1
|
Byrne CD and Targher G: NAFLD: A
multisystem disease. J Hepatol. 62 (Suppl 1):S47–S64.
2015.PubMed/NCBI View Article : Google Scholar
|
2
|
Fan JG, Kim SU and Wong VJJ: New trends on
obesity and NAFLD in asia. J Hepatol. 67:862–873. 2017.PubMed/NCBI View Article : Google Scholar
|
3
|
Estes C, Anstee QM, Arias-Loste MT, Bantel
H, Bellentani S, Caballeria J, Colombo M, Craxi A, Crespo J, Day
CP, et al: Modeling NAFLD disease burden in China, France, Germany,
Italy, Japan, Spain, United Kingdom, and United States for the
period 2016-2030. J Hepatol. 69:896–904. 2018.PubMed/NCBI View Article : Google Scholar
|
4
|
Ayonrinde OT, Adams LA, Mori TA, Beilin
LJ, de Klerk N, Pennell CE, White S and Olynyk JK: Sex differences
between parental pregnancy characteristics and nonalcoholic fatty
liver disease in adolescents. Hepatology. 67:108–122.
2018.PubMed/NCBI View Article : Google Scholar
|
5
|
Patel S, Lawlor DA, Callaway M,
Macdonald-Wallis C, Sattar N and Fraser A: Association of maternal
diabetes/glycosuria and pre-pregnancy body mass index with
offspring indicators of non-alcoholic fatty liver disease. BMC
Pediatr. 16(47)2016.PubMed/NCBI View Article : Google Scholar
|
6
|
Pereira TJ, Fonseca MA, Campbell KE, Moyce
BL, Cole LK, Hatch GM, Doucette CA, Klein J, Aliani M and Dolinsky
VW: Maternal obesity characterized by gestational diabetes
increases the susceptibility of rat offspring to hepatic steatosis
via a disrupted liver metabolome. J Physiol. 15:3181–3197.
2015.PubMed/NCBI View
Article : Google Scholar
|
7
|
Bouanane S, Merzouk H, Benkalfat NB,
Soulimane N, Merzouk SA, Gresti J, Tessier C and Narce M: Hepatic
and very low-density lipoprotein fatty acids in obese offspring of
overfed dams. Metabolism. 59:1701–1709. 2010.PubMed/NCBI View Article : Google Scholar
|
8
|
Liou CJ, Wu SJ, Shen SC, Chen LC, Chen YL
and Huang WC: Phloretin ameliorates hepatic steatosis through
regulation of lipogenesis and Sirt1/AMPK signaling in obese mice.
Cell Biosci. 10(114)2020.PubMed/NCBI View Article : Google Scholar
|
9
|
Wilson RB, Chen YJ, Sutherland BG, Sawyez
CG, Zhang R, Woolnough T, Hetherington AM, Peters KM, Patel K,
Kennelly JP, et al: The marine compound and elongation factor 1A1
inhibitor, didemnin B, provides benefit in western diet-induced
non-alcoholic fatty liver disease. Pharmacol Res.
161(105208)2020.PubMed/NCBI View Article : Google Scholar
|
10
|
Borengasser SJ, Lau F, Kang P, Blackburn
ML, Ronis MJ, Badger TM and Shankar K: Maternal obesity during
gestation impairs fatty acid oxidation and mitochondrial SIRT3
expression in rat offspring at weaning. PLoS One.
6(e24068)2011.PubMed/NCBI View Article : Google Scholar
|
11
|
Wankhade UD, Zhong Y, Kang P, Alfaro M,
Chintapalli SV, Thakali KM and Shankar K: Enhanced offspring
predisposition to steatohepatitis with maternal high-fat diet is
associated with epigenetic and microbiome alterations. PLoS One.
12(e0175675)2017.PubMed/NCBI View Article : Google Scholar
|
12
|
Yamaguchi R, Nakagawa Y, Liu YJ, Fujisawa
Y, Sai S, Nagata E, Sano S, Satake E, Matsushita R, Nakanishi T, et
al: Effects of maternal high-fat diet on serum lipid concentration
and expression of peroxisomal proliferator-activated receptors in
the early life of rat offspring. Horm Metab Res. 42:821–825.
2010.PubMed/NCBI View Article : Google Scholar
|
13
|
Paul HA, Bomhof MR, Vogel HJ and Reimer
RA: Diet-induced changes in maternal gut microbiota and metabolomic
profiles influence programming of offspring obesity risk in rats.
Sci Rep. 6(20683)2016.PubMed/NCBI View Article : Google Scholar
|
14
|
Glick D, Barth S and Macleod KF:
Autophagy: Cellular and molecular mechanisms. J Pathol. 221:3–12.
2010.PubMed/NCBI View Article : Google Scholar
|
15
|
Levine B and Kroemer G: Biological
functions of autophagy genes: A disease perspective. Cell.
176:11–42. 2019.PubMed/NCBI View Article : Google Scholar
|
16
|
Settembre C, De Cegli R, Mansueto G, Saha
PK, Vetrini F, Visvikis O, Huynh T, Carissimo A, Palmer D, Klisch
TJ, et al: TFEB controls cellular lipid metabolism through a
starvation-induced autoregulatory loop. Nat Cell Biol. 15:647–658.
2013.PubMed/NCBI View
Article : Google Scholar
|
17
|
Zhang H, Yan S, Khambu B, Ma F, Li Y, Chen
X, Martina JA, Puertollano R, Li Y, Chalasani N and Yin XM: Dynamic
MTORC1-TFEB feedback signaling regulates hepatic autophagy,
steatosis and liver injury in long-term nutrient oversupply.
Autophagy. 14:1779–1795. 2018.PubMed/NCBI View Article : Google Scholar
|
18
|
Li S, Dou X, Ning H, Song Q, Wei W, Zhang
X, Shen C, Li J, Sun C and Song Z: Sirtuin 3 acts as a negative
regulator of autophagy dictating hepatocyte susceptibility to
lipotoxicity. Hepatology. 66:936–952. 2017.PubMed/NCBI View Article : Google Scholar
|
19
|
Chao X, Wang H, Jaeschke H and Ding WX:
Role and mechanisms of autophagy in acetaminophen-induced liver
injury. Liver Int. 38:1363–1374. 2018.PubMed/NCBI View Article : Google Scholar
|
20
|
Chu Q, Zhang S, Chen M, Han W, Jia R, Chen
W and Zheng X: Cherry anthocyanins regulate NAFLD by promoting
autophagy pathway. Oxid Med Cell Longev.
2019(4825949)2019.PubMed/NCBI View Article : Google Scholar
|
21
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–408.
2001.PubMed/NCBI View Article : Google Scholar
|
22
|
Zhou B, Liu J, Kang R, Klionsky DJ,
Kroemer G and Tang D: Ferroptosis is a type of autophagy-dependent
cell death. Semin Cancer Biol. 66:89–100. 2020.PubMed/NCBI View Article : Google Scholar
|
23
|
Warnes G: Flow cytometric assays for the
study of autophagy. Methods. 82:21–28. 2015.PubMed/NCBI View Article : Google Scholar
|
24
|
Kim J, Kundu M, Viollet B and Guan KL:
AMPK and mTOR regulate autophagy through direct phosphorylation of
Ulk1. Nat Cell Biol. 13:132–141. 2011.PubMed/NCBI View
Article : Google Scholar
|
25
|
Jia J, Abudu YP, Claude-Taupin A, Gu Y,
Kumar S, Choi SW, Peters R, Mudd MH, Allers L, Salemi M, et al:
Galectins control MTOR and AMPK in response to lysosomal damage to
induce autophagy. Autophagy. 15:169–171. 2019.PubMed/NCBI View Article : Google Scholar
|
26
|
Zhou Y, Wu R, Cai FF, Zhou WJ, Lu YY,
Zhang H, Chen QL and Su SB: Xiaoyaosan decoction alleviated rat
liver fibrosis via the TGFβ/Smad and Akt/FoxO3 signaling pathways
based on network pharmacology analysis. J Ethnopharmacol.
264(113021)2021.PubMed/NCBI View Article : Google Scholar
|
27
|
Ayonrinde OT, Oddy WH, Adams LA, Mori TA,
Beilin LJ, de Klerk N and Olynyk JK: Infant nutrition and maternal
obesity influence the risk of non-alcoholic fatty liver disease in
adolescents. J Hepatol. 67:568–576. 2017.PubMed/NCBI View Article : Google Scholar
|
28
|
Cantoral A, Montoya A, Luna-Villa L,
Roldán-Valadez EA, Hernández-Ávila M, Kershenobich D, Perng W,
Peterson KE, Hu H, Rivera JA and Téllez-Rojo MM: Overweight and
obesity status from the prenatal period to adolescence and its
association with non-alcoholic fatty liver disease in young adults:
Cohort study. BJOG. 127:1200–1209. 2020.PubMed/NCBI View Article : Google Scholar
|
29
|
Zhou Y, Peng H, Xu H, Li J, Golovko M,
Cheng H, Lynch EC, Liu L, McCauley N, Kennedy L, et al: Maternal
diet intervention before pregnancy primes offspring lipid
metabolism in liver. Lab Invest. 100:553–569. 2020.PubMed/NCBI View Article : Google Scholar
|
30
|
Alisi A and Vajro P: Pre-natal and
post-natal environment monitoring to prevent non-alcoholic fatty
liver disease development. J Hepatol. 67:451–453. 2017.PubMed/NCBI View Article : Google Scholar
|
31
|
Simpson J, Smith AD, Fraser A, Sattar N,
Callaway M, Lindsay RS, Lawlor DA and Nelson SM: Cord blood
adipokines and lipids and adolescent nonalcoholic fatty liver
disease. J Clin Endocrinol Metab. 101:4661–4668. 2016.PubMed/NCBI View Article : Google Scholar
|
32
|
Devarajan A, Rajasekaran NS, Valburg C,
Ganapathy E, Bindra S and Freije WA: Maternal perinatal calorie
restriction temporally regulates the hepatic autophagy and redox
status in male rat. Free Radic Biol Med. 130:592–600.
2019.PubMed/NCBI View Article : Google Scholar
|
33
|
Singh R, Kaushik S, Wang Y, Xiang Y, Novak
I, Komatsu M, Tanaka K, Cuervo AM and Czaja MJ: Autophagy regulates
lipid metabolism. Nature. 458:1131–1135. 2009.PubMed/NCBI View Article : Google Scholar
|
34
|
Martinez-Lopez N and Singh R: Autophagy
and lipid droplets in the liver. Annual Rev Nutr. 35:215–237.
2015.PubMed/NCBI View Article : Google Scholar
|
35
|
González-Rodríguez A, Mayoral R, Agra N,
Valdecantos MP, Pardo V, Miquilena-Colina ME, Vargas-Castrillón J,
Lo Iacono O, Corazzari M, Fimia GM, et al: Impaired autophagic flux
is associated with increased endoplasmic reticulum stress during
the development of NAFLD. Cell Death Dis. 5(e1179)2014.PubMed/NCBI View Article : Google Scholar
|
36
|
Lin CW, Zhang H, Li M, Xiong X, Chen X,
Chen X, Dong XC and Yin XM: Pharmacological promotion of autophagy
alleviates steatosis and injury in alcoholic and non-alcoholic
fatty liver conditions in mice. J Hepatol. 58:993–999.
2013.PubMed/NCBI View Article : Google Scholar
|
37
|
Guo R, Nair S, Zhang Y and Ren J:
Adiponectin deficiency rescues high-fat diet-induced hepatic
injury, apoptosis and autophagy loss despite persistent steatosis.
Int J Obes (Lond). 41:1403–1412. 2017.PubMed/NCBI View Article : Google Scholar
|
38
|
Lu W, Mei J, Yang J, Wu Z, Liu J, Miao P,
Chen Y, Wen Z, Zhao Z, Kong H, et al: ApoE deficiency promotes
non-alcoholic fatty liver disease in mice via impeding AMPK/mTOR
mediated autophagy. Life Sci. 252(117601)2020.PubMed/NCBI View Article : Google Scholar
|
39
|
Lee DH, Park SH, Ahn J, Hong SP, Lee E,
Jang YJ, Ha TY, Huh YH, Ha SY, Jeon TI and Jung CH: Mir214-3p and
Hnf4a/Hnf4α reciprocally regulate Ulk1 expression and autophagy in
nonalcoholic hepatic steatosis. Autophagy, 2020 (Epub ahead of
print).
|
40
|
Liu C, Liu L, Zhu HD, Sheng JQ, Wu XL, He
XX, Tian DA, Liao JZ and Li PY: Celecoxib alleviates nonalcoholic
fatty liver disease by restoring autophagic flux. Sci Rep.
8(4108)2018.PubMed/NCBI View Article : Google Scholar
|
41
|
Garcia D, Hellberg K, Chaix A, Wallace M,
Herzig S, Badur MG, Lin T, Shokhirev MN, Pinto AFM, Ross DS, et al:
Genetic liver-specific AMPK activation protects against
diet-induced obesity and NAFLD. Cell Rep. 26:192–208.e6.
2019.PubMed/NCBI View Article : Google Scholar
|
42
|
Zhou Y, Peng H, Liu Z, Zhang KK, Jendrusch
C, Drake M, Hao Y and Xie L: Sex-associated preventive effects of
low-dose aspirin on obesity and non-alcoholic fatty liver disease
in mouse offspring with over-nutrition in utero. Lab Invest.
99:244–259. 2019.PubMed/NCBI View Article : Google Scholar
|
43
|
Inoki K, Kim J and Guan KL: AMPK and mTOR
in cellular energy homeostasis and drug targets. Annu Rev Pharmacol
Toxicol. 52:381–400. 2012.PubMed/NCBI View Article : Google Scholar
|
44
|
Soto-Avellaneda A and Morrison BE:
Signaling and other functions of lipids in autophagy: A review.
Lipids Health Dis. 19(214)2020.PubMed/NCBI View Article : Google Scholar
|
45
|
Rinella ME and Sanyal AJ: Management of
NAFLD: A stage-based approach. Nat Rev Gastroenterol Hepatol.
13:196–205. 2016.PubMed/NCBI View Article : Google Scholar
|
46
|
Fang C, Cai X, Hayashi S, Hao S, Sakiyama
H, Wang X, Yang Q, Akira S, Nishiguchi S, Fujiwara N, et al:
Caffeine-stimulated muscle IL-6 mediates alleviation of
non-alcoholic fatty liver disease. Biochim Biophys Acta Mol Cell
Biol Lipids. 1864:271–280. 2019.PubMed/NCBI View Article : Google Scholar
|
47
|
Hart KM, Fabre T, Sciurba JC, Gieseck RL,
Borthwick LA, Vannella KM, Acciani TH, de Queiroz Prado R, Thompson
RW, White S, et al: Type 2 immunity is protective in metabolic
disease but exacerbates NAFLD collaboratively with TGF-β. Sci
Transl Med. 9(eaal3694)2017.PubMed/NCBI View Article : Google Scholar
|
48
|
Chen P, Luo Q, Huang C, Gao Q, Li L, Chen
J, Chen B, Liu W, Zeng W and Chen Z: Pathogenesis of non-alcoholic
fatty liver disease mediated by YAP. Hepatol Int. 12:26–36.
2018.PubMed/NCBI View Article : Google Scholar
|
49
|
Stojsavljević S, Gomerčić Palčić M,
Virović Jukić L, Smirčić Duvnjak L and Duvnjak M: Adipokines and
proinflammatory cytokines, the key mediators in the pathogenesis of
nonalcoholic fatty liver disease. World J Gastroenterol.
20:18070–18091. 2014.PubMed/NCBI View Article : Google Scholar
|
50
|
Wei Y, Huang M, Liu X, Yuan Z, Peng Y,
Huang Z and Zhao T: Anti-fibrotic effect of plumbagin on
CCl4-lesioned rats. Cell Physiol Biochem. 35:1599–1608.
2015.PubMed/NCBI View Article : Google Scholar
|
51
|
Al-Hashem F, Al-Humayed S, Amin SN, Kamar
SS, Mansy SS, Hassan S, Abdel-Salam LO, Ellatif MA, Alfaifi M,
Haidara MA and Al-Ani B: Metformin inhibits mTOR-HIF-1α axis and
profibrogenic and inflammatory biomarkers in thioacetamide-induced
hepatic tissue alterations. J Cell Physiol. 234:9328–9337.
2018.PubMed/NCBI View Article : Google Scholar
|
52
|
Haukeland JW, Damås JK, Konopski Z, Løberg
EM, Haaland T, Goverud I, Torjesen PA, Birkeland K, Bjøro K and
Aukrust P: Systemic inflammation in nonalcoholic fatty liver
disease is characterized by elevated levels of CCL2. J Hepato.
44:1167–1174. 2006.PubMed/NCBI View Article : Google Scholar
|
53
|
García-Galiano D, Sánchez-Garrido MA,
Espejo I, Montero JL, Costán G, Marchal T, Membrives A,
Gallardo-Valverde JM, Muñoz-Castañeda JR, Arévalo E, et al: IL-6
and IGF-1 are independent prognostic factors of liver steatosis and
non-alcoholic steatohepatitis in morbidly obese patients. Obes
Surg. 17:493–503. 2007.PubMed/NCBI View Article : Google Scholar
|
54
|
Mridha AR, Wree A, Robertson AAB, Yeh MM,
Johnson CD, Van Rooyen DM, Haczeyni F, Teoh NC, Savard C, Ioannou
GN, et al: NLRP3 inflammasome blockade reduces liver inflammation
and fibrosis in experimental NASH in mice. J Hepatol. 66:1037–1046.
2017.PubMed/NCBI View Article : Google Scholar
|
55
|
Mouralidarane A, Soeda J, Visconti-Pugmire
C, Samuelsson AM, Pombo J, Maragkoudaki X, Butt A, Saraswati R,
Novelli M, Fusai G, et al: Maternal obesity programs offspring
nonalcoholic fatty liver disease by innate immune dysfunction in
mice. Hepatology. 58:128–138. 2013.PubMed/NCBI View Article : Google Scholar
|
56
|
Schuster S, Cabrera D, Arrese M and
Feldstein AE: Triggering and resolution of inflammation in NASH.
Nat Rev Gastroenterol Hepatol. 15:349–364. 2018.PubMed/NCBI View Article : Google Scholar
|
57
|
Gao B, Jeong WI and Tian Z: Liver: An
organ with predominant innate immunity. Hepatology. 47:729–736.
2008.PubMed/NCBI View Article : Google Scholar
|
58
|
Arrese M, Cabrera D, Kalergis AM and
Feldstein AE: Innate Immunity and Inflammation in NAFLD/NASH. Dig
Dis Sci. 61:1294–1303. 2016.PubMed/NCBI View Article : Google Scholar
|
59
|
Yu Y, Liu Y, An W, Song J, Zhang Y and
Zhao X: STING-mediated inflammation in Kupffer cells contributes to
progression of nonalcoholic steatohepatitis. J Clin Invest.
129:546–555. 2019.PubMed/NCBI View Article : Google Scholar
|
60
|
Hurrell BP, Galle-Treger L, Jahani PS,
Howard E, Helou DG, Banie H, Soroosh P and Akbari O: TNFR2
Signaling enhances ILC2 survival, function, and induction of airway
hyperreactivity. Cell Rep. 29:4509–4524.e5. 2019.PubMed/NCBI View Article : Google Scholar
|
61
|
Fang W, Deng Z, Benadjaoud F, Yang C and
Shi GP: Cathepsin B deficiency ameliorates liver lipid deposition,
inflammatory cell infiltration, and fibrosis after diet-induced
nonalcoholic steatohepatitis. Transl Res. 222:28–40.
2020.PubMed/NCBI View Article : Google Scholar
|