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Article Open Access

B7 homolog 6 promotes the progression of cervical cancer

  • Authors:
    • Ruimeng Guo
    • Guoyan Liu
    • Changying Li
    • Xuejing Liu
    • Yanying Xu
    • Weina Yang
    • Fang Wang
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology, The Second Hospital of Tianjin Medical University, Tianjin 300211, P.R. China, Department of Gynecology, The General Hospital of Tianjin Medical University, Tianjin 300053, P.R. China, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin 300211, P.R. China
    Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 774
    |
    Published online on: May 18, 2021
       https://doi.org/10.3892/etm.2021.10206
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Abstract

B7 homolog 6 (B7‑H6) was recently discovered to act as a co‑stimulatory molecule. In particular, the expression of B7‑H6 has been found to play an important biological role in several types of tumors. The aim of the present study was to determine the role of B7‑H6 in cervical cancer. Immunohistochemistry was used to analyze the expression levels of B7‑H6 in cervical precancerous and cancerous tissues. Furthermore, the expression of B7‑H6 was knocked down in HeLa cells using short hairpin RNA and the effects of B7‑H6 on HeLa cell proliferation, migration and invasion were determined using Cell Counting Kit‑8, colony formation, wound healing and Transwell invasion assays, respectively. In addition, flow cytometry was used to analyze the levels of cell apoptosis and the cell cycle distribution. The results of the immunohistochemical staining revealed that the expression levels of B7‑H6 were upregulated in cervical lesions. Furthermore, the expression levels of B7‑H6 were positively associated with the clinical stage of the cervical lesions. B7‑H6 knockdown suppressed the invasive, migratory and proliferative abilities of HeLa cells, and promoted G1 cell cycle arrest and apoptosis. In conclusion, the findings of the present study suggested that B7‑H6 may serve as a novel oncogene and may hold promise as a potential therapeutic target for cervical cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Guo R, Liu G, Li C, Liu X, Xu Y, Yang W and Wang F: B7 homolog 6 promotes the progression of cervical cancer. Exp Ther Med 22: 774, 2021.
APA
Guo, R., Liu, G., Li, C., Liu, X., Xu, Y., Yang, W., & Wang, F. (2021). B7 homolog 6 promotes the progression of cervical cancer. Experimental and Therapeutic Medicine, 22, 774. https://doi.org/10.3892/etm.2021.10206
MLA
Guo, R., Liu, G., Li, C., Liu, X., Xu, Y., Yang, W., Wang, F."B7 homolog 6 promotes the progression of cervical cancer". Experimental and Therapeutic Medicine 22.1 (2021): 774.
Chicago
Guo, R., Liu, G., Li, C., Liu, X., Xu, Y., Yang, W., Wang, F."B7 homolog 6 promotes the progression of cervical cancer". Experimental and Therapeutic Medicine 22, no. 1 (2021): 774. https://doi.org/10.3892/etm.2021.10206
Copy and paste a formatted citation
x
Spandidos Publications style
Guo R, Liu G, Li C, Liu X, Xu Y, Yang W and Wang F: B7 homolog 6 promotes the progression of cervical cancer. Exp Ther Med 22: 774, 2021.
APA
Guo, R., Liu, G., Li, C., Liu, X., Xu, Y., Yang, W., & Wang, F. (2021). B7 homolog 6 promotes the progression of cervical cancer. Experimental and Therapeutic Medicine, 22, 774. https://doi.org/10.3892/etm.2021.10206
MLA
Guo, R., Liu, G., Li, C., Liu, X., Xu, Y., Yang, W., Wang, F."B7 homolog 6 promotes the progression of cervical cancer". Experimental and Therapeutic Medicine 22.1 (2021): 774.
Chicago
Guo, R., Liu, G., Li, C., Liu, X., Xu, Y., Yang, W., Wang, F."B7 homolog 6 promotes the progression of cervical cancer". Experimental and Therapeutic Medicine 22, no. 1 (2021): 774. https://doi.org/10.3892/etm.2021.10206
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