tiano J, Takasu J, Miller E and Tsimikas S: Aged garlic
extract supplemented with B vitamins, folic acid and L-arginine
retards the progression of subclinical atherosclerosis: A
randomized clinical trial. Prev Med. 49:101–107. 2009.PubMed/NCBI View Article : Google Scholar
|
|
14
|
Matsumoto S, Nakanishi R, Li D, Alani A,
Rezaeian P, Prabhu S, Abraham J, Fahmy MA, Dailing C, Flores F, et
al: Aged garlic extract reduces low attenuation plaque in coronary
arteries of patients with metabolic syndrome in a prospective
randomized double-blind study. J Nutr. 146:427S–432S.
2016.PubMed/NCBI View Article : Google Scholar
|
|
15
|
Gruenwald J, Bongartz U, Bothe G and
Uebelhack R: Effects of aged garlic extract on arterial elasticity
in a placebo-controlled clinical trial using EndoPAT™ technology.
Exp Ther Med. 19:1490–1499. 2020.PubMed/NCBI View Article : Google Scholar
|
|
16
|
Gὁmez-Arbelἁez D, Lahera V, Oubina P,
Valero-Munoz M, Heras NL, Rodriguez Y, Garcia RG, Camacho PA and
Lopez-jaramillo P: Aged garlic extract improves adiponectin levels
in subjects with metabolic syndrome: A double-blind, placebo
controlled, randomized, crossover study. Mediators Inflamm.
285795(2013)2013.PubMed/NCBI View Article : Google Scholar
|
|
17
|
Zini A, Mann J, Mazor S and Vered Y: The
efficacy of aged garlic extract on gingivitis - a randomized
clinical trial. J Clin Dent. 29:52–56. 2018.PubMed/NCBI
|
|
18
|
Harauma A and Moriguchi T: Aged garlic
extract improves blood pressure in spontaneously hypertensive rats
more safely than raw garlic. J Nutr. 136 (Suppl 3):769S–773S.
2006.PubMed/NCBI View Article : Google Scholar
|
|
19
|
Matsutomo T, Ushijima M, Kodera Y,
Nakamoto M, Takashima M, Morihara N and Tamura K: Metabolomic study
on the antihypertensive effect of S-1-propenylcysteine in
spontaneously hypertensive rats using liquid chromatography coupled
with quadrupole-Orbitrap mass spectrometry. J Chromatogr B Analyt
Technol Biomed Life Sci. 1046:147–155. 2017.PubMed/NCBI View Article : Google Scholar
|
|
20
|
Matsutomo T, Ushijima M, Kunimura K and
Ohtani M: Metabolomic study reveals the acute hypotensive effect of
S-1-propenylcysteine accompanied by alteration of the plasma
histidine level in spontaneously hypertensive rats. J Pharm Biomed
Anal. 168:148–154. 2019.PubMed/NCBI View Article : Google Scholar
|
|
21
|
Ushijima M, Takashima M, Kunimura K,
Kodera Y, Morihara N and Tamura K: Effects of S-1-propenylcysteine,
a sulfur compound in aged garlic extract, on blood pressure and
peripheral circulation in spontaneously hypertensive rats. J Pharm
Pharmacol. 70:559–565. 2018.PubMed/NCBI View Article : Google Scholar
|
|
22
|
Matsutomo T: Potential benefits of garlic
and other dietary supplements for the management of hypertension
(Review). Exp Ther Med. 19:1479–1484. 2020.PubMed/NCBI View Article : Google Scholar
|
|
23
|
Chuah SC, Moore PK and Zhu YZ:
S-allylcysteine mediates cardioprotection in an acute myocardial
infarction rat model via a hydrogen sulfide-mediated pathway. Am J
Physiol Heart Circ Physiol. 293:H2693–H2701. 2007.PubMed/NCBI View Article : Google Scholar
|
|
24
|
Borek C: Antioxidant health effects of
aged garlic extract. J Nutr. 131 (Suppl 3):1010S–1015S.
2001.PubMed/NCBI View Article : Google Scholar
|
|
25
|
Yamato O, Tsuneyoshi T, Ushijima M,
Jikihara H and Yabuki A: Safety and efficacy of aged garlic extract
in dogs: upregulation of the nuclear factor erythroid 2-related
factor 2 (Nrf2) signaling pathway and Nrf2-regulated phase II
antioxidant enzymes. BMC Vet Res 29:. 14(373)2018.PubMed/NCBI View Article : Google Scholar
|
|
26
|
Tsuneyoshi T: BACH1 mediates the
antioxidant properties of aged garlic extract (Review). Exp Ther
Med. 19:1500–1503. 2020.PubMed/NCBI View Article : Google Scholar
|
|
27
|
Moriguchi T, Saito H and Nishiyama N: Aged
garlic extract prolongs longevity and improves spatial memory
deficit in senescence-accelerated mouse. Biol Pharm Bull.
19:305–307. 1996.PubMed/NCBI View Article : Google Scholar
|
|
28
|
Ogawa T, Kodera Y, Hirata D, Blackwell TK
and Mizunuma M: Natural thioallyl compounds increase oxidative
stress resistance and lifespan in Caenorhabditis elegans by
modulating SKN-1/Nrf. Sci Rep. 6(21611)2016.PubMed/NCBI View Article : Google Scholar
|
|
29
|
Kyo E, Uda N, Kasuga S and Itakura Y:
Immunomodulatory effects of aged garlic extract. J Nutr. 131 (Suppl
3):1075S–1079S. 2001.PubMed/NCBI View Article : Google Scholar
|
|
30
|
Suzuki J, Yamaguchi T, Matsutomo T, Amano
H, Morihara N and Kodera Y: S-1-Propenylcysteine promotes the
differentiation of B cells into IgA-producing cells by the
induction of Erk1/2-dependent Xbp1 expression in Peyer's patches.
Nutrition. 32:884–889. 2016.PubMed/NCBI View Article : Google Scholar
|
|
31
|
Suzuki J, Miki S, Ushijima M and Kodera Y:
Regulation of immune response by S-1-propenylcysteine
through autophagy-mediated protein degradation (Review). Exp Ther
Med. 19:1570–1573. 2020.PubMed/NCBI View Article : Google Scholar
|
|
32
|
Ushijima M, Sumioka I, Kakimoto M,
Yokoyama K, Uda N, Matsuura H, Kyo E, Suzuki A, Kasuga S, Itakura
Y, et al: Effect of garlic and garlic preparations on physiological
and psychological stress in mice. Phytother Res. 11:226–230.
1997.
|
|
33
|
Morihara N, Ushijima M, Kashimoto N,
Sumioka I, Nishihama T, Hayama M and Takeda H: Aged garlic extract
ameliorates physical fatigue. Biol Pharm Bull. 29:962–966.
2006.PubMed/NCBI View Article : Google Scholar
|
|
34
|
Kasuga S, Ushijima M, Morihara N, Itakura
Y and Nakata Y: Effect of aged garlic extract (AGE) on
hyperglycemia induced by immobilization stress in mice]. Nippon
Yakurigaku Zasshi. 114:191–197. 1999.(In Japanese). PubMed/NCBI View Article : Google Scholar
|
|
35
|
Kyo E, Uda N, Ushijima M, Kasuga S and
Itakura Y: Prevention of psychological stress-induced immune
suppression by aged garlic extract. Phytomedicine. 6:325–330.
1999.PubMed/NCBI View Article : Google Scholar
|
|
36
|
Morihara N, Hino A, Miki S, Takashima M
and Suzuki JI: Aged garlic extract suppresses inflammation in
apolipoprotein E-knockout mice. Mol Nutr Food Res.
61(1700308)2017.PubMed/NCBI View Article : Google Scholar
|
|
37
|
Suzuki JI, Kodera Y, Miki S, Ushijima M,
Takashima M, Matsutomo T and Morihara N: Anti-inflammatory action
of cysteine derivative S-1-propenylcysteine by inducing MyD88
degradation. Sci Rep. 8(14148)2018.PubMed/NCBI View Article : Google Scholar
|
|
38
|
Ohtani M and Nishimura T:
Sulfur-containing amino acids in aged garlic extract inhibit
inflammation in human gingival epithelial cells by suppressing
intercellular adhesion molecule-1 expression and IL-6 secretion.
Biomed Rep. 12:99–108. 2020.PubMed/NCBI View Article : Google Scholar
|
|
39
|
Miki S, Suzuki JI, Kunimura K and Morihara
N: Mechanisms underlying the attenuation of chronic inflammatory
diseases by aged garlic extract: Involvement of the activation of
AMP-activated protein kinase (Review). Exp Ther Med. 19:1462–1467.
2020.PubMed/NCBI View Article : Google Scholar
|
|
40
|
Nakagawa S, Kasuga S and Matsuura H:
Prevention of liver damage by aged garlic extract and its
components in mice. Phytother Res. 3:50–53. 1989.
|
|
41
|
Okuhara T: Clinical study of GE on
peripheral circulation. Jpn Pharmacol Ther. 22:3695–3701. 1994.
|
|
42
|
Wlosinska M, Nilsson AC, Hlebowicz J,
Malmsjö M, Fakhro M and Lindstedt S: Aged garlic extract preserves
cutaneous microcirculation in patients with increased risk for
cardiovascular diseases: A double-blinded placebo-controlled study.
Int Wound J. 16:1487–1493. 2019.PubMed/NCBI View Article : Google Scholar
|
|
43
|
Mizuno I, Sumioka I, Ushijima M, Yasuda K,
Mouri Y, Mizuho O, Ogasawara K and Kyo E: Improvement of peripheral
blood circulation in mouse and human with aged garlic extract
preparation combined with ginseng, oriental bezoar, antler velvet,
cuscuta seed and epimedium herb. Pharmacometrics. 67:371–378.
2004.
|
|
44
|
Guan J, Lin H, Xie M, Huang M, Zhang D, Ma
S, Bian W, Zhan Q and Zhao G: Higenamine exerts an antispasmodic
effect on cold-induced vasoconstriction by regulating the PI3K/Akt,
ROS/α2C-AR and PTK9 pathways independently. Asian Pac J Trop Med.
5:935–938. 2012.
|
|
45
|
Ning SY, Jiang BP, Xu L, Fang TH and Wu
MH: Effect of Liangxuehuayu Recipe on hemorheology in rats with
blood stasis syndrome. Asian Pac J Trop Med. 5:935–938.
2012.PubMed/NCBI View Article : Google Scholar
|
|
46
|
Ryan TJ and Copeman PW: Microvascular
pattern and blood stasis in skin disease. Br J Dermatol.
81:563–573. 1969.PubMed/NCBI View Article : Google Scholar
|
|
47
|
López-López JG, Pérez-Vizcaíno F,
Cogolludo AL, Ibarra M, Zaragozá-Arnáez F and Tamargo J: Nitric
oxide- and nitric oxide donors-induced relaxation and its
modulation by oxidative stress in piglet pulmonary arteries. Br J
Pharmacol. 133:615–624. 2001.PubMed/NCBI View Article : Google Scholar
|
|
48
|
Johnson JM and Proppe DW: Cardiovascular
adjustments to heat stress. In: Handbook of physiology. Section 4:
Environmental physiology. Fregley MJ and Blatteis CM (eds). Oxford
University Press, New York, NY. pp215–243. 1996.
|
|
49
|
Rowell LB: Human circulation: regulation
during physical stress. Oxford University Press, New York, NY,
1986.
|
|
50
|
Thompson-Torgerson CS, Holowatz LA,
Flavahan NA and Kenney WL: Cold-induced cutaneous vasoconstriction
is mediated by Rho kinase in vivo in human skin. Am J Physiol Heart
Circ Physiol. 292:H1700–H1705. 2007.PubMed/NCBI View Article : Google Scholar
|
|
51
|
Koganezawa T, Ishikawa T, Fujita Y,
Yamashita T, Tajima T, Honda M and Nakayama K: Local regulation of
skin blood flow during cooling involving presynaptic P2
purinoceptors in rats. Br J Pharmacol. 148:579–586. 2006.PubMed/NCBI View Article : Google Scholar
|
|
52
|
Takashima M, Kanamori Y, Kodera Y,
Morihara N and Tamura K: Aged garlic extract exerts
endothelium-dependent vasorelaxant effect on rat aorta by
increasing nitric oxide production. Phytomedicine. 24:56–61.
2017.PubMed/NCBI View Article : Google Scholar
|
|
53
|
Lindauer U, Megow D, Matsuda H and Dirnagl
U: Nitric oxide: A modulator, but not a mediator, of neurovascular
coupling in rat somatosensory cortex. Am J Physiol. 277:H799–H811.
1999.PubMed/NCBI View Article : Google Scholar
|
|
54
|
Hodges GJ, Traeger JA III, Tang T, Kosiba
WA, Zhao K and Johnson JM: Role of sensory nerves in the cutaneous
vasoconstrictor response to local cooling in humans. Am J Physiol
Heart Circ Physiol. 293:H784–H789. 2007.PubMed/NCBI View Article : Google Scholar
|
|
55
|
Zhao Y, Vanhoutte PM and Leung SWS:
Vascular nitric oxide: Beyond eNOS. J Pharmacol Sci. 129:83–94.
2015.PubMed/NCBI View Article : Google Scholar
|
|
56
|
Morihara N, Sumioka I, Moriguchi T, Uda N
and Kyo E: Aged garlic extract enhances production of nitric oxide.
Life Sci. 71:509–517. 2002.PubMed/NCBI View Article : Google Scholar
|
|
57
|
Binti Md Isa K, Kawasaki N, Ueyama K,
Sumii T and Kudo S: Effects of cold exposure and shear stress on
endothelial nitric oxide synthase activation. Biochem Biophys Res
Commun. 412:318–322. 2011.PubMed/NCBI View Article : Google Scholar
|
|
58
|
Zhang Y, Lee TS, Kolb EM, Sun K, Lu X,
Sladek FM, Kassab GS, Garland T Jr and Shyy JY: AMP-activated
protein kinase is involved in endothelial NO synthase activation in
response to shear stress. Arterioscler Thromb Vasc Biol.
26:1281–1287. 2006.PubMed/NCBI View Article : Google Scholar
|
|
59
|
Zheng Q, Yuan Y, Yi W, Lau WB, Wang Y,
Wang X, Sun Y, Lopez BL, Christopher TA, Peterson JM, et al:
C1q/TNF-related proteins, a family of novel adipokines, induce
vascular relaxation through the adiponectin
receptor-1/AMPK/eNOS/nitric oxide signaling pathway. Arterioscler
Thromb Vasc Biol. 31:2616–2623. 2011.PubMed/NCBI View Article : Google Scholar
|
