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Molecular markers associated with potentially malignant oral lesions (Review)

  • Authors:
    • Oana Mihaela Condurache Hritcu
    • Ana Emanuela Botez
    • Doinita Temelie Olinici
    • P. Onofrei
    • Laura Stoica
    • V. B. Grecu
    • Paula Mihaela Toader
    • Laura Gheucă‑Solovăstru
    • Elena Carmen Cotrutz
  • View Affiliations / Copyright

    Affiliations: Department of Cell and Molecular Biology, ‘Gr. T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania, Department of Dermatology, ‘Gr. T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania
    Copyright: © Condurache Hritcu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 834
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    Published online on: June 4, 2021
       https://doi.org/10.3892/etm.2021.10266
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Abstract

According to literature data, potentially premalignant oral lesions are the basis of over 85% of cell carcinomas. Despite multiple advances achieved during the last few decades in the diagnosis and treatment of oral squamous cell carcinomas, there has not been a significant change in the prognosis and 5‑year survival rate. The prevention of malignant transformation of these tumors by diagnosis and targeted treatment would be the ideal scenario. These potentially premalignant oral lesions represent an important subject for either the clinical or the research field, due to the higher malignant transformation observed in the last few years at different ages. To date, histopathological examination based on TNM criteria is considered the ‘golden standard’. However, this type of examination has its limitation due to staining procedures and photonic microscope examination. Identification of cellular and molecular markers specific to these oral lesions with potentially malignant transformation could lead to early detection, accurate diagnosis, prevention of the development of oral squamous cell carcinoma (OSCC) and facilitate a targeted therapeutic approach. In this review, we focused on a series of molecules that are implicated in the malignant transformation of these lesions and considered potential biomarkers.
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Copy and paste a formatted citation
Spandidos Publications style
Condurache Hritcu OM, Botez AE, Olinici DT, Onofrei P, Stoica L, Grecu VB, Toader PM, Gheucă‑Solovăstru L and Cotrutz EC: Molecular markers associated with potentially malignant oral lesions (Review). Exp Ther Med 22: 834, 2021.
APA
Condurache Hritcu, O.M., Botez, A.E., Olinici, D.T., Onofrei, P., Stoica, L., Grecu, V.B. ... Cotrutz, E.C. (2021). Molecular markers associated with potentially malignant oral lesions (Review). Experimental and Therapeutic Medicine, 22, 834. https://doi.org/10.3892/etm.2021.10266
MLA
Condurache Hritcu, O. M., Botez, A. E., Olinici, D. T., Onofrei, P., Stoica, L., Grecu, V. B., Toader, P. M., Gheucă‑Solovăstru, L., Cotrutz, E. C."Molecular markers associated with potentially malignant oral lesions (Review)". Experimental and Therapeutic Medicine 22.2 (2021): 834.
Chicago
Condurache Hritcu, O. M., Botez, A. E., Olinici, D. T., Onofrei, P., Stoica, L., Grecu, V. B., Toader, P. M., Gheucă‑Solovăstru, L., Cotrutz, E. C."Molecular markers associated with potentially malignant oral lesions (Review)". Experimental and Therapeutic Medicine 22, no. 2 (2021): 834. https://doi.org/10.3892/etm.2021.10266
Copy and paste a formatted citation
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Spandidos Publications style
Condurache Hritcu OM, Botez AE, Olinici DT, Onofrei P, Stoica L, Grecu VB, Toader PM, Gheucă‑Solovăstru L and Cotrutz EC: Molecular markers associated with potentially malignant oral lesions (Review). Exp Ther Med 22: 834, 2021.
APA
Condurache Hritcu, O.M., Botez, A.E., Olinici, D.T., Onofrei, P., Stoica, L., Grecu, V.B. ... Cotrutz, E.C. (2021). Molecular markers associated with potentially malignant oral lesions (Review). Experimental and Therapeutic Medicine, 22, 834. https://doi.org/10.3892/etm.2021.10266
MLA
Condurache Hritcu, O. M., Botez, A. E., Olinici, D. T., Onofrei, P., Stoica, L., Grecu, V. B., Toader, P. M., Gheucă‑Solovăstru, L., Cotrutz, E. C."Molecular markers associated with potentially malignant oral lesions (Review)". Experimental and Therapeutic Medicine 22.2 (2021): 834.
Chicago
Condurache Hritcu, O. M., Botez, A. E., Olinici, D. T., Onofrei, P., Stoica, L., Grecu, V. B., Toader, P. M., Gheucă‑Solovăstru, L., Cotrutz, E. C."Molecular markers associated with potentially malignant oral lesions (Review)". Experimental and Therapeutic Medicine 22, no. 2 (2021): 834. https://doi.org/10.3892/etm.2021.10266
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