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Article

Azithromycin combined with doxycycline in non‑gonococcal urethritis

  • Authors:
    • Zhongming Lu
    • Manli Hou
    • Dandan Li
    • Jing Cheng
    • Huazhou Deng
    • Jianping Yan
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, Shengzhou People's Hospital, Shengzhou Branch Hospital of The First Affiliated Hospital of Zhejiang University, Shaoxing, Zhejiang 312400, P.R. China, Department of Dermatology, Zaozhuang Hospital, Zaozhuang Mining Group, Zaozhuang, Shandong 277100, P.R. China, Department of Gynecology, Shengzhou People's Hospital, Shengzhou Branch Hospital of The First Affiliated Hospital of Zhejiang University, Shaoxing, Zhejiang 312400, P.R. China, Department of Dermatology, Shaoxing Shangyu People's Hospital, Shaoxing, Zhejiang 312300, P.R. China, Department of Doctor‑Patient Office, Shengzhou People's Hospital, Shengzhou Branch Hospital of The First Affiliated Hospital of Zhejiang University, Shaoxing, Zhejiang 312400, P.R. China, Department of Dermatology, Xinchang People's Hospital, Shaoxing, Zhejiang 312500, P.R. China
  • Pages: 3887-3894
    |
    Published online on: August 19, 2020
       https://doi.org/10.3892/etm.2020.9125
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Abstract

Non-gonococcal urethritis (NGU) is one of the most common sexually transmitted diseases caused by chlamydia or mycoplasma. The present study aimed to explore the clinical efficacy of azithromycin combined with doxycycline in patients with NGU and its effect on serum levels of inflammatory cytokine interleukin‑6 (IL‑6).A total of 98 patients with non‑gonococcal urethritis were prospectively selected, of which 46 patients were assigned to an azithromycin group (treated with azithromycin alone), while the rest were assigned to a combination group (treated with azithromycin and doxycycline). The conditions of the patients were evaluated and compared between the two groups. The treatment efficacy in patients in the combination group was significantly better than that in the azithromycin group, and the time to symptom relief, period of medication, recurrence rate within 1 year of withdrawal and level of serum IL‑6 in the combination group were significantly lower than those in the azithromycin group. The quality of life of patients in the combination group was significantly improved compared to those in the azithromycin group. However, there was no significant difference in the incidence of adverse reactions between the two groups. Azithromycin combined with doxycycline was revealed to be more effective than azithromycin monotherapy for NGU.
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Copy and paste a formatted citation
Spandidos Publications style
Lu Z, Hou M, Li D, Cheng J, Deng H and Yan J: Azithromycin combined with doxycycline in non‑gonococcal urethritis. Exp Ther Med 20: 3887-3894, 2020.
APA
Lu, Z., Hou, M., Li, D., Cheng, J., Deng, H., & Yan, J. (2020). Azithromycin combined with doxycycline in non‑gonococcal urethritis. Experimental and Therapeutic Medicine, 20, 3887-3894. https://doi.org/10.3892/etm.2020.9125
MLA
Lu, Z., Hou, M., Li, D., Cheng, J., Deng, H., Yan, J."Azithromycin combined with doxycycline in non‑gonococcal urethritis". Experimental and Therapeutic Medicine 20.4 (2020): 3887-3894.
Chicago
Lu, Z., Hou, M., Li, D., Cheng, J., Deng, H., Yan, J."Azithromycin combined with doxycycline in non‑gonococcal urethritis". Experimental and Therapeutic Medicine 20, no. 4 (2020): 3887-3894. https://doi.org/10.3892/etm.2020.9125
Copy and paste a formatted citation
x
Spandidos Publications style
Lu Z, Hou M, Li D, Cheng J, Deng H and Yan J: Azithromycin combined with doxycycline in non‑gonococcal urethritis. Exp Ther Med 20: 3887-3894, 2020.
APA
Lu, Z., Hou, M., Li, D., Cheng, J., Deng, H., & Yan, J. (2020). Azithromycin combined with doxycycline in non‑gonococcal urethritis. Experimental and Therapeutic Medicine, 20, 3887-3894. https://doi.org/10.3892/etm.2020.9125
MLA
Lu, Z., Hou, M., Li, D., Cheng, J., Deng, H., Yan, J."Azithromycin combined with doxycycline in non‑gonococcal urethritis". Experimental and Therapeutic Medicine 20.4 (2020): 3887-3894.
Chicago
Lu, Z., Hou, M., Li, D., Cheng, J., Deng, H., Yan, J."Azithromycin combined with doxycycline in non‑gonococcal urethritis". Experimental and Therapeutic Medicine 20, no. 4 (2020): 3887-3894. https://doi.org/10.3892/etm.2020.9125
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