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Review Open Access

Effects of astaxanthin on the protection of muscle health (Review)

  • Authors:
    • Sok Kuan Wong
    • Soelaiman Ima‑Nirwana
    • Kok‑Yong Chin
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Ya'acob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia
    Copyright: © Wong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2941-2952
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    Published online on: July 29, 2020
       https://doi.org/10.3892/etm.2020.9075
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Abstract

Sarcopenia refers to the involuntary and generalized deterioration of skeletal muscle mass and strength, which may lead to falls, frailty, physical disability, loss of independence, morbidity and mortality. The majority of molecular and cellular changes involved in the degeneration of muscle tissues are mediated by oxidative stress. Therefore, astaxanthin may act as a potential adjunct therapy for sarcopenia owing to its antioxidant activity. The present review examines the effects of astaxanthin on the promotion of skeletal muscle performance and prevention of muscle atrophy and the potential mechanisms underlying these effects. The available evidence till date was retrieved from PubMed and Medline electronic databases. The present review reported the beneficial effects of astaxanthin in preventing muscle degeneration in various animal models of sarcopenia. In humans, the effects of astaxanthin in combination with other antioxidants on muscle health are mixed, wherein positive and negligible effects were reported. Mechanistic studies revealed that astaxanthin promotes muscle health by reducing oxidative stress, myoblast apoptosis and proteolytic pathways while promoting mitochondria regeneration and formation of blood vessels. Thus, astaxanthin is a potential therapeutic agent for sarcopenia but its effects in humans require further validation.
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1 

Santilli V, Bernetti A, Mangone M and Paoloni M: Clinical definition of sarcopenia. Clin Cases Miner Bone Metab. 11:177–180. 2014.PubMed/NCBI

2 

Trajanoska K, Schoufour JD, Darweesh SK, Benz E, Medina-Gomez C, Alferink LJ, Lahousse L, Brusselle G, Stricker B, Darwish Murad S, et al: Sarcopenia and its clinical correlates in the general population: The rotterdam study. J Bone Miner Res. 33:1209–1218. 2018.PubMed/NCBI View Article : Google Scholar

3 

Beaudart C, Rizzoli R, Bruyère O, Reginster JY and Biver E: Sarcopenia: Burden and challenges for public health. Arch Public Health. 72:45. 2014.PubMed/NCBI View Article : Google Scholar

4 

Shafiee G, Keshtkar A, Soltani A, Ahadi Z, Larijani B and Heshmat R: Prevalence of sarcopenia in the world: A systematic review and meta-analysis of general population studies. J Diabetes Metab Disord. 16:21. 2017.PubMed/NCBI View Article : Google Scholar

5 

Goates S, Du K, Arensberg MB, Gaillard T, Guralnik J and Pereira SL: Economic impact of hospitalizations in US adults with sarcopenia. J Frailty Aging. 8:93–99. 2019.PubMed/NCBI View Article : Google Scholar

6 

World Population Ageing: World Population Ageing 2017. United Nations New York, 2017.

7 

Kwak JY and Kwon KS: Pharmacological interventions for treatment of sarcopenia: Current status of drug development for sarcopenia. Ann Geriatr Med Res. 23:98–104. 2019.PubMed/NCBI View Article : Google Scholar

8 

Aoi W and Sakuma K: Oxidative stress and skeletal muscle dysfunction with aging. Curr Aging Sci. 4:101–109. 2011.PubMed/NCBI View Article : Google Scholar

9 

Londhe P and Guttridge DC: Inflammation induced loss of skeletal muscle. Bone. 80:131–142. 2015.PubMed/NCBI View Article : Google Scholar

10 

Andreux PA, van Diemen MPJ, Heezen MR, Auwerx J, Rinsch C, Groeneveld GJ and Singh A: Mitochondrial function is impaired in the skeletal muscle of pre-frail elderly. Sci Rep. 8(8548)2018.PubMed/NCBI View Article : Google Scholar

11 

Fujino H, Kondo H, Nagatomo F and Ishihara A: Capillary growth and regression in skeletal muscle. J Phys Fit Sports Med. 3:483–491. 2014.

12 

Lee SP, Mar GY and Ng LT: Effects of tocotrienol-rich fraction on exercise endurance capacity and oxidative stress in forced swimming rats. Eur J Appl Physiol. 107:587–595. 2009.PubMed/NCBI View Article : Google Scholar

13 

Servais S, Letexier D, Favier R, Duchamp C and Desplanches D: Prevention of unloading-induced atrophy by vitamin E supplementation: Links between oxidative stress and soleus muscle proteolysis? Free Radic Biol Med. 42:627–635. 2007.PubMed/NCBI View Article : Google Scholar

14 

Higuera-Ciapara I, Felix-Valenzuela L and Goycoolea FM: Astaxanthin: A review of its chemistry and applications. Crit Rev Food Sci Nutr. 46:185–196. 2006.PubMed/NCBI View Article : Google Scholar

15 

Dose J, Matsugo S, Yokokawa H, Koshida Y, Okazaki S, Seidel U, Eggersdorfer M, Rimbach G and Esatbeyoglu T: Free radical scavenging and cellular antioxidant properties of astaxanthin. Int J Mol Sci. 17(103)2016.PubMed/NCBI View Article : Google Scholar

16 

Park JS, Chyun JH, Kim YK, Line LL and Chew BP: Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans. Nutr Metab. 7:18. 2010.PubMed/NCBI View Article : Google Scholar

17 

McCall B, McPartland CK, Moore R, Frank-Kamenetskii A and Booth BW: Effects of astaxanthin on the proliferation and migration of breast cancer cells in vitro. Antioxidants. 7(135)2018.PubMed/NCBI View Article : Google Scholar

18 

Sila A, Ghlissi Z, Kamoun Z, Makni M, Nasri M, Bougatef A and Sahnoun Z: Astaxanthin from shrimp by-products ameliorates nephropathy in diabetic rats. Eur J Nutr. 54:301–307. 2015.PubMed/NCBI View Article : Google Scholar

19 

Kang H and Kim H: Astaxanthin and β-carotene in Helicobacter pylori-induced Gastric Inflammation: A mini-review on action mechanisms. J Cancer Prev. 22:57–61. 2017.PubMed/NCBI View Article : Google Scholar

20 

Rao AR, Sarada R, Shylaja MD and Ravishankar GA: Evaluation of hepatoprotective and antioxidant activity of astaxanthin and astaxanthin esters from microalga-Haematococcus pluvialis. J Food Sci Tech. 52:6703–6710. 2015.PubMed/NCBI View Article : Google Scholar

21 

Feng Y, Chu A, Luo Q, Wu M, Shi X and Chen Y: The protective effect of astaxanthin on cognitive function via inhibition of oxidative stress and inflammation in the brains of chronic T2DM Rats. Front Pharmacol. 9(748)2018.PubMed/NCBI View Article : Google Scholar

22 

Fassett RG and Coombes JS: Astaxanthin: A potential therapeutic agent in cardiovascular disease. Mar Drugs. 9:447–465. 2011.PubMed/NCBI View Article : Google Scholar

23 

Hashimoto H, Arai K, Hayashi S, Okamoto H, Takahashi J, Chikuda M and Obara Y: Effects of astaxanthin on antioxidation in human aqueous humor. J Clin Biochem Nutr. 53:1–7. 2013.PubMed/NCBI View Article : Google Scholar

24 

Davinelli S, Nielsen ME and Scapagnini G: Astaxanthin in skin health, repair, and disease: A comprehensive review. Nutrients. 10(522)2018.PubMed/NCBI View Article : Google Scholar

25 

Brown DR, Gough LA, Deb SK, Sparks SA and McNaughton LR: Astaxanthin in exercise metabolism, performance and recovery: A review. Front Nutr. 4(76)2017.PubMed/NCBI View Article : Google Scholar

26 

Yu T, Dohl J, Chen Y, Gasier HG and Deuster PA: Astaxanthin but not quercetin preserves mitochondrial integrity and function, ameliorates oxidative stress, and reduces heat-induced skeletal muscle injury. J Cell Physiol. 234:13292–13302. 2019.PubMed/NCBI View Article : Google Scholar

27 

Aoi W, Maoka T, Abe R, Fujishita M and Tominaga K: Comparison of the effect of non-esterified and esterified astaxanthins on endurance performance in mice. J Clin Biochem Nutr. 62:161–166. 2018.PubMed/NCBI View Article : Google Scholar

28 

Polotow TG, Vardaris CV, Mihaliuc AR, Gonçalves MS, Pereira B, Ganini D and Barros MP: Astaxanthin supplementation delays physical exhaustion and prevents redox imbalances in plasma and soleus muscles of Wistar rats. Nutrients. 6:5819–5838. 2014.PubMed/NCBI View Article : Google Scholar

29 

Kawamura A, Aoi W, Abe R, Kobayashi Y, Wada S, Kuwahata M and Higashi A: Combined intake of astaxanthin, β-carotene, and resveratrol elevates protein synthesis during muscle hypertrophy in mice. Nutrition. 69(110561)2019.PubMed/NCBI View Article : Google Scholar

30 

Kanazashi M, Okumura Y, Al-Nassan S, Murakami S, Kondo H, Nagatomo F, Fujita N, Ishihara A, Roy RR and Fujino H: Protective effects of astaxanthin on capillary regression in atrophied soleus muscle of rats. Acta Physiol. 207:405–415. 2013.PubMed/NCBI View Article : Google Scholar

31 

Kanazashi M, Tanaka M, Murakami S, Kondo H, Nagatomo F, Ishihara A, Roy RR and Fujino H: Amelioration of capillary regression and atrophy of the soleus muscle in hindlimb-unloaded rats by astaxanthin supplementation and intermittent loading. Exp Physiol. 99:1065–1077. 2014.PubMed/NCBI View Article : Google Scholar

32 

Kanazashi M, Tanaka M, Nakanishi R, Maeshige N and Fujino H: Effects of astaxanthin supplementation and electrical stimulation on muscle atrophy and decreased oxidative capacity in soleus muscle during hindlimb unloading in rats. J Physiol Sci. 69:757–767. 2019.PubMed/NCBI View Article : Google Scholar

33 

Yoshihara T, Yamamoto Y, Shibaguchi T, Miyaji N, Kakigi R, Naito H, Goto K, Ohmori D, Yoshioka T and Sugiura T: Dietary astaxanthin supplementation attenuates disuse-induced muscle atrophy and myonuclear apoptosis in the rat soleus muscle. J Physiol Sci. 67:181–190. 2017.PubMed/NCBI View Article : Google Scholar

34 

Yoshihara T, Sugiura T, Miyaji N, Yamamoto Y, Shibaguchi T, Kakigi R, Naito H, Goto K, Ohmori D and Yoshioka T: Effect of a combination of astaxanthin supplementation, heat stress, and intermittent reloading on satellite cells during disuse muscle atrophy. J Zhejiang Univ Sci B. 19:844–852. 2018.PubMed/NCBI View Article : Google Scholar

35 

Wang F, Zhang QB, Zhou Y, Chen S, Huang PP, Liu Y and Xu YH: The mechanisms and treatments of muscular pathological changes in immobilization-induced joint contracture: A literature review. Chin J Traumatol. 22:93–98. 2019.PubMed/NCBI View Article : Google Scholar

36 

Frimel TN, Kapadia F, Gaidosh GS, Li Y, Walter GA and Vandenborne K: A model of muscle atrophy using cast immobilization in mice. Muscle Nerve. 32:672–674. 2005.PubMed/NCBI View Article : Google Scholar

37 

Morey-Holton ER and Globus RK: Hindlimb unloading rodent model: Technical aspects. J Appl Physiol (1985). 92:1367–1377. 2002.PubMed/NCBI View Article : Google Scholar

38 

Shibaguchi T, Yamaguchi Y, Miyaji N, Yoshihara T, Naito H, Goto K, Ohmori D, Yoshioka T and Sugiura T: Astaxanthin intake attenuates muscle atrophy caused by immobilization in rats. Physiol Rep. 4(e12885)2016.PubMed/NCBI View Article : Google Scholar

39 

Maezawa T, Tanaka M, Kanazashi M, Maeshige N, Kondo H, Ishihara A and Fujino H: Astaxanthin supplementation attenuates immobilization-induced skeletal muscle fibrosis via suppression of oxidative stress. J Physiol Sci. 67:603–611. 2017.PubMed/NCBI View Article : Google Scholar

40 

Nishida Y, Nawaz A, Kado T, Takikawa A, Igarashi Y, Onogi Y, Wada T, Sasaoka T, Yamamoto S, Sasahara M, et al: Astaxanthin stimulates mitochondrial biogenesis in insulin resistant muscle via activation of AMPK pathway. J Cachexia Sarcopenia Muscle. 11:241–258. 2020.PubMed/NCBI View Article : Google Scholar

41 

Inoue H, Shimamoto S, Takahashi H, Kawashima Y, Wataru S, Ijiri D and Ohtsuka A: Effects of astaxanthin-rich dried cell powder from Paracoccus carotinifaciens on carotenoid composition and lipid peroxidation in skeletal muscle of broiler chickens under thermo-neutral or realistic high temperature conditions. Anim Sci J. 90:229–236. 2019.PubMed/NCBI View Article : Google Scholar

42 

Mancini RA and Hunt MC: Current research in meat color. Meat Sci. 71:100–121. 2005.PubMed/NCBI View Article : Google Scholar

43 

Zeferino CP, Komiyama CM, Pelícia VC, Fascina VB, Aoyagi MM, Coutinho LL, Sartori JR and Moura AS: Carcass and meat quality traits of chickens fed diets concurrently supplemented with vitamins C and E under constant heat stress. Animal. 10:163–171. 2016.PubMed/NCBI View Article : Google Scholar

44 

Bloomer RJ, Fry A, Schilling B, Chiu L, Hori N and Weiss L: Astaxanthin supplementation does not attenuate muscle injury following eccentric exercise in resistance-trained men. Int J Sport Nutr Exerc Metab. 15:401–412. 2005.PubMed/NCBI View Article : Google Scholar

45 

Djordjevic B, Baralic I, Kotur-Stevuljevic J, Stefanovic A, Ivanisevic J, Radivojevic N, Andjelkovic M and Dikic N: Effect of astaxanthin supplementation on muscle damage and oxidative stress markers in elite young soccer players. J Sports Med Phys Fitness. 52:382–392. 2012.PubMed/NCBI

46 

Liu SZ, Ali AS, Campbell MD, Kilroy K, Shankland EG, Roshanravan B, Marcinek DJ and Conley KE: Building strength, endurance, and mobility using an astaxanthin formulation with functional training in elderly. J Cachexia Sarcopenia Muscle. 9:826–833. 2018.PubMed/NCBI View Article : Google Scholar

47 

Takami M, Aoi W, Terajima H, Tanimura Y, Wada S and Higashi A: Effect of dietary antioxidant-rich foods combined with aerobic training on energy metabolism in healthy young men. J Clin Biochem Nutr. 64:79–85. 2019.PubMed/NCBI View Article : Google Scholar

48 

Scicchitano BM, Pelosi L, Sica G and Musarò A: The physiopathologic role of oxidative stress in skeletal muscle. Mech Ageing Dev. 170:37–44. 2018.PubMed/NCBI View Article : Google Scholar

49 

Brioche T and Lemoine-Morel S: Oxidative stress, sarcopenia, antioxidant strategies and exercise: Molecular aspects. Curr Pharm Des. 22:2664–2678. 2016.PubMed/NCBI View Article : Google Scholar

50 

Meng SJ and Yu LJ: Oxidative stress, molecular inflammation and sarcopenia. Int J Mol Sci. 11:1509–1526. 2010.PubMed/NCBI View Article : Google Scholar

51 

Sztretye M, Dienes B, Gönczi M, Czirják T, Csernoch L, Dux L, Szentesi P and Keller-Pintér A: Astaxanthin: A potential mitochondrial-targeted antioxidant treatment in diseases and with aging. Oxid Med Cell Longev. 3849692:2019.PubMed/NCBI View Article : Google Scholar

52 

Aoi W, Naito Y, Sakuma K, Kuchide M, Tokuda H, Maoka T, Toyokuni S, Oka S, Yasuhara M and Yoshikawa T: Astaxanthin limits exercise-induced skeletal and cardiac muscle damage in mice. Antioxid Redox Signal. 5:139–144. 2003.PubMed/NCBI View Article : Google Scholar

53 

Zhou Y, Baker JS, Chen X, Wang Y, Chen H, Davison GW and Yan X: High-dose astaxanthin supplementation suppresses antioxidant enzyme activity during moderate-intensity swimming training in mice. Nutrients. 11(1244)2019.PubMed/NCBI View Article : Google Scholar

54 

Kurutas EB: The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: Current state. Nutr J. 15:71. 2016.PubMed/NCBI View Article : Google Scholar

55 

Vomund S, Schäfer A, Parnham MJ, Brüne B and von Knethen A: Nrf2, the master regulator of anti-oxidative responses. Int J Mol Sci. 18(2772)2017.PubMed/NCBI View Article : Google Scholar

56 

Bellezza I, Giambanco I, Minelli A and Donato R: Nrf2-Keap1 signaling in oxidative and reductive stress. Biochim Biophys Acta Mol Cell Res. 1865:721–733. 2018.PubMed/NCBI View Article : Google Scholar

57 

Guo C, Sun L, Chen X and Zhang D: Oxidative stress, mitochondrial damage and neurodegenerative diseases. Neural Regen Res. 8:2003–2014. 2013.PubMed/NCBI View Article : Google Scholar

58 

Ren J, Pulakat L, Whaley-Connell A and Sowers JR: Mitochondrial biogenesis in the metabolic syndrome and cardiovascular disease. J Mol Med. 88:993–1001. 2010.PubMed/NCBI View Article : Google Scholar

59 

Coen PM, Musci RV, Hinkley JM and Miller BF: Mitochondria as a target for mitigating Sarcopenia. Front Physiol. 9(1883)2018.PubMed/NCBI View Article : Google Scholar

60 

Liang H and Ward WF: PGC-1alpha: A key regulator of energy metabolism. Adv Physiol Educ. 30:145–151. 2006.PubMed/NCBI View Article : Google Scholar

61 

Litvinova L, Atochin DN, Fattakhov N, Vasilenko M, Zatolokin P and Kirienkova E: Nitric oxide and mitochondria in metabolic syndrome. Front Physiol. 6(20)2015.PubMed/NCBI View Article : Google Scholar

62 

Austin S and St-Pierre J: PGC1 alpha and mitochondrial metabolism-emerging concepts and relevance in ageing and neurodegenerative disorders. J Cell Sci. 125:4963–4971. 2012.PubMed/NCBI View Article : Google Scholar

63 

Liu PH, Aoi W, Takami M, Terajima H, Tanimura Y, Naito Y, Itoh Y and Yoshikawa T: The astaxanthin-induced improvement in lipid metabolism during exercise is mediated by a PGC-1α increase in skeletal muscle. J Clin Biochem Nutr. 54:86–89. 2014.PubMed/NCBI View Article : Google Scholar

64 

Gordon BS, Kelleher AR and Kimball SR: Regulation of muscle protein synthesis and the effects of catabolic states. Int J Biochem Cell Biol. 45:2147–2157. 2013.PubMed/NCBI View Article : Google Scholar

65 

Sandri M: Protein breakdown in muscle wasting: Role of autophagy-lysosome and ubiquitin-proteasome. Int J Biochem Cell Biol. 45:2121–2129. 2013.PubMed/NCBI View Article : Google Scholar

66 

Latres E, Amini AR, Amini AA, Griffiths J, Martin FJ, Wei Y, Lin HC, Yancopoulos GD and Glass DJ: Insulin-like growth factor-1 (IGF-1) inversely regulates atrophy-induced genes via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway. J Biol Chem. 280:2737–2744. 2005.PubMed/NCBI View Article : Google Scholar

67 

Ziaaldini MM, Marzetti E, Picca A and Murlasits Z: Biochemical pathways of sarcopenia and their modulation by physical exercise: A narrative review. Front Med. 4(167)2017.PubMed/NCBI View Article : Google Scholar

68 

Sanchez AM, Candau RB and Bernardi H: FoxO transcription factors: Their roles in the maintenance of skeletal muscle homeostasis. Cell Mol Life Sci. 71:1657–1671. 2014.PubMed/NCBI View Article : Google Scholar

69 

Smuder AJ, Kavazis AN, Hudson MB, Nelson WB and Powers SK: Oxidation enhances myofibrillar protein degradation via calpain and caspase-3. Free Radic Biol Med. 49:1152–1160. 2010.PubMed/NCBI View Article : Google Scholar

70 

Dumont NA, Bentzinger CF, Sincennes MC and Rudnicki MA: Satellite cells and skeletal muscle regeneration. Compr Physiol. 5:1027–1059. 2015.PubMed/NCBI View Article : Google Scholar

71 

McKenna CF and Fry CS: Altered satellite cell dynamics accompany skeletal muscle atrophy during chronic illness, disuse, and aging. Curr Opin Clin Nutr Metab Care. 20:447–452. 2017.PubMed/NCBI View Article : Google Scholar

72 

Hoier B and Hellsten Y: Exercise-induced capillary growth in human skeletal muscle and the dynamics of VEGF. Microcirculation. 21:301–314. 2014.PubMed/NCBI View Article : Google Scholar

73 

Fujino H, Kohzuki H, Takeda I, Kiyooka T, Miyasaka T, Mohri S, Shimizu J and Kajiya F: Regression of capillary network in atrophied soleus muscle induced by hindlimb unweighting. J Appl Physiol. 98:1407–1413. 2005.PubMed/NCBI View Article : Google Scholar

74 

Miyachi M, Matsuno T, Asano K and Mataga I: Anti-inflammatory effects of astaxanthin in the human gingival keratinocyte line NDUSD-1. J Clin Biochem Nutr. 56:171–178. 2015.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Wong S, Ima‑Nirwana S and Chin KY: Effects of astaxanthin on the protection of muscle health (Review). Exp Ther Med 20: 2941-2952, 2020.
APA
Wong, S., Ima‑Nirwana, S., & Chin, K. (2020). Effects of astaxanthin on the protection of muscle health (Review). Experimental and Therapeutic Medicine, 20, 2941-2952. https://doi.org/10.3892/etm.2020.9075
MLA
Wong, S., Ima‑Nirwana, S., Chin, K."Effects of astaxanthin on the protection of muscle health (Review)". Experimental and Therapeutic Medicine 20.4 (2020): 2941-2952.
Chicago
Wong, S., Ima‑Nirwana, S., Chin, K."Effects of astaxanthin on the protection of muscle health (Review)". Experimental and Therapeutic Medicine 20, no. 4 (2020): 2941-2952. https://doi.org/10.3892/etm.2020.9075
Copy and paste a formatted citation
x
Spandidos Publications style
Wong S, Ima‑Nirwana S and Chin KY: Effects of astaxanthin on the protection of muscle health (Review). Exp Ther Med 20: 2941-2952, 2020.
APA
Wong, S., Ima‑Nirwana, S., & Chin, K. (2020). Effects of astaxanthin on the protection of muscle health (Review). Experimental and Therapeutic Medicine, 20, 2941-2952. https://doi.org/10.3892/etm.2020.9075
MLA
Wong, S., Ima‑Nirwana, S., Chin, K."Effects of astaxanthin on the protection of muscle health (Review)". Experimental and Therapeutic Medicine 20.4 (2020): 2941-2952.
Chicago
Wong, S., Ima‑Nirwana, S., Chin, K."Effects of astaxanthin on the protection of muscle health (Review)". Experimental and Therapeutic Medicine 20, no. 4 (2020): 2941-2952. https://doi.org/10.3892/etm.2020.9075
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