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Article

Involvement of proinflammatory cytokines in angiotensin II‑induced hypertension in rat

  • Authors:
    • Minela Aida Maranduca
    • Daniela Maria Tanase
    • Daniel Constantin Branisteanu
    • Dragomir Nicolae Serban
    • Daciana Elena Branisteanu
    • Ionela Lacramioara Serban
  • View Affiliations / Copyright

    Affiliations: Department of Physiology, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania, Department of Internal Medicine, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania, Department of Ophthalmology, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania, Department of Dermatology, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania
  • Pages: 3541-3545
    |
    Published online on: August 5, 2020
       https://doi.org/10.3892/etm.2020.9100
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Abstract

Rightfully considered as essential for hydro‑electrolytic homeostasis, angiotensin II (Ang II) is the main product of the renin‑angiotensin system (RAS). Ang II is one of the most important factors that contribute to the regulation of systemic arterial blood pressure (ABP). This major role is based on the effects exerted by RAS: Upon the kidney (RAS involvement in the control of salt and water excretion), upon the brain (RAS involvement in the control of water intake), and upon the sympathetic nervous system. It is currently known that there is a tight bidirectional link between high ABP and chronic kidney disease (CKD). Ang II causes vasoconstriction in the renal microvasculature, predominantly in the preglomerular arterioles. High ABP affects the target organs (eyes, brain, heart, kidneys) and it is known both as a cause and as an effect of CKD. Thus, there is a positive feedback mechanism that contributes even more to the increase in ABP and the progression of CKD. Along with its main hemodynamic effects, Ang II has direct proinflammatory actions, that also affect the structure and function of the kidney and heart. This study investigated the role of RAS and Ang II in the inflammation that accompanies the hypertension experimentally induced by Ang II in rats. Our data support the hypothesis that anti‑inflammatory medication might alleviate the morphological and/or functional changes of the kidneys and heart that are related to Ang II‑induced hypertension.
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1 

Haulica I, Bild W and Serban DN: Angiotensin peptides and their pleiotropic actions. J Renin Angiotensin Aldosterone Syst. 6:121–131. 2005.PubMed/NCBI View Article : Google Scholar

2 

Benigni A, Cassis P and Remuzzi G: Angiotensin II revisited: New roles in inflammation, immunology and aging. EMBO Mol Med. 2:247–257. 2010.PubMed/NCBI View Article : Google Scholar

3 

Ames MK, Atkins CE and Pitt B: The renin-angiotensin-aldosterone system and its suppression. J Vet Intern Med. 33:363–382. 2019.PubMed/NCBI View Article : Google Scholar

4 

Stanca HT, Suvac E, Munteanu M, Jianu DC, Motoc AG, Roşca GC and Boruga O: Giant cell arteritis with arteritic anterior ischemic optic neuropathy. Rom J Morphol Embryol. 58:281–285. 2017.PubMed/NCBI

5 

Stanca HT, Petrović Z and Munteanu M: Transluminal Nd: YAG laser embolysis - A reasonable method to reperfuse occluded branch retinal arteries. Vojnosanit Pregl. 71:1072–1077. 2014.PubMed/NCBI View Article : Google Scholar

6 

McMaster WG, Kirabo A, Madhur MS and Harrison DG: Inflammation, immunity, and hypertensive end-organ damage. Circ Res. 116:1022–1033. 2015.PubMed/NCBI View Article : Google Scholar

7 

Ruiz-Ortega M, Esteban V, Rupérez M, Sánchez-López E, Rodríguez-Vita J, Carvajal G and Egido J: Renal and vascular hypertension-induced inflammation: Role of angiotensin II. Curr Opin Nephrol Hypertens. 15:159–166. 2006.PubMed/NCBI View Article : Google Scholar

8 

Pauletto P and Rattazzi M: Inflammation and hypertension: The search for a link. Nephrol Dial Transplant. 21:850–853. 2006.PubMed/NCBI View Article : Google Scholar

9 

Savoiu Balint G, Iovanescu G, Stanca HT, Popoiu CM, Boia E, Popovici RA and Bolintineanu SL: The protective effect of HDL-cholesterol in patients with essential hypertension. Rev Chim Buchar. 68:949–952. 2017.

10 

Paget V, Legedz L, Gaudebout N, Girerd N, Bricca G, Milon H, Vincent M and Lantelme P: N-terminal pro-brain natriuretic peptide: A powerful predictor of mortality in hypertension. Hypertension. 57:702–709. 2011.PubMed/NCBI View Article : Google Scholar

11 

Dornas WC and Silva ME: Animal models for the study of arterial hypertension. J Biosci. 36:731–737. 2011.PubMed/NCBI View Article : Google Scholar

12 

Directive. 2010/63/eu of the European Parliament and of the Council of 22 September 2010 on the protection of animals used for scientific purposes. OJEU. L276:33–79. 2010.

13 

Buñag RD: Validation in awake rats of a tail-cuff method for measuring systolic pressure. J Appl Physiol. 34:279–282. 1973.PubMed/NCBI View Article : Google Scholar

14 

Murphy PG, Grondin J, Altares M and Richardson PM: Induction of interleukin-6 in axotomized sensory neurons. J Neurosci. 15:5130–5138. 1995.PubMed/NCBI View Article : Google Scholar

15 

Winer BJ: Statistical principles in experimental design. 2nd edition. McGraw-Hill, New York, NY, 1971.

16 

Hildebrandt P, Boesen M, Olsen M, Wachtell K and Groenning B: N-terminal pro brain natriuretic peptide in arterial hypertension - a marker for left ventricular dimensions and prognosis. Eur J Heart Fail. 6:313–317. 2004.PubMed/NCBI View Article : Google Scholar

17 

Jeppesen JL, Nielsen SJ, Torp-Pedersen C, Hansen TW, Olsen MH, Berg ND, Linneberg A, Madsbad S and Fenger M: Genetic variation in the natriuretic peptide system, circulating natriuretic peptide levels, and blood pressure: An ambulatory blood pressure study. Am J Hypertens. 25:1095–1100. 2012.PubMed/NCBI View Article : Google Scholar

18 

Sarzani R, Spannella F, Giulietti F, Balietti P, Cocci G and Bordicchia M: Cardiac natriuretic peptides, hypertension and cardiovascular risk. High Blood Press Cardiovasc Prev. 24:115–126. 2017.PubMed/NCBI View Article : Google Scholar

19 

Rubattu S, Forte M, Marchitti S and Volpe M: Molecular implications of natriuretic peptides in the protection from hypertension and target organ damage development. Int J Mol Sci. 20:1–12. 2019.PubMed/NCBI View Article : Google Scholar

20 

Mostafa F, Sad I, Elshamaa M, Badr A, Eldayem S, Ashmawy I and Abd Elrahim YA: Left ventricular dysfunction by conventional and tissue Doppler echocardiography in pediatric hemodialysis patients: Relation with plasma brain natriuretic peptide levels. Med Sci Atheroscler Dis. 3:e18–e28. 2018.PubMed/NCBI View Article : Google Scholar

21 

Cui H, Huo G, Liu L, Fan L, Ye P, Cao J, Bai Y, Wang F and Hu Y: Association of cardiac and renal function with extreme N-terminal fragment pro-B-type natriuretic peptide levels in elderly patients. BMC Cardiovasc Disord. 12(57)2012.PubMed/NCBI View Article : Google Scholar

22 

Dávila DF, Donis JH, Odreman R, Gonzalez M and Landaeta A: Patterns of left ventricular hypertrophy in essential hypertension: Should echocardiography guide the pharmacological treatment? Int J Cardiol. 124:134–138. 2008.PubMed/NCBI View Article : Google Scholar

23 

Devereux RB, Roman MJ, Ganau A, de Simone G, Okin PM and Kligfield P: Cardiac and arterial hypertrophy and atherosclerosis in hypertension. Hypertension. 23:802–809. 1994.PubMed/NCBI View Article : Google Scholar

24 

Alberts BM, Bruce C, Basnayake K, Ghezzi P, Davies KA and Mullen LM: Secretion of IL-1β from monocytes in gout is redox independent. Front Immunol. 10(70)2019.PubMed/NCBI View Article : Google Scholar

25 

Navar LG, Prieto MC, Satou R and Kobori H: Intrarenal angiotensin II and its contribution to the genesis of chronic hypertension. Curr Opin Pharmacol. 11:180–186. 2011.PubMed/NCBI View Article : Google Scholar

26 

Bujak M and Frangogiannis NG: The role of IL-1 in the pathogenesis of heart disease. Arch Immunol Ther Exp (Warsz). 57:165–176. 2009.PubMed/NCBI View Article : Google Scholar

27 

Gupta J, Dominic EA, Fink JC, Ojo AO, Barrows IR, Reilly MP, Townsend RR, Joffe MM, Rosas SE, Wolman M, et al: CRIC Study Investigators: Association between inflammation and cardiac geometry in chronic kidney disease: Findings from the CRIC study. PLoS One. 10(e0124772)2015.PubMed/NCBI View Article : Google Scholar

28 

Granger JP: An emerging role for inflammatory cytokines in hypertension. Am J Physiol Heart Circ Physiol. 290:H923–H924. 2006.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Maranduca MA, Tanase DM, Branisteanu DC, Serban DN, Branisteanu DE and Serban IL: Involvement of proinflammatory cytokines in angiotensin II‑induced hypertension in rat. Exp Ther Med 20: 3541-3545, 2020.
APA
Maranduca, M.A., Tanase, D.M., Branisteanu, D.C., Serban, D.N., Branisteanu, D.E., & Serban, I.L. (2020). Involvement of proinflammatory cytokines in angiotensin II‑induced hypertension in rat. Experimental and Therapeutic Medicine, 20, 3541-3545. https://doi.org/10.3892/etm.2020.9100
MLA
Maranduca, M. A., Tanase, D. M., Branisteanu, D. C., Serban, D. N., Branisteanu, D. E., Serban, I. L."Involvement of proinflammatory cytokines in angiotensin II‑induced hypertension in rat". Experimental and Therapeutic Medicine 20.4 (2020): 3541-3545.
Chicago
Maranduca, M. A., Tanase, D. M., Branisteanu, D. C., Serban, D. N., Branisteanu, D. E., Serban, I. L."Involvement of proinflammatory cytokines in angiotensin II‑induced hypertension in rat". Experimental and Therapeutic Medicine 20, no. 4 (2020): 3541-3545. https://doi.org/10.3892/etm.2020.9100
Copy and paste a formatted citation
x
Spandidos Publications style
Maranduca MA, Tanase DM, Branisteanu DC, Serban DN, Branisteanu DE and Serban IL: Involvement of proinflammatory cytokines in angiotensin II‑induced hypertension in rat. Exp Ther Med 20: 3541-3545, 2020.
APA
Maranduca, M.A., Tanase, D.M., Branisteanu, D.C., Serban, D.N., Branisteanu, D.E., & Serban, I.L. (2020). Involvement of proinflammatory cytokines in angiotensin II‑induced hypertension in rat. Experimental and Therapeutic Medicine, 20, 3541-3545. https://doi.org/10.3892/etm.2020.9100
MLA
Maranduca, M. A., Tanase, D. M., Branisteanu, D. C., Serban, D. N., Branisteanu, D. E., Serban, I. L."Involvement of proinflammatory cytokines in angiotensin II‑induced hypertension in rat". Experimental and Therapeutic Medicine 20.4 (2020): 3541-3545.
Chicago
Maranduca, M. A., Tanase, D. M., Branisteanu, D. C., Serban, D. N., Branisteanu, D. E., Serban, I. L."Involvement of proinflammatory cytokines in angiotensin II‑induced hypertension in rat". Experimental and Therapeutic Medicine 20, no. 4 (2020): 3541-3545. https://doi.org/10.3892/etm.2020.9100
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