Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
July-2021 Volume 22 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2021 Volume 22 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Clinical, biological and electroencephalographic monitoring of newborns with neurological risk in the Neonatal Intensive Care Unit

  • Authors:
    • Florina Marinela Doandes
    • Aniko-Maria Manea
    • Nicoleta  Lungu
    • Daniela Cioboata
    • Timea Brandibur
    • Oana Costescu
    • Anca  Hudisteanu
    • Eugen Radu Boia
    • Marioara Boia
  • View Affiliations / Copyright

    Affiliations: Neonatology and Puericulture Department, ‘Victor Babeş’ University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania, Department of Oto‑Rhino‑Laryngology, ‘Victor Babeş’ University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania
    Copyright: © Doandes et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 760
    |
    Published online on: May 13, 2021
       https://doi.org/10.3892/etm.2021.10192
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Newborns admitted to the Neonatal Intensive Care Unit (NICU) require increased attention regarding neurological assessment and monitoring, due to immaturity or certain conditions that occur during the perinatal and neonatal period. Hypoxic‑ischemic encephalopathy (HIE) following perinatal asphyxia is one of the most studied clinical conditions due to the risk of medium‑ and long‑term neurobehavioral outcome. We studied 43 newborns with HIE, for all 3 degrees of impairment, performed amplitude‑integrated electroencephalography (aEEG) in the first hours of life and collected common laboratory tests, following serum glycemia at admission and creatinine, creatine kinase (CK) and lactate dehydrogenase (LDH) at admission and in the 3rd day of life. Newborns with mild HIE presented normal aEEG pattern and slightly elevated CK. A total of 80.9% of the newborns with moderate HIE had seizure patterns in aEEG, while among those with severe HIE, 71.4% had seizure patterns in aEEG and 28.5% burst suppression. CK and LDH were mean elevated in those with moderate HIE, and the newborns with severe HIE had also high creatinine values at admission and in the 3rd day of life. Statistically significant differences between the 3 degrees of HIE were noted in terms of creatinine (P=0.009) and CK (P=0.008) at admission and LDH in the 3rd day of life (P=0.036). Hypoglycemia was common in our study group. In conclusion, common blood tests in association with aEEG monitoring and rigorous neurological assessment can predict short‑term outcome of HIE and multiorgan dysfunction and can help clinicians predict even long‑term outcomes in severe HIE.
View Figures
View References

1 

Graham EM, Ruis KA, Hartman AL, Northington FJ and Fox HE: A systematic review of the role of intrapartum hypoxia-ischemia in the causation of neonatal encephalopathy. Am J Obstret Gynecol. 199:587–595. 2008.PubMed/NCBI View Article : Google Scholar

2 

de Haan M, Wyatt JS, Roth S, Vargha-Khadem F, Gadian D and Mishkin M: Brain and congnitive-behavioural development after asphyxia at term birth. Dev Sci. 9:350–358. 2006.PubMed/NCBI View Article : Google Scholar

3 

Lawn JE, Cousens S and Zupan J: for the Lancet Survival Steering team. 4 million neonatal deaths: When? Where? Why? Lancet. 365:891–900. 2005.PubMed/NCBI View Article : Google Scholar

4 

Antonucci R, Porcella A and Pilloni MD: Perinatal asphyxia in the term newborn. J Pediatr Neonat Individual Med. 3(e030269)2014.

5 

Robertson NJ and Groenendaal F: Hypoxic-ischaemic brain injury. In: Rennie and Robertson's Textbook of Neonatology. 5th edition, 40.4:. Elsevier Limited, pp114-1155, 2012.

6 

Zaigham M, Lundberg F and Olofsson P: Protein S100B in umbilical cord blood as a potential biomarker of hypoxic-ischemic encephalopathy in asphyxiated newborns. Early Hum Dev. 112:48–53. 2017.PubMed/NCBI View Article : Google Scholar

7 

Massey SL, Jensen FE and Abend NS: Electroencephalographic monitoring for seizure identification and prognosis in term neonates. Semin Fetal Neonatal Med. 23:168–74. 2018.PubMed/NCBI View Article : Google Scholar

8 

Nelson K and Leviton A: How much of neonatal encephalopathy is due to birth asphyxia? Am J Dis Child. 145:1325–1331. 1991.PubMed/NCBI View Article : Google Scholar

9 

Sarnat HB and Sarnat MS: Neonatal encephalopathy following fetal distress: A clinical and electroencephalographic study. Arch Neurol. 33:696–705. 1976.PubMed/NCBI View Article : Google Scholar

10 

Elsadek AE, FathyBarseem N, Suliman HA, Elshorbagy HH, Kamal NM, Talaat IM, Al-Shokary AH, Abdel Maksoud YH, Ibrahim AO, Attia AM, et al: Hepatic injury in neonates with perinatal asphyxia. Global Pediatric Health. 8:2021.PubMed/NCBI View Article : Google Scholar

11 

Michniewicz B, Al Saad SR, Karbowski LM, Gadzinowski J, Szymankiewicz M and Szpecht D: Organ complications of infants with hypoxic-ischemic encephalopathy before. Ther Hypothermia Temp Manag. 11:58–63. 2021.PubMed/NCBI View Article : Google Scholar

12 

Munteanu AI, Manea AM, Jinca CM and Boia M: Basic biochemical and hematological parameters in perinatal asphyxia and their correlation with hypoxic ischemic encephalopathy. Exp Ther Med. 21(259)2021.PubMed/NCBI View Article : Google Scholar

13 

Hansen AR and Soul JS: Perinatal asphyxia and hypoxic-ischemic encephalopathy. Cloherty and Stark's Manual of Neonatal Care. 8th edition. 55:790–810. 2017.

14 

Glass HC and Shellhass RA: Acute symptomatic seizures in neonates. Semin Pediatr Neurol. 32(100768)2019.PubMed/NCBI View Article : Google Scholar

15 

Sansevere AJ and Bergin AM: Neonatal seizures in Cloherty and Stark's Manual of Neonatal Care, 8th edition 56: 812-828, 2017.

16 

Reddy S, Dutta S and Narang A: Evaluation of lactate dehydrogenase, creatine kinase and hepatic enzymes for the retrospective diagnosis of perinatal asphyxia among sick neonates. Indian Pediatr. 45:144–147. 2008.PubMed/NCBI

17 

Alkholy UM, Abdalmonem N, Zaki A, Ali YF, Mohamed SA, Abdelsalam NI, Hashim MIA, Sekkien MA and Elsherbiny YM: Early predictors of brain damage in full-term newborns with hypoxic ischemic encephalopathy. Neuropsychiatr Dis Treat. 13:2133–2139. 2017.PubMed/NCBI View Article : Google Scholar

18 

Hellstrom-Westas L, Rosen I, de Vries LS and Greisen G: Amplitude-integrated EEG classification and interpretation in preterm and term infants. Neoreviews. 7:e76–e87. 2006.

19 

Toet MC, Hellström-Westas L, Groenendaal F, Eken P and de Vries LS: Amplitude integrated EEG 3 and 6 h after birth in full term neonates with hypoxic-ischaemic encephalopathy. Arch Dis Child Fetal Neonatal Ed. 81:F19–F23. 1999.PubMed/NCBI View Article : Google Scholar

20 

Chang PD, Chow DS, Alber A, Lin YK and Youn YA: Predictive values of location and volumetric MRI injury patterns for neurodevelopmental outcomes in hypoxic-ischemic encephalopathy neonates. Brain Sci. 10:1–9. 2020.PubMed/NCBI View Article : Google Scholar

21 

Hayakawa M, Ito Y, Saito S, Mitsuda N, Hosono S, Yoda H, Cho K, Otsuki K, Ibara S, Terui K, et al: Incidence and prediction of outcome in hypoxic-ischemic encephalopathy in Japan. Pediatr Int. 56:215–221. 2014.PubMed/NCBI View Article : Google Scholar

22 

Kharoshankaya L, Stevenson NJ, Livingstone V, Murray DM, Murphy BP, Ahearne CE and Boylan GB: Seizure burden and neurodevelopmental outcome in neonates with hypoxic-ischemic encephalopathy. Dev Med Child Neurol. 58:1242–1248. 2016.PubMed/NCBI View Article : Google Scholar

23 

Beken S, Aydin B, Dilli D, Erol S, Zenciroğlu A and Okumuş N: Can biochemical markers predict the severity of hypoxic-ischemic encephalopathy? Turk Pediatr. 56:62–68. 2014.PubMed/NCBI

24 

Hadzimuratovic E, Skrablin S, Hadzimuratovic A and Dinarevic SM: Postasphyxial renal injury in newborns as a prognostic factor of neurological outcome. J Matern Fetal Neonatal Med. 27:407–410. 2014.PubMed/NCBI View Article : Google Scholar

25 

Sabir H and Hoehn T: Comparison of two amplitude-integrated electroencephalography (aEEG) monitors in term neonates. J Med Syst. 41(114)2017.PubMed/NCBI View Article : Google Scholar

26 

Shalak LF, Laptook AR, Velaphi SC and Perlman JM: Amplitude-integrated electroencephalography coupled with an early neurologic examination enhances prediction of term infants at risk for persistent encephalopathy. Pediatrics. 111:351–357. 2003.PubMed/NCBI View Article : Google Scholar

27 

Tao JD and Mathur AM: Using amplitude-integrated EEG in neonatal intensive care. J Perinatol. 30 (Suppl):S73–S81. 2010.PubMed/NCBI View Article : Google Scholar

28 

Hellström-Westas L and Rosen I: Continuous brain-function monitoring: State of the art in clinical practice. Semin Fetal Neonat Med. 11:503–511. 2006.PubMed/NCBI View Article : Google Scholar

29 

Thoresen M, Hellstrom-Westas L, Liu X and de Vries LS: Effect of hypothermia on amplitude-integrated electroencephalogram in infants with asphyxia. Pediatrics. 126:e131–e139. 2010.PubMed/NCBI View Article : Google Scholar

30 

Jose A, Matthai J and Paul S: Correlation of EEG, CT and MRI brain with neurological outcome at 12 months in term newborns with hypoxic ischemic encephalopathy. J Clin Neonatol. 2:125–130. 2013.PubMed/NCBI View Article : Google Scholar

31 

Glass HC, Glidden D, Jeremy RJ, Barkovich AJ, Ferriero DM and Miller SP: Clinical neonatal seizures are independently associated with outcome in infants at risk for hypoxic-ischemic brain injury. J Pediatr. 155:318–323. 2009.PubMed/NCBI View Article : Google Scholar

32 

Shankaran S: Neonatal encephalopathy: Treatment with hypothermia. Neo Rev. 11:e85–e92. 2010.

33 

Hellström-Westas L, Rosén I and Svenningsen NW: Predictive value of early continuous amplitude integrated EEG recordings on outcome after severe birth asphyxia in full term infants. Arch Dis Child Fetal Neonatal. 72:F34–F38. 1995.PubMed/NCBI View Article : Google Scholar

34 

Stamatin M and Paduraru L: Specific medical and ethical aspects in the care of life-threatening illnesses in newborn. Rev Rom Bioet. 7:67–73. 2009.

35 

ter Horst HJ, Sommer C, Bergman KA, Fock JM, van Weerden TW and Bos AF: Prognostic significance of amplitude-integrated EEG during the first 72 h after birth in severely asphyxiated neonates. Pediatr Res. 55:1026–1033. 2004.PubMed/NCBI View Article : Google Scholar

36 

van Rooij LG, Toet MC, Osredkar D, van Huffelen AC, Groenendaal F and de Vries LS: Recovery of amplitude integrated electroencephalographic background patterns within 24 h of perinatal asphyxia. Arch Dis Child Fetal Neonatal. 90:F245–F251. 2005.PubMed/NCBI View Article : Google Scholar

37 

Basti C, Maranella E, Cimini N, Catalucci A, Ciccarelli S, Del Torto M, Di Luca L, Di Natale C, Mareri A, Nardi V, et al: Seizure burden and neurodevelopmental outcome in newborns with hypoxic-ischemic encephalopathy treated with therapeutic hypothermia: A single center observational study. Seizure. 83:154–159. 2020.PubMed/NCBI View Article : Google Scholar

38 

Mizrahi EM: Neonatal seizures and neonatal epileptic syndromes. Neurol Clin. 19:427–63. 2001.PubMed/NCBI View Article : Google Scholar

39 

Murray DM, Boylan GB, Ali I, Ryan CA, Murphy BP and Connolly S: Defining the gap between electrographic seizure burden, clinical expression and staff recognition of neonatal seizures. Arch Dis Child Fetal Neonatal Ed. 93:F187–F191. 2008.PubMed/NCBI View Article : Google Scholar

40 

Clancy ARR and Lewis D: Occult neonatal seizures. Epilepsia. 29:256–261. 1988.PubMed/NCBI View Article : Google Scholar

41 

Ronen GM, Buckley D, Penney S and Streiner DL: Long-term prognosis in children with neonatal seizures: A population-based study. Neurology. 69:1816–1822. 2007.PubMed/NCBI View Article : Google Scholar

42 

Rutherford MA, Pennock JM and Dubowitz LMS: Cranial ultrasound and magnetic resonance imaging in hypoxic ischaemic encephalopathy: A comparison with outcome. Dev Med Child Neurol. 36:813–825. 1994.PubMed/NCBI View Article : Google Scholar

43 

Nelson K and Ellenberg J: Apgar scores as predictors of chronic neurologic disability. Pediatrics. 68:36–44. 1981.PubMed/NCBI

44 

Matyas M and Zaharie G: Antioxidants at newborns, antioxidants. Intech Open, 2019. DOI: 10.5772/intechopen.85175. https://www.intechopen.com/books/antioxidants/antioxidants-at-newborns. Accessed May 19, 2019.

45 

Perlman JM, Wyllie J, Kattwinkel J, Wyckoff MH, Aziz K, Guinsburg R, Kim HS, Liley HG, Mildenhall L, Simon WM, et al: Part 7: Neonatal resuscitation: 2015 International consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations. Pediatrics. 136 (Suppl 2):S120–S166. 2015.PubMed/NCBI View Article : Google Scholar

46 

Shoji H and Koletzko B: Oxidative stress and antioxidant protection in the perinatal period. Curr Opin Clin Nutr Metab Care. 10:324–328. 2007.PubMed/NCBI View Article : Google Scholar

47 

Laptook AR, Shankaran S, Ambalavanan N, Carlo WA, McDonald SA, Higgins RD and Das A: Hypothermia Subcommittee of the NICHD Neonatal Research Network. Outcome of term infants using apgar scores at 10 min following hypoxic-ischemic encephalopathy. Pediatrics. 124:1619–1626. 2009.PubMed/NCBI View Article : Google Scholar

48 

Hankins GDV, Koen S, Gei AF, Lopez SM, Van Hook JW and Anderson GD: Neonatal organ system injury in acute birth asphyxia sufficient to result in neonatal encephalopathy. Obstet Gynecol. 99:688–691. 2002.PubMed/NCBI View Article : Google Scholar

49 

Halvorsen CP, Olson L, Araújo AC, Karlsson M, Nguyễn TT, Khu DTK, Le HTT, Nguyễn HTB, Winbladh B and Russom A: A rapid smartphone-based lactate dehydrogenase test for neonatal diagnostics at the point of care. Sci Rep. 9(9301)2019.PubMed/NCBI View Article : Google Scholar

50 

Lv H, Wang Q, Wu S, Yang L, Ren P, Yang Y, Gao J and Li L: Neonatal hypoxic ischemic encephalopathy-related biomarkers in serum and cerebrospinal fluid. Clin Chim Acta. 450:282–297. 2015.PubMed/NCBI View Article : Google Scholar

51 

Alsina M, Martín-Ancel A, Alarcon-Allen A, Arca G, Gayá F and García-Alix A: The severity of hypoxic-ischemic encephalopathy correlates with multiple organ dysfunction in the hypothermia era. Pediatr Crit Care Med. 18:234–240. 2017.PubMed/NCBI View Article : Google Scholar

52 

Cristea C, Rotaru O, Burnei-Russu A, Vladareanu R and Vladareanu S: The assessment of fetal neurobehavior by KANET test. Prenatal diagnosis. Editorial Group: MEDICHUB MEDIA. DOI: 10.26416/Peri.2.2.2018.1812, 2018. https://www.medichub.ro/reviste/perinatologia/evaluarea-comportamentului-neurologic-fetal-prin-testul-kanet-id-1812-cmsid-72. Accessed June 23, 2018.

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Doandes FM, Manea A, Lungu N, Cioboata D, Brandibur T, Costescu O, Hudisteanu A, Boia ER and Boia M: Clinical, biological and electroencephalographic monitoring of newborns with neurological risk in the Neonatal Intensive Care Unit. Exp Ther Med 22: 760, 2021.
APA
Doandes, F.M., Manea, A., Lungu, N., Cioboata, D., Brandibur, T., Costescu, O. ... Boia, M. (2021). Clinical, biological and electroencephalographic monitoring of newborns with neurological risk in the Neonatal Intensive Care Unit. Experimental and Therapeutic Medicine, 22, 760. https://doi.org/10.3892/etm.2021.10192
MLA
Doandes, F. M., Manea, A., Lungu, N., Cioboata, D., Brandibur, T., Costescu, O., Hudisteanu, A., Boia, E. R., Boia, M."Clinical, biological and electroencephalographic monitoring of newborns with neurological risk in the Neonatal Intensive Care Unit". Experimental and Therapeutic Medicine 22.1 (2021): 760.
Chicago
Doandes, F. M., Manea, A., Lungu, N., Cioboata, D., Brandibur, T., Costescu, O., Hudisteanu, A., Boia, E. R., Boia, M."Clinical, biological and electroencephalographic monitoring of newborns with neurological risk in the Neonatal Intensive Care Unit". Experimental and Therapeutic Medicine 22, no. 1 (2021): 760. https://doi.org/10.3892/etm.2021.10192
Copy and paste a formatted citation
x
Spandidos Publications style
Doandes FM, Manea A, Lungu N, Cioboata D, Brandibur T, Costescu O, Hudisteanu A, Boia ER and Boia M: Clinical, biological and electroencephalographic monitoring of newborns with neurological risk in the Neonatal Intensive Care Unit. Exp Ther Med 22: 760, 2021.
APA
Doandes, F.M., Manea, A., Lungu, N., Cioboata, D., Brandibur, T., Costescu, O. ... Boia, M. (2021). Clinical, biological and electroencephalographic monitoring of newborns with neurological risk in the Neonatal Intensive Care Unit. Experimental and Therapeutic Medicine, 22, 760. https://doi.org/10.3892/etm.2021.10192
MLA
Doandes, F. M., Manea, A., Lungu, N., Cioboata, D., Brandibur, T., Costescu, O., Hudisteanu, A., Boia, E. R., Boia, M."Clinical, biological and electroencephalographic monitoring of newborns with neurological risk in the Neonatal Intensive Care Unit". Experimental and Therapeutic Medicine 22.1 (2021): 760.
Chicago
Doandes, F. M., Manea, A., Lungu, N., Cioboata, D., Brandibur, T., Costescu, O., Hudisteanu, A., Boia, E. R., Boia, M."Clinical, biological and electroencephalographic monitoring of newborns with neurological risk in the Neonatal Intensive Care Unit". Experimental and Therapeutic Medicine 22, no. 1 (2021): 760. https://doi.org/10.3892/etm.2021.10192
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team