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Article Open Access

Salvianolic acid B protects against sepsis‑induced liver injury via activation of SIRT1/PGC‑1α signaling

Retraction in: /10.3892/etm.2025.12959
  • Authors:
    • Hongling Su
    • Zhisheng Ma
    • Aixia Guo
    • Hong Wu
    • Xiangmin Yang
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Xidian Group Hospital, Xi'an, Shaanxi 710000, P.R. China, Department of General Surgery, Xidian Group Hospital, Xi'an, Shaanxi 710000, P.R. China
    Copyright: © Su et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2675-2683
    |
    Published online on: July 17, 2020
       https://doi.org/10.3892/etm.2020.9020
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Abstract

Liver injury occurs frequently during sepsis, which leads to high mortality and morbidity. A previous study has suggested that salvianolic acid B (SalB) is protective against sepsis‑induced lung injury. However, whether SalB is able to protect against sepsis‑induced liver injury remains unclear. The present study aimed to investigate the effects of SalB on sepsis‑induced liver injury and its potential underlying mechanisms. Sepsis was induced in mice using a cecal ligation and puncture (CLP) method. The mice were treated with SalB (30 mg/kg intraperitoneally) at 0.5, 2 and 8 h after CLP induction. Pathological alterations of the liver were assessed using hematoxylin and eosin staining. The serum levels of alanine transaminase (ALT), aspartate aminotransferase (AST), tumor necrosis factor (TNF)‑α and interleukin (IL)‑6 were measured. The hepatic mRNA levels of TNF‑α, IL‑6, Bax and Bcl‑2 were also detected. The results suggested that treatment with SalB ameliorated sepsis‑induced liver injury in the mice, as supported by the mitigated pathologic changes and lowered serum aminotransferase levels. SalB also decreased the levels of the inflammatory cytokines TNF‑α and IL‑6 in the serum and the liver of the CLP model mice. In addition, SalB significantly downregulated Bax expression and upregulated Bcl‑2 expression, and upregulated the expression levels of SIRT1 and PGC‑1α. However, when sirtuin 1 (SIRT1) small interfering RNA was co‑administered with SalB, the protective effects of SalB were attenuated and the expression levels of SIRT1 and PGC‑1α were reduced. In summary, these results indicate that SalB mitigates sepsis‑induced liver injury via reduction of the inflammatory response and hepatic apoptosis, and the underlying mechanism may be associated with the activation of SIRT1/PGC‑1α signaling.
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1 

Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard GR, Chiche JD, Coopersmith CM, et al: The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 315:801–810. 2016.

2 

Mayr FB, Yende S and Angus DC: Epidemiology of severe sepsis. Virulence. 5:4–11. 2014.

3 

Gofton TE and Young GB: Sepsis-associated encephalopathy. Nat Rev Neurol. 8:557–566. 2012.

4 

Jin L, Wang Q, Zhang H, Tai S, Liu H and Zhang D: A synthetic peptide AWRK6 alleviates lipopolysaccharide-induced liver injury. Int J Mol Sci. 19(E2661)2018.

5 

Yang L, Zhang H and Chen P: Sulfur dioxide attenuates sepsis-induced cardiac dysfunction via inhibition of NLRP3 inflammasome activation in rats. Nitric Oxide. 81:11–20. 2018.

6 

Hu Q, Knight PH, Ren Y, Ren H, Zheng J, Wu X, Ren J and Sawyer RG: The emerging role of stimulator of interferons genes signaling in sepsis: Inflammation, autophagy and cell death. Acta Physiol (Oxf). 225(e13194)2018.

7 

Kramer L, Jordan B, Druml W, Bauer P and Metnitz PG: Austrian epidemiologic study on intensive care ASG: Incidence and prognosis of early hepatic dysfunction in critically ill patients-a prospective multicenter study. Crit Care Med. 35:1099–1104. 2007.

8 

Yan J and Li S and Li S: The role of the liver in sepsis. Int Rev Immunol. 33:498–510. 2014.

9 

Yao Y, Feng Y and Lin W: Systematic review and meta-analysis of randomized controlled trials comparing compound danshen dripping pills and isosorbide dinitrate in treating angina pectoris. Int J Cardiol. 182:46–47. 2015.

10 

Guo C, Yin Y, Duan J, Zhu Y, Yan J, Wei G, Guan Y, Wu X, Wang Y, Xi M and Wen A: Neuroprotective effect and underlying mechanism of sodium danshensu [3-(3,4-dihydroxyphenyl) lactic acid from radix and rhizoma Salviae miltiorrhizae = danshen] against cerebral ischemia and reperfusion injury in rats. Phytomedicine. 22:283–289. 2015.

11 

Xu S, Zhong A, Bu X, Ma H, Li W, Xu X and Zhang J: Salvianolic acid B inhibits platelets-mediated inflammatory response in vascular endothelial cells. Thromb Res. 135:137–145. 2015.

12 

Zhang JP, Zhang YY, Zhang Y, Gao YG, Ma JJ, Wang N, Wang JY, Xie Y, Zhang FH and Chu L: Salvia miltiorrhiza (Danshen) injection ameliorates iron overload-induced cardiac damage in mice. Planta Med. 79:744–752. 2013.

13 

Yang CW, Liu H, Li XD, Sui SG and Liu YF: Salvianolic acid B protects against acute lung injury by decreasing TRPM6 and TRPM7 expressions in a rat model of sepsis. J Cell Biochem. 119:701–711. 2018.

14 

Escribano-Lopez I, Diaz-Morales N, Iannantuoni F, Lopez-Domenech S, de Marañon AM, Abad-Jimenez Z, Bañuls C, Rovira-Llopis S, Herance JR, Rocha M and Victor VM: The mitochondrial antioxidant SS-31 increases SIRT1 levels and ameliorates inflammation, oxidative stress and leukocyte-endothelium interactions in type 2 diabetes. Sci Rep. 8(15862)2018.

15 

Ma R, Liang W, Sun Q, Qiu X, Lin Y, Ge X, Jueraitetibaike K, Xie M, Zhou J, Huang X, et al: Sirt1/Nrf2 pathway is involved in oocyte aging by regulating cyclin B1. Aging (Albany NY). 10:2991–3004. 2018.

16 

Zhang T, Chi Y, Kang Y, Lu H, Niu H, Liu W and Li Y: Resveratrol ameliorates podocyte damage in diabetic mice via SIRT1/PGC-1α mediated attenuation of mitochondrial oxidative stress. J Cell Physiol. 234:5033–5043. 2019.

17 

Zhao L, An R, Yang Y, Yang X, Liu H, Yue L, Li X, Lin Y, Reiter RJ and Qu Y: Melatonin alleviates brain injury in mice subjected to cecal ligation and puncture via attenuating inflammation, apoptosis, and oxidative stress: The role of SIRT1 signaling. J Pineal Res. 59:230–239. 2015.

18 

Gao XH, Xu XX, Pan R, Wang C, Sheng R, Xia YF and Dai Y: Qi-Shao-Shuang-Gan, a combination of astragalus membranaceus saponins with paeonia lactiflora glycosides, ameliorates polymicrobial sepsis induced by cecal ligation and puncture in mice. Inflammation. 34:10–21. 2011.

19 

Liu B, Jian Z, Li Q, Li K, Wang Z, Liu L, Tang L, Yi X, Wang H, Li C and Gao T: Baicalein protects human melanocytes from H2O2-induced apoptosis via inhibiting mitochondria-dependent caspase activation and the p38 MAPK pathway. Free Radic Biol Med. 53:183–193. 2012.

20 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.

21 

Wu X, Zhang B, Fan R, Zhao L, Wang Y, Zhang S, Kaye AD, Huang L and Pei J: U50,488H inhibits neutrophil accumulation and TNF-α induction induced by ischemia-reperfusion in rat heart. Cytokine. 56:503–507. 2011.

22 

Doi K, Leelahavanichkul A, Yuen PS and Star RA: Animal models of sepsis and sepsis-induced kidney injury. J Clin Invest. 119:2868–2878. 2009.

23 

Parker SJ and Watkins PE: Experimental models of gram-negative sepsis. Br J Surg. 88:22–30. 2001.

24 

Wichterman KA, Baue AE and Chaudry IH: Sepsis and septic shock-a review of laboratory models and a proposal. J Surg Res. 29:189–201. 1980.

25 

Buras JA, Holzmann B and Sitkovsky M: Animal models of sepsis: Setting the stage. Nat Rev Drug Discov. 4:854–865. 2005.

26 

Yan M and Yu Y, Mao X, Feng J, Wang Y, Chen H, Xie K and Yu Y: Hydrogen gas inhalation attenuates sepsis-induced liver injury in a FUNDC1-dependent manner. Int Immun. 71:61–67. 2019.

27 

Bozza FA, Salluh JI, Japiassu AM, Soares M, Assis EF, Gomes RN, Bozza MT, Castro-Faria-Neto HC and Bozza PT: Cytokine profiles as markers of disease severity in sepsis: A multiplex analysis. Crit Care. 11(R49)2007.

28 

An R, Zhao L, Xu J, Xi C, Li H, Shen G, Zhang W, Zhang S and Sun L: Resveratrol alleviates sepsisinduced myocardial injury in rats by suppressing neutrophil accumulation, the induction of TNFα and myocardial apoptosis via activation of Sirt1. Mol Med Rep. 14:5297–5303. 2016.

29 

Gao X, Yan X, Yin Y, Lin X, Zhang Q, Xia Y and Cao J: Therapeutic targeting of apoptosis inhibitor of macrophage (AIM)/CD5L in sepsis. Am J Resp Cell Mol Biol. 60:323–334. 2018.

30 

Marino G, Niso-Santano M, Baehrecke EH and Kroemer G: Self-consumption: The interplay of autophagy and apoptosis. Nat Rev Mol Cell Biol. 15:81–94. 2014.

31 

Zheng D, Yu Y, Li M, Wang G, Chen R, Fan GC, Martin C, Xiong S and Peng T: Inhibition of MicroRNA 195 prevents apoptosis and multiple-organ injury in mouse models of sepsis. J Infect Dis. 213:1661–1670. 2016.

32 

Hotchkiss RS, Tinsley KW, Swanson PE, Grayson MH, Osborne DF, Wagner TH, Cobb JP, Coopersmith C and Karl IE: Depletion of dendritic cells, but not macrophages, in patients with sepsis. J Immunol. 168:2493–2500. 2002.

33 

Hotchkiss RS, Tinsley KW, Swanson PE, Schmieg RE Jr, Hui JJ, Chang KC, Osborne DF, Freeman BD, Cobb JP, Buchman TG and Karl IE: Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans. J Immunol. 166:6952–6963. 2001.

34 

Bouras M, Asehnoune K and Roquilly A: Contribution of dendritic cell responses to sepsis-induced immunosuppression and to susceptibility to secondary pneumonia. Front Immunol. 9(2590)2018.

35 

Wei S, Gao Y, Dai X, Fu W, Cai S, Fang H, Zeng Z and Chen Z: SIRT1-mediated HMGB1 deacetylation suppresses sepsis-associated acute kidney injury. Am J Physiol Renal Physiol. 1:F20–F21. 2018.

36 

Ding M, Feng N, Tang D, Feng J, Li Z, Jia M, Liu Z, Gu X, Wang Y, Fu F and Pei J: Melatonin prevents Drp1-mediated mitochondrial fission in diabetic hearts through SIRT1-PGC1α pathway. J Pineal Res. 65(e12491)2018.

37 

Yue L, Zhao L, Liu H, Li X, Wang B, Guo H, Gao L, Feng D and Qu Y: Adiponectin protects against glutamate-induced excitotoxicity via activating SIRT1-dependent PGC-1α expression in HT22 hippocampal neurons. Oxid Med Cell Longev. 2016(2957354)2016.

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Copy and paste a formatted citation
Spandidos Publications style
Su H, Ma Z, Guo A, Wu H and Yang X: Salvianolic acid B protects against sepsis‑induced liver injury via activation of SIRT1/PGC‑1α signaling Retraction in /10.3892/etm.2025.12959. Exp Ther Med 20: 2675-2683, 2020.
APA
Su, H., Ma, Z., Guo, A., Wu, H., & Yang, X. (2020). Salvianolic acid B protects against sepsis‑induced liver injury via activation of SIRT1/PGC‑1α signaling Retraction in /10.3892/etm.2025.12959. Experimental and Therapeutic Medicine, 20, 2675-2683. https://doi.org/10.3892/etm.2020.9020
MLA
Su, H., Ma, Z., Guo, A., Wu, H., Yang, X."Salvianolic acid B protects against sepsis‑induced liver injury via activation of SIRT1/PGC‑1α signaling Retraction in /10.3892/etm.2025.12959". Experimental and Therapeutic Medicine 20.3 (2020): 2675-2683.
Chicago
Su, H., Ma, Z., Guo, A., Wu, H., Yang, X."Salvianolic acid B protects against sepsis‑induced liver injury via activation of SIRT1/PGC‑1α signaling Retraction in /10.3892/etm.2025.12959". Experimental and Therapeutic Medicine 20, no. 3 (2020): 2675-2683. https://doi.org/10.3892/etm.2020.9020
Copy and paste a formatted citation
x
Spandidos Publications style
Su H, Ma Z, Guo A, Wu H and Yang X: Salvianolic acid B protects against sepsis‑induced liver injury via activation of SIRT1/PGC‑1α signaling Retraction in /10.3892/etm.2025.12959. Exp Ther Med 20: 2675-2683, 2020.
APA
Su, H., Ma, Z., Guo, A., Wu, H., & Yang, X. (2020). Salvianolic acid B protects against sepsis‑induced liver injury via activation of SIRT1/PGC‑1α signaling Retraction in /10.3892/etm.2025.12959. Experimental and Therapeutic Medicine, 20, 2675-2683. https://doi.org/10.3892/etm.2020.9020
MLA
Su, H., Ma, Z., Guo, A., Wu, H., Yang, X."Salvianolic acid B protects against sepsis‑induced liver injury via activation of SIRT1/PGC‑1α signaling Retraction in /10.3892/etm.2025.12959". Experimental and Therapeutic Medicine 20.3 (2020): 2675-2683.
Chicago
Su, H., Ma, Z., Guo, A., Wu, H., Yang, X."Salvianolic acid B protects against sepsis‑induced liver injury via activation of SIRT1/PGC‑1α signaling Retraction in /10.3892/etm.2025.12959". Experimental and Therapeutic Medicine 20, no. 3 (2020): 2675-2683. https://doi.org/10.3892/etm.2020.9020
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