Tolerogenic dendritic cells suppress titanium particle‑induced inflammation

Wang,Wenzhao; Han,Bing; Chen,Jianan; Tian,Huichao; Sun,Mingjie; Jiang,Yunpeng; Xie,Wei

doi:10.3892/etm.2021.10144

Tolerogenic dendritic cells suppress titanium particle‑induced inflammation

Authors:
- Wenzhao Wang
- Bing Han
- Jianan Chen
- Huichao Tian
- Mingjie Sun
- Yunpeng Jiang
- Wei Xie
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Affiliations: Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China, Department of Orthopedic, Jinan Central Hospital Affiliated to Shandong First Medical University, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250013, P.R. China, Department of Orthopedic, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, P.R. China
Published online on: May 3, 2021 https://doi.org/10.3892/etm.2021.10144
Article Number: 712
Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Aseptic loosening is a major complication of prosthetic joint surgery. The leading cause of arthroplasty failure is particulate wear debris such as titanium particles. Dendritic cells (DCs) are one type of immune cells that play an important role in the initiation and progression of inflammatory processes. DCs can develop into tolerogenic DCs (tolDCs), which present an alternative therapeutic strategy for inflammatory disorders. Previously, antigen‑specific tolDCs were generated, which showed a promising effect in treating inflammatory arthritis and immune thrombocytopenia. The present study reports that tolDCs effectively inhibited titanium particle‑induced inflammation in an air‑pouch mouse model by decreasing pro‑inflammatory cytokines. In addition, a mechanistic study demonstrated that tolDCs significantly protected against titanium particle‑induced inflammatory processes in vitro by releasing anti‑inflammatory cytokines, such as interleukin‑10. Collectively, these findings not only demonstrate that tolDCs play an important role in inhibiting titanium particle‑induced inflammation but also provide a potential alternative for the prevention or treatment of titanium particle‑induced inflammation.

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