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Article

Distribution pattern of invasion‑related bio‑markers in head Marjolin's ulcer

  • Authors:
    • Zhihui Ni
    • Zhao Zheng
    • Enxing Yu
    • Can Zu
    • Dongdong Huang
    • Ke Wu
    • Jiangnan Hu
    • Sheng Ye
    • Qichuan Zhuge
    • Jianjing Yang
    • Linhui Ruan
  • View Affiliations / Copyright

    Affiliations: Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China, Department of Pharmaceutical Sciences, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
  • Pages: 3316-3323
    |
    Published online on: July 23, 2020
       https://doi.org/10.3892/etm.2020.9034
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Abstract

Marjolin's ulcer (MU) is a rare and aggressive cutaneous malignancy that typically presented in an area of traumatized or chronically inflamed skin and particularly in burn scars. Among them, the MU in the scalp with extensive invasion of the skull is exceptional and severe. The principle of management for MU is to obtain an early diagnosis and perform prompt surgical interventions. The invasive capacity of MU may vary among different sites of the scalp, which may require different therapeutic strategies for surgical excision. However, no clear evidence has been provided to determine the invasion ability of MU at different regions of the lesion as a surgical guidance. In present study, a 41‑year‑old female with a 40‑year history of scalp ulceration has been examined. After resection of the MU lesion, hematoxylin and eosin (H&E) staining was performed to confirm the pathology of the cutaneous malignancy after surgical excision. Furthermore, reverse transcription‑quantitative PCR experiment was performed out to determine the expression levels of invasion‑associated biomarkers at different sites of the scalp affected by MU. Pathological analysis with H&E staining indicated a differentiated squamous cell carcinoma with invasion of the skull. The invasion‑associated biomarkers were highly expressed in the core region compared to the middle region as well as the edge of MU tissue. Taken together, the present study suggests that the expression pattern of invasion‑associated biomarkers varies between different regions of the MU lesion. High expression levels in the core region of MU indicates that the resection of the center area may be critical for the successful surgical treatment of MU.
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1 

Yu N, Long X, Lujan-Hernandez JR, Hassan KZ, Bai M, Wang Y, Wang X and Zhao R: Marjolin's ulcer: A preventable malignancy arising from scars. World J Surg Oncol. 11(313)2013.PubMed/NCBI View Article : Google Scholar

2 

Saaiq M and Ashraf B: Marjolin's ulcers in the post-burned lesions and scars. World J Clin Cases. 2:507–514. 2014.PubMed/NCBI View Article : Google Scholar

3 

Copcu E: Marjolin's ulcer: A preventable complication of burns? Plast Reconstr Surg. 124:156e–164e. 2009.PubMed/NCBI View Article : Google Scholar

4 

Cocchetto V, Magrin P, de Paula RA, Aidé M, Monte Razo L and Pantaleão L: Squamous cell carcinoma in chronic wound: Marjolin ulcer. Dermatol Online J. 19(7)2013.PubMed/NCBI

5 

Huang CY, Feng CH, Hsiao YC, Chuang SS and Yang JY: Burn scar carcinoma. J Dermatolog Treat. 21:350–356. 2010.PubMed/NCBI View Article : Google Scholar

6 

Gül U and Kiliç A: Squamous cell carcinoma developing on burn scar. Ann Plast Surg. 56:406–408. 2006.PubMed/NCBI View Article : Google Scholar

7 

Takada H, Ibaragi S, Eguchi T, Okui T, Obata K, Masui M, Morisawa A, Takabatake K, Kawai H, Yoshioka N, et al: Semaphorin 4D promotes bone invasion in head and neck squamous cell carcinoma. Int J Oncol. 51:625–632. 2017.PubMed/NCBI View Article : Google Scholar

8 

Siriwardena SBSM, Tsunematsu T, Qi G, Ishimaru N and Kudo Y: Invasion-related factors as potential diagnostic and therapeutic targets in oral squamous cell carcinoma-a review. Int J Mol Sci. 19(1462)2018.PubMed/NCBI View Article : Google Scholar

9 

Glentis A, Gurchenkov V and Matic Vignjevic D: Assembly, heterogeneity, and breaching of the basement membranes. Cell Adh Migr. 8:236–245. 2014.PubMed/NCBI View Article : Google Scholar

10 

Obayashi M, Yoshida M, Tsunematsu T, Ogawa I, Sasahira T, Kuniyasu H, Imoto I, Abiko Y, Xu D, Fukunaga S, et al: microRNA-203 suppresses invasion and epithelial-mesenchymal transition induction via targeting NUAK1 in head and neck cancer. Oncotarget. 7:8223–8239. 2016.PubMed/NCBI View Article : Google Scholar

11 

Witz IP: The tumor microenvironment: The making of a paradigm. Cancer Microenviron. 2 (Suppl 1):9–17. 2009.PubMed/NCBI View Article : Google Scholar

12 

Hu J, Chen L, Huang X, Wu K, Ding S, Wang W, Wang B, Smith C, Ren C, Ni H, et al: Calpain inhibitor MDL28170 improves the transplantation-mediated therapeutic effect of bone marrow-derived mesenchymal stem cells following traumatic brain injury. Stem Cell Res Ther. 10(96)2019.PubMed/NCBI View Article : Google Scholar

13 

Ni H, Yang S, Siaw-Debrah F, Hu J, Wu K, He Z, Yang J, Pan S, Lin X, Ye H, et al: Exosomes derived from bone mesenchymal stem cells ameliorate early inflammatory responses following traumatic brain injury. Front Neurosci. 13(14)2019.PubMed/NCBI View Article : Google Scholar

14 

Ding S, Zhuge W, Hu J, Yang J, Wang X, Wen F, Wang C and Zhuge Q: Baicalin reverses the impairment of synaptogenesis induced by dopamine burden via the stimulation of GABAAR-TrkB interaction in minimal hepatic encephalopathy. Psychopharmacology (Berl). 235:1163–1178. 2018.PubMed/NCBI View Article : Google Scholar

15 

Sinha S, Su S, Workentine M, Agabalyan N, Cheng M, Gabriel V and Biernaskie J: Transcriptional analysis reveals evidence of chronically impeded ECM turnover and epithelium-to-mesenchyme transition in scar tissue giving rise to Marjolin's ulcer. J Burn Care Res. 38:e14–e22. 2017.PubMed/NCBI View Article : Google Scholar

16 

Sherrill JD, Kc K, Wu D, Djukic Z, Caldwell JM, Stucke EM, Kemme KA, Costello MS, Mingler MK, Blanchard C, et al: Desmoglein-1 regulates esophageal epithelial barrier function and immune responses in eosinophilic esophagitis. Mucosal Immunol. 7:718–29. 2014.PubMed/NCBI View Article : Google Scholar

17 

Dos Reis PP, Bharadwaj RR, Machado J, Macmillan C, Pintilie M, Sukhai MA, Perez-Ordonez B, Gullane P, Irish J and Kamel-Reid S: Claudin 1 overexpression increases invasion and is associated with aggressive histological features in oral squamous cell carcinoma. Cancer. 113:3169–3180. 2008.PubMed/NCBI View Article : Google Scholar

18 

Oku N, Sasabe E, Ueta E, Yamamoto T and Osaki T: Tight junction protein claudin-1 enhances the invasive activity of oral squamous cell carcinoma cells by promoting cleavage of laminin-5 gamma2 chain via matrix metalloproteinase (MMP)-2 and membrane-type MMP-1. Cancer Res. 66:5251–5257. 2006.PubMed/NCBI View Article : Google Scholar

19 

Tunggal JA, Helfrich I, Schmitz A, Schwarz H, Günzel D, Fromm M, Kemler R, Krieg T and Niessen CM: E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions. EMBO J. 24:1146–1156. 2005.PubMed/NCBI View Article : Google Scholar

20 

Huang CC, Lee TJ, Chang PH, Lee YS, Chuang CC, Jhang YJ, Chen YW, Chen CW and Tsai CN: Desmoglein 3 is overexpressed in inverted papilloma and squamous cell carcinoma of sinonasal cavity. Laryngoscope. 120:26–29. 2010.PubMed/NCBI View Article : Google Scholar

21 

de Vicente JC, Lequerica-Fernández P, Santamaría J and Fresno MF: Expression of MMP-7 and MT1-MMP in oral squamous cell carcinoma as predictive indicator for tumor invasion and prognosis. J Oral Pathol Med. 36:415–424. 2007.PubMed/NCBI View Article : Google Scholar

22 

Bodnar M, Szylberg L, Kazmierczak W and Marszalek A: Differentiated expression of membrane type metalloproteinases (MMP-14, MMP-15) and pro-MMP2 in laryngeal squamous cell carcinoma. A novel mechanism. J Oral Pathol Med. 42:267–274. 2013.PubMed/NCBI View Article : Google Scholar

23 

Kwon YJ, Lee SJ, Koh JS, Kim SH, Kim YJ and Park JH: Expression patterns of aurora kinase B, heat shock protein 47, and periostin in esophageal squamous cell carcinoma. Oncol Res. 18:141–151. 2009.PubMed/NCBI View Article : Google Scholar

24 

Reddy KB, Nabha SM and Atanaskova N: Role of MAP kinase in tumor progression and invasion. Cancer Metastasis Rev. 22:395–403. 2003.PubMed/NCBI View Article : Google Scholar

25 

Samantaray S, Sharma R, Chattopadhyaya TK, Gupta SD and Ralhan R: Increased expression of MMP-2 and MMP-9 in esophageal squamous cell carcinoma. J Cancer Res Clin Oncol. 130:37–44. 2004.PubMed/NCBI View Article : Google Scholar

26 

Yokoyama K, Kamata N, Fujimoto R, Tsutsumi S, Tomonari M, Taki M, Hosokawa H and Nagayama M: Increased invasion and matrix metalloproteinase-2 expression by Snail-induced mesenchymal transition in squamous cell carcinomas. Int J Oncol. 22:891–898. 2003.PubMed/NCBI

27 

Ibbetson SJ, Pyne NT, Pollard AN, Olson MF and Samuel MS: Mechanotransduction pathways promoting tumor progression are activated in invasive human squamous cell carcinoma. Am J Pathol. 183:930–937. 2013.PubMed/NCBI View Article : Google Scholar

28 

Kashyap MK, Marimuthu A, Peri S, Kumar GS, Jacob HK, Prasad TS, Mahmood R, Kumar KV, Kumar MV, Meltzer SJ, et al: Overexpression of periostin and lumican in esophageal squamous cell carcinoma. Cancers (Basel). 2:133–142. 2010.PubMed/NCBI View Article : Google Scholar

29 

Jimi E, Shin M, Furuta H, Tada Y and Kusukawa J: The RANKL/RANK system as a therapeutic target for bone invasion by oral squamous cell carcinoma (Review). Int J Oncol. 42:803–809. 2013.PubMed/NCBI View Article : Google Scholar

30 

Kitazawa S and Kitazawa R: RANK ligand is a prerequisite for cancer-associated osteolytic lesions. J Pathol. 198:228–236. 2002.PubMed/NCBI View Article : Google Scholar

31 

Chuang FH, Hsue SS, Wu CW and Chen YK: Immunohistochemical expression of RANKL, RANK, and OPG in human oral squamous cell carcinoma. J Oral Pathol Med. 38:753–758. 2009.PubMed/NCBI View Article : Google Scholar

32 

Murata T, Naomoto Y, Yamatsuji T, Okawa T, Shirakawa Y, Gunduz M, Nobuhisa T, Takaoka M, Sirmali M, Nakajima M, et al: Localization of FAK is related with colorectal carcinogenesis. Int J Oncol. 32:791–796. 2008.PubMed/NCBI

33 

Schober M and Fuchs E: Tumor-initiating stem cells of squamous cell carcinomas and their control by TGF-β and integrin/focal adhesion kinase (FAK) signaling. Proc Natl Acad Sci USA. 108:10544–10549. 2011.PubMed/NCBI View Article : Google Scholar

34 

Miyazaki T, Kato H, Nakajima M, Sohda M, Fukai Y, Masuda N, Manda R, Fukuchi M, Tsukada K and Kuwano H: FAK overexpression is correlated with tumour invasiveness and lymph node metastasis in oesophageal squamous cell carcinoma. Br J Cancer. 89:140–145. 2003.PubMed/NCBI View Article : Google Scholar

35 

Grandis JR, Drenning SD, Zeng Q, Watkins SC, Melhem MF, Endo S, Johnson DE, Huang L, He Y and Kim JD: Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo. Proc Natl Acad Sci USA. 97:4227–4232. 2000.PubMed/NCBI View Article : Google Scholar

36 

Kijima T, Niwa H, Steinman RA, Drenning SD, Gooding WE, Wentzel AL, Xi S and Grandis JR: STAT3 activation abrogates growth factor dependence and contributes to head and neck squamous cell carcinoma tumor growth in vivo. Cell Growth Differ. 13:355–362. 2002.PubMed/NCBI

37 

Rubin Grandis J, Melhem MF, Gooding WE, Day R, Holst VA, Wagener MM, Drenning SD and Tweardy DJ: Levels of TGF-alpha and EGFR protein in head and neck squamous cell carcinoma and patient survival. J Natl Cancer Inst. 90:824–832. 1998.PubMed/NCBI View Article : Google Scholar

38 

Hanawa M, Suzuki S, Dobashi Y, Yamane T, Kono K, Enomoto N and Ooi A: EGFR protein overexpression and gene amplification in squamous cell carcinomas of the esophagus. Int J Cancer. 118:1173–1180. 2006.PubMed/NCBI View Article : Google Scholar

39 

Li Z, Liu J, Li L, Shao S, Wu J, Bian L and He Y: Epithelial mesenchymal transition induced by the CXCL9/CXCR3 axis through AKT activation promotes invasion and metastasis in tongue squamous cell carcinoma. Oncol Rep. 39:1356–1368. 2018.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Ni Z, Zheng Z, Yu E, Zu C, Huang D, Wu K, Hu J, Ye S, Zhuge Q, Yang J, Yang J, et al: Distribution pattern of invasion‑related bio‑markers in head Marjolin's ulcer. Exp Ther Med 20: 3316-3323, 2020.
APA
Ni, Z., Zheng, Z., Yu, E., Zu, C., Huang, D., Wu, K. ... Ruan, L. (2020). Distribution pattern of invasion‑related bio‑markers in head Marjolin's ulcer. Experimental and Therapeutic Medicine, 20, 3316-3323. https://doi.org/10.3892/etm.2020.9034
MLA
Ni, Z., Zheng, Z., Yu, E., Zu, C., Huang, D., Wu, K., Hu, J., Ye, S., Zhuge, Q., Yang, J., Ruan, L."Distribution pattern of invasion‑related bio‑markers in head Marjolin's ulcer". Experimental and Therapeutic Medicine 20.4 (2020): 3316-3323.
Chicago
Ni, Z., Zheng, Z., Yu, E., Zu, C., Huang, D., Wu, K., Hu, J., Ye, S., Zhuge, Q., Yang, J., Ruan, L."Distribution pattern of invasion‑related bio‑markers in head Marjolin's ulcer". Experimental and Therapeutic Medicine 20, no. 4 (2020): 3316-3323. https://doi.org/10.3892/etm.2020.9034
Copy and paste a formatted citation
x
Spandidos Publications style
Ni Z, Zheng Z, Yu E, Zu C, Huang D, Wu K, Hu J, Ye S, Zhuge Q, Yang J, Yang J, et al: Distribution pattern of invasion‑related bio‑markers in head Marjolin's ulcer. Exp Ther Med 20: 3316-3323, 2020.
APA
Ni, Z., Zheng, Z., Yu, E., Zu, C., Huang, D., Wu, K. ... Ruan, L. (2020). Distribution pattern of invasion‑related bio‑markers in head Marjolin's ulcer. Experimental and Therapeutic Medicine, 20, 3316-3323. https://doi.org/10.3892/etm.2020.9034
MLA
Ni, Z., Zheng, Z., Yu, E., Zu, C., Huang, D., Wu, K., Hu, J., Ye, S., Zhuge, Q., Yang, J., Ruan, L."Distribution pattern of invasion‑related bio‑markers in head Marjolin's ulcer". Experimental and Therapeutic Medicine 20.4 (2020): 3316-3323.
Chicago
Ni, Z., Zheng, Z., Yu, E., Zu, C., Huang, D., Wu, K., Hu, J., Ye, S., Zhuge, Q., Yang, J., Ruan, L."Distribution pattern of invasion‑related bio‑markers in head Marjolin's ulcer". Experimental and Therapeutic Medicine 20, no. 4 (2020): 3316-3323. https://doi.org/10.3892/etm.2020.9034
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