Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
August-2021 Volume 22 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2021 Volume 22 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review Open Access

Role of radio‑ablative technique for optimizing the survival of patients with locally advanced pancreatic adenocarcinoma (Review)

  • Authors:
    • Ioana Iancu
    • Adrian Bartoș
    • Cristian Liviu Cioltean
    • Caius Breazu
    • Cornel Iancu
    • Dana Bartoș
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Regional Institute of Gastroenterology and Hepatology, 400162 Cluj‑Napoca, Romania
    Copyright: © Iancu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 853
    |
    Published online on: June 8, 2021
       https://doi.org/10.3892/etm.2021.10285
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Pancreatic ductal adenocarcinoma (PDAC) is one of the most common and frequently diagnosed malignant tumor of the pancreas with few treatment options and poor life expectancy. Despite the advances in the surgical field, 40% of the patients are diagnosed with locally advanced disease which is not suitable for surgery. Radio‑frequency ablation (RFA) has been described as a new ‘weapon’ in the multimodal treatment of PDAC, representing a cytoreductive procedure which must be completed with radiotherapy or chemo‑radiotherapy. A systematic research was carried out utilizing the PubMed database in regards to this subject, to evaluate the role of RFA in PDAC management. Abstracts, letters‑to‑the‑editor and non‑English language manuscripts were excluded. The literature showed that RFA can be used in open and laparoscopic surgery but it is also feasible for endoscopic ultrasound (EUS‑guided RFA) or percutaneous approach. Even though we found optimistic and encouraging reports on overall survival (OS), randomized studies are still required to corroborate these findings. Our review research underline that surgical resection remains the only radical treatment option, RFA being a safe and feasible technique reserved for unresectable, non‑metastatic pancreatic tumors. Its combination with oncological treatment can improve the OS of these patients.
View Figures
View References

1 

Schima W, Ba-Ssalamah A, Kölblinger C, Kulinna-Cosentini C, Puespoek A and Götzinger P: Pancreatic adenocarcinoma. Eur Radiol. 17:638–649. 2007.PubMed/NCBI View Article : Google Scholar

2 

Neoptolemos JP, Dunn JA, Stocken DD, Almond J, Link K, Beger H, Bassi C, Falconi M, Pederzoli P, Dervenis C, et al: Adjuvant chemoradiotherapy and chemotherapy in resectable pancreatic cancer: A randomised controlled trial. Lancet. 358:1576–1585. 2001.PubMed/NCBI View Article : Google Scholar

3 

Girelli R, Frigerio I, Giardino A, Regi P, Gobbo S, Malleo G, Salvia R and Bassi C: Results of 100 pancreatic radiofrequency ablations in the context of a multimodal strategy for stage III ductal adenocarcinoma. Langenbecks Arch Surg. 398:63–69. 2013.PubMed/NCBI View Article : Google Scholar

4 

Singh SM, Longmire WP Jr and Reber HA: Surgical palliation for pancreatic cancer. The UCLA experience. Ann Surg. 212:132–139. 1990.PubMed/NCBI View Article : Google Scholar

5 

Huguet F, Girard N, Guerche CS, Hennequin C, Mornex F and Azria D: Chemoradiotherapy in the management of locally advanced pancreatic carcinoma: A qualitative systematic review. J Clin Oncol. 27:2269–2277. 2009.PubMed/NCBI View Article : Google Scholar

6 

Paiella S, Salvia R, Ramera M, Girelli R, Frigerio I, Giardino A, Allegrini V and Bassi C: Local ablative strategies for ductal pancreatic cancer (radiofrequency ablation, irreversible electroporation): A review. Gastroenterol Res Pract. 2016(4508376)2016.PubMed/NCBI View Article : Google Scholar

7 

Rocha Lima CM, Green MR, Rotche R, Miller WH Jr, Jeffrey GM, Cisar LA, Morganti A, Orlando N, Gruia G and Miller LL: Irinotecan plus gemcitabine results in no survival advantage compared with gemcitabine monotherapy in patients with locally advanced or metastatic pancreatic cancer despite increased tumor response rate. J Clin Oncol. 22:3776–3783. 2004.PubMed/NCBI View Article : Google Scholar

8 

Louvet C, Labianca R, Hammel P, Lledo G, Zampino MG, André T, Zaniboni A, Ducreux M, Aitini E, Taïeb J, et al: Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer: Results of a GERCOR and GISCAD phase III trial. J Clin Oncol. 23:3509–3516. 2005.PubMed/NCBI View Article : Google Scholar

9 

Poplin E, Feng Y, Berlin J, Rothenberg ML, Hochster H, Mitchell E, Alberts S, O'Dwyer P, Haller D, Catalano P, et al: Phase III, randomized study of gemcitabine and oxaliplatin versus gemcitabine (fixed-dose rate infusion) compared with gemcitabine (30-min infusion) in patients with pancreatic carcinoma E6201: A trial of the Eastern cooperative oncology group. J Clin Oncol. 27:3778–3785. 2009.PubMed/NCBI View Article : Google Scholar

10 

Hidalgo M: Pancreatic cancer. N Engl J Med. 362:1605–1617. 2010.PubMed/NCBI View Article : Google Scholar

11 

Heinemann V, Haas M and Boeck S: Neoadjuvant treatment of borderline resectable and non-resectable pancreatic cancer. Ann Oncol. 24:2484–2492. 2013.PubMed/NCBI View Article : Google Scholar

12 

He J, Page AJ, Weiss M, Wolfgang CL, Herman JM and Pawlik TM: Management of borderline and locally advanced pancreatic cancer: Where do we stand? World J Gastroenterol. 20:2255–2266. 2014.PubMed/NCBI View Article : Google Scholar

13 

Vauthey JN and Dixon E: AHPBA/SSO/SSAT consensus conference on resectable and borderline resectable pancreatic cancer: Rationale and overview of the conference. Ann Surg Oncol. 16:1725–1726. 2009.PubMed/NCBI View Article : Google Scholar

14 

Halperin DM and Varadhachary GR: Resectable, borderline resectable, and locally advanced pancreatic cancer: What does it matter? Curr Oncol Rep. 16(366)2014.PubMed/NCBI View Article : Google Scholar

15 

Katz MH, Crane CH and Varadhachary G: Management of borderline resectable pancreatic cancer. Semin Radiat Oncol. 24:105–112. 2014.PubMed/NCBI View Article : Google Scholar

16 

Benson AB III, D'Angelica MI, Abbott DE, Abrams TA, Alberts SR, Saenz DA, Are C, Brown DB, Chang DT, Covey AM, et al: NCCN guidelines insights: Hepatobiliary cancers, version 1.2017. J Natl Compr Canc Netw. 15:563–573. 2017.PubMed/NCBI View Article : Google Scholar

17 

Katz MHG and Varadhachary GR: Borderline resectable pancreatic cancer-at the crossroads of precision medicine. Cancer. 125:1584–1587. 2019.PubMed/NCBI View Article : Google Scholar

18 

Varadhachary GR: Preoperative therapies for resectable and borderline resectable pancreatic cancer. J Gastrointest Oncol. 2:136–142. 2011.PubMed/NCBI View Article : Google Scholar

19 

Gazelle GS, Goldberg SN, Solbiati L and Livraghi T: Tumor ablation with radio-frequency energy. Radiology. 217:633–646. 2000.PubMed/NCBI View Article : Google Scholar

20 

Rovere-Querini P and Manfredi AA: Tumor destruction and in situ delivery of antigen presenting cells promote anti-neoplastic immune responses: Implications for the immunotherapy of pancreatic cancer. JOP. 5:308–314. 2004.PubMed/NCBI

21 

Siriwardena AK: Radiofrequency ablation for locally advanced cancer of the pancreas. JOP. 7:1–4. 2006.PubMed/NCBI

22 

Girelli R, Frigerio I, Salvia R, Barbi E, Tinazzi Martini P and Bassi C: Feasibility and safety of radiofrequency ablation for locally advanced pancreatic cancer. Br J Surg. 97:220–225. 2010.PubMed/NCBI View Article : Google Scholar

23 

Dromi SA, Walsh MP, Herby S, Traughber B, Xie J, Sharma KV, Sekhar KP, Luk A, Liewehr DJ, Dreher MR, et al: Radiofrequency ablation induces antigen-presenting cell infiltration and amplification of weak tumor-induced immunity. Radiology. 251:58–66. 2009.PubMed/NCBI View Article : Google Scholar

24 

Giardino A, Girelli R, Frigerio I, Regi P, Cantore M, Alessandra A, Lusenti A, Salvia R, Bassi C and Pederzoli P: Triple approach strategy for patients with locally advanced pancreatic carcinoma. HPB (Oxford). 15:623–627. 2013.PubMed/NCBI View Article : Google Scholar

25 

Shrestha B, Sun Y, Faisal F, Kim V, Soares K, Blair A, Herman JM, Narang A, Dholakia AS, Rosati L, et al: Long-term survival benefit of upfront chemotherapy in patients with newly diagnosed borderline resectable pancreatic cancer. Cancer Med. 6:1552–1562. 2017.PubMed/NCBI View Article : Google Scholar

26 

Chu KF and Dupuy DE: Thermal ablation of tumours: Biological mechanisms and advances in therapy. Nat Rev Cancer. 14:199–208. 2014.PubMed/NCBI View Article : Google Scholar

27 

Hansler J, Wissniowski TT, Schuppan D, Witte A, Bernatik T, Hahn EG and Strobel D: Activation and dramatically increased cytolytic activity of tumor specific T lymphocytes after radio-frequency ablation in patients with hepatocellular carcinoma and colorectal liver metastases. World J Gastroenterol. 12:3716–3721. 2006.PubMed/NCBI View Article : Google Scholar

28 

Morganti AG, Massaccesi M, La Torre G, Caravatta L, Piscopo A, Tambaro R, Sofo L, Sallustio G, Ingrosso M, Macchia G, et al: A systematic review of resectability and survival after concurrent chemoradiation in primarily unresectable pancreatic cancer. Ann Surg Oncol. 17:194–205. 2010.PubMed/NCBI View Article : Google Scholar

29 

D'Onofrio M, Barbi E, Girelli R, Tinazzi Martini P, De Robertis R, Ciaravino V, Salvia R, Butturini G, Frigerio I, Milazzo T, et al: Variation of tumoral marker after radiofrequency ablation of pancreatic adenocarcinoma. J Gastrointest Oncol. 7:213–220. 2016.PubMed/NCBI View Article : Google Scholar

30 

Matsui Y, Nakagawa A, Kamiyama Y, Yamamoto K, Kubo N and Nakase Y: Selective thermocoagulation of unresectable pancreatic cancers by using radiofrequency capacitive heating. Pancreas. 20:14–20. 2000.PubMed/NCBI View Article : Google Scholar

31 

Spiliotis JD, Datsis AC, Michalopoulos NV, Kekelos SP, Vaxevanidou A, Rogdakis AG and Christopoulou AN: Radiofrequency ablation combined with palliative surgery may prolong survival of patients with advanced cancer of the pancreas. Langenbecks Arch Surg. 392:55–60. 2007.PubMed/NCBI View Article : Google Scholar

32 

Spiliotis JD, Datsis AC, Michalopoulos NV, Kekelos SP, Vaxevanidou A, Rogdakis AG and Christopoulou AN: High operative risk of cool-tip radiofrequency ablation for unresectable pancreatic head cancer. J Surg Oncol. 96:89–90. 2007.PubMed/NCBI View Article : Google Scholar

33 

Frigerio I, Girelli R, Giardino A, Regi P, Salvia R and Bassi C: Short term chemotherapy followed by radiofrequency ablation in stage III pancreatic cancer: Results from a single center. J Hepatobiliary Pancreat Sci. 20:574–577. 2013.PubMed/NCBI View Article : Google Scholar

34 

Wu Y, Tang Z, Fang H, Gao S, Chen J, Wang Y and Yan H: High operative risk of cool-tip radiofrequency ablation for unresectable pancreatic head cancer. J Surg Oncol. 94:392–395. 2006.PubMed/NCBI View Article : Google Scholar

35 

Fegrachi S, Molenaar IQ, Klaessens JH, Besselink MG, Offerhaus JA and van Hillegersberg R: Radiofrequency ablation of the pancreas with and without intraluminal duodenal cooling in a porcine model. J Surg Res. 184:867–872. 2013.PubMed/NCBI View Article : Google Scholar

36 

Fegrachi S, Besselink MG, van Santvoort HC, van Hillegersberg R and Molenaar IQ: Radiofrequency ablation for unresectable locally advanced pancreatic cancer: A systematic review. HPB (Oxford). 16:119–123. 2014.PubMed/NCBI View Article : Google Scholar

37 

Fegrachi S, Molenaar IQ, Klaessens JH, Besselink MG, Offerhaus JA and van Hillegersberg R: Radiofrequency ablation of the pancreas: Two-week follow-up in a porcine model. Eur J Surg Oncol. 40:1000–1007. 2014.PubMed/NCBI View Article : Google Scholar

38 

Date RS, Biggins J, Paterson I, Denton J, McMahon RF and Siriwardena AK: Development and validation of an experimental model for the assessment of radiofrequency ablation of pancreatic parenchyma. Pancreas. 30:266–271. 2005.PubMed/NCBI View Article : Google Scholar

39 

Date RS and Siriwardena AK: Radiofrequency ablation of the pancreas. II: Intra-operative ablation of non-resectable pancreatic cancer. A description of technique and initial outcome. JOP. 6:588–592. 2005.PubMed/NCBI

40 

Hadjicostas P, Malakounides N, Varianos C, Kitiris E, Lerni F and Symeonides P: Radiofrequency ablation in pancreatic cancer. HPB (Oxford). 8:61–64. 2006.PubMed/NCBI View Article : Google Scholar

41 

Casadei R, Ricci C, Pezzilli R, Serra C, Calculli L, Morselli-Labate AM, Santini D and Minni F: A prospective study on radiofrequency ablation locally advanced pancreatic cancer. Hepatobiliary Pancreat Dis Int. 9:306–311. 2010.PubMed/NCBI

42 

Figueroa-Barojas P, Bakhru MR, Habib NA, Ellen K, Millman J, Jamal-Kabani A, Gaidhane M and Kahaleh M: Safety and efficacy of radiofrequency ablation in the management of unresectable bile duct and pancreatic cancer: A novel palliation technique. J Oncol. 2013(910897)2013.PubMed/NCBI View Article : Google Scholar

43 

Varshney S, Sewkani A, Sharma S, Kapoor S, Naik S, Sharma A and Patel K: Radiofrequency ablation of unresectable pancreatic carcinoma: Feasibility, efficacy and safety. JOP. 7:74–78. 2006.PubMed/NCBI

44 

Rombouts SJ, Vogel JA, van Santvoort HC, van Lienden KP, van Hillegersberg R, Busch OR, Besselink MG and Molenaar IQ: Systematic review of innovative ablative therapies for the treatment of locally advanced pancreatic cancer. Br J Surg. 102:182–193. 2015.PubMed/NCBI View Article : Google Scholar

45 

Gemenetzis G, Groot VP, Blair AB, Laheru DA, Zheng L, Narang AK, Fishman EK, Hruban RH, Yu J, Burkhart RA, et al: Survival in locally advanced pancreatic cancer after neoadjuvant therapy and surgical resection. Ann Surg. 270:340–347. 2019.PubMed/NCBI View Article : Google Scholar

46 

He J, Blair AB, Groot VP, Javed AA, Burkhart RA, Gemenetzis G, Hruban RH, Waters KM, Poling J, Zheng L, et al: Is a pathological complete response following neoadjuvant chemoradiation associated with prolonged survival in patients with pancreatic cancer? Ann Surg. 268:1–8. 2018.PubMed/NCBI View Article : Google Scholar

47 

Alistar A, Morris BB, Desnoyer R, Klepin HD, Hosseinzadeh K, Clark C, Cameron A, Leyendecker J, D'Agostino R Jr, Topaloglu U, et al: Safety and tolerability of the first-in-class agent CPI-613 in combination with modified FOLFIRINOX in patients with metastatic pancreatic cancer: A single-centre, open-label, dose-escalation, phase 1 trial. Lancet Oncol. 18:770–778. 2017.PubMed/NCBI View Article : Google Scholar

48 

Song TJ, Seo DW, Lakhtakia S, Reddy N, Oh DW, Park DH, Lee SS, Lee SK and Kim MH: Initial experience of EUS-guided radiofrequency ablation of unresectable pancreatic cancer. Gastrointest Endosc. 83:440–443. 2016.PubMed/NCBI View Article : Google Scholar

49 

Carrafiello G, Ierardi AM, Fontana F, Petrillo M, Floridi C, Lucchina N, Cuffari S, Dionigi G, Rotondo A and Fugazzola C: Microwave ablation of pancreatic head cancer: Safety and efficacy. J Vasc Interv Radiol. 24:1513–1520. 2013.PubMed/NCBI View Article : Google Scholar

50 

D'Onofrio M, Crosara S, De Robertis R, Butturini G, Salvia R, Paiella S, Bassi C and Mucelli RP: Percutaneous radiofrequency ablation of unresectable locally advanced pancreatic cancer: Preliminary results. Technol Cancer Res Treat. 16:285–294. 2017.PubMed/NCBI View Article : Google Scholar

51 

Niu L, He L, Zhou L, Mu F, Wu B, Li H, Yang Z, Zuo J and Xu K: Percutaneous ultrasonography and computed tomography guided pancreatic cryoablation: Feasibility and safety assessment. Cryobiology. 65:301–307. 2012.PubMed/NCBI View Article : Google Scholar

52 

Ierardi AM, Biondetti P, Coppola A, Fumarola EM, Biasina AM, Alessio Angileri S and Carrafiello G: Percutaneous microwave thermosphere ablation of pancreatic tumours. Gland Surg. 7:59–66. 2018.PubMed/NCBI View Article : Google Scholar

53 

Rossi S, Viera FT, Ghittoni G, Cobianchi L, Rosa LL, Siciliani L, Bortolotto C, Veronese L, Vercelli A, Gallotti A and Ravetta V: Radiofrequency ablation of pancreatic neuroendocrine tumors: A pilot study of feasibility, efficacy, and safety. Pancreas. 43:938–945. 2014.PubMed/NCBI View Article : Google Scholar

54 

Vogl TJ, Panahi B, Albrecht MH, Naguib NNN, Nour-Eldin NA, Gruber-Rouh T, Thompson ZM and Basten LM: Microwave ablation of pancreatic tumors. Minim Invasive Ther Allied Technol. 27:33–40. 2018.PubMed/NCBI View Article : Google Scholar

55 

D'Onofrio M, Zamboni G, Faccioli N, Capelli P and Pozzi Mucelli R: Ultrasonography of the pancreas. 4. Contrast-enhanced imaging. Abdom Imaging. 32:171–181. 2007.PubMed/NCBI View Article : Google Scholar

56 

Crinò SF, D'Onofrio M, Bernardoni L, Frulloni L, Iannelli M, Malleo G, Paiella S, Larghi A and Gabbrielli A: EUS-guided radiofrequency ablation (EUS-RFA) of solid pancreatic neoplasm using an 18-gauge needle electrode: Feasibility, safety, and technical success. J Gastrointestin Liver Dis. 27:67–72. 2018.PubMed/NCBI View Article : Google Scholar

57 

Keane MG, Bramis K, Pereira SP and Fusai GK: Systematic review of novel ablative methods in locally advanced pancreatic cancer. World J Gastroenterol. 20:2267–2278. 2014.PubMed/NCBI View Article : Google Scholar

58 

Pai M, Habib N, Senturk H, Lakhtakia S, Reddy N, Cicinnati VR, Kaba I, Beckebaum S, Drymousis P, Kahaleh M and Brugge W: Endoscopic ultrasound guided radiofrequency ablation, for pancreatic cystic neoplasms and neuroendocrine tumors. World J Gastrointest Surg. 7:52–59. 2015.PubMed/NCBI View Article : Google Scholar

59 

Paiella S, De Pastena M, D'Onofrio M, Crinò SF, Pan TL, De Robertis R, Elio G, Martone E, Bassi C and Salvia R: Palliative therapy in pancreatic cancer-interventional treatment with radiofrequency ablation/irreversible electroporation. Transl Gastroenterol Hepatol. 3(80)2018.PubMed/NCBI View Article : Google Scholar

60 

Carrafiello G, Ierardi AM, Piacentino F, Lucchina N, Dionigi G, Cuffari S and Fugazzola C: Microwave ablation with percutaneous approach for the treatment of pancreatic adenocarcinoma. Cardiovasc Intervent Radiol. 35:439–442. 2012.PubMed/NCBI View Article : Google Scholar

61 

Li J, Chen X, Yang H, Wang X, Yuan D, Zeng Y, Wen T, Yan L and Li B: Tumour cryoablation combined with palliative bypass surgery in the treatment of unresectable pancreatic cancer: A retrospective study of 142 patients. Postgrad Med J. 87:89–95. 2011.PubMed/NCBI View Article : Google Scholar

62 

Xiong LL, Hwang JH, Huang XB, Yao SS, He CJ, Ge XH, Ge HY and Wang XF: Early clinical experience using high intensity focused ultrasound for palliation of inoperable pancreatic cancer. JOP. 10:123–129. 2009.PubMed/NCBI

63 

Xiaoping L and Leizhen Z: Advances of high intensity focused ultrasound (HIFU) for pancreatic cancer. Int J Hyperthermia. 29:678–682. 2013.PubMed/NCBI View Article : Google Scholar

64 

Diana M, Schiraldi L, Liu YY, Memeo R, Mutter D, Pessaux P and Marescaux J: High intensity focused ultrasound (HIFU) applied to hepato-bilio-pancreatic and the digestive system-current state of the art and future perspectives. Hepatobiliary Surg Nutr. 5:329–344. 2016.PubMed/NCBI View Article : Google Scholar

65 

Ning Z, Xie J, Chen Q, Zhang C, Xu L, Song L and Meng Z: HIFU is safe, effective, and feasible in pancreatic cancer patients: A monocentric retrospective study among 523 patients. Onco Targets Ther. 12:1021–1029. 2019.PubMed/NCBI View Article : Google Scholar

66 

Martin RC: Irreversible electroporation of locally advanced pancreatic head adenocarcinoma. J Gastrointest Surg. 17:1850–1856. 2013.PubMed/NCBI View Article : Google Scholar

67 

Martin RC II, McFarland K, Ellis S and Velanovich V: Irreversible electroporation in locally advanced pancreatic cancer: Potential improved overall survival. Ann Surg Oncol. 20 (Suppl 3):S443–S449. 2013.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Iancu I, Bartoș A, Cioltean CL, Breazu C, Iancu C and Bartoș D: Role of radio‑ablative technique for optimizing the survival of patients with locally advanced pancreatic adenocarcinoma (Review). Exp Ther Med 22: 853, 2021.
APA
Iancu, I., Bartoș, A., Cioltean, C.L., Breazu, C., Iancu, C., & Bartoș, D. (2021). Role of radio‑ablative technique for optimizing the survival of patients with locally advanced pancreatic adenocarcinoma (Review). Experimental and Therapeutic Medicine, 22, 853. https://doi.org/10.3892/etm.2021.10285
MLA
Iancu, I., Bartoș, A., Cioltean, C. L., Breazu, C., Iancu, C., Bartoș, D."Role of radio‑ablative technique for optimizing the survival of patients with locally advanced pancreatic adenocarcinoma (Review)". Experimental and Therapeutic Medicine 22.2 (2021): 853.
Chicago
Iancu, I., Bartoș, A., Cioltean, C. L., Breazu, C., Iancu, C., Bartoș, D."Role of radio‑ablative technique for optimizing the survival of patients with locally advanced pancreatic adenocarcinoma (Review)". Experimental and Therapeutic Medicine 22, no. 2 (2021): 853. https://doi.org/10.3892/etm.2021.10285
Copy and paste a formatted citation
x
Spandidos Publications style
Iancu I, Bartoș A, Cioltean CL, Breazu C, Iancu C and Bartoș D: Role of radio‑ablative technique for optimizing the survival of patients with locally advanced pancreatic adenocarcinoma (Review). Exp Ther Med 22: 853, 2021.
APA
Iancu, I., Bartoș, A., Cioltean, C.L., Breazu, C., Iancu, C., & Bartoș, D. (2021). Role of radio‑ablative technique for optimizing the survival of patients with locally advanced pancreatic adenocarcinoma (Review). Experimental and Therapeutic Medicine, 22, 853. https://doi.org/10.3892/etm.2021.10285
MLA
Iancu, I., Bartoș, A., Cioltean, C. L., Breazu, C., Iancu, C., Bartoș, D."Role of radio‑ablative technique for optimizing the survival of patients with locally advanced pancreatic adenocarcinoma (Review)". Experimental and Therapeutic Medicine 22.2 (2021): 853.
Chicago
Iancu, I., Bartoș, A., Cioltean, C. L., Breazu, C., Iancu, C., Bartoș, D."Role of radio‑ablative technique for optimizing the survival of patients with locally advanced pancreatic adenocarcinoma (Review)". Experimental and Therapeutic Medicine 22, no. 2 (2021): 853. https://doi.org/10.3892/etm.2021.10285
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team