Cascades between miRNAs, lncRNAs and the NF‑κB signaling pathway in gastric cancer (Review)
- Authors:
- Risheng Chen
- Mingxiu Yang
- Weiguo Huang
- Baiyun Wang
-
Affiliations: Department of Anesthesiology, Affiliated Nanhua Hospital of University of South China, Hengyang, Hunan 421001, P.R. China, Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology (2016TP1015), Cancer Research Institute, Hengyang Medical College of University of South China, Hengyang, Hunan 421001, P.R. China - Published online on: May 17, 2021 https://doi.org/10.3892/etm.2021.10201
- Article Number: 769
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Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018.PubMed/NCBI View Article : Google Scholar | |
Biagioni A, Skalamera I, Peri S, Schiavone N, Cianchi F, Giommoni E, Magnelli L and Papucci L: Update on gastric cancer treatments and gene therapies. Cancer Metast Rev. 38:537–548. 2019.PubMed/NCBI View Article : Google Scholar | |
Abozeid M, Rosato A and Sommaggio R: Immunotherapeutic strategies for gastric carcinoma: A review of preclinical and clinical recent development. Biomed Res Int. 2017(5791262)2017.PubMed/NCBI View Article : Google Scholar | |
Schernberg A, Rivin Del Campo E, Rousseau B, Matzinger O, Loi M, Maingon P and Huguet F: Adjuvant chemoradiation for gastric carcinoma: State of the art and perspectives. Clin Transl Radiat Oncol. 10:13–22. 2018.PubMed/NCBI View Article : Google Scholar | |
Song Z, Wu Y, Yang J, Yang D and Fang X: Progress in the treatment of advanced gastric cancer. Tumour Biol. 39(1010428317714626)2017.PubMed/NCBI View Article : Google Scholar | |
Zhang HD, Jiang LH, Sun DW, Li J and Ji ZL: The role of miR-130a in cancer. Breast Cancer. 24:521–527. 2017.PubMed/NCBI View Article : Google Scholar | |
Chen Q, Lu X and Zhang X: Noncanonical NF-κB signaling pathway in liver diseases. J Clin Transl Hepatol. 9:81–89. 2021.PubMed/NCBI View Article : Google Scholar | |
Smale ST: Hierarchies of NF-κB target-gene regulation. Nat Immunol. 12:689–694. 2011.PubMed/NCBI View Article : Google Scholar | |
Hoesel B and Schmid JA: The complexity of NF-κB signaling in inflammation and cancer. Mol Cancer. 12(86)2013.PubMed/NCBI View Article : Google Scholar | |
Chen Z, Liu M, Liu X, Huang S, Li L, Song B, Li H, Ren Q, Hu Z, Zhou Y and Qiao L: COX-2 regulates E-cadherin expression through the NF-kappaB/Snail signaling pathway in gastric cancer. Int J Mol Med. 32:93–100. 2013.PubMed/NCBI View Article : Google Scholar | |
Koyama S: Differential expression of intracellular apoptotic signaling molecules in tumor and tumor-infiltrating lymphocytes during development of invasion and/or metastasis of gastric carcinoma. Dig Dis Sci. 48:2290–2300. 2003.PubMed/NCBI View Article : Google Scholar | |
Yamanaka N, Sasaki N, Tasaki A, Nakashima H, Kubo M, Morisaki T, Noshiro H, Yao T, Tsuneyoshi M, Tanaka M and Katano M: Nuclear factor-kappaB p65 is a prognostic indicator in gastric carcinoma. Anticancer Res. 24:1071–1075. 2004.PubMed/NCBI | |
Lee BL, Lee HS, Jung J, Cho SJ, Chung HY, Kim WH, Jin YW, Kim CS and Nam SY: Nuclear factor-kappaB activation correlates with better prognosis and Akt activation in human gastric cancer. Clin Cancer Res. 11:2518–2525. 2005.PubMed/NCBI View Article : Google Scholar | |
Dong H, Lei J, Ding L, Wen Y, Ju H and Zhang X: MicroRNA: Function, detection, and bioanalysis. Chem Rev. 113:6207–6233. 2013.PubMed/NCBI View Article : Google Scholar | |
Su W, Mo Y, Wu F, Guo K, Li J, Luo Y, Ye H, Guo H, Li D and Yang Z: MiR-135b reverses chemoresistance of non-small cell lung cancer cells by downregulation of FZD1. Biomed Pharmacother. 84:123–129. 2016.PubMed/NCBI View Article : Google Scholar | |
Nezu Y, Hagiwara K, Yamamoto Y, Fujiwara T, Matsuo K, Yoshida A, Kawai A, Saito T and Ochiya T: MiR-135b, a key regulator of malignancy, is linked to poor prognosis in human myxoid liposarcoma. Oncogene. 35:6177–6188. 2016.PubMed/NCBI View Article : Google Scholar | |
Majeed W, Iftikhar A, Khaliq T, Aslam B, Muzaffar H, Atta K, Mahmood A and Waris S: Gastric carcinoma: Recent trends in diagnostic biomarkers and molecular targeted therapies. Asian Pac J Cancer Prev. 17:3053–3060. 2016.PubMed/NCBI | |
Matsuoka T and Yashiro M: Biomarkers of gastric cancer: Current topics and future perspective. World J Gastroenterol. 24:2818–2832. 2018.PubMed/NCBI View Article : Google Scholar | |
Bhan A, Soleimani M and Mandal SS: Long noncoding RNA and cancer: A new paradigm. Cancer Res. 77:3965–3981. 2017.PubMed/NCBI View Article : Google Scholar | |
Sanchez Calle A, Kawamura Y, Yamamoto Y, Takeshita F and Ochiya T: Emerging roles of long non-coding RNA in cancer. Cancer Sci. 109:2093–2100. 2018.PubMed/NCBI View Article : Google Scholar | |
Peng L, Yuan X, Jiang B, Tang Z and Li G: lncRNAs: Key players and novel insights into cervical cancer. Tumour Biol. 37:2779–2788. 2016.PubMed/NCBI View Article : Google Scholar | |
Li J, Meng H, Bai Y and Wang K: Regulation of lncRNA and its role in cancer metastasis. Oncol Res. 23:205–217. 2016.PubMed/NCBI View Article : Google Scholar | |
Dinescu S, Ignat S, Lazar AD, Constantin C, Neagu M and Costache M: Epitranscriptomic Signatures in lncRNAs and their possible roles in cancer. Genes (Basel). 10(52)2019.PubMed/NCBI View Article : Google Scholar | |
Ghafouri-Fard S, Abak A, Fattahi F, Hussen BM, Bahroudi Z, Shoorei H and Taheri M: The interaction between miRNAs/lncRNAs and nuclear factor-κB (NF-κB) in human disorders. Biomed Pharmacother. 138(111519)2021.PubMed/NCBI View Article : Google Scholar | |
Li M and Guan H: Noncoding RNAs regulating NF-κB signaling. Adv Exp Med Biol. 927:317–336. 2016.PubMed/NCBI View Article : Google Scholar | |
Chen W, Li Z, Bai L and Lin Y: NF-kappaB in lung cancer, a carcinogenesis mediator and a prevention and therapy target. Front Biosci (Landmark Ed). 16:1172–1185. 2011.PubMed/NCBI View Article : Google Scholar | |
Li X, Zhang Z, Yu M, Li L, Du G, Xiao W and Yang H: Involvement of miR-20a in promoting gastric cancer progression by targeting early growth response 2 (EGR2). Int J Mol Sci. 14:16226–16239. 2013.PubMed/NCBI View Article : Google Scholar | |
Zhu M, Zhou X, Du Y, Huang Z, Zhu J, Xu J, Cheng G, Shu Y, Liu P, Zhu W and Wang T: MiR-20a induces cisplatin resistance of a human gastric cancer cell line via targeting CYLD. Mol Med Rep. 14:1742–1750. 2016.PubMed/NCBI View Article : Google Scholar | |
Ma X and Ning S: Shikimic acid promotes estrogen receptor(ER)-positive breast cancer cells proliferation via activation of NF-κB signaling. Toxicol Lett. 312:65–71. 2019.PubMed/NCBI View Article : Google Scholar | |
Yu J, Xie F, Bao X, Chen W and Xu Q: MiR-300 inhibits epithelial to mesenchymal transition and metastasis by targeting Twist in human epithelial cancer. Mol Cancer. 13(121)2014.PubMed/NCBI View Article : Google Scholar | |
Kang Y, Zhang Y, Sun Y, Wen Y and Sun F: MicroRNA-300 suppresses metastasis of oral squamous cell carcinoma by inhibiting epithelial-to-mesenchymal transition. Onco Targets Ther. 11:5657–5666. 2018.PubMed/NCBI View Article : Google Scholar | |
He FY, Liu HJ, Guo Q and Sheng JL: Reduced miR-300 expression predicts poor prognosis in patients with laryngeal squamous cell carcinoma. Eur Rev Med Pharmacol Sci. 21:760–764. 2017.PubMed/NCBI | |
Cui R, Kim T, Fassan M, Meng W, Sun HL, Jeon YJ, Vicentini C, Tili E, Peng Y, Scarpa A, et al: MicroRNA-224 is implicated in lung cancer pathogenesis through targeting caspase-3 and caspase-7. Oncotarget. 6:21802–21815. 2015.PubMed/NCBI View Article : Google Scholar | |
He X, Zhang Z, Li M, Li S, Ren L, Zhu H, Xiao B and Shi R: Expression and role of oncogenic miRNA-224 in esophageal squamous cell carcinoma. BMC Cancer. 15(575)2015.PubMed/NCBI View Article : Google Scholar | |
Shen G, Li X, Jia YF, Piazza GA and Xi Y: Hypoxia-regulated microRNAs in human cancer. Acta Pharmacol Sin. 34:336–341. 2013.PubMed/NCBI View Article : Google Scholar | |
He C, Wang L, Zhang J and Xu H: Hypoxia-inducible microRNA-224 promotes the cell growth, migration and invasion by directly targeting RASSF8 in gastric cancer. Mol Cancer. 16(35)2017.PubMed/NCBI View Article : Google Scholar | |
Huang Y, Yang YB, Zhang XH, Yu XL, Wang ZB and Cheng XC: MicroRNA-21 gene and cancer. Med Oncol. 30(376)2013.PubMed/NCBI View Article : Google Scholar | |
Shin VY, Jin H, Ng EK, Cheng AS, Chong WW, Wong CY, Leung WK, Sung JJ and Chu KM: NF-κB targets miR-16 and miR-21 in gastric cancer: Involvement of prostaglandin E receptors. Carcinogenesis. 32:240–245. 2011.PubMed/NCBI View Article : Google Scholar | |
Sha M, Ye J, Zhang LX, Luan ZY, Chen YB and Huang JX: Celastrol induces apoptosis of gastric cancer cells by miR-21 Inhibiting PI3K/Akt-NF-κB signaling pathway. Pharmacology. 93:39–46. 2014.PubMed/NCBI View Article : Google Scholar | |
Ni S, Zhao L, Wang X, Wu ZH, Hua RX, Wan CH, Zhang JY, Zhang XW, Huang MZ, Gan L, et al: CBX7 regulates stem cell-like properties of gastric cancer cells via p16 and AKT-NF-κB-miR-21 pathways. J Hematol Oncol. 11(17)2018.PubMed/NCBI View Article : Google Scholar | |
Zhang X, Li Y, Qi P and Ma Z: Biology of MiR-17-92 cluster and its progress in lung cancer. Int J Med Sci. 15:1443–1448. 2018.PubMed/NCBI View Article : Google Scholar | |
Liu F, Cheng L, Xu J, Guo F and Chen W: MiR-17-92 functions as an oncogene and modulates NF-κB signaling by targeting TRAF3 in MGC-803 human gastric cancer cells. Int J Oncol. 53:2241–2257. 2018.PubMed/NCBI View Article : Google Scholar | |
Yang XD and Sun SC: Targeting signaling factors for degradation, an emerging mechanism for TRAF functions. Immunol Rev. 266:56–71. 2015.PubMed/NCBI View Article : Google Scholar | |
Luo Y, Wu J, Wu Q, Li X, Wu J, Zhang J, Rong X, Rao J, Liao Y, Bin J, et al: MiR-577 regulates TGF-β induced cancer progression through a SDPR-Modulated positive-feedback loop with ERK-NF-κB in gastric cancer. Mol Ther. 27:1166–1182. 2019.PubMed/NCBI View Article : Google Scholar | |
Li N, Zhang QY, Zou JL, Li ZW, Tian TT, Dong B, Liu XJ, Ge S, Zhu Y, Gao J and Shen L: MiR-215 promotes malignant progression of gastric cancer by targeting RUNX1. Oncotarget. 7:4817–4828. 2016.PubMed/NCBI View Article : Google Scholar | |
Wu Y, Zhang J, Zheng Y, Ma C, Liu XE and Sun X: MiR-216a-3p inhibits the proliferation, migration, and invasion of human gastric cancer cells via targeting RUNX1 and activating the NF-κB signaling pathway. Oncol Res. 26:157–171. 2018.PubMed/NCBI View Article : Google Scholar | |
Mathis BJ, Lai Y, Qu C, Janicki JS and Cui T: CYLD-mediated signaling and diseases. Curr Drug Targets. 16:284–294. 2015.PubMed/NCBI View Article : Google Scholar | |
Xia JT, Chen LZ, Jian WH, Wang KB, Yang YZ, He WL, He YL, Chen D and Li W: MicroRNA-362 induces cell proliferation and apoptosis resistance in gastric cancer by activation of NF-κB signaling. J Transl Med. 12(33)2014.PubMed/NCBI View Article : Google Scholar | |
Wang YY, Ye ZY, Zhao ZS, Li L, Wang YX, Tao HQ, Wang HJ and He XJ: Clinicopathologic significance of miR-10b expression in gastric carcinoma. Hum Pathol. 44:1278–1285. 2013.PubMed/NCBI View Article : Google Scholar | |
Chen XL, Hong LL, Wang KL, Liu X, Wang JL, Lei L, Xu ZY, Cheng XD and Ling ZQ: Deregulation of CSMD1 targeted by microRNA-10b drives gastric cancer progression through the NF-κB pathway. Int J Biol Sci. 15:2075–2086. 2019.PubMed/NCBI View Article : Google Scholar | |
Yang F, Xu Y, Liu C, Ma C, Zou S, Xu X, Jia J and Liu Z: NF-κB/miR-223-3p/ARID1A axis is involved in Helicobacter pylori CagA-induced gastric carcinogenesis and progression. Cell Death Dis. 9(12)2018.PubMed/NCBI View Article : Google Scholar | |
Murata M: Inflammation and cancer. Environ Health Prev. 23(50)2018.PubMed/NCBI View Article : Google Scholar | |
Shao L, Chen Z, Soutto M, Zhu S, Lu H, Romero-Gallo J, Peek R, Zhang S and El-Rifai W: Helicobacter pylori-induced miR-135b-5p promotes cisplatin resistance in gastric cancer. FASEB J. 33:264–274. 2019.PubMed/NCBI View Article : Google Scholar | |
Ma J, Liu J, Wang Z, Gu X, Fan Y, Zhang W, Xu L, Zhang J and Cai D: NF-kappaB-dependent microRNA-425 upregulation promotes gastric cancer cell growth by targeting PTEN upon IL-1β induction. Mol Cancer. 13(40)2014.PubMed/NCBI View Article : Google Scholar | |
Yang SM, Huang C, Li XF, Yu MZ, He Y and Li J: MiR-21 confers cisplatin resistance in gastric cancer cells by regulating PTEN. Toxicology. 306:162–168. 2013.PubMed/NCBI View Article : Google Scholar | |
Wu W, Yang J, Feng X, Wang H, Ye S, Yang P, Tan W, Wei G and Zhou Y: MicroRNA-32 (miR-32) regulates phosphatase and tensin homologue (PTEN) expression and promotes growth, migration, and invasion in colorectal carcinoma cells. Mol Cancer. 12(30)2013.PubMed/NCBI View Article : Google Scholar | |
Luo Z, Zheng Y and Zhang W: Pleiotropic functions of miR107 in cancer networks. Onco Targets Ther. 11:4113–4124. 2018.PubMed/NCBI View Article : Google Scholar | |
Zheng Q, Chen C, Guan H, Kang W and Yu C: Prognostic role of microRNAs in human gastrointestinal cancer: A systematic review and meta-analysis. Oncotarget. 8:46611–46623. 2017.PubMed/NCBI View Article : Google Scholar | |
Li F, Liu B, Gao Y, Liu Y, Xu Y, Tong W and Zhang A: Upregulation of MicroRNA-107 induces proliferation in human gastric cancer cells by targeting the transcription factor FOXO1. FEBS Lett. 588:538–544. 2014.PubMed/NCBI View Article : Google Scholar | |
Zhang C, Tian W, Meng L, Qu L and Shou C: PRL-3 promotes gastric cancer migration and invasion through a NF-κB-HIF-1α-miR-210 axis. J Mol Med (Berl). 94:401–415. 2016.PubMed/NCBI View Article : Google Scholar | |
Li Y, Bai W and Zhang X: Identifying heterogeneous subtypes of gastric cancer and subtype-specific subpaths of microRNA-target pathways. Mol Med Rep. 17:3583–3590. 2018.PubMed/NCBI View Article : Google Scholar | |
Kalinowski FC, Brown RA, Ganda C, Giles KM, Epis MR, Horsham J and Leedman PJ: MicroRNA-7: A tumor suppressor miRNA with therapeutic potential. Int J Biochem Cell Biol. 54:312–317. 2014.PubMed/NCBI View Article : Google Scholar | |
Zhao XD, Lu YY, Guo H, Xie HH, He LJ, Shen GF, Zhou JF, Li T, Hu SJ, Zhou L, et al: MicroRNA-7/NF-κB signaling regulatory feedback circuit regulates gastric carcinogenesis. J Cell Biol. 210:613–627. 2015.PubMed/NCBI View Article : Google Scholar | |
Li M, Pan M, You C and Dou J: The therapeutic potential of miR-7 in cancers. Mini Rev Med Chem. 19:1707–1716. 2019.PubMed/NCBI View Article : Google Scholar | |
Ye T, Yang M, Huang D, Wang X, Xue B, Tian N, Xu X, Bao L, Hu H, Lv T and Huang Y: MicroRNA-7 as a potential therapeutic target for aberrant NF-κB-driven distant metastasis of gastric cancer. J Exp Clin Canc Res. 38(55)2019.PubMed/NCBI View Article : Google Scholar | |
Chen WQ, Hu L, Chen GX and Deng HX: Role of microRNA-7 in digestive system malignancy. World J Gastrointest Oncol. 8:121–127. 2016.PubMed/NCBI View Article : Google Scholar | |
Wang SM, Tie J, Wang WL, Hu SJ, Yin JP, Yi XF, Tian ZH, Zhang XY, Li MB, Li ZS, et al: POU2F2-oriented network promotes human gastric cancer metastasis. Gut. 65:1427–1438. 2016.PubMed/NCBI View Article : Google Scholar | |
Guo Y, Zhang T, Shi Y, Zhang J, Li M, Lu F, Zhang J, Chen X and Ding S: Helicobacter pylori inhibits GKN1 expression via the CagA/p-ERK/AUF1 pathway. Helicobacter. 25(e12665)2020.PubMed/NCBI View Article : Google Scholar | |
Chung Nien Chin S, O'Connor L, Scurr M, Busada JT, Graham AN, Alipour Talesh G, Tran CP, Sarkar S, Minamoto T, Giraud AS, et al: Coordinate expression loss of GKN1 and GKN2 in gastric cancer via impairment of a glucocorticoid-responsive enhancer. Am J Physiol Gastrointest Liver Physiol. 319:G175–G188. 2020.PubMed/NCBI View Article : Google Scholar | |
Zhang Z, Xue H, Dong Y, Zhang J, Pan Y, Shi L, Xiong P, Zhu J, Li W, Zheng W, et al: GKN2 promotes oxidative stress-induced gastric cancer cell apoptosis via the Hsc70 pathway. J Exp Clin Cancer Res. 38(338)2019.PubMed/NCBI View Article : Google Scholar | |
Kim O, Yoon JH, Choi WS, Ashktorab H, Smoot DT, Nam SW, Lee JY and Park WS: GKN2 contributes to the homeostasis of gastric mucosa by inhibiting GKN1 activity. J Cell Physiol. 229:762–771. 2014.PubMed/NCBI View Article : Google Scholar | |
Crone SG, Jacobsen A, Federspiel B, Bardram L, Krogh A, Lund AH and Friis-Hansen L: MicroRNA-146a inhibits G protein-coupled receptor-mediated activation of NF-κB by targeting CARD10 and COPS8 in gastric cancer. Mol Cancer. 11(71)2012.PubMed/NCBI View Article : Google Scholar | |
Chen Y, Zhou B, Xu L, Fan H, Xie J and Wang D: MicroRNA-146a promotes gastric cancer cell apoptosis by targeting transforming growth factor β-activated kinase 1. Mol Med Rep. 16:755–763. 2017.PubMed/NCBI View Article : Google Scholar | |
Meng DF, Sun R, Liu GY, Peng LX, Zheng LS, Xie P, Lin ST, Mei Y, Qiang YY, Li CZ, et al: S100A14 suppresses metastasis of nasopharyngeal carcinoma by inhibition of NF-κB signaling through degradation of IRAK1. Oncogene. 39:5307–5322. 2020.PubMed/NCBI View Article : Google Scholar | |
Wee ZN, Yatim SM, Kohlbauer VK, Feng M, Goh JY, Bao Y, Lee PL, Zhang S, Wang PP, Lim E, et al: IRAK1 is a therapeutic target that drives breast cancer metastasis and resistance to paclitaxel. Nat Commun. 6(8746)2015.PubMed/NCBI View Article : Google Scholar | |
Diaconu S, Predescu A, Moldoveanu A, Pop CS and Fierbinteanu-Braticevici C: Helicobacter pylori infection: Old and new. J Med Life. 10:112–117. 2017.PubMed/NCBI | |
Matsushima K, Isomoto H, Inoue N, Nakayama T, Hayashi T, Nakayama M, Nakao K, Hirayama T and Kohno S: MicroRNA signatures in Helicobacter pylori-infected gastric mucosa. Int J Cancer. 128:361–370. 2011.PubMed/NCBI View Article : Google Scholar | |
Darnet S, Moreira FC, Hamoy IG, Burbano R, Khayat A, Cruz A, Magalhães L, Silva A, Santos S, Demachki S, et al: High-Throughput sequencing of miRNAs reveals a tissue signature in gastric cancer and suggests novel potential biomarkers. Bioinform Biol Insights. 9 (Suppl 1):1–8. 2015.PubMed/NCBI View Article : Google Scholar | |
Assumpcao MB, Moreira FC, Hamoy IG, Magalhães L, Vidal A, Pereira A, Burbano R, Khayat A, Silva A, Santos S, et al: High-Throughput miRNA sequencing reveals a field effect in gastric cancer and suggests an epigenetic network mechanism. Bioinform Biol Insights. 9:111–117. 2015.PubMed/NCBI View Article : Google Scholar | |
Ranjbar R, Hesari A, Ghasemi F and Sahebkar A: Expression of microRNAs and IRAK1 pathway genes are altered in gastric cancer patients with Helicobacter pylori infection. J Cell Biochem. 119:7570–7576. 2018.PubMed/NCBI View Article : Google Scholar | |
Li N, Wang J, Yu W, Dong K, You F, Si B, Tang B, Zhang Y, Wang T and Qiao B: MicroRNA-146a inhibits the inflammatory responses induced by interleukin-17A during the infection of Helicobacter pylori. Mol Med Rep. 19:1388–1395. 2019.PubMed/NCBI View Article : Google Scholar | |
Zhang W, Wang Y, Zhu Z, Zheng Y and Song B: Propofol inhibits proliferation, migration and invasion of gastric cancer cells by up-regulating microRNA-195. INT J Biol Macromol. 120(Pt A):975–984. 2018.PubMed/NCBI View Article : Google Scholar | |
Sui H, Lou A, Li Z and Yang J: Lidocaine inhibits growth, migration and invasion of gastric carcinoma cells by up-regulation of miR-145. BMC CANCER. 19(233)2019.PubMed/NCBI View Article : Google Scholar | |
Xu L, Ge F, Hu Y, Yu Y, Guo K and Miao C: Sevoflurane postconditioning attenuates hepatic ischemia-reperfusion injury by limiting HMGB1/TLR4/NF-κB Pathway via modulating microRNA-142 in vivo and in vitro. Front Pharmacol. 12(646307)2021.PubMed/NCBI View Article : Google Scholar | |
Yang C, Gao J, Yan N, Wu B, Ren Y, Li H and Liang J: Propofol inhibits the growth and survival of gastric cancer cells in vitro through the upregulation of ING3. Oncol Rep. 37:587–593. 2017.PubMed/NCBI View Article : Google Scholar | |
Peng Z and Zhang Y: Propofol inhibits proliferation and accelerates apoptosis of human gastric cancer cells by regulation of microRNA-451 and MMP-2 expression. Genet Mol Res 15, 2016. | |
Yu W, Liang X, Li X, Zhang Y, Sun Z, Liu Y and Wang J: MicroRNA-195: A review of its role in cancers. Onco Targets Ther. 11:7109–7123. 2018.PubMed/NCBI View Article : Google Scholar | |
Qiu T, Zhou X, Wang J, Du Y, Xu J, Huang Z, Zhu W, Shu Y and Liu P: MiR-145, miR-133a and miR-133b inhibit proliferation, migration, invasion and cell cycle progression via targeting transcription factor Sp1 in gastric cancer. FEBS Lett. 588:1168–1177. 2014.PubMed/NCBI View Article : Google Scholar | |
Soto G, Naranjo González M and Calero F: Intravenous lidocaine infusion. Rev Esp Anestesiol Reanim. 65:269–274. 2018.PubMed/NCBI View Article : Google Scholar | |
Zhang L, Lei J, Fang ZL and Xiong JP: MiR-128b is down-regulated in gastric cancer and negatively regulates tumour cell viability by targeting PDK1/Akt/NF-κB axis. J Biosci. 41:77–85. 2016.PubMed/NCBI View Article : Google Scholar | |
Jiao Y, Yang H, Qian J, Gong Y, Liu H, Wu S, Cao L and Tang L: MiR-3664-5P suppresses the proliferation and metastasis of gastric cancer by attenuating the NF-κB signaling pathway through targeting MTDH. Int J Oncol. 54:845–858. 2019.PubMed/NCBI View Article : Google Scholar | |
Dastmalchi N, Khojasteh SMB, Nargesi MM and Safaralizadeh R: The correlation between lncRNAs and Helicobacter pylori in gastric cancer. Pathog Dis. 77(ftaa004)2019.PubMed/NCBI View Article : Google Scholar | |
Peng WX, Koirala P and Mo YY: lncRNA-mediated regulation of cell signaling in cancer. Oncogene. 36:5661–5667. 2017.PubMed/NCBI View Article : Google Scholar | |
Gupta SC, Awasthee N, Rai V, Chava S, Gunda V and Challagundla KB: Long non-coding RNAs and nuclear factor-κB crosstalk in cancer and other human diseases. Biochim Biophys Acta Rev Cancer. 1873(188316)2020.PubMed/NCBI View Article : Google Scholar | |
Kong Y, Hsieh CH and Alonso LC: ANRIL: A lncRNA at the CDKN2A/B Locus with roles in cancer and metabolic disease. Front Endocrinol (Lausanne). 9(405)2018.PubMed/NCBI View Article : Google Scholar | |
Deng W, Zhang Y, Cai J, Zhang J, Liu X, Yin J, Bai Z, Yao H and Zhang Z: lncRNA-ANRIL promotes gastric cancer progression by enhancing NF-κB signaling. Exp Biol Med (Maywood). 244:953–959. 2019.PubMed/NCBI View Article : Google Scholar | |
Yu X, Zheng H, Chan MT and Wu WKK: BANCR: A cancer-related long non-coding RNA. Am J Cancer Res. 7:1779–1787. 2017.PubMed/NCBI | |
Zhang ZX, Liu ZQ, Jiang B, Lu XY, Ning XF, Yuan CT and Wang AL: BRAF activated non-coding RNA (BANCR) promoting gastric cancer cells proliferation via regulation of NF-κB1. Biochem Bioph Res Commun. 465:225–231. 2015.PubMed/NCBI View Article : Google Scholar | |
Zhang JX, Chen ZH, Chen DL, Tian XP, Wang CY, Zhou ZW, Gao Y, Xu Y, Chen C, Zheng ZS, et al: LINC01410-miR-532-NCF2-NF-κB feedback loop promotes gastric cancer angiogenesis and metastasis. Oncogene. 37:2660–2675. 2018.PubMed/NCBI View Article : Google Scholar | |
Zheng J, Zhang H, Ma R, Liu H and Gao P: Long non-coding RNA KRT19P3 suppresses proliferation and metastasis through COPS7A-mediated NF-κB pathway in gastric cancer. Oncogene. 38:7073–7088. 2019.PubMed/NCBI View Article : Google Scholar | |
Mattiuzzi C and Lippi G: Current cancer epidemiology. J Epidemiol Glob Health. 9:217–222. 2019.PubMed/NCBI View Article : Google Scholar | |
Marta ZN, Agnieszka W, Jacek P, Jeleń A, Adrian K, Dagmara SK, Sałagacka-Kubiak A and Balcerczak E: NFKB2 gene expression in patients with peptic ulcer diseases and gastric cancer. Mol Biol Rep. 47:2015–2021. 2020.PubMed/NCBI View Article : Google Scholar |