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Efficacy of antibiotic‑impregnated shunt versus conventional shunts to reduce cerebrospinal fluid infections in children: A systematic review and meta‑analysis

  • Authors:
    • Yanzhao Qiu
    • Yonglin Wu
  • View Affiliations / Copyright

    Affiliations: Department of Paediatrics, Huzhou Hospital of Traditional Chinese Medicine Affiliated Zhejiang University of Traditional Chinese Medicine, Huzhou, Zhejiang 313000, P.R. China
    Copyright: © Qiu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3775-3781
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    Published online on: August 14, 2020
       https://doi.org/10.3892/etm.2020.9122
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Abstract

Hydrocephalus is among the most common pediatric conditions treated by neurosurgeons. An antibiotic‑impregnated shunt (AIS) was designed to reduce the rate of shunt infections. The objective of this systematic review and meta‑analysis was to assess the efficiency of AIS in reducing the rate of shunt infection compared with standard shunts (SSs). A systematic search of PubMed, EMBASE, Medline, Cochrane Library, TRIP Database, CINAHL and Google Scholar databases was performed. Eligible studies included observational studies and randomized controlled trials (RCT) that compared the effects of AIS and SS for preventing shunt infections in pediatric patients. Twelve observational studies and one RCT conducted from January 2005 through October 2019 involving 7,952 pediatric patients were included in the analysis. The use of AIS significantly decreased the risk of CRI [risk ratio (RR) 0.42; 95% confidence interval: 0.33 to 0.53; P<0.00001] with no statistical heterogeneity across the included studies (I2=42%). This analysis demonstrates that the use of AIS significantly reduces the risk of shunt infection in pediatric patients.
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Copy and paste a formatted citation
Spandidos Publications style
Qiu Y and Wu Y: Efficacy of antibiotic‑impregnated shunt versus conventional shunts to reduce cerebrospinal fluid infections in children: A systematic review and meta‑analysis. Exp Ther Med 20: 3775-3781, 2020.
APA
Qiu, Y., & Wu, Y. (2020). Efficacy of antibiotic‑impregnated shunt versus conventional shunts to reduce cerebrospinal fluid infections in children: A systematic review and meta‑analysis. Experimental and Therapeutic Medicine, 20, 3775-3781. https://doi.org/10.3892/etm.2020.9122
MLA
Qiu, Y., Wu, Y."Efficacy of antibiotic‑impregnated shunt versus conventional shunts to reduce cerebrospinal fluid infections in children: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 20.4 (2020): 3775-3781.
Chicago
Qiu, Y., Wu, Y."Efficacy of antibiotic‑impregnated shunt versus conventional shunts to reduce cerebrospinal fluid infections in children: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 20, no. 4 (2020): 3775-3781. https://doi.org/10.3892/etm.2020.9122
Copy and paste a formatted citation
x
Spandidos Publications style
Qiu Y and Wu Y: Efficacy of antibiotic‑impregnated shunt versus conventional shunts to reduce cerebrospinal fluid infections in children: A systematic review and meta‑analysis. Exp Ther Med 20: 3775-3781, 2020.
APA
Qiu, Y., & Wu, Y. (2020). Efficacy of antibiotic‑impregnated shunt versus conventional shunts to reduce cerebrospinal fluid infections in children: A systematic review and meta‑analysis. Experimental and Therapeutic Medicine, 20, 3775-3781. https://doi.org/10.3892/etm.2020.9122
MLA
Qiu, Y., Wu, Y."Efficacy of antibiotic‑impregnated shunt versus conventional shunts to reduce cerebrospinal fluid infections in children: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 20.4 (2020): 3775-3781.
Chicago
Qiu, Y., Wu, Y."Efficacy of antibiotic‑impregnated shunt versus conventional shunts to reduce cerebrospinal fluid infections in children: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 20, no. 4 (2020): 3775-3781. https://doi.org/10.3892/etm.2020.9122
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