Open Access

Cascades between miRNAs, lncRNAs and the NF‑κB signaling pathway in gastric cancer (Review)

  • Authors:
    • Risheng Chen
    • Mingxiu Yang
    • Weiguo Huang
    • Baiyun Wang
  • View Affiliations

  • Published online on: May 17, 2021     https://doi.org/10.3892/etm.2021.10201
  • Article Number: 769
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Gastric cancer is a common digestive tract malignancy that is mainly treated with surgery combined with perioperative adjuvant chemoradiotherapy and biological targeted therapy. However, the diagnosis rate of early gastric cancer is low and both postoperative recurrence and distant metastasis are thorny problems. Therefore, it is essential to study the pathogenesis of gastric cancer and search for more effective means of treatment. The nuclear factor‑κB (NF‑κB) signaling pathway has an important role in the occurrence and development of gastric cancer and recent studies have revealed that microRNAs (miRNAs) and long non‑coding RNAs (lncRNAs) are able to regulate this pathway through a variety of mechanisms. Understanding these interrelated molecular mechanisms is helpful in guiding improvements in gastric cancer treatment. In the present review, the functional associations between miRNAs, lncRNAs and the NF‑κB signaling pathway in the occurrence, development and prognosis of gastric cancer were discussed. It was concluded that miRNAs and lncRNAs have complex relations with the NF‑κB signaling pathway in gastric cancer. miRNAs/target genes/NF‑κB/target proteins, signaling molecules/NF‑κB/miRNAs/target genes, lncRNAs/miRNAs/NF‑κB/genes or mRNAs, lncRNAs/target genes/NF‑Κb/target proteins, and lncRNAs/NF‑κB/target proteins cascades are all important factors in the occurrence and development of gastric cancer.
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July-2021
Volume 22 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Chen R, Yang M, Huang W and Wang B: Cascades between miRNAs, lncRNAs and the NF‑κB signaling pathway in gastric cancer (Review). Exp Ther Med 22: 769, 2021
APA
Chen, R., Yang, M., Huang, W., & Wang, B. (2021). Cascades between miRNAs, lncRNAs and the NF‑κB signaling pathway in gastric cancer (Review). Experimental and Therapeutic Medicine, 22, 769. https://doi.org/10.3892/etm.2021.10201
MLA
Chen, R., Yang, M., Huang, W., Wang, B."Cascades between miRNAs, lncRNAs and the NF‑κB signaling pathway in gastric cancer (Review)". Experimental and Therapeutic Medicine 22.1 (2021): 769.
Chicago
Chen, R., Yang, M., Huang, W., Wang, B."Cascades between miRNAs, lncRNAs and the NF‑κB signaling pathway in gastric cancer (Review)". Experimental and Therapeutic Medicine 22, no. 1 (2021): 769. https://doi.org/10.3892/etm.2021.10201