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Potential protective effect of hesperidin on hypoxia/reoxygenation‑induced hepatocyte injury

  • Authors:
    • Shilai Li
    • Jijin Zhu
    • Ling Pan
    • Peiqi Wan
    • Quanlin Qin
    • Daqing Luo
    • Wenhui Pan
    • Yuqing Wei
    • Yansong Xu
    • Liming Shang
    • Xinping Ye
  • View Affiliations / Copyright

    Affiliations: Department of Emergency, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China, Department of Nephrology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China, Department of Infectious Diseases, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 764
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    Published online on: May 13, 2021
       https://doi.org/10.3892/etm.2021.10196
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Abstract

Hesperidin (HDN) has been reported to have hydrogen radical‑ and hydrogen peroxide‑removal activities and to serve an antioxidant role in biological systems. However, whether HDN protects hepatocytes (HCs) against hypoxia/reoxygenation (H/R)‑induced injury remains unknown. The present study aimed to explore the role of HDN in H/R‑induced injury. HCs were isolated and cultured under H/R conditions with or without HDN treatment. HC damage was markedly induced under H/R, as indicated by cell viability, supernatant lactate dehydrogenase levels and alanine aminotransferase levels; however, HDN treatment significantly reversed HC injury. Oxidative stress markers (malondialdehyde, superoxide dismutase, glutathioneand reactive oxygen species) were increased markedly during H/R in HCs; however, this effect was significantly attenuated after exposure to HDN. Compared with those of the control group, the mRNA expression levels of IL‑6 and TNF‑α in HCs and the concentrations of IL‑6 and TNF‑α in the supernatants increased significantly following H/R, and HDN significantly ameliorated these effects. Western blotting demonstrated that microtubule‑associated protein 1 light chain 3α (MAP1LC3A, also known as LC3) and Beclin‑1 protein expression levels increased, while sequestosome 1 levels decreased during H/R following exposure to HDN. The number of GFP‑LC3 puncta in HCs following exposure to HDN was increased compared with that observed in HCs without HDN exposure under the H/R conditions after bafilomycin A1 treatment. In summary, the present study demonstrated that HDN attenuated HC oxidative stress and inflammatory responses while enhancing autophagy during H/R. HDN may have a potential protective effect on HCs during H/R‑induced injury.
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1 

Nastos C, Kalimeris K, Papoutsidakis N, Tasoulis MK, Lykoudis PM, Theodoraki K, Nastou D, Smyrniotis V and Arkadopoulos N: Global consequences of liver ischemia/reperfusion injury. Oxid Med Cell Longev. 2014(906965)2014.PubMed/NCBI View Article : Google Scholar

2 

Schemmer P, Lemasters JJ and Clavien PA: Ischemia/Reperfusion injury in liver surgery and transplantation. HPB Surg. 2012(453295)2012.PubMed/NCBI View Article : Google Scholar

3 

Sinning C, Westermann D and Clemmensen P: Oxidative stress in ischemia and reperfusion: Current concepts, novel ideas and future perspectives. Biomark Med. 11:11031–11040. 2017.PubMed/NCBI View Article : Google Scholar

4 

Halladin NL: Oxidative and inflammatory biomarkers of ischemia and reperfusion injuries. Dan Med J. 62(B5054)2015.PubMed/NCBI

5 

Tan S, Yokoyama Y, Wang Z, Zhou F, Nielsen V, Murdoch AD, Adams C and Parks DA: Hypoxia-Reoxygenation is as damaging as ischemia-reperfusion in the rat liver. Crit Care Med. 26:1089–1095. 1998.PubMed/NCBI View Article : Google Scholar

6 

Portal L, Martin V, Assaly R, de Tassigny A, Michineau S, Berdeaux A, Ghaleh B and Pons S: A model of hypoxia-reoxygenation on isolated adult mouse cardiomyocytes: Characterization, comparison with ischemia-reperfusion, and application to the cardioprotective effect of regular treadmill exercise. J Cardiovasc Pharmacol Ther. 18:367–375. 2013.PubMed/NCBI View Article : Google Scholar

7 

Zou X, Liu Q, Guo S, Zhu J, Han J, Xia Z, Du Y, Wei L and Shang J: A novel zebrafish larvae hypoxia/reoxygenation model for assessing myocardial ischemia/reperfusion injury. Zebrafish. 16:434–442. 2019.PubMed/NCBI View Article : Google Scholar

8 

Jimenez-Castro MB, Cornide-Petronio ME, Gracia-Sancho J and Peralta C: Inflammasome-Mediated inflammation in liver ischemia-reperfusion injury. Cells. 8(1131)2019.PubMed/NCBI View Article : Google Scholar

9 

Parhiz H, Roohbakhsh A, Soltani F, Rezaee R and Iranshahi M: Antioxidant and anti-inflammatory properties of the citrus flavonoids hesperidin and hesperetin: An updated review of their molecular mechanisms and experimental models. Phytother Res. 29:323–331. 2015.PubMed/NCBI View Article : Google Scholar

10 

Elhelaly AE, AlBasher G, Alfarraj S, Almeer R, Bahbah EI, Fouda MMA, Bungau SG, Aleya L and Abdel-Daim MM: Protective effects of hesperidin and diosmin against acrylamide-induced liver, kidney, and brain oxidative damage in rats. Environ Sci Pollut Res Int. 26:35151–35162. 2019.PubMed/NCBI View Article : Google Scholar

11 

Pandey P, Sayyed U, Tiwari RK, Siddiqui MH, Pathak N and Bajpai P: Hesperidin induces ROS-mediated apoptosis along with cell cycle arrest at G2/M phase in human gall bladder carcinoma. Nutr Cancer. 71:676–687. 2019.PubMed/NCBI View Article : Google Scholar

12 

Mo'men YS, Hussein RM and Kandeil MA: Involvement of PI3K/Akt pathway in the protective effect of hesperidin against a chemically induced liver cancer in rats. J Biochem Mol Toxicol. 33(e22305)2019.PubMed/NCBI View Article : Google Scholar

13 

Park HK, Kang SW and Park MS: Hesperidin ameliorates hepatic ischemia-reperfusion injury in sprague-dawley rats. Transplant Proc. 51:2828–2832. 2019.PubMed/NCBI View Article : Google Scholar

14 

Park WS, Park MS, Kang SW, Jin SA, Jeon Y, Hwang J and Kim SK: Hesperidin shows protective effects on renal function in ischemia-induced acute kidney injury (Sprague-Dawley Rats). Transplant Proc. 51:2838–2841. 2019.PubMed/NCBI View Article : Google Scholar

15 

Li X, Hu X, Wang J, Xu W, Yi C, Ma R and Jiang H: Inhibition of autophagy via activation of PI3K/Akt/mTOR pathway contributes to the protection of hesperidin against myocardial ischemia/reperfusion injury. Int J Mol Med. 42:1917–1924. 2018.PubMed/NCBI View Article : Google Scholar

16 

Meng X, Wei M, Wang D, Qu X, Zhang K, Zhang N and Li X: The protective effect of hesperidin against renal ischemia-reperfusion injury involves the TLR-4/NF-κB/iNOS pathway in rats. Physiol Int. 107:82–91. 2020.PubMed/NCBI View Article : Google Scholar

17 

Li S, Qin Q, Luo D, Pan W, Wei Y, Xu Y, Zhu J and Shang L: Hesperidin ameliorates liver ischemia/reperfusion injury via activation of the akt pathway. Mol Med Rep. 22:4519–4530. 2020.PubMed/NCBI View Article : Google Scholar

18 

He S, Wang X, Zhong Y, Tang L, Zhang Y, Ling Y, Tan Z, Yang P and Chen A: Hesperetin post-treatment prevents rat cardiomyocytes from hypoxia/reoxygenation injury in vitro via activating PI3K/Akt signaling pathway. Biomed Pharmacother. 91:1106–1112. 2017.PubMed/NCBI View Article : Google Scholar

19 

Ebegboni VJ, Dickenson JM and Sivasubramaniam SD: Antioxidative effects of flavonoids and their metabolites against hypoxia/reoxygenation-induced oxidative stress in a human first trimester trophoblast cell line. Food Chem. 272:117–125. 2019.PubMed/NCBI View Article : Google Scholar

20 

Lei Z, Deng M, Yi Z, Sun Q, Shapiro RA, Xu H, Li T, Loughran PA, Griepentrog JE, Huang H, et al: cGAS-mediated autophagy protects the liver from ischemia-reperfusion injury independently of STING. Am J Physiol Gastrointest Liver Physiol. 314:G655–G667. 2018.PubMed/NCBI View Article : Google Scholar

21 

Sun Q, Loughran P, Shapiro R, Shrivastava IH, Antoine DJ, Li T, Yan Z, Fan J, Billiar TR and Scott MJ: Redox-Dependent regulation of hepatocyte absent in melanoma 2 inflammasome activation in sterile liver injury in mice. Hepatology. 65:253–268. 2017.PubMed/NCBI View Article : Google Scholar

22 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

23 

Li S, Yi Z, Deng M, Scott MJ, Yang C, Li W, Lei Z, Santerre NM, Loughran P and Billiar TR: TSLP protects against liver I/R injury via activation of the PI3K/Akt pathway. JCI Insight. 4(e129013)2019.PubMed/NCBI View Article : Google Scholar

24 

Iranshahi M, Rezaee R, Parhiz H, Roohbakhsh A and Soltani F: Protective effects of flavonoids against microbes and toxins: The cases of hesperidin and hesperetin. Life Sci. 137:125–132. 2015.PubMed/NCBI View Article : Google Scholar

25 

Cernanec J, Guilak F, Weinberg JB, Pisetsky DS and Fermor B: Influence of hypoxia and reoxygenation on cytokine-induced production of proinflammatory mediators in articular cartilage. Arthritis Rheum. 46:968–975. 2002.PubMed/NCBI View Article : Google Scholar

26 

Cheng Y, Xiong J, Chen Q, Xia J, Zhang Y, Yang X, Tao K, Zhang S and He S: Hypoxia/reoxygenation-induced HMGB1 translocation and release promotes islet proinflammatory cytokine production and early islet graft failure through TLRs signaling. Biochim Biophys Acta Mol Basis Dis. 1863:354–364. 2017.PubMed/NCBI View Article : Google Scholar

27 

Chenevier-Gobeaux C, Simonneau C, Lemarechal H, Bonnefont-Rousselot D, Poiraudeau S, Rannou F, Ekindjian OG, Anract P and Borderie D: Effect of hypoxia/reoxygenation on the cytokine-induced production of nitric oxide and superoxide anion in cultured osteoarthritic synoviocytes. Osteoarthritis Cartilage. 21:874–881. 2013.PubMed/NCBI View Article : Google Scholar

28 

Fernandez AR, Sánchez-Tarjuelo R, Cravedi P, Ochando J and López-Hoyos M: Review: Ischemia reperfusion injury-A translational perspective in organ transplantation. Int J Mol Sci. 21(8549)2020.PubMed/NCBI View Article : Google Scholar

29 

Arriel RA, Rodrigues JF, Souza HLR, Meireles A, Leitao LFM, Crisafulli A and Marocolo M: Ischemia-Reperfusion intervention: From enhancements in exercise performance to accelerated performance recovery-a systematic review and meta-analysis. Int J Environ Res Public Health. 17(8161)2020.PubMed/NCBI View Article : Google Scholar

30 

Nieuwenhuijs-Moeke GJ, Pischke SE, Berger SP, Sanders JSF, Pol RA, Struys M, Ploeg RJ and Leuvenink HGD: Ischemia and reperfusion injury in kidney transplantation: Relevant mechanisms in injury and repair. J Clin Med. 9(253)2020.PubMed/NCBI View Article : Google Scholar

31 

Yi Z, Deng M, Scott MJ, Fu G, Loughran PA, Lei Z, Li S, Sun P, Yang C, Li W, et al: Immune-Responsive gene 1/itaconate activates nuclear factor erythroid 2-related factor 2 in hepatocytes to protect against liver ischemia-reperfusion injury. Hepatology. 72:1394–1411. 2020.PubMed/NCBI View Article : Google Scholar

32 

Guan LY, Fu PY, Li PD, Li ZN, Liu HY, Xin MG and Li W: Mechanisms of hepatic ischemia-reperfusion injury and protective effects of nitric oxide. World J Gastrointest Surg. 6:122–128. 2014.PubMed/NCBI View Article : Google Scholar

33 

Nita M and Grzybowski A: The role of the reactive oxygen species and oxidative stress in the pathomechanism of the age-related ocular diseases and other pathologies of the anterior and posterior eye segments in adults. Oxid Med Cell Longev. 2016(3164734)2016.PubMed/NCBI View Article : Google Scholar

34 

He L, He T, Farrar S, Ji L, Liu T and Ma X: Antioxidants maintain cellular redox homeostasis by elimination of reactive oxygen species. Cell Physiol Biochem. 44:532–553. 2017.PubMed/NCBI View Article : Google Scholar

35 

Chen X, Wei W, Li Y, Huang J and Ci X: Hesperetin relieves cisplatin-induced acute kidney injury by mitigating oxidative stress, inflammation and apoptosis. Chem Biol Interact. 308:269–278. 2019.PubMed/NCBI View Article : Google Scholar

36 

Turk E, Kandemir FM, Yildirim S, Caglayan C, Kucukler S and Kuzu M: Protective effect of hesperidin on sodium arsenite-induced nephrotoxicity and hepatotoxicity in rats. Biol Trace Elem Res. 189:95–108. 2019.PubMed/NCBI View Article : Google Scholar

37 

Xie L, Gu Z, Liu H, Jia B, Wang Y, Cao M, Song R, Zhang Z and Bian Y: The anti-depressive effects of hesperidin and the relative mechanisms based on the NLRP3 inflammatory signaling pathway. Front Pharmacol. 11(1251)2020.PubMed/NCBI View Article : Google Scholar

38 

Heo SD, Kim J, Choi Y, Ekanayake P, Ahn M and Shin T: Hesperidin improves motor disability in rat spinal cord injury through anti-inflammatory and antioxidant mechanism via Nrf-2/HO-1 pathway. Neurosci Lett. 715(134619)2020.PubMed/NCBI View Article : Google Scholar

39 

Zhou B, Kreuzer J, Kumsta C, Wu L, Kamer KJ, Cedillo L, Zhang Y, Li S, Kacergis MC, Webster CM, et al: Mitochondrial permeability uncouples elevated autophagy and lifespan extension. Cell. 177:299–314. 2019.PubMed/NCBI View Article : Google Scholar

40 

Wang K: Autophagy and apoptosis in liver injury. Cell Cycle. 14:1631–1642. 2015.PubMed/NCBI View Article : Google Scholar

41 

Li J, Lin W and Zhuang L: CD5L-Induced activation of autophagy is associated with hepatoprotection in ischemic reperfusion injury via the CD36/ATG7 axis. Exp Ther Med. 19:2588–2596. 2020.PubMed/NCBI View Article : Google Scholar

42 

Saiprasad G, Chitra P, Manikandan R and Sudhandiran G: Hesperidin induces apoptosis and triggers autophagic markers through inhibition of Aurora-A mediated phosphoinositide-3-kinase/Akt/mammalian target of rapamycin and glycogen synthase kinase-3 beta signalling cascades in experimental colon carcinogenesis. Eur J Cancer. 50:2489–2507. 2014.PubMed/NCBI View Article : Google Scholar

43 

Zhu B, Yang C, Wu J and Hua F: Autophagic activation may be involved in the mechanism of hesperidin's therapeutic effects on cognitive impairment. J Neurol Sci. 351:202–203. 2015.PubMed/NCBI View Article : Google Scholar

44 

He J, Liu J, Huang Y, Tang X, Xiao H and Hu Z: Oxidative stress, inflammation, and autophagy: Potential targets of mesenchymal stem cells-based therapies in ischemic stroke. Front Neurosci. 15(641157)2021.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Li S, Zhu J, Pan L, Wan P, Qin Q, Luo D, Pan W, Wei Y, Xu Y, Shang L, Shang L, et al: Potential protective effect of hesperidin on hypoxia/reoxygenation‑induced hepatocyte injury. Exp Ther Med 22: 764, 2021.
APA
Li, S., Zhu, J., Pan, L., Wan, P., Qin, Q., Luo, D. ... Ye, X. (2021). Potential protective effect of hesperidin on hypoxia/reoxygenation‑induced hepatocyte injury. Experimental and Therapeutic Medicine, 22, 764. https://doi.org/10.3892/etm.2021.10196
MLA
Li, S., Zhu, J., Pan, L., Wan, P., Qin, Q., Luo, D., Pan, W., Wei, Y., Xu, Y., Shang, L., Ye, X."Potential protective effect of hesperidin on hypoxia/reoxygenation‑induced hepatocyte injury". Experimental and Therapeutic Medicine 22.1 (2021): 764.
Chicago
Li, S., Zhu, J., Pan, L., Wan, P., Qin, Q., Luo, D., Pan, W., Wei, Y., Xu, Y., Shang, L., Ye, X."Potential protective effect of hesperidin on hypoxia/reoxygenation‑induced hepatocyte injury". Experimental and Therapeutic Medicine 22, no. 1 (2021): 764. https://doi.org/10.3892/etm.2021.10196
Copy and paste a formatted citation
x
Spandidos Publications style
Li S, Zhu J, Pan L, Wan P, Qin Q, Luo D, Pan W, Wei Y, Xu Y, Shang L, Shang L, et al: Potential protective effect of hesperidin on hypoxia/reoxygenation‑induced hepatocyte injury. Exp Ther Med 22: 764, 2021.
APA
Li, S., Zhu, J., Pan, L., Wan, P., Qin, Q., Luo, D. ... Ye, X. (2021). Potential protective effect of hesperidin on hypoxia/reoxygenation‑induced hepatocyte injury. Experimental and Therapeutic Medicine, 22, 764. https://doi.org/10.3892/etm.2021.10196
MLA
Li, S., Zhu, J., Pan, L., Wan, P., Qin, Q., Luo, D., Pan, W., Wei, Y., Xu, Y., Shang, L., Ye, X."Potential protective effect of hesperidin on hypoxia/reoxygenation‑induced hepatocyte injury". Experimental and Therapeutic Medicine 22.1 (2021): 764.
Chicago
Li, S., Zhu, J., Pan, L., Wan, P., Qin, Q., Luo, D., Pan, W., Wei, Y., Xu, Y., Shang, L., Ye, X."Potential protective effect of hesperidin on hypoxia/reoxygenation‑induced hepatocyte injury". Experimental and Therapeutic Medicine 22, no. 1 (2021): 764. https://doi.org/10.3892/etm.2021.10196
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