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Molecular mechanisms and associated cell signalling pathways underlying the anticancer properties of phytochemical compounds from Aloe species (Review)

  • Authors:
    • Hanna Svitina
    • Josias H. Hamman
    • Chrisna Gouws
  • View Affiliations / Copyright

    Affiliations: Centre of Excellence for Pharmaceutical Sciences (Pharmacen™), North‑West University, Potchefstroom, North West 2520, South Africa
    Copyright: © Svitina et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 852
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    Published online on: June 8, 2021
       https://doi.org/10.3892/etm.2021.10284
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Abstract

Naturally occurring components from various species of Aloe have been used as traditional folk medicine since the ancient times. Over the last few decades, the therapeutic effects of extracts and phytochemical compounds obtained from Aloe vera have been proven in preclinical and clinical studies. Recently, compounds from other Aloe species apart from Aloe vera have been investigated for the treatment of different diseases, with a particular focus on cancer. In the present review, the effects of phytochemical compounds obtained from different Aloe species are discussed, with a specific focus on the effects on cell signalling in cancer and normal cells, and their selectivity and efficacy. This information will be useful for the application of Aloe‑derived compounds as therapeutic agents, either alone or in combination with other standard drugs for cancer treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Svitina H, Hamman JH and Gouws C: Molecular mechanisms and associated cell signalling pathways underlying the anticancer properties of phytochemical compounds from <em>Aloe</em> species (Review). Exp Ther Med 22: 852, 2021.
APA
Svitina, H., Hamman, J.H., & Gouws, C. (2021). Molecular mechanisms and associated cell signalling pathways underlying the anticancer properties of phytochemical compounds from <em>Aloe</em> species (Review). Experimental and Therapeutic Medicine, 22, 852. https://doi.org/10.3892/etm.2021.10284
MLA
Svitina, H., Hamman, J. H., Gouws, C."Molecular mechanisms and associated cell signalling pathways underlying the anticancer properties of phytochemical compounds from <em>Aloe</em> species (Review)". Experimental and Therapeutic Medicine 22.2 (2021): 852.
Chicago
Svitina, H., Hamman, J. H., Gouws, C."Molecular mechanisms and associated cell signalling pathways underlying the anticancer properties of phytochemical compounds from <em>Aloe</em> species (Review)". Experimental and Therapeutic Medicine 22, no. 2 (2021): 852. https://doi.org/10.3892/etm.2021.10284
Copy and paste a formatted citation
x
Spandidos Publications style
Svitina H, Hamman JH and Gouws C: Molecular mechanisms and associated cell signalling pathways underlying the anticancer properties of phytochemical compounds from <em>Aloe</em> species (Review). Exp Ther Med 22: 852, 2021.
APA
Svitina, H., Hamman, J.H., & Gouws, C. (2021). Molecular mechanisms and associated cell signalling pathways underlying the anticancer properties of phytochemical compounds from <em>Aloe</em> species (Review). Experimental and Therapeutic Medicine, 22, 852. https://doi.org/10.3892/etm.2021.10284
MLA
Svitina, H., Hamman, J. H., Gouws, C."Molecular mechanisms and associated cell signalling pathways underlying the anticancer properties of phytochemical compounds from <em>Aloe</em> species (Review)". Experimental and Therapeutic Medicine 22.2 (2021): 852.
Chicago
Svitina, H., Hamman, J. H., Gouws, C."Molecular mechanisms and associated cell signalling pathways underlying the anticancer properties of phytochemical compounds from <em>Aloe</em> species (Review)". Experimental and Therapeutic Medicine 22, no. 2 (2021): 852. https://doi.org/10.3892/etm.2021.10284
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