lncRNA WT1‑AS is upregulated in osteoporosis and regulates the apoptosis of osteoblasts by interacting with p53
- Chaoqun Wang
- Quan Xie
- Wen Sun
- Ying Zhou
- Yu Liu
Affiliations: Department of Nuclear Medicine, Hainan General Hospital, Haikou, Hainan 570311, P.R. China, Department of Nuclear Medicine, The First Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570100, P.R. China, Cancer Institute Of Hainan Medicail University, The First Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570100, P.R. China
- Published online on: May 9, 2021 https://doi.org/10.3892/etm.2021.10166
Copyright: © Wang
et al. This is an open access article distributed under the
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In cervical cancer, cellular tumor antigen p53 (p53) interacts with long non‑coding WT1 antisense RNA (WT1‑AS) and this protein serves an important role in osteoporosis. The present study aimed to investigate the role of WT1‑AS in osteoporosis. WT1‑AS was upregulated in the plasma of patients with osteoporosis and was positively correlated with p53 expression. Altered expression of WT1‑AS and p53 separated patients with osteoporosis from healthy controls. Expression levels of WT1‑AS and p53 decreased with prolonged treatment. In osteoblasts, WT1‑AS overexpression resulted in increased p53 expression, while WT1‑AS small interfering RNA (siRNA) silencing resulted in decreased p53 expression. In addition, WT1‑AS overexpression resulted in increased apoptosis rate, while WT1‑AS siRNA silencing resulted in decreased apoptosis rate in osteoblasts. p53 overexpression attenuated the effects of WT1‑AS siRNA silencing on cell apoptosis. Therefore, WT1‑AS was upregulated during osteoporosis and regulated the apoptosis of osteoblasts by interacting with p53.