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Article

Clinical impact of echocardiography parameters and molecular biomarkers in heart failure: Correlation of ACE2 and MCP‑1 polymorphisms with echocardiography parameters: A comparative study

  • Authors:
    • Mălina Suciu‑Petrescu
    • Anamaria Truta
    • Mihai Domnutiu Suciu
    • Adrian Pavel Trifa
    • Denisa Petrescu
    • Horia Ștefan Roșianu
    • Octavia Sabin
    • Daciana Elena Popa
    • Antonia Eugenia Macarie
    • Ștefan Cristian Vesa
    • Anca Dana Buzoianu
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, Toxicology and Clinical Pharmacology, ‘Iuliu Hațieganu’ University of Medicine and Pharmacy, 400337 Cluj‑Napoca, Romania, Research Center for Functional Genomics, Biomedicine and Translational Medicine, ‘Iuliu Hațieganu’ University of Medicine and Pharmacy, 400337 Cluj‑Napoca, Romania, Department of Urology, Clinical Institute of Urology and Kidney Transplant, ‘Iuliu Hatieganu’ University of Medicine and Pharmacy, 400066 Cluj‑Napoca, Romania, Department of Medical Genetics, ‘Iuliu Hațieganu’ University of Medicine and Pharmacy, 400349 Cluj‑Napoca, Romania, Department of Endocrinology, Emergency Clinical County Hospital Cluj, ‘Iuliu Hatieganu’ University of Medicine and Pharmacy, 400349 Cluj‑Napoca, Romania, Department of Cardiology, ‘Niculae Stăncioiu’ Heart Institute, 400001 Cluj‑Napoca, Romania, Department of Geriatrics‑Gerontology, ‘Iuliu Haţieganu’ University of Medicine and Pharmacy, 400139 Cluj‑Napoca, Romania
  • Article Number: 686
    |
    Published online on: April 28, 2021
       https://doi.org/10.3892/etm.2021.10118
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Abstract

Heart failure is still the leading cause of hospitalization in patients over 65 years of age and is defined as a multifactorial pathology which involves environmental factors and also genetic predispositions. The aim of the present study was to evaluate a possible correlation between single nucleotide polymorphisms (SNPs) of angiotensin converting enzyme 2 (ACE2) and monocyte chemoattractant protein‑1 (MCP‑1) genes and cardiac remodeling in Caucasian patients diagnosed with heart failure. Our comparative translational research study included 116 patients diagnosed with heart failure and was carried out in Cluj‑Napoca, Romania between September 2017 and March 2019. Three SNPs, namely rs4646156, rs4646174 and rs1024611, were genotyped using a Taqman real‑time PCR technique. Our results showed that carriers of the AA genotype for ACE2 rs4646156 had a significant dilatation of the left ventricle (LV) with signs of LV hypertrophy (LVH), while TT carriers had a significant left atrial dilatation. For ACE2 rs4646174, homozygotes for the C allele presented a dilated LV with signs of LVH with statistical significance and had a tendency towards a lower ejection fraction. MCP‑1 rs1024611 AA variant carriers had a significant LVH in the dominant model. In conclusion, our study showed a strong association between echocardiographic parameters of cardiac remodeling and SNPs rs4646156, rs4646174 of ACE2 and rs1024611 of MCP‑1.
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Copy and paste a formatted citation
Spandidos Publications style
Suciu‑Petrescu M, Truta A, Suciu MD, Trifa AP, Petrescu D, Roșianu HȘ, Sabin O, Popa DE, Macarie AE, Vesa ȘC, Vesa ȘC, et al: Clinical impact of echocardiography parameters and molecular biomarkers in heart failure: Correlation of <em>ACE2</em> and <em>MCP‑1</em> polymorphisms with echocardiography parameters: A comparative study. Exp Ther Med 22: 686, 2021.
APA
Suciu‑Petrescu, M., Truta, A., Suciu, M.D., Trifa, A.P., Petrescu, D., Roșianu, H.Ș. ... Buzoianu, A.D. (2021). Clinical impact of echocardiography parameters and molecular biomarkers in heart failure: Correlation of <em>ACE2</em> and <em>MCP‑1</em> polymorphisms with echocardiography parameters: A comparative study. Experimental and Therapeutic Medicine, 22, 686. https://doi.org/10.3892/etm.2021.10118
MLA
Suciu‑Petrescu, M., Truta, A., Suciu, M. D., Trifa, A. P., Petrescu, D., Roșianu, H. Ș., Sabin, O., Popa, D. E., Macarie, A. E., Vesa, Ș. C., Buzoianu, A. D."Clinical impact of echocardiography parameters and molecular biomarkers in heart failure: Correlation of <em>ACE2</em> and <em>MCP‑1</em> polymorphisms with echocardiography parameters: A comparative study". Experimental and Therapeutic Medicine 22.1 (2021): 686.
Chicago
Suciu‑Petrescu, M., Truta, A., Suciu, M. D., Trifa, A. P., Petrescu, D., Roșianu, H. Ș., Sabin, O., Popa, D. E., Macarie, A. E., Vesa, Ș. C., Buzoianu, A. D."Clinical impact of echocardiography parameters and molecular biomarkers in heart failure: Correlation of <em>ACE2</em> and <em>MCP‑1</em> polymorphisms with echocardiography parameters: A comparative study". Experimental and Therapeutic Medicine 22, no. 1 (2021): 686. https://doi.org/10.3892/etm.2021.10118
Copy and paste a formatted citation
x
Spandidos Publications style
Suciu‑Petrescu M, Truta A, Suciu MD, Trifa AP, Petrescu D, Roșianu HȘ, Sabin O, Popa DE, Macarie AE, Vesa ȘC, Vesa ȘC, et al: Clinical impact of echocardiography parameters and molecular biomarkers in heart failure: Correlation of <em>ACE2</em> and <em>MCP‑1</em> polymorphisms with echocardiography parameters: A comparative study. Exp Ther Med 22: 686, 2021.
APA
Suciu‑Petrescu, M., Truta, A., Suciu, M.D., Trifa, A.P., Petrescu, D., Roșianu, H.Ș. ... Buzoianu, A.D. (2021). Clinical impact of echocardiography parameters and molecular biomarkers in heart failure: Correlation of <em>ACE2</em> and <em>MCP‑1</em> polymorphisms with echocardiography parameters: A comparative study. Experimental and Therapeutic Medicine, 22, 686. https://doi.org/10.3892/etm.2021.10118
MLA
Suciu‑Petrescu, M., Truta, A., Suciu, M. D., Trifa, A. P., Petrescu, D., Roșianu, H. Ș., Sabin, O., Popa, D. E., Macarie, A. E., Vesa, Ș. C., Buzoianu, A. D."Clinical impact of echocardiography parameters and molecular biomarkers in heart failure: Correlation of <em>ACE2</em> and <em>MCP‑1</em> polymorphisms with echocardiography parameters: A comparative study". Experimental and Therapeutic Medicine 22.1 (2021): 686.
Chicago
Suciu‑Petrescu, M., Truta, A., Suciu, M. D., Trifa, A. P., Petrescu, D., Roșianu, H. Ș., Sabin, O., Popa, D. E., Macarie, A. E., Vesa, Ș. C., Buzoianu, A. D."Clinical impact of echocardiography parameters and molecular biomarkers in heart failure: Correlation of <em>ACE2</em> and <em>MCP‑1</em> polymorphisms with echocardiography parameters: A comparative study". Experimental and Therapeutic Medicine 22, no. 1 (2021): 686. https://doi.org/10.3892/etm.2021.10118
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