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Long non‑coding RNA DUXAP8 promotes tumorigenesis by regulating IGF1R via miR‑9‑3p in hepatocellular carcinoma

  • Authors:
    • Qiang Guan
    • Bo Yuan
    • Xiaobin Zhang
    • Tinghai Yan
    • Jiangong Li
    • Wuzhong Xu
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, People's Hospital of Dongying, Dongying, Shandong 257091, P.R. China, Department of Oncology, People's Hospital of Wudi, Binzhou, Shandong 251900, P.R. China
    Copyright: © Guan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 755
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    Published online on: May 12, 2021
       https://doi.org/10.3892/etm.2021.10187
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Abstract

Hepatocellular carcinoma (HCC) is the third leading cause of cancer‑related death worldwide with a low 5‑year survival rate. Long non‑coding RNA (lncRNA) double homeobox A pseudogene 8 (DUXAP8) is an oncogene and a potential biomarker in various tumors, such as ovarian, colorectal and non‑small‑cell lung cancer. However, the function and molecular mechanism underlying DUXAP8 in HCC progression is not completely understood. The expression of DUXAP8, microRNA (miR)‑9‑3p and insulin‑like growth factor 1 receptor (IGF1R) in HCC tissues and cells was detected via reverse transcription‑quantitative PCR. The expression levels of IGF1R and epithelial‑mesenchymal transition‑associated proteins (Snail, Slug, E‑cadherin, N‑cadherin and vimentin) were assessed via western blotting. The effects of DUXAP8, miR‑9‑3p and IGF1R on proliferation, migration and invasion were examined by conducting Cell Counting Kit‑8 and Transwell assays, respectively. The interaction between miR‑9‑3p and DUXAP8 or IGF1R was predicted using StarBase or TargetScan, and further assessed using dual luciferase reporter and RNA immunoprecipitation assays. DUXAP8 and IGF1R were upregulated and miR‑9‑3p was downregulated in HCC tissues and cells compared with adjacent healthy tissues and a normal liver cell line, respectively. miR‑9‑3p overexpression decreased the protein expression level of IGF1R, and miR‑9‑3p knockdown enhanced the protein expression level of IGF1R in HCC cells compared with the corresponding control groups. Moreover, compared with the corresponding control groups, DUXAP8 knockdown and miR‑9‑3p overexpression increased E‑cadherin protein expression levels, and decreased Snail, Slug, N‑cadherin and vimentin protein expression levels. However, miR‑9‑3p inhibitor and IGF1R overexpression reversed DUXAP8 knockdown‑ and miR‑9‑3p overexpression‑induced effects, respectively. In addition, compared with the corresponding control groups, DUXAP8 knockdown and miR‑9‑3p overexpression suppressed proliferation, migration and invasion, which was reversed by miR‑9‑3p inhibitor and IGF1R overexpression, respectively. Moreover, miR‑9‑3p as the target of DUXAP8 and IGF1R as the target of miR‑9‑3p were verified in HCC cells. lncRNA DUXAP8 contributed to HCC tumorigenesis via the miR‑9‑3p/IGF1R axis, providing a novel therapeutic approach for HCC diagnosis and treatment.
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1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2017. CA Cancer J Clin. 67:7–30. 2017.PubMed/NCBI View Article : Google Scholar

2 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018.PubMed/NCBI View Article : Google Scholar

3 

Erstad DJ and Tanabe KK: Prognostic and therapeutic implications of microvascular invasion in hepatocellular carcinoma. Ann Surg Oncol. 26:1474–1493. 2019.PubMed/NCBI View Article : Google Scholar

4 

Mercer TR, Dinger ME and Mattick JS: Long Non-coding RNAs: Insights into functions. Nat Rev Genet. 10:155–159. 2009.PubMed/NCBI View Article : Google Scholar

5 

Marchese FP, Raimondi I and Huarte M: The multidimensional mechanisms of long noncoding RNA function. Genome Biol. 18(206)2017.PubMed/NCBI View Article : Google Scholar

6 

Kong L and Zhang C: LncRNA DLX6-AS1 aggravates the development of ovarian cancer via modulating FHL2 by sponging miR-195-5p. Cancer Cell Int. 20(370)2020.PubMed/NCBI View Article : Google Scholar

7 

Yang Q, Wan Q, Zhang L, Li Y, Zhang P, Li D, Feng C, Yi F, Zhang L, Ding X, et al: Analysis of LncRNA expression in cell differentiation. RNA Biol. 15:413–422. 2018.PubMed/NCBI View Article : Google Scholar

8 

Wu Y and Qian Z: Long non-coding RNAs (lncRNAs) and microRNAs regulatory pathways in the tumorigenesis and pathogenesis of glioma. Discov Med. 28:129–138. 2019.PubMed/NCBI

9 

Yang Y, Chen L, Gu J, Zhang H, Yuan J, Lian Q, Lv G, Wang S, Wu Y, Yang YT, et al: Recurrently deregulated lncRNAs in hepatocellular carcinoma. Nat Commun. 8(14421)2017.PubMed/NCBI View Article : Google Scholar

10 

Li B, Mao R, Liu C, Zhang W, Tang Y and Guo Z: LncRNA FAL1 promotes cell proliferation and migration by acting as a CeRNA of miR-1236 in hepatocellular carcinoma cells. Life Sci. 197:122–129. 2018.PubMed/NCBI View Article : Google Scholar

11 

Ma J, Li T and Han X: Knockdown of LncRNA ANRIL suppresses cell proliferation, metastasis, and invasion via regulating miR-122-5p expression in hepatocellular carcinoma. J Cancer Res Clin Oncol. 144:205–214. 2018.PubMed/NCBI View Article : Google Scholar

12 

Zhao X, Hao S, Wang M, Xing D and Wang C: Knockdown of pseudogene DUXAP8 expression in glioma suppresses tumor cell proliferation. Oncol Lett. 17:3511–3516. 2019.PubMed/NCBI View Article : Google Scholar

13 

Jiang B, Hailong S, Yuan J, Zhao H, Xia W, Zha Z, Bin W and Liu Z: Identification of oncogenic long noncoding RNA SNHG12 and DUXAP8 in human bladder cancer through a comprehensive profiling analysis. Biomed Pharmacother. 108:500–507. 2018.PubMed/NCBI View Article : Google Scholar

14 

Huang T, Wang X, Yang X, Ji J, Wang Q, Yue X and Dong Z: Long non-coding RNA DUXAP8 enhances renal cell carcinoma progression via downregulating miR-126. Med Sci Monit. 24:7340–7347. 2018.PubMed/NCBI View Article : Google Scholar

15 

Sun M, Nie FQ, Zang C, Wang Y, Hou J, Wei C, Li W, He X and Lu KH: The pseudogene DUXAP8 promotes non-small-cell lung cancer cell proliferation and invasion by epigenetically silencing EGR1 and RHOB. Mol Ther. 25:739–751. 2017.PubMed/NCBI View Article : Google Scholar

16 

Afonso-Grunz F and Muller S: Principles of miRNA-mRNA interactions: Beyond sequence complementarity. Cell Mol Life Sci. 72:3127–3141. 2015.PubMed/NCBI View Article : Google Scholar

17 

Zha Z, Jia F, Hu P, Mai E and Lei T: MicroRNA-574-3p inhibits the malignant behavior of liver cancer cells by targeting ADAM28. Oncol Lett. 20:3015–3023. 2020.PubMed/NCBI View Article : Google Scholar

18 

Liu CH, Jing XN, Liu XL, Qin SY, Liu MW and Hou CH: Tumor-suppressor miRNA-27b-5p regulates the growth and metastatic behaviors of ovarian carcinoma cells by targeting CXCL1. J Ovarian Res. 13(92)2020.PubMed/NCBI View Article : Google Scholar

19 

Fang F, Chang RM, Yu L, Lei X, Xiao S, Yang H and Yang LY: MicroRNA-188-5p suppresses tumor cell proliferation and metastasis by directly targeting FGF5 in hepatocellular carcinoma. J Hepatol. 63:874–885. 2015.PubMed/NCBI View Article : Google Scholar

20 

Chen Y, Zhao ZX, Huang F, Yuan XW, Deng L and Tang D: MicroRNA-1271 functions as a potential tumor suppressor in hepatitis B virus-associated hepatocellular carcinoma through the AMPK signaling pathway by binding to CCNA1. J Cell Physiol. 234:3555–3569. 2019.PubMed/NCBI View Article : Google Scholar

21 

Higashi T, Hayashi H, Ishimoto T, Takeyama H, Kaida T, Arima K, Taki K, Sakamoto K, Kuroki H, Okabe H, et al: MiR-9-3p plays a tumour-suppressor role by targeting TAZ (WWTR1) in hepatocellular carcinoma cells. Br J Cancer. 113:252–258. 2015.PubMed/NCBI View Article : Google Scholar

22 

Erickson KE and Rukhlenko OS: Modeling cell line-specific recruitment of signaling proteins to the insulin-like growth factor 1 receptor. PLoS Comput Biol. 15(e1006706)2019.PubMed/NCBI View Article : Google Scholar

23 

Lin JF, Tsai TF, Lin YC, Chen HE, Chou KY and Hwang TI: Benzyl isothiocyanate suppresses IGF1R, FGFR3 and mTOR expression by upregulation of miR-99a-5p in human bladder cancer cells. Int J Oncol. 54:2106–2116. 2019.PubMed/NCBI View Article : Google Scholar

24 

Zhang Y, Huang S, Guo Y and Li L: MiR-1294 confers cisplatin resistance in ovarian Cancer cells by targeting IGF1R. Biomed Pharmacother. 106:1357–1363. 2018.PubMed/NCBI View Article : Google Scholar

25 

Khalil A and Jameson MJ: Downregulation of igf1r expression inhibits growth and enhances cisplatin sensitivity of head and neck squamous cell carcinoma cells in vitro. Horm Cancer. 10:11–23. 2019.PubMed/NCBI View Article : Google Scholar

26 

Liu W, Kang L, Han J, Wang Y, Shen C, Yan Z, Tai Y and Zhao C: MiR-342-3p suppresses hepatocellular carcinoma proliferation through inhibition of IGF-1R-mediated Warburg effect. Onco Targets Ther. 11:1643–1653. 2018.PubMed/NCBI View Article : Google Scholar

27 

Ren L, Yao Y, Wang Y and Wang S: MiR-505 suppressed the growth of hepatocellular carcinoma cells via targeting IGF-1R. Biosci Rep. 39(BSR20182442)2019.PubMed/NCBI View Article : Google Scholar

28 

Ye Y, Zhuang J, Wang G, He S, Zhang S, Wang G, Ni J, Wang J and Xia W: MicroRNA-495 suppresses cell proliferation and invasion of hepatocellular carcinoma by directly targeting insulin-like growth factor receptor-1. Exp Ther Med. 15:1150–1158. 2018.PubMed/NCBI View Article : Google Scholar

29 

Liu MD, Wu H, Wang S, Pang P, Jin S, Sun CF and Liu FY: MiR-1275 promotes cell migration, invasion and proliferation in squamous cell carcinoma of head and neck via up-regulating IGF-1R and CCR7. Gene. 646:1–7. 2018.PubMed/NCBI View Article : Google Scholar

30 

Zhou Y, Zhang Z, Wang N, Chen J, Zhang X, Guo M, John Zhong L and Wang Q: Suppressor of cytokine signalling-2 limits IGF1R-mediated regulation of epithelial-mesenchymal transition in lung adenocarcinoma. Cell Death Dis. 9(429)2018.PubMed/NCBI View Article : Google Scholar

31 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

32 

Li JH, Liu S, Zhou H, Qu LH and Yang JH: StarBase v2.0: Decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data. Nucleic Acids Res. 42 (Database Issue):D92–D97. 2014.PubMed/NCBI View Article : Google Scholar

33 

Yang JH, Li JH, Shao P, Zhou H, Chen YQ and Qu LH: StarBase: A database for exploring microRNA-mRNA interaction maps from Argonaute CLIP-Seq and Degradome-Seq data. Nucleic Acids Res. 39 (Database Issue):D202–D209. 2011.PubMed/NCBI View Article : Google Scholar

34 

Li Y: MIR31HG exhibits oncogenic property and acts as a sponge for miR-361-3p in cervical carcinoma. Biochem Biophys Res Commun. 529:890–897. 2020.PubMed/NCBI View Article : Google Scholar

35 

Sun F and Wu K: Long Noncoding RNA PVT1 promotes prostate cancer metastasis by increasing NOP2 expression via targeting tumor suppressor MicroRNAs. Onco Targets Ther. 13:6755–6765. 2020.PubMed/NCBI View Article : Google Scholar

36 

Shi X, Huo J, Gao X, Cai H and Zhu W: A newly identified lncRNA H1FX-AS1 targets DACT1 to inhibit cervical cancer via sponging miR-324-3p. Cancer Cell Int. 20(358)2020.PubMed/NCBI View Article : Google Scholar

37 

Wu R, Zhao B, Ren X, Wu S, Liu M, Wang Z and Liu W: MiR-27a-3p targeting GSK3β promotes triple-negative breast cancer proliferation and migration through Wnt/β-catenin pathway. Cancer Manag Res. 12:6241–6249. 2020.PubMed/NCBI View Article : Google Scholar

38 

Li G, Qi HW, Dong HG, Bai P, Sun M and Liu HY: Targeting deubiquitinating enzyme USP26 by microRNA-203 regulates Snail1's pro-metastatic functions in esophageal cancer. Cancer Cell Int. 20(355)2020.PubMed/NCBI View Article : Google Scholar

39 

Ma HF, Lv GX and Zhang DH: miR-381 mediates the development of head and neck squamous cell carcinoma via targeting STC2. Onco Targets Ther. 13:4485–4493. 2020.PubMed/NCBI View Article : Google Scholar

40 

Huo X, Han S, Wu G, Latchoumanin O, Zhou G, Hebbard L, George J and Qiao L: Dysregulated long noncoding RNAs (lncRNAs) in hepatocellular carcinoma: Implications for tumorigenesis, disease progression, and liver cancer stem cells. Mol Cancer. 16(165)2017.PubMed/NCBI View Article : Google Scholar

41 

Zhang H, Xu HB, Kurban E and Luo HW: LncRNA SNHG14 promotes hepatocellular carcinoma progression via H3K27 acetylation activated PABPC1 by PTEN signaling. Cell Death Dis. 11(646)2020.PubMed/NCBI View Article : Google Scholar

42 

He H, Wang Y, Ye P, Yi D, Cheng Y, Tang H, Zhu Z, Wang X and Jin S: Long noncoding RNA ZFPM2-AS1 acts as a miRNA sponge and promotes cell invasion through regulation of miR-139/GDF10 in hepatocellular carcinoma. J Exp Clin Cancer Res. 39(159)2020.PubMed/NCBI View Article : Google Scholar

43 

Yin D, Hua L, Wang J and Liu Y: Long non-coding RNA DUXAP8 facilitates cell viability, migration, and glycolysis in non-small-cell lung cancer via regulating HK2 and LDHA by inhibition of miR-409-3p. Onco Targets Ther. 13:7111–7123. 2020.PubMed/NCBI View Article : Google Scholar

44 

Meng Q, Li Z, Pan J and Sun X: Long noncoding RNA DUXAP8 regulates proliferation and apoptosis of ovarian cancer cells via targeting miR-590-5p. Hum Cell. 33:1240–1251. 2020.PubMed/NCBI View Article : Google Scholar

45 

Xu LJ, Yu XJ, Wei B, Hui HX, Sun Y, Dai J and Chen XF: Long non-coding RNA DUXAP8 regulates proliferation and invasion of esophageal squamous cell cancer. Eur Rev Med Pharmacol Sci. 22:2646–2652. 2018.PubMed/NCBI View Article : Google Scholar

46 

Lin MG, Hong YK, Zhang Y, Lin BB and He XJ: Mechanism of lncRNA DUXAP8 in promoting proliferation of bladder cancer cells by regulating PTEN. Eur Rev Med Pharmacol Sci. 22:3370–3377. 2018.PubMed/NCBI View Article : Google Scholar

47 

Yang L, Mu Y, Cui H, Liang Y and Su X: MiR-9-3p augments apoptosis induced by H2O2 through down regulation of Herpud1 in glioma. PLoS One. 12(e0174839)2017.PubMed/NCBI View Article : Google Scholar

48 

Ding Y, Pan Y, Liu S, Jiang F and Jiao J: Elevation of MiR-9-3p suppresses the epithelial-mesenchymal transition of nasopharyngeal carcinoma cells via down-regulating FN1, ITGB1 and ITGAV. Cancer Biol Ther. 18:414–424. 2017.PubMed/NCBI View Article : Google Scholar

49 

Cai H, Yang X, Gao Y, Xu Z, Yu B, Xu T, Li X, Xu W, Wang X and Hua L: Exosomal MicroRNA-9-3p secreted from BMSCs downregulates ESM1 to suppress the development of bladder cancer. Mol Ther Nucleic Acids. 18:787–800. 2019.PubMed/NCBI View Article : Google Scholar

50 

Yang S, Cai H, Hu B and Tu J: LncRNA SAMMSON negatively regulates miR-9-3p in hepatocellular carcinoma cells and has prognostic values. Biosci Rep. 39(BSR20190615)2019.PubMed/NCBI View Article : Google Scholar

51 

Tang J, Li Y, Liu K, Zhu Q, Yang WH, Xiong LK and Guo DL: Exosomal miR-9-3p suppresses HBGF-5 expression and is a functional biomarker in hepatocellular carcinoma. Minerva Med. 109:15–23. 2018.PubMed/NCBI View Article : Google Scholar

52 

Militello G, Weirick T, John D, Döring C, Dimmeler S and Uchida S: Screening and validation of lncRNAs and circRNAs as miRNA sponges. Brief Bioinform. 18:780–788. 2017.PubMed/NCBI View Article : Google Scholar

53 

Olgun G, Sahin O and Tastan O: Discovering lncRNA mediated sponge interactions in breast cancer molecular subtypes. BMC Genomics. 19(650)2018.PubMed/NCBI View Article : Google Scholar

54 

Yoon JH, Abdelmohsen K and Gorospe M: Functional interactions among microRNAs and long noncoding RNAs. Semin Cell Dev Biol. 34:9–14. 2014.PubMed/NCBI View Article : Google Scholar

55 

Li DS, Ainiwaer JL, Sheyhiding I, Zhang Z and Zhang LW: Identification of key long non-coding RNAs as competing endogenous RNAs for miRNA-mRNA in lung adenocarcinoma. Eur Rev Med Pharmacol Sci. 20:2285–2295. 2016.PubMed/NCBI

56 

Lin P, Wen DY, Li Q, He Y, Yang H and Chen G: Genome-wide analysis of prognostic lncRNAs, miRNAs, and mRNAs forming a competing endogenous RNA Network in hepatocellular carcinoma. Cell Physiol Biochem. 48:1953–1967. 2018.PubMed/NCBI View Article : Google Scholar

57 

Schwartz MA and Ginsberg MH: Networks and crosstalk: Integrin signalling spreads. Nat Cell Biol. 4:E65–E68. 2002.PubMed/NCBI View Article : Google Scholar

58 

Han X, Wang X, Zhao B, Chen G, Sheng Y, Wang W and Teng M: MicroRNA-187 inhibits tumor growth and metastasis via targeting of IGF-1R in hepatocellular carcinoma. Mol Med Rep. 16:2241–2246. 2017.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Guan Q, Yuan B, Zhang X, Yan T, Li J and Xu W: Long non‑coding RNA DUXAP8 promotes tumorigenesis by regulating IGF1R via miR‑9‑3p in hepatocellular carcinoma. Exp Ther Med 22: 755, 2021.
APA
Guan, Q., Yuan, B., Zhang, X., Yan, T., Li, J., & Xu, W. (2021). Long non‑coding RNA DUXAP8 promotes tumorigenesis by regulating IGF1R via miR‑9‑3p in hepatocellular carcinoma. Experimental and Therapeutic Medicine, 22, 755. https://doi.org/10.3892/etm.2021.10187
MLA
Guan, Q., Yuan, B., Zhang, X., Yan, T., Li, J., Xu, W."Long non‑coding RNA DUXAP8 promotes tumorigenesis by regulating IGF1R via miR‑9‑3p in hepatocellular carcinoma". Experimental and Therapeutic Medicine 22.1 (2021): 755.
Chicago
Guan, Q., Yuan, B., Zhang, X., Yan, T., Li, J., Xu, W."Long non‑coding RNA DUXAP8 promotes tumorigenesis by regulating IGF1R via miR‑9‑3p in hepatocellular carcinoma". Experimental and Therapeutic Medicine 22, no. 1 (2021): 755. https://doi.org/10.3892/etm.2021.10187
Copy and paste a formatted citation
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Spandidos Publications style
Guan Q, Yuan B, Zhang X, Yan T, Li J and Xu W: Long non‑coding RNA DUXAP8 promotes tumorigenesis by regulating IGF1R via miR‑9‑3p in hepatocellular carcinoma. Exp Ther Med 22: 755, 2021.
APA
Guan, Q., Yuan, B., Zhang, X., Yan, T., Li, J., & Xu, W. (2021). Long non‑coding RNA DUXAP8 promotes tumorigenesis by regulating IGF1R via miR‑9‑3p in hepatocellular carcinoma. Experimental and Therapeutic Medicine, 22, 755. https://doi.org/10.3892/etm.2021.10187
MLA
Guan, Q., Yuan, B., Zhang, X., Yan, T., Li, J., Xu, W."Long non‑coding RNA DUXAP8 promotes tumorigenesis by regulating IGF1R via miR‑9‑3p in hepatocellular carcinoma". Experimental and Therapeutic Medicine 22.1 (2021): 755.
Chicago
Guan, Q., Yuan, B., Zhang, X., Yan, T., Li, J., Xu, W."Long non‑coding RNA DUXAP8 promotes tumorigenesis by regulating IGF1R via miR‑9‑3p in hepatocellular carcinoma". Experimental and Therapeutic Medicine 22, no. 1 (2021): 755. https://doi.org/10.3892/etm.2021.10187
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