Antidepressant‑like effects of Z‑ligustilide on chronic unpredictable mild stress‑induced depression in rats

  • Authors:
    • Jian-Chun Ma
    • Hao-Liang Zhang
    • Hui-Ping Huang
    • Zao-Liang Ma
    • Su-Fang Chen
    • Zhi-Kun Qiu
    • Ji-Sheng Chen
  • View Affiliations

  • Published online on: April 25, 2021     https://doi.org/10.3892/etm.2021.10109
  • Article Number: 677
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Abstract

Depression is a significant public health issue and its neuropathogenesis is associated with the dysfunction of progesterone and allopregnanolone biosynthesis. Z‑ligustilide (LIG), one of the main components of the herb Angelica sinensis (Oliv.) Diels (AS), is reported to have antidepressant activities. The present study aimed to evaluate the antidepressant‑like effects of LIG via behavioral tests and to measure the levels of progesterone and allopregnanolone in the prefrontal cortex and hippocampus. The results demonstrated that LIG (20 and 40 mg/kg) exerted antidepressant‑like effects, confirmed by increased mobility, locomotion, rearing frequency and preference to sucrose. Furthermore, the levels of progesterone and allopregnanolone in the prefrontal cortex and hippocampus were markedly increased following treatment with LIG (20 and 40 mg/kg), indicating that both neurosteroids could serve a significant role in the antidepressant‑like effects of LIG.
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July-2021
Volume 22 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Ma J, Zhang H, Huang H, Ma Z, Chen S, Qiu Z and Chen J: Antidepressant‑like effects of Z‑ligustilide on chronic unpredictable mild stress‑induced depression in rats. Exp Ther Med 22: 677, 2021
APA
Ma, J., Zhang, H., Huang, H., Ma, Z., Chen, S., Qiu, Z., & Chen, J. (2021). Antidepressant‑like effects of Z‑ligustilide on chronic unpredictable mild stress‑induced depression in rats. Experimental and Therapeutic Medicine, 22, 677. https://doi.org/10.3892/etm.2021.10109
MLA
Ma, J., Zhang, H., Huang, H., Ma, Z., Chen, S., Qiu, Z., Chen, J."Antidepressant‑like effects of Z‑ligustilide on chronic unpredictable mild stress‑induced depression in rats". Experimental and Therapeutic Medicine 22.1 (2021): 677.
Chicago
Ma, J., Zhang, H., Huang, H., Ma, Z., Chen, S., Qiu, Z., Chen, J."Antidepressant‑like effects of Z‑ligustilide on chronic unpredictable mild stress‑induced depression in rats". Experimental and Therapeutic Medicine 22, no. 1 (2021): 677. https://doi.org/10.3892/etm.2021.10109