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Article

Association of oral Epstein‑Barr virus with periodontal health in Japanese adults

  • Authors:
    • Cheng-Yih Su
    • Hideo Shigeishi
    • Hiroshi Murodumi
    • Masaru Sugiyama
    • Kouji Ohta
    • Toshinobu Takemoto
  • View Affiliations / Copyright

    Affiliations: Department of Oral Health Management, Program of Oral Health Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734‑8553, Japan, Department of Public Oral Health, Program of Oral Health Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734‑8553, Japan, Department of Oral and Maxillofacial Surgery, Program of Dentistry, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734‑8553, Japan
  • Article Number: 767
    |
    Published online on: May 17, 2021
       https://doi.org/10.3892/etm.2021.10199
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Abstract

Previous studies have demonstrated that oral Epstein‑Barr virus (EBV) is associated with periodontitis. However, the relationship between periodontitis and oral EBV has not been fully elucidated by reducing the effects of confounding factors. The aim of the present study was to clarify the association between oral Epstein‑Barr virus (EBV) and oral health status among middle‑aged and older Japanese individuals. A total of 124 patients (46 males and 78 females; mean age, 69.2 years; age range, 35‑90 years) who visited Hiroshima University Hospital between October 2018 and December 2019 were recruited into the present study. EBV DNA positivity was determined in 124 oral rinse samples using quantitative PCR. Periodontal disease‑related bacteria were also detected by PCR analysis. EBV DNA was determined as positive in 16 of the 124 enrolled patients (12.9%). No significant difference was identified between EBV DNA and clinical factors (sex, age, remaining teeth, denture use, smoking or medical history). Of the 38 patients with periodontal pockets ≥6 mm, 10 were EBV DNA positive (26.3%). There was a significant association between EBV DNA positivity and probing depth (P=0.01). Additionally, a significant association was identified between bleeding on probing (BOP) and EBV DNA positivity (P=0.03). To investigate the relationship between EBV and periodontal health status, propensity score‑matching was determined between participants without ≥4 mm periodontal pockets and BOP (participants with good periodontal health) and those with ≥4 mm periodontal pockets, BOP or both (participants with poor periodontal health). A total of 35 matched pairs were identified among the patients. Patients with poor periodontal health exhibited a higher EBV DNA positivity rate (25.7%) than those with good periodontal health (0.0%). Additionally, there was a significant association between EBV DNA positivity and periodontal health status (P=0.001). T. denticola‑positive participants exhibited a higher EBV DNA positivity rate than negative participants (17.6 vs. 9.6%). However, there was no significant difference. The results indicated that oral EBV may be markedly associated with periodontitis in middle‑aged and older Japanese individuals.
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Copy and paste a formatted citation
Spandidos Publications style
Su C, Shigeishi H, Murodumi H, Sugiyama M, Ohta K and Takemoto T: Association of oral Epstein‑Barr virus with periodontal health in Japanese adults. Exp Ther Med 22: 767, 2021.
APA
Su, C., Shigeishi, H., Murodumi, H., Sugiyama, M., Ohta, K., & Takemoto, T. (2021). Association of oral Epstein‑Barr virus with periodontal health in Japanese adults. Experimental and Therapeutic Medicine, 22, 767. https://doi.org/10.3892/etm.2021.10199
MLA
Su, C., Shigeishi, H., Murodumi, H., Sugiyama, M., Ohta, K., Takemoto, T."Association of oral Epstein‑Barr virus with periodontal health in Japanese adults". Experimental and Therapeutic Medicine 22.1 (2021): 767.
Chicago
Su, C., Shigeishi, H., Murodumi, H., Sugiyama, M., Ohta, K., Takemoto, T."Association of oral Epstein‑Barr virus with periodontal health in Japanese adults". Experimental and Therapeutic Medicine 22, no. 1 (2021): 767. https://doi.org/10.3892/etm.2021.10199
Copy and paste a formatted citation
x
Spandidos Publications style
Su C, Shigeishi H, Murodumi H, Sugiyama M, Ohta K and Takemoto T: Association of oral Epstein‑Barr virus with periodontal health in Japanese adults. Exp Ther Med 22: 767, 2021.
APA
Su, C., Shigeishi, H., Murodumi, H., Sugiyama, M., Ohta, K., & Takemoto, T. (2021). Association of oral Epstein‑Barr virus with periodontal health in Japanese adults. Experimental and Therapeutic Medicine, 22, 767. https://doi.org/10.3892/etm.2021.10199
MLA
Su, C., Shigeishi, H., Murodumi, H., Sugiyama, M., Ohta, K., Takemoto, T."Association of oral Epstein‑Barr virus with periodontal health in Japanese adults". Experimental and Therapeutic Medicine 22.1 (2021): 767.
Chicago
Su, C., Shigeishi, H., Murodumi, H., Sugiyama, M., Ohta, K., Takemoto, T."Association of oral Epstein‑Barr virus with periodontal health in Japanese adults". Experimental and Therapeutic Medicine 22, no. 1 (2021): 767. https://doi.org/10.3892/etm.2021.10199
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