Open Access

Protective role of selenium on thyroid morphology in iodine‑induced autoimmune thyroiditis in Wistar rats

  • Authors:
    • Ioana Vasiliu
    • Delia-Gabriela Ciobanu-Apostol
    • Ioana Armasu
    • Ovidiu Bredetean
    • Ionela Lacramioara Serban
    • Cristina Preda
  • View Affiliations

  • Published online on: July 23, 2020     https://doi.org/10.3892/etm.2020.9029
  • Pages: 3425-3437
  • Copyright: © Vasiliu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Excess iodine may induce and exacerbate autoimmune thyroiditis (AIT) in humans and animals. In order to assess the potential protective mechanisms of selenium (Se) in thyroid autoimmunity, the effects of inorganic Se (sodium selenite) administration on thyroid morphology and follicular cytology were investigated in adult Wistar rats with iodine‑induced AIT. A total of 48 adult Wistar rats (24 females, 24 males) were allocated to one of four dietary regimens: C0, control; C1, only potassium iodine (KI); C2, concomitant KI and Se; C3, only KI initially, followed by Se administration. For AIT induction the rats were fed with 0.05% KI for 56 days. Se‑treated rats received 0.3 mg/l sodium selenite in drinking water. Thyroid tissues were collected for pathologic diagnosis after 7 days in C0 group, 56 days in C1 and C2 groups, and 112 days in C3 group. In C1 group, moderate to severe thyroiditis was observed in 83% of males and 50% of female rats (P=0.223). In C3 group 16.7% of male rats developed moderate thyroiditis and none in C2 group, whereas no females were identified with moderate to severe thyroiditis in C2 or C3 group. Thus, the administration of Se was proven to have protective effects against thyroiditis cytology in both male and female Wistar rats.
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October-2020
Volume 20 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Vasiliu I, Ciobanu-Apostol D, Armasu I, Bredetean O, Serban IL and Preda C: Protective role of selenium on thyroid morphology in iodine‑induced autoimmune thyroiditis in Wistar rats. Exp Ther Med 20: 3425-3437, 2020
APA
Vasiliu, I., Ciobanu-Apostol, D., Armasu, I., Bredetean, O., Serban, I.L., & Preda, C. (2020). Protective role of selenium on thyroid morphology in iodine‑induced autoimmune thyroiditis in Wistar rats. Experimental and Therapeutic Medicine, 20, 3425-3437. https://doi.org/10.3892/etm.2020.9029
MLA
Vasiliu, I., Ciobanu-Apostol, D., Armasu, I., Bredetean, O., Serban, I. L., Preda, C."Protective role of selenium on thyroid morphology in iodine‑induced autoimmune thyroiditis in Wistar rats". Experimental and Therapeutic Medicine 20.4 (2020): 3425-3437.
Chicago
Vasiliu, I., Ciobanu-Apostol, D., Armasu, I., Bredetean, O., Serban, I. L., Preda, C."Protective role of selenium on thyroid morphology in iodine‑induced autoimmune thyroiditis in Wistar rats". Experimental and Therapeutic Medicine 20, no. 4 (2020): 3425-3437. https://doi.org/10.3892/etm.2020.9029