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MicroRNA‑296‑5p inhibits cell proliferation by targeting HMGA1 in colorectal cancer

  • Authors:
    • Guohui Yan
    • Shuidi Yan
    • Jiajia Wang
    • Shen Lei
    • Weimin Tian
    • Xin Yue
    • Yang Zhang
  • View Affiliations / Copyright

    Affiliations: The Medical Department of the Xiamen University, Xiamen, Fujian 361000, P.R. China, Center of Clinical Laboratory, Zhongshan Hospital, School of Medicine, Xiamen University, Xiamen, Fujian 361004, P.R. China, The Medical Department of the Fujian Medical University, Fuzhou, Fujian 350000, P.R. China, Department of Paediatrics, Zhongshan Hospital, School of Medicine, Xiamen University, Xiamen, Fujian 361004, P.R. China, Department of Imaging, Zhongshan Hospital, School of Medicine, Xiamen University, Xiamen, Fujian 361004, P.R. China
  • Article Number: 793
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    Published online on: May 24, 2021
       https://doi.org/10.3892/etm.2021.10225
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Abstract

An increasing body of evidence indicates the involvement of microRNAs (miRNAs/miRs) in the initiation and progression of colorectal cancer (CRC). miR‑296‑5p was recently identified as a tumor suppressor in a variety of human cancer types; however, its function in CRC remains largely unknown. The present study demonstrated that the expression of miR‑296‑5p was significantly downregulated in CRC tissues and cell lines. The overexpression of miR‑296‑5p markedly inhibited proliferation, and induced cell cycle arrest and apoptosis in CRC cells. Bioinformatics analysis suggested that high mobility group AT‑hook 1 (HMGA1) may be a target of miR‑296‑5p in CRC cells. Further experiments showed that miR‑296‑5p bound the 3'‑untranslated region of HMGA1 and decreased its expression in CRC cells. HMGA1 was overexpressed in CRC tissues and was inversely correlated with the expression of miR‑296‑5p. The restoration of HMGA1 significantly reversed the inhibitory effect of miR‑296‑5p on the proliferation of CRC cells. Overall, the findings of the present study indicate that miR‑296‑5p suppressed the progression of CRC, at least partially via targeting HMGA1. Thus, miR‑296‑5p is a potential target for novel therapies in CRC.
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Copy and paste a formatted citation
Spandidos Publications style
Yan G, Yan S, Wang J, Lei S, Tian W, Yue X and Zhang Y: MicroRNA‑296‑5p inhibits cell proliferation by targeting HMGA1 in colorectal cancer. Exp Ther Med 22: 793, 2021.
APA
Yan, G., Yan, S., Wang, J., Lei, S., Tian, W., Yue, X., & Zhang, Y. (2021). MicroRNA‑296‑5p inhibits cell proliferation by targeting HMGA1 in colorectal cancer. Experimental and Therapeutic Medicine, 22, 793. https://doi.org/10.3892/etm.2021.10225
MLA
Yan, G., Yan, S., Wang, J., Lei, S., Tian, W., Yue, X., Zhang, Y."MicroRNA‑296‑5p inhibits cell proliferation by targeting HMGA1 in colorectal cancer". Experimental and Therapeutic Medicine 22.2 (2021): 793.
Chicago
Yan, G., Yan, S., Wang, J., Lei, S., Tian, W., Yue, X., Zhang, Y."MicroRNA‑296‑5p inhibits cell proliferation by targeting HMGA1 in colorectal cancer". Experimental and Therapeutic Medicine 22, no. 2 (2021): 793. https://doi.org/10.3892/etm.2021.10225
Copy and paste a formatted citation
x
Spandidos Publications style
Yan G, Yan S, Wang J, Lei S, Tian W, Yue X and Zhang Y: MicroRNA‑296‑5p inhibits cell proliferation by targeting HMGA1 in colorectal cancer. Exp Ther Med 22: 793, 2021.
APA
Yan, G., Yan, S., Wang, J., Lei, S., Tian, W., Yue, X., & Zhang, Y. (2021). MicroRNA‑296‑5p inhibits cell proliferation by targeting HMGA1 in colorectal cancer. Experimental and Therapeutic Medicine, 22, 793. https://doi.org/10.3892/etm.2021.10225
MLA
Yan, G., Yan, S., Wang, J., Lei, S., Tian, W., Yue, X., Zhang, Y."MicroRNA‑296‑5p inhibits cell proliferation by targeting HMGA1 in colorectal cancer". Experimental and Therapeutic Medicine 22.2 (2021): 793.
Chicago
Yan, G., Yan, S., Wang, J., Lei, S., Tian, W., Yue, X., Zhang, Y."MicroRNA‑296‑5p inhibits cell proliferation by targeting HMGA1 in colorectal cancer". Experimental and Therapeutic Medicine 22, no. 2 (2021): 793. https://doi.org/10.3892/etm.2021.10225
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