Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
September-2020 Volume 20 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2020 Volume 20 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Efficacy and safety of sodium valproate plus lamotrigine in children with refractory epilepsy

  • Authors:
    • Dongli Zhang
    • Li Qiu
    • Yuan Zhang
    • Yan Sang
    • Nuo Zheng
    • Xiaoming Liu
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Xuzhou Children's Hospital, Xuzhou Medical University, Xuzhou, Jiangsu 221000, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2698-2704
    |
    Published online on: July 10, 2020
       https://doi.org/10.3892/etm.2020.8984
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Efficacy and safety of sodium valproate (SV) and lamotrigine (LTG) in treating refractory epilepsy (RE) in children and the predictive value of serum neuron‑specific enolase (NSE) and central nervous system specific S100β protein (S100β) on efficacy assessment were explored. A total of 110 RE children admitted to Xuzhou Children's Hospital, Xuzhou Medical University were enrolled. Patients treated with SV alone served as the control group (n=51), and those treated with SV plus LTG as the study group (n=59). Serum NSE and S100β expression levels were measured by enzyme‑linked immunosorbent assay (ELISA). The efficacy, seizure frequency, adverse reactions, concentration of serum brain derived neurotrophic factor (BDNF) and nerve growth factor (NGF), and expression of serum NSE and S100β were observed and compared. The total effective rate in the study group was significantly higher than that in the control group, and the seizure frequency and incidence of adverse reactions were significantly lower than that in the control group. The study group showed remarkably higher BDNF and NGF than the control group after treatment. The expression of serum NSE and S100β in effectively treated children were significantly lower than that in ineffectively treated children. The area under the curve (AUC) of serum NSE and S100β were 0.828 and 0.814 respectively. SV combined with LTG is better and safer than SV alone in the treatment of RE in children. Serum NSE and S100β are of high value in predicting the efficacy.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Armeno M, Verini A, Del Pino M, Araujo MB, Mestre G, Reyes G and Caraballo RH: A prospective study on changes in nutritional status and growth following two years of ketogenic diet (KD) therapy in children with refractory epilepsy. Nutrients. 11(1596)2019.PubMed/NCBI View Article : Google Scholar

2 

McGovern RA, Banks GP and McKhann GM: Responsive stimulation in the management of medically refractory epilepsy. In: Epilepsy Surgery and Intrinsic Brain Tumor Surgery. Fountas K and Kapsalaki E (eds). Springer, Cham, pp205-211, 2019.

3 

Sirven JI, Pedley TA and Wilterdink JL: Evaluation and management of drug-resistant epilepsy. UpToDate. https://www.uptodate.com/contents/evaluation-and-management-of-drug-resistant-epilepsy. Accessed August 13, 2018.

4 

Mishra S: Refractory epilepsy in children: A short review. South Asian Res J Med Sci. 1:24–29. 2019.

5 

Nigro SE: The efficacy of neurofeedback for pediatric epilepsy. Appl Psychophysiol Biofeedback. 44:285–290. 2019.PubMed/NCBI View Article : Google Scholar

6 

Moosa ANV: Antiepileptic drug treatment of epilepsy in children. Continuum (Minneap Minn). 25:381–407. 2019.PubMed/NCBI View Article : Google Scholar

7 

Golyala A and Kwan P: Drug development for refractory epilepsy: The past 25 years and beyond. Seizure. 44:147–156. 2017.PubMed/NCBI View Article : Google Scholar

8 

Balagura G, Iapadre G, Verrotti A and Striano P: Moving beyond sodium valproate: Choosing the right anti-epileptic drug in children. Expert Opin Pharmacother. 20:1449–1456. 2019.PubMed/NCBI View Article : Google Scholar

9 

Fu J, Peng L, Wang W, He H, Zeng S, Chen TC and Chen Y: Sodium valproate reduces neuronal apoptosis in acute pentylenetetrazole-induced seizures via inhibiting ER stress. Neurochem Res. 44:2517–2526. 2019.PubMed/NCBI View Article : Google Scholar

10 

Brown C and Smith C: Sodium valproate. Pract Diabetes. 35:186–187. 2018.

11 

Çavuş I, Romanyshyn JC, Kennard JT, Farooque P, Williamson A, Eid T, Spencer SS, Duckrow R, Dziura J and Spencer DD: Elevated basal glutamate and unchanged glutamine and GABA in refractory epilepsy: Microdialysis study of 79 patients at the yale epilepsy surgery program. Ann Neurol. 80:35–45. 2016.PubMed/NCBI View Article : Google Scholar

12 

Johannessen Landmark C and Patsalos PN: Drug interactions involving the new second- and third-generation antiepileptic drugs. Expert Rev Neurother. 10:119–140. 2010.PubMed/NCBI View Article : Google Scholar

13 

Reimers A: Lamotrigine, bipolar disorder, and the pill-free week. Bipolar Disord. 21:372–373. 2019.PubMed/NCBI View Article : Google Scholar

14 

Yasam VR, Jakki SL, Senthil V, Eswaramoorthy M, Shanmuganathan S, Arjunan K and Nanjan MJ: A pharmacological overview of lamotrigine for the treatment of epilepsy. Expert Rev Clin Pharmacol. 9:1533–1546. 2016.PubMed/NCBI View Article : Google Scholar

15 

Poolos NP, Castagna CE, Williams S, Miller AB and Story TJ: Association between antiepileptic drug dose and long-term response in patients with refractory epilepsy. Epilepsy Behav. 69:59–68. 2017.PubMed/NCBI View Article : Google Scholar

16 

Lanteaume L, Guedj E, Bastien-Toniazzo M, Magalahaes A, Mundler O and Bartolomei F: Cognitive and metabolic correlates of emotional vulnerability in patients with temporal lobe epilepsy. J Neurol Neurosurg Psychiatry. 83:522–528. 2012.PubMed/NCBI View Article : Google Scholar

17 

Ollenberger GP, Byrne AJ, Berlangieri SU, Rowe CC, Pathmaraj K, Reutens DC, Berkovic SF, Scheffer IE and Scott AM: Assessment of the role of FDG PET in the diagnosis and management of children with refractory epilepsy. Eur J Nucl Med Mol Imaging. 32:1311–1316. 2005.PubMed/NCBI View Article : Google Scholar

18 

Hornbeck PV: Enzyme-linked immunosorbent assays. Curr Protoc Immunol. 110:2.1.1–23. 2015.PubMed/NCBI View Article : Google Scholar

19 

Ramaratnam S, Panebianco M and Marson AG: Lamotrigine add-on for drug-resistant partial epilepsy. Cochrane Database Syst Rev: CD001909, 2016.

20 

Verrotti A, Iapadre G, Di Donato G, Di Francesco L, Zagaroli L, Matricardi S, Belcastro V and Iezzi ML: Pharmacokinetic considerations for anti-epileptic drugs in children. Expert Opin Drug Metab Toxicol. 15:199–211. 2019.PubMed/NCBI View Article : Google Scholar

21 

Pagura JR and Alessi R: Epilepsy and seizures. In: The Sports Medicine Physician. Piedade SR, Imhoff AB, Clatworthy M, Moises Cohen M and Espregueira-Mendes J (eds). Springer Cham, pp235-240, 2019.

22 

Hernan AE and Holmes GL: Antiepileptic drug treatment strategies in neonatal epilepsy Elsevier. Prog Brain Res. 226:179–193. 2016.PubMed/NCBI View Article : Google Scholar

23 

Li Q, Li QQ, Jia JN, Cao S, Wang ZB, Wang X, Luo C, Zhou HH, Liu ZQ and Mao XY: Sodium valproate ameliorates neuronal apoptosis in a kainic acid model of epilepsy via enhancing PKC-dependent GABAAR γ2 Serine 327 phosphorylation. Neurochem Res. 43:2343–2352. 2018.PubMed/NCBI View Article : Google Scholar

24 

Rosenberg EC, Patra PH and Whalley BJ: Therapeutic effects of cannabinoids in animal models of seizures, epilepsy, epileptogenesis, and epilepsy-related neuroprotection. Epilepsy Behav. 70B:319–327. 2017.PubMed/NCBI View Article : Google Scholar

25 

Han SA, Yang EJ, Song MK and Kim SJ: Effects of lamotrigine on attention-deficit hyperactivity disorder in pediatric epilepsy patients. Korean J Pediatr. 60:189–195. 2017.PubMed/NCBI View Article : Google Scholar

26 

Korley FK, Diaz-Arrastia R, Wu AHB, Yue JK, Manley GT, Sair HI, Van Eyk J, Everett AD, Okonkwo DO, Valadka AB, et al: TRACK-TBI investigators: Circulating brain-derived neurotrophic factor has diagnostic and prognostic value in traumatic brain injury. J Neurotrauma. 33:215–225. 2016.PubMed/NCBI View Article : Google Scholar

27 

Bathina S and Das UN: Brain-derived neurotrophic factor and its clinical implications. Arch Med Sci. 11:1164–1178. 2015.PubMed/NCBI View Article : Google Scholar

28 

Tan XH, Song ZB, Wang H, Wang Q and He JL: Influence of adjuvant levetiracetam therapy on serum nerve cytokines and apoptosis molecules in patients with refractory partial epileptic seizure. Hainan Yixueyuan Xuebao. 23:145–149. 2017.(In Chinese).

29 

Skaper SD: Nerve growth factor: A neuroimmune crosstalk mediator for all seasons. Immunology. 151:1–15. 2017.PubMed/NCBI View Article : Google Scholar

30 

Tuszynski MH, Yang JH, Barba D, U HS, Bakay RA, Pay MM, Masliah E, Conner JM, Kobalka P, Roy S, et al: Nerve growth factor gene therapy: Activation of neuronal responses in Alzheimer disease. JAMA Neurol. 72:1139–1147. 2015.PubMed/NCBI View Article : Google Scholar

31 

Silveira DC, Holmes GL, Schachter SC, Geula C and Schomer DL: Increased susceptibility to generalized seizures after immunolesions of the basal forebrain cholinergic neurons in rats. Brain Res. 878:223–227. 2000.PubMed/NCBI View Article : Google Scholar

32 

Wang F, Lin Y, Kang D, Chen F, Lin K and Su X: Distribution and expression of brain-derived neurotrophic factor, nerve growth factor, and neurotrophic factor-3 in refractory epilepsy-associated focal cortical dysplasia. Clin Neuropathol. 36:233–239. 2017.PubMed/NCBI View Article : Google Scholar

33 

Alpdemir M, Özcan O, Alpdemir MF, Şeneş M, Azak A, Duranay M and Yücel M: Serum neuron specific enolase and S-100B levels in hemodialysis and peritoneal dialysis patients. Eur Arch Med Res. 35:83–87. 2019.

34 

Shaik AJ, Reddy K, Mohammed N, Tandra SR, Rukmini Mridula Kandadai and Baba Kss S: Neuron specific enolase as a marker of seizure related neuronal injury. Neurochem Int. 131(104509)2019.PubMed/NCBI View Article : Google Scholar

35 

Calik M, Abuhandan M, Kandemir H, Güzel B, Solmaz A, Celik H, Taskin A and Iscan A: Interictal serum S-100B protein levels in intractable epilepsy: A case-control study. Neurosci Lett. 558:58–61. 2014.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang D, Qiu L, Zhang Y, Sang Y, Zheng N and Liu X: Efficacy and safety of sodium valproate plus lamotrigine in children with refractory epilepsy. Exp Ther Med 20: 2698-2704, 2020.
APA
Zhang, D., Qiu, L., Zhang, Y., Sang, Y., Zheng, N., & Liu, X. (2020). Efficacy and safety of sodium valproate plus lamotrigine in children with refractory epilepsy. Experimental and Therapeutic Medicine, 20, 2698-2704. https://doi.org/10.3892/etm.2020.8984
MLA
Zhang, D., Qiu, L., Zhang, Y., Sang, Y., Zheng, N., Liu, X."Efficacy and safety of sodium valproate plus lamotrigine in children with refractory epilepsy". Experimental and Therapeutic Medicine 20.3 (2020): 2698-2704.
Chicago
Zhang, D., Qiu, L., Zhang, Y., Sang, Y., Zheng, N., Liu, X."Efficacy and safety of sodium valproate plus lamotrigine in children with refractory epilepsy". Experimental and Therapeutic Medicine 20, no. 3 (2020): 2698-2704. https://doi.org/10.3892/etm.2020.8984
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang D, Qiu L, Zhang Y, Sang Y, Zheng N and Liu X: Efficacy and safety of sodium valproate plus lamotrigine in children with refractory epilepsy. Exp Ther Med 20: 2698-2704, 2020.
APA
Zhang, D., Qiu, L., Zhang, Y., Sang, Y., Zheng, N., & Liu, X. (2020). Efficacy and safety of sodium valproate plus lamotrigine in children with refractory epilepsy. Experimental and Therapeutic Medicine, 20, 2698-2704. https://doi.org/10.3892/etm.2020.8984
MLA
Zhang, D., Qiu, L., Zhang, Y., Sang, Y., Zheng, N., Liu, X."Efficacy and safety of sodium valproate plus lamotrigine in children with refractory epilepsy". Experimental and Therapeutic Medicine 20.3 (2020): 2698-2704.
Chicago
Zhang, D., Qiu, L., Zhang, Y., Sang, Y., Zheng, N., Liu, X."Efficacy and safety of sodium valproate plus lamotrigine in children with refractory epilepsy". Experimental and Therapeutic Medicine 20, no. 3 (2020): 2698-2704. https://doi.org/10.3892/etm.2020.8984
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team