Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
September-2020 Volume 20 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2020 Volume 20 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Atherosclerosis prediction by microarray-based DNA methylation analysis

  • Authors:
    • Wei-Da Chen
    • Ting Song
    • Qiu-Hong Cao
    • Rui Li
    • Hua Wang
    • Xiu-Bao Chen
    • Ze-Tao Chen
  • View Affiliations / Copyright

    Affiliations: Health Care Department, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, P.R. China, Health Care Department, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250011, P.R. China, Department of Anesthesiology, Jinan Center Hospital, Jinan, Shandong 250013, P.R. China
  • Pages: 2863-2869
    |
    Published online on: July 21, 2020
       https://doi.org/10.3892/etm.2020.9025
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Using a series of DNA methylation analysis, pathogenesis was investigated to identify the specific DNA methylation markers for diagnosing atherosclerosis. Firstly, with the chip platform of Illumina Human Methylation 450 BeadChip, a total of 1,458 CpGs, covering 971 differential methylated genes were extracted with stringent filtering criteria. Secondly, hierarchical clustering as a heat map was used to check on the dependability of differential methylated genes. Thirdly, the related GO terms and pathways were enriched by up- and down-methylated genes, respectively, after verifying the capacity of these differential methylated genes to distinguish between atherosclerosis and healthy controls. In total, 971 differential DNA methylated genes were identified (1,458 CpGs). Several important function regions were also identified, including cell adhesion, PI3K-Akt signaling pathway and transcription from RNA polymerase II promoter. This study indicates that patients with atherosclerosis have high levels of DNA methylation, which is promising for early diagnosis and treatment of atherosclerosis.
View Figures

Figure 1

Figure 2

View References

1 

Hasanov Z, Ruckdeschel T, Kapel S, Mogler C, Appak S, Spegg C and Augustin HG: Role of Endosialin during atherosclerosis progression. Atherosclerosis. 241(e14)2015. View Article : Google Scholar

2 

Salic K, Wielinga PY, Verschuren L, Gjorstrup P, Kleemann R and Kooistra T: Intervention with anti-inflammatory RVE1 attenuates atherosclerosis without decreasing plasma cholesterol and adds to the anti-atherogenic effect of atorvastatin. Atherosclerosis. 235(e267)2014. View Article : Google Scholar

3 

Campbell LA and Rosenfeld ME: Infection and atherosclerosis development. Arch Med Res. 46:339–350. 2015.PubMed/NCBI View Article : Google Scholar

4 

Ross R: The pathogenesis of atherosclerosis: A perspective for the 1990s. Nature. 362:801–809. 1993.PubMed/NCBI View Article : Google Scholar

5 

Campbell JH, Efendy JL, Smith NJ and Campbell GR: Molecular basis by which garlic suppresses atherosclerosis. J Nutr. 131:1006–1009. 2001.PubMed/NCBI View Article : Google Scholar

6 

Portales-Casamar E, Lussier AA, Jones MJ, MacIsaac JL, Edgar RD, Mah SM, Barhdadi A, Provost S, Lemieux-Perreault LP, Cynader MS, et al: DNA methylation signature of human fetal alcohol spectrum disorder. Epigenetics Chromatin. 9(25)2016.PubMed/NCBI View Article : Google Scholar

7 

Razin A and Riggs AD: DNA methylation and gene function. Science. 210:604–610. 1980.PubMed/NCBI View Article : Google Scholar

8 

Esteller M and Herman JG: Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours. J Pathol. 196:1–7. 2002.PubMed/NCBI View Article : Google Scholar

9 

Masliah E, Dumaop W, Galasko D and Desplats P: Distinctive patterns of DNA methylation associated with Parkinson disease: Identification of concordant epigenetic changes in brain and peripheral blood leukocytes. Epigenetics. 8:1030–1038. 2013.PubMed/NCBI View Article : Google Scholar

10 

Gopalakrishnan S, Van Emburgh BO and Robertson KD: DNA methylation in development and human disease. Mutat Res. 647:30–38. 2008.PubMed/NCBI View Article : Google Scholar

11 

Wu P, Farrell WE, Haworth KE, Emes RD, Kitchen MO, Glossop JR, Hanna FW and Fryer AA: Maternal genome-wide DNA methylation profiling in gestational diabetes shows distinctive disease-associated changes relative to matched healthy pregnancies. Epigenetics. 13:122–128. 2018.PubMed/NCBI View Article : Google Scholar

12 

Chen CY and Ye F: Particle swarm optimization algorithm and its application to clustering analysis. In: IEEE International Conference on Networking, Sensing and Control. IEEE, Taiwan. pp789–794. 2004. View Article : Google Scholar

13 

Diday E and Simon JC: Clustering analysis. Commun Cybern. 10:47–94. 1976.

14 

Deu-Pons J, Schroeder MP and Lopez-Bigas N: Heatmap: An interactive heatmap viewer for the web. Bioinformatics. 30:1757–1758. 2014.PubMed/NCBI View Article : Google Scholar

15 

Kestler HA, Müller A, Kraus JM, Buchholz M, Gress TM, Liu H, Kane DW, Zeeberg BR and Weinstein JN: VennMaster: Area-proportional Euler diagrams for functional GO analysis of microarrays. BMC Bioinformatics. 9(67)2008.PubMed/NCBI View Article : Google Scholar

16 

Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, et al: Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet. 25:25–29. 2000.PubMed/NCBI View Article : Google Scholar

17 

Du Z, Zhou X, Ling Y, Zhang Z and Su Z: agriGO: A GO analysis toolkit for the agricultural community. Nucleic Acids Res. 38:64–70. 2010.PubMed/NCBI View Article : Google Scholar

18 

Ogata H, Goto S, Sato K, Fujibucji W, Bono H and Kanehisa M: KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 27:29–34. 1999.PubMed/NCBI View Article : Google Scholar

19 

Kim HJ: Role of nucleotide-binding and oligomerization domain 2 protein (NOD2) in the development of atherosclerosis. Korean J Physiol Pharmacol. 19:479–484. 2015.PubMed/NCBI View Article : Google Scholar

20 

Bernhard D, Pfister G, Huck CW, Kind M, Salvenmoser W, Bonn GK and Wick G: Disruption of vascular endothelial homeostasis by tobacco smoke: Impact on atherosclerosis. FASEB J. 17:2302–2304. 2003.PubMed/NCBI View Article : Google Scholar

21 

McCully KS: Homocysteine and the pathogenesis of atherosclerosis. Expert Rev Clin Pharmacol. 8:211–219. 2015.PubMed/NCBI View Article : Google Scholar

22 

Goncharov NV, Avdonin PV, Nadeev AD, Zharkikh IL and Jenkins RO: Reactive oxygen species in pathogenesis of atherosclerosis. Curr Pharm Des. 21:1134–1146. 2015.PubMed/NCBI View Article : Google Scholar

23 

Ma X, Ma C and Zheng X: MicroRNA-155 in the pathogenesis of atherosclerosis: A conflicting role? Heart Lung Circ. 22:811–818. 2013. View Article : Google Scholar

24 

Khyzha N, Alizada A, Wilson MD and Fish JE: Epigenetics of atherosclerosis: Emerging mechanisms and methods. Trends Mol Med. 23:332–347. 2017.PubMed/NCBI View Article : Google Scholar

25 

Bustos FJ, Ampuero E, Jury N, Aguilar R, Falahi F, Toledo J, Ahumada J, Lata J, Cubillos P, Henríquez B, et al: Epigenetic editing of the Dlg4/PSD95 gene improves cognition in aged and Alzheimer's disease mice. Brain. 140:3252–3268. 2017.PubMed/NCBI View Article : Google Scholar

26 

Kawamoto R, Ninomiya D, Hasegawa Y, Kasai Y, Kusunoki T, Ohtsuka N, Kumagi T and Abe M: Mildly elevated serum bilirubin levels are negatively associated with carotid atherosclerosis among elderly persons. PLoS One. 9(e114281)2014.PubMed/NCBI View Article : Google Scholar

27 

Zhai C, Cheng J, Mujahid H, Wang H, Kong J, Yin Y, Li J, Zhang Y, Ji X and Chen W: Selective inhibition of PI3K/Akt/mTOR signaling pathway regulates autophagy of macrophage and vulnerability of atherosclerotic plaque. PLoS One. 9(e90563)2014.PubMed/NCBI View Article : Google Scholar

28 

Lu XL, Zhao CH, Yao XL and Zhang H: Quercetin attenuates high fructose feeding-induced atherosclerosis by suppressing inflammation and apoptosis via ROS-regulated PI3K/AKT signaling pathway. Biomed Pharmacother. 85:658–671. 2017.PubMed/NCBI View Article : Google Scholar

29 

Cui C, Wang X, Shang XM, Li L, Ma Y, Zhao GY, Song YX, Geng XB, Zhao BQ, Tian MR, et al: lncRNA 430945 promotes the proliferation and migration of vascular smooth muscle cells via the ROR2/RhoA signaling pathway in atherosclerosis. Mol Med Rep. 19:4663–4672. 2019.PubMed/NCBI View Article : Google Scholar

30 

Yu MH, Lin MC, Huang CN, Chan KC and Wang CJ: Acarbose inhibits the proliferation and migration of vascular smooth muscle cells via targeting Ras signaling. Vascul Pharmacol. 103-105:8–15. 2018. View Article : Google Scholar

31 

Jain T, Nikolopoulou EA, Xu Q and Qu A: Hypoxia inducible factor as a therapeutic target for atherosclerosis. Pharmacol Ther. 183:22–33. 2018.PubMed/NCBI View Article : Google Scholar

32 

Tanaka T and Eckardt KU: HIF activation against CVD in CKD: Novel treatment opportunities. Semin Nephrol. 38:267–276. 2018.PubMed/NCBI View Article : Google Scholar

33 

Feng S, Bowden N, Fragiadaki M, Souilhol C, Hsiao S, Mahmoud M, Allen S, Pirri D, Ayllon BT, Akhtar S, et al: Mechanical activation of hypoxia-inducible factor 1α drives endothelial dysfunction at atheroprone sites. Arterioscler Thromb Vasc Biol. 37:2087–2101. 2017.PubMed/NCBI View Article : Google Scholar

34 

Chen R, Xiong S, Yang Y, Fu W, Wang Y and Ge J: The relationship between human cytomegalovirus infection and atherosclerosis development. Mol Cell Biochem. 249:91–96. 2003.PubMed/NCBI

35 

Perng YC, Campbell JA, Lenschow DJ and Yu D: Human cytomegalovirus pUL79 is an elongation factor of RNA polymerase II for viral gene transcription. PLoS Pathog. 10(e1004350)2014.PubMed/NCBI View Article : Google Scholar

36 

Tabaei S and Tabaee SS: DNA methylation abnormalities in atherosclerosis. Artif Cell Nanomed Biotechnol. 47:2031–2041. 2019.PubMed/NCBI View Article : Google Scholar

37 

Jiang D, Sun M, You L, Lu K, Gao L, Hu C, Wu S, Chang G, Tao H and Zhang D: DNA methylation and hydroxymethylation are associated with the degree of coronary atherosclerosis in elderly patients with coronary heart disease. Life Sci. 224:241–248. 2019.PubMed/NCBI View Article : Google Scholar

38 

Aavik E, Babu M and Ylä-Herttula S: DNA methylation processes in atheosclerotic plaque. Atherosclerosis. 281:168–179. 2019.PubMed/NCBI View Article : Google Scholar

39 

Sayols-Baixeras S, Hernáez A, Subirana I, Lluis-Ganella C, Muñoz D, Fitó M, Marrugat J and Elosua R: DNA methylation and high-density lipoprotein functionality - brief report: The REGICOR study (Registre Gironi del Cor). Arterioscler Thromb Vasc Biol. 37:567–569. 2017.PubMed/NCBI View Article : Google Scholar

40 

Balakrishnan A, Guruprasad KP, Satyamoorthy K and Joshi MB: Interleukin-6 determines protein stabilization of DNA methyltransferases and alters DNA promoter methylation of genes associated with insulin signaling and angiogenesis. Lab Invest. 98:1143–1158. 2018.PubMed/NCBI View Article : Google Scholar

41 

Nazarenko MS, Markov AV, Lebedev IN, Sleptsov AA, Frolov AV, Barbash OL and Puzyrev VP: DNA methylation profiling of the vascular tissues in the setting of atherosclerosis. Mol Biol (Mosk). 47:398–404. 2013.PubMed/NCBI View Article : Google Scholar : (In Russian).

42 

Nazarenko MS, Markov AV, Lebedev IN, Freidin MB, Sleptcov AA, Koroleva IA, Frolov AV, Popov VA, Barbarash OL and Puzyrev VP: A comparison of genome-wide DNA methylation patterns between different vascular tissues from patients with coronary heart disease. PLoS One. 10(e0122601)2015.PubMed/NCBI View Article : Google Scholar

43 

Riffo-Campos AL, Fuentes-Trillo A, Tang WY, Soriano Z, De Marco G, Rentero-Garrido P, Adam-Felici V, Lendinez- Tortajada V, Francesconi K and Goessler W: In silico epigenetics of metal exposure and subclinical atherosclerosis in middle aged men: Pilot results from the Aragon Workers Health Study. Philos Trans R Soc Lond B Biol Sci. 373(1748)2018.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Chen W, Song T, Cao Q, Li R, Wang H, Chen X and Chen Z: Atherosclerosis prediction by microarray-based DNA methylation analysis. Exp Ther Med 20: 2863-2869, 2020.
APA
Chen, W., Song, T., Cao, Q., Li, R., Wang, H., Chen, X., & Chen, Z. (2020). Atherosclerosis prediction by microarray-based DNA methylation analysis. Experimental and Therapeutic Medicine, 20, 2863-2869. https://doi.org/10.3892/etm.2020.9025
MLA
Chen, W., Song, T., Cao, Q., Li, R., Wang, H., Chen, X., Chen, Z."Atherosclerosis prediction by microarray-based DNA methylation analysis". Experimental and Therapeutic Medicine 20.3 (2020): 2863-2869.
Chicago
Chen, W., Song, T., Cao, Q., Li, R., Wang, H., Chen, X., Chen, Z."Atherosclerosis prediction by microarray-based DNA methylation analysis". Experimental and Therapeutic Medicine 20, no. 3 (2020): 2863-2869. https://doi.org/10.3892/etm.2020.9025
Copy and paste a formatted citation
x
Spandidos Publications style
Chen W, Song T, Cao Q, Li R, Wang H, Chen X and Chen Z: Atherosclerosis prediction by microarray-based DNA methylation analysis. Exp Ther Med 20: 2863-2869, 2020.
APA
Chen, W., Song, T., Cao, Q., Li, R., Wang, H., Chen, X., & Chen, Z. (2020). Atherosclerosis prediction by microarray-based DNA methylation analysis. Experimental and Therapeutic Medicine, 20, 2863-2869. https://doi.org/10.3892/etm.2020.9025
MLA
Chen, W., Song, T., Cao, Q., Li, R., Wang, H., Chen, X., Chen, Z."Atherosclerosis prediction by microarray-based DNA methylation analysis". Experimental and Therapeutic Medicine 20.3 (2020): 2863-2869.
Chicago
Chen, W., Song, T., Cao, Q., Li, R., Wang, H., Chen, X., Chen, Z."Atherosclerosis prediction by microarray-based DNA methylation analysis". Experimental and Therapeutic Medicine 20, no. 3 (2020): 2863-2869. https://doi.org/10.3892/etm.2020.9025
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team