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Review Open Access

Updates and new medical treatments for vitiligo (Review)

  • Authors:
    • David Emmanuel Kubelis‑López
    • Natalia Aranza Zapata‑Salazar
    • Salvador Luis Said‑Fernández
    • Celia Nohemí Sánchez‑Domínguez
    • Mauricio Andrés Salinas‑Santander
    • Herminia Guadalupe Martínez‑Rodríguez
    • Osvaldo Tomás Vázquez‑Martínez
    • Uwe Wollina
    • Torello Lotti
    • Jorge Ocampo‑Candiani
  • View Affiliations

    Affiliations: Department of Dermatology, Faculty of Medicine and University Hospital ‘Dr. José Eleuterio González’, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León 64460, México, Department of Biochemistry and Molecular Medicine, Faculty of Medicine and University Hospital ‘Dr. José Eleuterio González’, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León 64460, México, Department of Research, Faculty of Medicine Saltillo Unit, Universidad Autónoma de Coahuila, Saltillo 25000, México, Department of Dermatology and Allergology and Skin Cancer Center, Städtisches Klinikum Dresden, D‑01067 Dresden, Germany, Department of Dermatology and Venereology, University of Rome G. Marconi, I‑00193 Rome, Italy
  • Published online on: May 25, 2021     https://doi.org/10.3892/etm.2021.10229
  • Article Number: 797
  • Copyright: © Kubelis‑López et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Vitiligo is a multifactorial disease characterized by the loss of skin pigment, which results in achromic macules and patches. There are currently several medical treatments available, which aim to arrest progression and induce skin repigmentation. These treatments alone or combined have exhibited varying degrees of pigmentation, and the majority are safe and effective. All therapies for vitiligo are limited, and no known treatment can consistently produce repigmentation in all patients. Individualized treatment is appropriate according to the location, clinical presentation and the presence of disease activity. The present review summarizes the medical treatments available for vitiligo: Systemic and topic pharmacological therapies, physical and depigmentation treatments. Several treatments are still underway and have not yet been approved. However, due to the promising preliminary results, these are also mentioned in the present review.
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1 

Ezzedine K, Eleftheriadou V, Whitton M and van Geel N: Vitiligo. Lancet. 386:74–84. 2015.PubMed/NCBI View Article : Google Scholar

2 

Krüger C and Schallreuter KU: A review of the worldwide prevalence of vitiligo in children/adolescents and adults. Int J Dermatol. 51:1206–1212. 2012.PubMed/NCBI View Article : Google Scholar

3 

Gauthier Y, Cario Andre M and Taïeb A: A critical appraisal of vitiligo etiologic theories. Is melanocyte loss a melanocytorrhagy? Pigment Cell Res. 16:322–332. 2003.PubMed/NCBI View Article : Google Scholar

4 

D'Mello SA, Finlay GJ, Baguley BC and Askarian-Amiri ME: Signaling pathways in melanogenesis. Int J Mol Sci. 17(1144)2016.PubMed/NCBI View Article : Google Scholar

5 

Videira IF, Moura DF and Magina S: Mechanisms regulating melanogenesis. An Bras Dermatol. 88:76–83. 2013.PubMed/NCBI View Article : Google Scholar

6 

Costin GE and Hearing VJ: Human skin pigmentation: Melanocytes modulate skin color in response to stress. FASEB J. 21:976–994. 2007.PubMed/NCBI View Article : Google Scholar

7 

Hara M, Toyoda M, Yaar M, Bhawan J, Avila EM, Penner IR and Gilchrest BA: Innervation of melanocytes in human skin. J Exp Med. 184:1385–1395. 1996.PubMed/NCBI View Article : Google Scholar

8 

Ohbayashi N and Fukuda M: Recent advances in understanding the molecular basis of melanogenesis in melanocytes. F1000Res 9: F1000 Faculty Rev-608, 2020.

9 

Slominski A, Tobin DJ, Shibahara S and Wortsman J: Melanin pigmentation in mammalian skin and its hormonal regulation. Physiol Rev. 84:1155–1228. 2004.PubMed/NCBI View Article : Google Scholar

10 

Slominski A, Zmijewski MA and Pawelek J: L-tyrosine and L-dihydroxyphenylalanine as hormone-like regulators of melanocyte functions. Pigment Cell Melanoma Res. 25:14–27. 2012.PubMed/NCBI View Article : Google Scholar

11 

Iannella G, Greco A, Didona D, Didona B, Granata G, Manno A, Pasquariello B and Magliulo G: Vitiligo: Pathogenesis, clinical variants and treatment approaches. Autoimmun Rev. 15:335–343. 2016.PubMed/NCBI View Article : Google Scholar

12 

Boniface K, Seneschal J, Picardo M and Taïeb A: Vitiligo: Focus on clinical aspects, immunopathogenesis, and therapy. Clin Rev Allergy Immunol. 54:52–67. 2018.PubMed/NCBI View Article : Google Scholar

13 

Kundu RV, Mhlaba JM, Rangel SM and Le Poole IC: The convergence theory for vitiligo: A reappraisal. Exp Dermatol. 28:647–655. 2019.PubMed/NCBI View Article : Google Scholar

14 

Moretti S, Spallanzani A, Amato L, Hautmann G, Gallerani I and Fabbri P: Vitiligo and epidermal microenvironment: Possible involvement of keratinocyte-derived cytokines. Arch Dermatol. 138:273–274. 2002.PubMed/NCBI View Article : Google Scholar

15 

Rodrigues M, Ezzedine K, Hamzavi I, Pandya AG, Harris JE and Group VW: New discoveries in the pathogenesis and classification of vitiligo. J Am Acad Dermatol. 77:1–13. 2017.PubMed/NCBI View Article : Google Scholar

16 

Passeron T: Medical and maintenance treatments for vitiligo. Dermatol Clin. 35:163–170. 2017.PubMed/NCBI View Article : Google Scholar

17 

Whitton ME, Pinart M, Batchelor J, Leonardi-Bee J, González U, Jiyad Z, Eleftheriadou V and Ezzedine K: Interventions for vitiligo. Cochrane Database Syst Rev. (CD003263)2015.PubMed/NCBI View Article : Google Scholar : doi: 10.1002/14651858.CD003263.pub5.

18 

Taieb A, Alomar A, Böhm M, Dell'anna ML, De Pase A, Eleftheriadou V, Ezzedine K, Gauthier Y, Gawkrodger DJ, Jouary T, et al: Guidelines for the management of vitiligo: The European dermatology forum consensus. Br J Dermatol. 168:5–19. 2013.PubMed/NCBI View Article : Google Scholar

19 

Gawkrodger DJ, Ormerod AD, Shaw L, Mauri-Sole I, Whitton ME, Watts MJ, Anstey AV, Ingham J, Young K, Therapy Guidelines and Audit Subcommittee: British Association of Dermatologists et al. Guideline for the diagnosis and management of vitiligo. Br J Dermatol. 159:1051–1076. 2008.PubMed/NCBI View Article : Google Scholar

20 

Njoo MD, Spuls PI, Bos JD, Westerhof W and Bossuyt PM: Nonsurgical repigmentation therapies in vitiligo. Meta-analysis of the literature. Arch Dermatol. 134:1532–1540. 1998.PubMed/NCBI View Article : Google Scholar

21 

Faria AR, Tarlé RG, Dellatorre G, Mira MT and Castro CC: Vitiligo-Part 2-classification, histopathology and treatment. An Bras Dermatol. 89:784–790. 2014.PubMed/NCBI View Article : Google Scholar

22 

Rodrigues M, Ezzedine K, Hamzavi I, Pandya AG, Harris JE and Group VW: Current and emerging treatments for vitiligo. J Am Acad Dermatol. 77:17–29. 2017.PubMed/NCBI View Article : Google Scholar

23 

Bleuel R and Eberlein B: Therapeutic management of vitiligo. J Dtsch Dermatol Ges. 16:1309–1313. 2018.PubMed/NCBI View Article : Google Scholar

24 

Lotti T, Agarwal K, Podder I, Satolli F, Kassir M, Schwartz RA, Wollina U, Grabbe S, Navarini AA, Mueller SM and Goldust M: Safety of the current drug treatments for vitiligo. Expert Opin Drug Saf. 19:499–511. 2020.PubMed/NCBI View Article : Google Scholar

25 

Kwinter J, Pelletier J, Khambalia A and Pope E: High-potency steroid use in children with vitiligo: A retrospective study. J Am Acad Dermatol. 56:236–241. 2007.PubMed/NCBI View Article : Google Scholar

26 

Ballona R: ‘Soft steroids’ o corticoides suaves en Dermatología Pediátrica. Dermatol Pediatr Lat. 3:150–157. 2005.

27 

Felsten LM, Alikhan A and Petronic-Rosic V: Vitiligo: A comprehensive overview Part II: Treatment options and approach to treatment. J Am Acad Dermatol. 65:493–514. 2011.PubMed/NCBI View Article : Google Scholar

28 

Lee JH, Kwon HS, Jung HM, Lee H, Kim GM, Yim HW and Bae JM: Treatment outcomes of topical calcineurin inhibitor therapy for patients with vitiligo: A systematic review and Meta-analysis. JAMA Dermatol. 155:929–938. 2019.PubMed/NCBI View Article : Google Scholar

29 

Chang HC, Hsu YP and Huang YC: The effectiveness of topical calcineurin inhibitors compared with topical corticosteroids in the treatment of vitiligo: A systematic review and meta-analysis. J Am Acad Dermatol. 82:243–245. 2020.PubMed/NCBI View Article : Google Scholar

30 

Ebrahim HM, Elkot R and Albalate W: Combined microneedling with tacrolimus vs. tacrolimus monotherapy for vitiligo treatment. J Dermatolog Treat: Feb 11, 2020 (Epub ahead of print).

31 

Abd-Elazim NE, Yassa HA and Mahran AM: Microdermabrasion and topical tacrolimus: A novel combination therapy of vitiligo. J Cosmet Dermatol. 19:1447–1455. 2020.PubMed/NCBI View Article : Google Scholar

32 

Bikle D and Christakos S: New aspects of vitamin D metabolism and action-addressing the skin as source and target. Nat Rev Endocrinol. 16:234–252. 2020.PubMed/NCBI View Article : Google Scholar

33 

Holick MF: Vitamin D deficiency. N Engl J Med. 357:266–281. 2007.PubMed/NCBI View Article : Google Scholar

34 

Slominski AT, Kim TK, Hobrath JV, Oak ASW, Tang EKY, Tieu EW, Li W, Tuckey RC and Jetten AM: Endogenously produced nonclassical vitamin D hydroxy-metabolites act as ‘biased’ agonists on VDR and inverse agonists on RORα and RORγ. J Steroid Biochem Mol Biol. 173:42–56. 2017.PubMed/NCBI View Article : Google Scholar

35 

Slominski AT, Chaiprasongsuk A, Janjetovic Z, Kim TK, Stefan J, Slominski RM, Hanumanthu VS, Raman C, Qayyum S, Song Y, et al: Photoprotective properties of Vitamin D and lumisterol hydroxyderivatives. Cell Biochem Biophys. 78:165–180. 2020.PubMed/NCBI View Article : Google Scholar

36 

Slominski AT, Kim TK, Takeda Y, Janjetovic Z, Brozyna AA, Skobowiat C, Wang J, Postlethwaite A, Li W, Tuckey RC and Jetten AM: RORα and RORγ are expressed in human skin and serve as receptors for endogenously produced noncalcemic 20-hydroxy- and 20,23-dihydroxyvitamin D. FASEB J. 28:2775–2789. 2014.PubMed/NCBI View Article : Google Scholar

37 

Slominski RM, Tuckey RC, Manna PR, Jetten AM, Postlethwaite A, Raman C and Slominski AT: Extra-adrenal glucocorticoid biosynthesis: Implications for autoimmune and inflammatory disorders. Genes Immun. 21:150–168. 2020.PubMed/NCBI View Article : Google Scholar

38 

Aranow C: Vitamin D and the immune system. J Investig Med. 59:881–886. 2011.PubMed/NCBI View Article : Google Scholar

39 

Chiavérini C, Passeron T and Ortonne JP: Treatment of vitiligo by topical calcipotriol. J Eur Acad Dermatol Venereol. 16:137–138. 2002.PubMed/NCBI View Article : Google Scholar

40 

Rodríguez-Martín M, García Bustínduy M, Sáez Rodríguez M and Noda Cabrera A: Randomized, double-blind clinical trial to evaluate the efficacy of topical tacalcitol and sunlight exposure in the treatment of adult nonsegmental vitiligo. Br J Dermatol. 160:409–414. 2009.PubMed/NCBI View Article : Google Scholar

41 

Kumaran MS, Kaur I and Kumar B: Effect of topical calcipotriol, betamethasone dipropionate and their combination in the treatment of localized vitiligo. J Eur Acad Dermatol Venereol. 20:269–273. 2006.PubMed/NCBI View Article : Google Scholar

42 

Ibrahim ZA, Hassan GF, Elgendy HY and Al-Shenawy HA: Evaluation of the efficacy of transdermal drug delivery of calcipotriol plus betamethasone versus tacrolimus in the treatment of vitiligo. J Cosmet Dermatol. 18:581–588. 2019.PubMed/NCBI View Article : Google Scholar

43 

Naini FF, Shooshtari AV, Ebrahimi B and Molaei R: The effect of pseudocatalase/superoxide dismutase in the treatment of vitiligo: A pilot study. J Res Pharm Pract. 1:77–80. 2012.PubMed/NCBI View Article : Google Scholar

44 

Schallreuter KU, Krüger C, Würfel BA, Panske A and Wood JM: From basic research to the bedside: Efficacy of topical treatment with pseudocatalase PC-KUS in 71 children with vitiligo. Int J Dermatol. 47:743–753. 2008.PubMed/NCBI View Article : Google Scholar

45 

Bakis-Petsoglou S, Le Guay JL and Wittal R: A randomized, double-blinded, placebo-controlled trial of pseudocatalase cream and narrowband ultraviolet B in the treatment of vitiligo. Br J Dermatol. 161:910–917. 2009.PubMed/NCBI View Article : Google Scholar

46 

Alshiyab DM, Al-Qarqaz FA, Muhaidat JM, Alkhader YS, Al-Sheyab RF and Jafaar SI: Comparison of the efficacy of Tacrolimus 0.1% ointment and Tacrolimus 0.1% plus topical pseudocatalase/superoxide dismutase gel in children with limited vitiligo: A randomized controlled trial. J Dermatolog Treat: Feb 11, 2020 (Epub ahead of print).

47 

Agarwal K, Podder I, Kassir M, Vojvodic A, Schwartz RA, Wollina U, Valle Y, Lotti T, Rokni GR, Grabbe S and Goldust M: Therapeutic options in vitiligo with special emphasis on immunomodulators: A comprehensive update with review of literature. Dermatol Ther. 33(e13215)2020.PubMed/NCBI View Article : Google Scholar

48 

Tsuji T and Hamada T: Topically administered fluorouracil in vitiligo. Arch Dermatol. 119:722–727. 1983.PubMed/NCBI

49 

Abdelwahab M, Salah M, Samy N, Rabie A and Farrag A: Effect of Topical 5-fluorouracil alone versus its combination with erbium:YAG (2940 nm) laser in treatment of vitiligo. Clin Cosmet Investig Dermatol. 13:77–85. 2020.PubMed/NCBI View Article : Google Scholar

50 

Sethi S, Mahajan BB, Gupta RR and Ohri A: Comparative evaluation of the therapeutic efficacy of dermabrasion, dermabrasion combined with topical 5% 5-fluorouracil cream, and dermabrasion combined with topical placentrex gel in localized stable vitiligo. Int J Dermatol. 46:875–879. 2007.PubMed/NCBI View Article : Google Scholar

51 

Anbar T, Westerhof W, Abdel-Rahman A, El-Khayyat M and El-Metwally Y: Treatment of periungual vitiligo with erbium-YAG-laser plus 5-flurouracil: A left to right comparative study. J Cosmet Dermatol. 5:135–139. 2006.PubMed/NCBI View Article : Google Scholar

52 

Mohamed HA, Mohammed GF, Gomaa AH and Eyada MM: Carbon dioxide laser plus topical 5-fluorouracil: A new combination therapeutic modality for acral vitiligo. J Cosmet Laser Ther. 17:216–223. 2015.PubMed/NCBI View Article : Google Scholar

53 

Mina M, Elgarhy L, Al-Saeid H and Ibrahim Z: Comparison between the efficacy of microneedling combined with 5-fluorouracil vs. microneedling with tacrolimus in the treatment of vitiligo. J Cosmet Dermatol. 17:744–751. 2018.PubMed/NCBI View Article : Google Scholar

54 

Abdelmaksoud A, Dave DD, Lotti T and Vestita M: Topical methotrexate 1% gel for treatment of vitiligo: A case report and review of the literature. Dermatol Ther. 32(e13013)2019.PubMed/NCBI View Article : Google Scholar

55 

Eldelee SA, Gheida SF, Sarhan NI, Ibrahim ZA and Elfar NN: Evaluation of the effect of combined intralesional injection of prostaglandin F2α with narrow band UVB phototherapy in treatment of resistant cases of vitiligo. J Dermatolog Treat: Sep 4, 2019 (Epub ahead of print).

56 

Jha AK, Prasad S and Sinha R: Bimatoprost ophthalmic solution in facial vitiligo. J Cosmet Dermatol. 17:437–440. 2018.PubMed/NCBI View Article : Google Scholar

57 

Kanokrungsee S, Pruettivorawongse D and Rajatanavin N: Clinical outcomes of topical bimatoprost for nonsegmental facial vitiligo: A preliminary study. J Cosmet Dermatol. 20:812–818. 2021.PubMed/NCBI View Article : Google Scholar

58 

Nowroozpoor Dailami K, Hosseini A, Rahmatpour Rokni G, Saeedi M, Morteza-Semnani K, Sadeghi Z, Ghasemzadeh Diva SM, Goldust M, Lotti T, Vojvodic A, et al: Efficacy of topical latanoprost in the treatment of eyelid vitiligo: A randomized, double-blind clinical trial study. Dermatol Ther. 33(e13175)2020.PubMed/NCBI View Article : Google Scholar

59 

Kamala Subhashini P, Sankar K, Chandrakala K and Venkataramana V: Comparative study of efficacy and safety of topical active fragment of basic fibroblast growth factor (B FGF) 0.1% solution V/S betamethasone valerate 0.1% ointment in the treatment of vitiligo patients. IOSR J Dental Med Sci. 14:41–47. 2015.

60 

Shah B, Godse K, Mahajan S, Grandhi S, Shendkar S, Sharma A, Teli C, Pathak R and Parsad D: Efficacy and safety of basic fibroblast growth factor (bFGF) related decapeptide solution plus Tacrolimus 0.1% ointment versus Tacrolimus 0.1% ointment in the treatment of stable vitiligo. Dermatol Ther. 32(e13109)2019.PubMed/NCBI View Article : Google Scholar

61 

Liu LY, Strassner JP, Refat MA, Harris JE and King BA: Repigmentation in vitiligo using the Janus kinase inhibitor tofacitinib may require concomitant light exposure. J Am Acad Dermatol. 77:675–682.e671. 2017.PubMed/NCBI View Article : Google Scholar

62 

Hamzavi I, Jain H, McLean D, Shapiro J, Zeng H and Lui H: Parametric modeling of narrowband UV-B phototherapy for vitiligo using a novel quantitative tool: The Vitiligo Area Scoring Index. Arch Dermatol. 140:677–683. 2004.PubMed/NCBI View Article : Google Scholar

63 

Rothstein B, Joshipura D, Saraiya A, Abdat R, Ashkar H, Turkowski Y, Sheth V, Huang V, Au SC, Kachuk C, et al: Treatment of vitiligo with the topical Janus kinase inhibitor ruxolitinib. J Am Acad Dermatol. 76:1054–1060.e1. 2017.PubMed/NCBI View Article : Google Scholar

64 

Rosmarin D, Pandya AG, Lebwohl M, Grimes P, Hamzavi I, Gottlieb AB, Butler K, Kuo F, Sun K, Ji T, et al: Ruxolitinib cream for treatment of vitiligo: A randomised, controlled, phase 2 trial. Lancet. 396:110–120. 2020.PubMed/NCBI View Article : Google Scholar

65 

Mobasher P, Guerra R, Li SJ, Frangos J, Ganesan AK and Huang V: Open-label pilot study of tofacitinib 2% for the treatment of refractory vitiligo. Br J Dermatol. 182:1047–1049. 2020.PubMed/NCBI View Article : Google Scholar

66 

Kim SM, Lee HS and Hann SK: The efficacy of low-dose oral corticosteroids in the treatment of vitiligo patients. Int J Dermatol. 38:546–550. 1999.PubMed/NCBI View Article : Google Scholar

67 

Seiter S, Ugurel S, Tilgen W and Reinhold U: Use of high-dose methylprednisolone pulse therapy in patients with progressive and stable vitiligo. Int J Dermatol. 39:624–627. 2000.PubMed/NCBI View Article : Google Scholar

68 

Imamura S and Tagami H: Treatment of vitiligo with oral corticosteroids. Dermatology. 153:179–185. 1976.PubMed/NCBI View Article : Google Scholar

69 

Banerjee K, Barbhuiya JN, Ghosh AP, Dey SK and Karmakar PR: The efficacy of low-dose oral corticosteroids in the treatment of vitiligo patient. Indian J Dermatol Venereol Leprol. 69:135–137. 2003.PubMed/NCBI

70 

Pasricha JS and Khaitan BK: Oral mini-pulse therapy with betamethasone in vitiligo patients having extensive or fast-spreading disease. Int J Dermatol. 32:753–757. 1993.PubMed/NCBI View Article : Google Scholar

71 

Kanwar AJ, Mahajan R and Parsad D: Low-dose oral mini-pulse dexamethasone therapy in progressive unstable vitiligo. J Cutan Med Surg. 17:259–268. 2013.PubMed/NCBI View Article : Google Scholar

72 

Radakovic-Fijan S, Fürnsinn-Friedl AM, Hönigsmann H and Tanew A: Oral dexamethasone pulse treatment for vitiligo. J Am Acad Dermatol. 44:814–817. 2001.PubMed/NCBI View Article : Google Scholar

73 

Majid I, Imran S and Batool S: Apremilast is effective in controlling the progression of adult vitiligo: A case series. Dermatol Ther. 32(e12923)2019.PubMed/NCBI View Article : Google Scholar

74 

Huff SB and Gottwald LD: Repigmentation of tenacious vitiligo on apremilast. Case Rep Dermatol Med. 2017(2386234)2017.PubMed/NCBI View Article : Google Scholar

75 

Craiglow BG and King BA: Tofacitinib citrate for the treatment of vitiligo: A pathogenesis-directed therapy. JAMA Dermatol. 151:1110–1112. 2015.PubMed/NCBI View Article : Google Scholar

76 

Komnitski M, Komnitski A, Komnitski Junior A and Silva de Castro CC: Partial repigmentation of vitiligo with tofacitinib, without exposure to ultraviolet radiation. An Bras Dermatol. 95:473–476. 2020.PubMed/NCBI View Article : Google Scholar

77 

Scheinberg M, Ferreira SB and Santos DDCB: Tofacitinib-induced remission simultaneously in arthritis and vitiligo. Eur J Rheumatol. 8:55–56. 2021.PubMed/NCBI View Article : Google Scholar

78 

Song X, Xu A, Pan W, Wallin B, Kivlin R, Lu S, Cao C, Bi Z and Wan Y: Minocycline protects melanocytes against H2O2-induced cell death via JNK and p38 MAPK pathways. Int J Mol Med. 22:9–16. 2008.PubMed/NCBI

79 

Parsad D and Kanwar A: Oral minocycline in the treatment of vitiligo-a preliminary study. Dermatol Ther. 23:305–307. 2010.PubMed/NCBI View Article : Google Scholar

80 

Singh A, Kanwar AJ, Parsad D and Mahajan R: Randomized controlled study to evaluate the effectiveness of dexamethasone oral minipulse therapy versus oral minocycline in patients with active vitiligo vulgaris. Indian J Dermatol Venereol Leprol. 80:29–35. 2014.PubMed/NCBI View Article : Google Scholar

81 

Njoo MD, Das PK, Bos JD and Westerhof W: Association of the Kobner phenomenon with disease activity and therapeutic responsiveness in vitiligo vulgaris. Arch Dermatol. 135:407–413. 1999.PubMed/NCBI View Article : Google Scholar

82 

Siadat AH, Zeinali N, Iraji F, Abtahi-Naeini B, Nilforoushzadeh MA, Jamshidi K and Khosravani P: Narrow-band ultraviolet B versus oral minocycline in treatment of unstable vitiligo: A prospective comparative trial. Dermatol Res Pract. 2014(240856)2014.PubMed/NCBI View Article : Google Scholar

83 

Al-Kuraishy H, Hussian N, Al-Naimi M and Al-Gareeb A: Statins role in vitiligo: A mini-review. Turkish J Dermatol. 14:1–7. 2020.

84 

Agarwal P, Rashighi M, Essien KI, Richmond JM, Randall L, Pazoki-Toroudi H, Hunter CA and Harris JE: Simvastatin prevents and reverses depigmentation in a mouse model of vitiligo. J Invest Dermatol. 135:1080–1088. 2015.PubMed/NCBI View Article : Google Scholar

85 

Nguyen S, Chuah SY, Fontas E, Khemis A, Jhingan A, Thng STG and Passeron T: Atorvastatin in combination with narrowband UV-B in adult patients with active vitiligo: A randomized clinical trial. JAMA Dermatol. 154:725–726. 2018.PubMed/NCBI View Article : Google Scholar

86 

Iraji F, Banihashemi SH, Faghihi G, Shahmoradi Z, Tajmirriahi N and Jazi SB: A comparison of betamethasone valerate 0.1% cream twice daily plus oral simvastatin versus betamethasone valerate 0.1% Cream alone in the treatment of vitiligo patients. Adv Biomed Res. 6(34)2017.PubMed/NCBI View Article : Google Scholar

87 

Noël M, Gagné C, Bergeron J, Jobin J and Poirier P: Positive pleiotropic effects of HMG-CoA reductase inhibitor on vitiligo. Lipids Health Dis. 3(7)2004.PubMed/NCBI View Article : Google Scholar

88 

Vanderweil SG, Amano S, Ko WC, Richmond JM, Kelley M, Senna MM, Pearson A, Chowdary S, Hartigan C, Barton B and Harris JE: A double-blind, placebo-controlled, phase-II clinical trial to evaluate oral simvastatin as a treatment for vitiligo. J Am Acad Dermatol. 76:150–151.e3. 2017.PubMed/NCBI View Article : Google Scholar

89 

Alghamdi K and Khurrum H: Methotrexate for the treatment of generalized vitiligo. Saudi Pharm J. 21:423–424. 2013.PubMed/NCBI View Article : Google Scholar

90 

Garza-Mayers AC and Kroshinsky D: Low-dose methotrexate for vitiligo. J Drugs Dermatol. 16:705–706. 2017.PubMed/NCBI

91 

Nageswaramma S, Vani T and Indira N: Efficacy of methotrexate in vitiligo. IOSR J Dental Med Sci. 17:16–19. 2018.

92 

Singh H, Kumaran MS, Bains A and Parsad D: A randomized comparative study of oral corticosteroid minipulse and low-dose oral methotrexate in the treatment of unstable vitiligo. Dermatology. 231:286–290. 2015.PubMed/NCBI View Article : Google Scholar

93 

ElGhareeb MI, Metwalli M and AbdelMoneim N: Combination of oral methotrexate and oral mini-pulse dexamethasone vs. either agent alone in vitiligo treatment with follow up by dermoscope. Dermatol Ther. 33(e13586)2020.PubMed/NCBI View Article : Google Scholar

94 

Madarkar M, Ankad B and Manjula R: Comparative study of safety and efficacy of oral betamethasone pulse therapy and azathioprine in vitiligo. Clin Dermatol Rev. 3:121–125. 2019.

95 

Radmanesh M and Saedi K: The efficacy of combined PUVA and low-dose azathioprine for early and enhanced repigmentation in vitiligo patients. J Dermatolog Treat. 17:151–153. 2006.PubMed/NCBI View Article : Google Scholar

96 

Taneja A, Kumari A, Vyas K, Khare AK, Gupta LK and Mittal AK: Cyclosporine in treatment of progressive vitiligo: An open-label, single-arm interventional study. Indian J Dermatol Venereol Leprol. 85:528–531. 2019.PubMed/NCBI View Article : Google Scholar

97 

Mutalik S, Shah S, Sidwadkar V and Khoja M: Efficacy of cyclosporine after autologous noncultured melanocyte transplantation in localized stable vitiligo-a pilot, open label, comparative study. Dermatol Surg. 43:1339–1347. 2017.PubMed/NCBI View Article : Google Scholar

98 

Bishnoi A, Vinay K, Kumaran MS and Parsad D: Oral mycophenolate mofetil as a stabilizing treatment for progressive non-segmental vitiligo: Results from a prospective, randomized, investigator-blinded pilot study. Arch Dermatol Res: Jul 31, 2020 (Epub ahead of print).

99 

Slominski AT, Zmijewski MA, Plonka PM, Szaflarski JP and Paus R: How UV light touches the brain and endocrine system through skin, and Why. Endocrinology. 159:1992–2007. 2018.PubMed/NCBI View Article : Google Scholar

100 

Skobowiat C, Postlethwaite AE and Slominski AT: Skin exposure to ultraviolet B rapidly activates systemic neuroendocrine and immunosuppressive responses. Photochem Photobiol. 93:1008–1015. 2017.PubMed/NCBI View Article : Google Scholar

101 

Skobowiat C and Slominski AT: UVB activates hypothalamic-pituitary-adrenal axis in C57BL/6 Mice. J Invest Dermatol. 135:1638–1648. 2015.PubMed/NCBI View Article : Google Scholar

102 

Wu CS, Yu CL, Lan CC and Yu HS: Narrow-band ultraviolet-B stimulates proliferation and migration of cultured melanocytes. Exp Dermatol. 13:755–763. 2004.PubMed/NCBI View Article : Google Scholar

103 

Mohammad TF, Al-Jamal M, Hamzavi IH, Harris JE, Leone G, Cabrera R, Lim HW, Pandya AG and Esmat SM: The Vitiligo Working Group recommendations for narrowband ultraviolet B light phototherapy treatment of vitiligo. J Am Acad Dermatol. 76:879–888. 2017.PubMed/NCBI View Article : Google Scholar

104 

Bae JM, Jung HM, Hong BY, Lee JH, Choi WJ and Kim GM: Phototherapy for Vitiligo: A systematic review and Meta-analysis. JAMA Dermatol. 153:666–674. 2017.PubMed/NCBI View Article : Google Scholar

105 

Li R, Qiao M, Wang X, Zhao X and Sun Q: Effect of narrow band ultraviolet B phototherapy as monotherapy or combination therapy for vitiligo: A Meta-analysis. Photodermatol Photoimmunol Photomed. 33:22–31. 2017.PubMed/NCBI View Article : Google Scholar

106 

Tovar-Garza A, Hinojosa JA, Hynan LS and Pandya AG: Addition of oral minipulse dexamethasone to narrowband ultraviolet B phototherapy and topical steroids helps arrest disease activity in patients with vitiligo. Br J Dermatol. 180:193–194. 2019.PubMed/NCBI View Article : Google Scholar

107 

Phan K, Phan S, Shumack S and Gupta M: Repigmentation in vitiligo using Janus kinase (JAK) inhibitors with phototherapy: Systematic review and meta-analysis. J Dermatolog Treat: Apr 2, 2020 (Epub ahead of print).

108 

Khemis A, Fontas E, Moulin S, Montaudié H, Lacour JP and Passeron T: Apremilast in Combination with narrowband UVB in the treatment of vitiligo: A 52-week monocentric prospective randomized placebo-controlled study. J Invest Dermatol. 140:1533–1537.e2. 2020.PubMed/NCBI View Article : Google Scholar

109 

Lim HW, Grimes PE, Agbai O, Hamzavi I, Henderson M, Haddican M, Linkner RV and Lebwohl M: Afamelanotide and narrowband UV-B phototherapy for the treatment of vitiligo: A randomized multicenter trial. JAMA Dermatol. 151:42–50. 2015.PubMed/NCBI View Article : Google Scholar

110 

Chang HC, Lin MH and Tsai HH: Efficacy of combination therapy with fractional carbon dioxide laser and Ultraviolet B phototherapy for vitiligo: A systematic review and Meta-analysis. Aesthet Surg J. 40:NP46–NP50. 2020.PubMed/NCBI View Article : Google Scholar

111 

Wu CS, Lan CC, Wang LF, Chen GS and Yu HS: Effects of psoralen plus ultraviolet A irradiation on cultured epidermal cells in vitro and patients with vitiligo in vivo. Br J Dermatol. 156:122–129. 2007.PubMed/NCBI View Article : Google Scholar

112 

Parsad D, Kanwar AJ and Kumar B: Psoralen-ultraviolet A vs. narrow-band ultraviolet B phototherapy for the treatment of vitiligo. J Eur Acad Dermatol Venereol. 20:175–177. 2006.PubMed/NCBI View Article : Google Scholar

113 

Bhatnagar A, Kanwar AJ, Parsad D and De D: Psoralen and ultraviolet A and narrow-band ultraviolet B in inducing stability in vitiligo, assessed by vitiligo disease activity score: An open prospective comparative study. J Eur Acad Dermatol Venereol. 21:1381–1385. 2007.PubMed/NCBI View Article : Google Scholar

114 

Grimes PE: Psoralen photochemotherapy for vitiligo. Clin Dermatol. 15:921–926. 1997.PubMed/NCBI View Article : Google Scholar

115 

Karagaiah P, Valle Y, Sigova J, Zerbinati N, Vojvodic P, Parsad D, Schwartz RA, Grabbe S, Goldust M and Lotti T: Emerging drugs for the treatment of vitiligo. Expert Opin Emerg Drugs. 25:7–24. 2020.PubMed/NCBI View Article : Google Scholar

116 

Shi Q, Li K, Fu J, Wang Y, Ma C, Li Q, Li C and Gao T: Comparison of the 308-nm excimer laser with the 308-nm excimer lamp in the treatment of vitiligo-a randomized bilateral comparison study. Photodermatol Photoimmunol Photomed. 29:27–33. 2013.PubMed/NCBI View Article : Google Scholar

117 

Do JE, Shin JY, Kim DY, Hann SK and Oh SH: The effect of 308nm excimer laser on segmental vitiligo: A retrospective study of 80 patients with segmental vitiligo. Photodermatol Photoimmunol Photomed. 27:147–151. 2011.PubMed/NCBI View Article : Google Scholar

118 

Lopes C, Trevisani VF and Melnik T: Efficacy and safety of 308-nm monochromatic excimer lamp versus other phototherapy devices for vitiligo: A systematic review with meta-analysis. Am J Clin Dermatol. 17:23–32. 2016.PubMed/NCBI View Article : Google Scholar

119 

Bae JM, Hong BY, Lee JH, Lee JH and Kim GM: The efficacy of 308-nm excimer laser/light (EL) and topical agent combination therapy versus EL monotherapy for vitiligo: A systematic review and meta-analysis of randomized controlled trials (RCTs). J Am Acad Dermatol. 74:907–915. 2016.PubMed/NCBI View Article : Google Scholar

120 

Lotti T, Wollina U, Tchernev G, Valle Y, Lotti J, França K, Satolli F, Rovesti M, Tirant M, Lozev I, et al: An innovative therapeutic protocol for vitiligo: Experience with the use of fraxel herbium laser, topical latanoprost and successive irradiation with UVA-1 laser. Open Access Maced J Med Sci. 6:49–51. 2018.PubMed/NCBI View Article : Google Scholar

121 

Grimes PE and Nashawati R: Depigmentation therapies for vitiligo. Dermatol Clin. 35:219–227. 2017.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Kubelis‑López DE, Zapata‑Salazar NA, Said‑Fernández SL, Sánchez‑Domínguez CN, Salinas‑Santander MA, Martínez‑Rodríguez HG, Vázquez‑Martínez OT, Wollina U, Lotti T, Ocampo‑Candiani J, Ocampo‑Candiani J, et al: Updates and new medical treatments for vitiligo (Review). Exp Ther Med 22: 797, 2021.
APA
Kubelis‑López, D.E., Zapata‑Salazar, N.A., Said‑Fernández, S.L., Sánchez‑Domínguez, C.N., Salinas‑Santander, M.A., Martínez‑Rodríguez, H.G. ... Ocampo‑Candiani, J. (2021). Updates and new medical treatments for vitiligo (Review). Experimental and Therapeutic Medicine, 22, 797. https://doi.org/10.3892/etm.2021.10229
MLA
Kubelis‑López, D. E., Zapata‑Salazar, N. A., Said‑Fernández, S. L., Sánchez‑Domínguez, C. N., Salinas‑Santander, M. A., Martínez‑Rodríguez, H. G., Vázquez‑Martínez, O. T., Wollina, U., Lotti, T., Ocampo‑Candiani, J."Updates and new medical treatments for vitiligo (Review)". Experimental and Therapeutic Medicine 22.2 (2021): 797.
Chicago
Kubelis‑López, D. E., Zapata‑Salazar, N. A., Said‑Fernández, S. L., Sánchez‑Domínguez, C. N., Salinas‑Santander, M. A., Martínez‑Rodríguez, H. G., Vázquez‑Martínez, O. T., Wollina, U., Lotti, T., Ocampo‑Candiani, J."Updates and new medical treatments for vitiligo (Review)". Experimental and Therapeutic Medicine 22, no. 2 (2021): 797. https://doi.org/10.3892/etm.2021.10229
Copy and paste a formatted citation
x
Spandidos Publications style
Kubelis‑López DE, Zapata‑Salazar NA, Said‑Fernández SL, Sánchez‑Domínguez CN, Salinas‑Santander MA, Martínez‑Rodríguez HG, Vázquez‑Martínez OT, Wollina U, Lotti T, Ocampo‑Candiani J, Ocampo‑Candiani J, et al: Updates and new medical treatments for vitiligo (Review). Exp Ther Med 22: 797, 2021.
APA
Kubelis‑López, D.E., Zapata‑Salazar, N.A., Said‑Fernández, S.L., Sánchez‑Domínguez, C.N., Salinas‑Santander, M.A., Martínez‑Rodríguez, H.G. ... Ocampo‑Candiani, J. (2021). Updates and new medical treatments for vitiligo (Review). Experimental and Therapeutic Medicine, 22, 797. https://doi.org/10.3892/etm.2021.10229
MLA
Kubelis‑López, D. E., Zapata‑Salazar, N. A., Said‑Fernández, S. L., Sánchez‑Domínguez, C. N., Salinas‑Santander, M. A., Martínez‑Rodríguez, H. G., Vázquez‑Martínez, O. T., Wollina, U., Lotti, T., Ocampo‑Candiani, J."Updates and new medical treatments for vitiligo (Review)". Experimental and Therapeutic Medicine 22.2 (2021): 797.
Chicago
Kubelis‑López, D. E., Zapata‑Salazar, N. A., Said‑Fernández, S. L., Sánchez‑Domínguez, C. N., Salinas‑Santander, M. A., Martínez‑Rodríguez, H. G., Vázquez‑Martínez, O. T., Wollina, U., Lotti, T., Ocampo‑Candiani, J."Updates and new medical treatments for vitiligo (Review)". Experimental and Therapeutic Medicine 22, no. 2 (2021): 797. https://doi.org/10.3892/etm.2021.10229
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