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Effects of levetiracetam and lacosamide on therapeutic efficacy and neural function in patients with epilepsy

  • Authors:
    • Airong Liu
    • Qiuling Gu
    • Mingjing Wang
  • View Affiliations / Copyright

    Affiliations: Hong Kong Middle Road Clinic, Integrated Chinese and Western Medicine Hospital of Qingdao (The 5th People's Hospital of Qingdao), Qingdao, Shandong 266073, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3687-3694
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    Published online on: August 19, 2020
       https://doi.org/10.3892/etm.2020.9126
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Abstract

The present study aimed to investigate the effects of levetiracetam tablets and lacosamide (LCM) on therapeutic efficacy and neural function in patients with epilepsy. We assigned 252 patients with refractory partial seizures admitted to our hospital to receive either levetiracetam tablets [120 patients, the control group (CG)] or levetiracetam tablets combined with LCM [132 patients, the joint group (JG)]. The bone mineral density and neural function between the two groups at 6 months before and after treatment were compared. The total response rate was higher in the JG than in the CG (P<0.05). There was no significant difference in the comparison of the multiple indexes between the two groups before treatment (P>0.05). The frequency of seizures was reduced after treatment in the two groups, however, it was lower in the JG compared with the CG (P<0.05). The levels of neurological indicators were significantly reduced after treatment in the two groups (P<0.05), however, the reduction was more marked in the JG than in the CG. The bone mineral density (BMD) of the femoral neck decreased after treatment in the two groups (P<0.05), but there was no difference between the two groups after treatment (P>0.05). The calcium content decreased after treatment in the two groups (P<0.05), but there was no difference between the two groups after treatment (P>0.05). The comparison of other bone metabolism markers between the two groups exhibited no significant differences. The combination therapy greatly increased the quality of life score and the 1‑year drug retention rate. To sum up, levetiracetam tablets combined with LCM significantly enhanced the therapeutic effect and improved the neural function in patients with refractory partial seizures, however this therapy may cause a slight adverse effect on BMD and bone metabolism in the short term.
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Copy and paste a formatted citation
Spandidos Publications style
Liu A, Gu Q and Wang M: Effects of levetiracetam and lacosamide on therapeutic efficacy and neural function in patients with epilepsy. Exp Ther Med 20: 3687-3694, 2020.
APA
Liu, A., Gu, Q., & Wang, M. (2020). Effects of levetiracetam and lacosamide on therapeutic efficacy and neural function in patients with epilepsy. Experimental and Therapeutic Medicine, 20, 3687-3694. https://doi.org/10.3892/etm.2020.9126
MLA
Liu, A., Gu, Q., Wang, M."Effects of levetiracetam and lacosamide on therapeutic efficacy and neural function in patients with epilepsy". Experimental and Therapeutic Medicine 20.4 (2020): 3687-3694.
Chicago
Liu, A., Gu, Q., Wang, M."Effects of levetiracetam and lacosamide on therapeutic efficacy and neural function in patients with epilepsy". Experimental and Therapeutic Medicine 20, no. 4 (2020): 3687-3694. https://doi.org/10.3892/etm.2020.9126
Copy and paste a formatted citation
x
Spandidos Publications style
Liu A, Gu Q and Wang M: Effects of levetiracetam and lacosamide on therapeutic efficacy and neural function in patients with epilepsy. Exp Ther Med 20: 3687-3694, 2020.
APA
Liu, A., Gu, Q., & Wang, M. (2020). Effects of levetiracetam and lacosamide on therapeutic efficacy and neural function in patients with epilepsy. Experimental and Therapeutic Medicine, 20, 3687-3694. https://doi.org/10.3892/etm.2020.9126
MLA
Liu, A., Gu, Q., Wang, M."Effects of levetiracetam and lacosamide on therapeutic efficacy and neural function in patients with epilepsy". Experimental and Therapeutic Medicine 20.4 (2020): 3687-3694.
Chicago
Liu, A., Gu, Q., Wang, M."Effects of levetiracetam and lacosamide on therapeutic efficacy and neural function in patients with epilepsy". Experimental and Therapeutic Medicine 20, no. 4 (2020): 3687-3694. https://doi.org/10.3892/etm.2020.9126
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