Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
August-2021 Volume 22 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2021 Volume 22 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data1.xlsx
    • Supplementary_Data2.pdf
Article

B‑cell receptor‑associated protein 31 promotes migration and invasion in ovarian cancer cells

  • Authors:
    • Haiyan Liang
    • Jiqiao Dong
    • Ziyan Cheng
    • Qian Li
    • Dingqing Feng
    • Bin Ling
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology and Obstetrics, China‑Japan Friendship Hospital, Beijing 100029, P.R. China, GeneX Health Life Co., Ltd., Beijing 100195, P.R. China, The Experimental High School Attached To Beijing Normal University, Beijing 100032, P.R. China
  • Article Number: 858
    |
    Published online on: June 9, 2021
       https://doi.org/10.3892/etm.2021.10290
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

B cell receptor associated protein 31 (BAP31) is a member of the B cell receptor that functions as a transporter for numerous types of newly formed proteins from the endoplasmic reticulum to the Golgi apparatus. Previous studies found that that BAP31 serves an important role in the pathogenesis of malignancy but its specific effect on ovarian cancer is not clear. The present study aimed to investigate whether BAP31 affects ovarian cancer and its underlying mechanism. In the present study, ovarian cancer tissue, human ovarian normal epithelial cell line IOSE80 and five ovarian cancer cell lines (A2780, Hey‑T30, COC1, SKOV3 and OVCAR3) underwent reverse transcription‑quantitative PCR, western blotting, Cell Counting Kit‑8, Transwell and co‑immunoprecipitation (Co‑IP) assay and transcriptome sequencing. Previous studies showed that compared with healthy tissues, the expression level of BAP31 protein was found to be significantly higher in various types of cancer tissues, implying that BAP31 may serve an important role in the pathogenesis of cancer. The present study found that BAP31 expression was upregulated in five ovarian cancer cell lines and ovarian cancer tissue, such that BAP31 knockdown [performed using two short hairpin (sh)RNA plasmids] decreased proliferation, invasion and migration. In addition, BAP31 knockdown was found to downregulate the expression of N‑cadherin and upregulate the expression of E‑cadherin on transcriptional level by controlling the nuclear aggregation of TWIST1, a transcriptional regulator of N‑cadherin and E‑cadherin. There was no interaction between BAP31 and E‑cadherin or N‑cadherin using Co‑IP detection, while BAP31, E‑cadherin and N‑cadherin interacted with TWIST1 protein. E‑cadherin and N‑cadherin expression levels recovered when TWIST1 was overexpressed in the shBCAP31 cells. These results suggest that BAP31 can regulate the migration and invasion of ovarian cancer cells through the epithelial‑mesenchymal transition pathway at the transcriptional level, which may be beneficial for the identification of potentially novel targets for ovarian cancer therapy.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2020. CA Cancer J Clin. 70:7–30. 2020.PubMed/NCBI View Article : Google Scholar

2 

Su Z, Graybill WS and Zhu Y: Detection and monitoring of ovarian cancer. Clin Chim Acta. 415:341–345. 2013.PubMed/NCBI View Article : Google Scholar

3 

Torre LA, Trabert B, DeSantis CE, Miller KD, Samimi G, Runowicz CD, Gaudet MM, Jemal A and Siegel RL: Ovarian cancer statistics, 2018. CA Cancer J Clin. 68:284–296. 2018.PubMed/NCBI View Article : Google Scholar

4 

Narod S: Can advanced-stage ovarian cancer be cured. Nat Rev Clin Oncol. 13:255–261. 2016.PubMed/NCBI View Article : Google Scholar

5 

Lim D and Oliva E: Precursors and pathogenesis of ovarian carcinoma. Pathology. 45:229–242. 2013.PubMed/NCBI View Article : Google Scholar

6 

Vang R, Shih IeM and Kurman RJ: Ovarian low-grade and high-grade serous carcinoma: Pathogenesis, clinicopathologic and molecular biologic features, and diagnostic problems. Adv Anat Pathol. 16:267–282. 2009.PubMed/NCBI View Article : Google Scholar

7 

Nelson BH: The impact of T-cell immunity on ovarian cancer outcomes. Immunol Rev. 222:101–116. 2008.PubMed/NCBI View Article : Google Scholar

8 

Kim KM, Adachi T, Nielsen PJ, Terashima M, Lamers MC, Köhler G and Reth M: Two new proteins preferentially associated with membrane immunoglobulin D. EMBO J. 13:3793–3800. 1994.PubMed/NCBI

9 

Adachi T, Schamel WW, Kim KM, Watanabe T, Becker B, Nielsen PJ and Reth M: The specificity of association of the IgD molecule with the accessory proteins BAP31/BAP29 lies in the IgD transmembrane sequence. EMBO J. 15:1534–1541. 1996.PubMed/NCBI

10 

Namba T, Tian F, Chu K, Hwang SY, Yoon KW, Byun S, Hiraki M, Mandinova A and Lee SW: CDIP1-BAP31 complex transduces apoptotic signals from endoplasmic reticulum to mitochondria under endoplasmic reticulum stress. Cell Rep. 5:331–339. 2013.PubMed/NCBI View Article : Google Scholar

11 

Breckenridge DG, Stojanovic M, Marcellus RC and Shore GC: Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol. J Cell Biol. 160:1115–1127. 2003.PubMed/NCBI View Article : Google Scholar

12 

Wakana Y, Takai S, Nakajima K, Tani K, Yamamoto A, Watson P, Stephens DJ, Hauri HP and Tagaya M: Bap31 is an itinerant protein that moves between the peripheral endoplasmic reticulum (ER) and a juxtanuclear compartment related to ER-associated Degradation. Mol Biol Cell. 19:1825–1836. 2008.PubMed/NCBI View Article : Google Scholar

13 

Matroule JY, Carthy CM, Granville DJ, Jolois O, Hunt DW and Piette J: Mechanism of colon cancer cell apoptosis mediated by pyropheophorbide-a methylester photosensitization. Oncogene. 20:4070–4084. 2001.PubMed/NCBI View Article : Google Scholar

14 

Yu S, Wang F, Fan L, Wei Y, Li H, Sun Y, Yang A, Jin B, Song C and Yang K: BAP31, a promising target for the immunotherapy of malignant melanomas. J Exp Clin Cancer Res. 34(36)2015.PubMed/NCBI View Article : Google Scholar

15 

Tan N, Liu Q, Liu X, Gong Z, Zeng Y, Pan G, Xu Q and He S: Low expression of B-cell-associated protein 31 in human primary hepatocellular carcinoma correlates with poor prognosis. Histopathology. 68:221–229. 2016.PubMed/NCBI View Article : Google Scholar

16 

Wang A, Zhang Y and Cao P: Inhibition of BAP31 expression inhibits cervical cancer progression by suppressing metastasis and inducing intrinsic and extrinsic apoptosis. Biochem Biophys Res Commun. 508:499–506. 2019.PubMed/NCBI View Article : Google Scholar

17 

Ma C, Jin RM, Chen KJ, Hao T, Li BS, Zhao DH and Jiang H: Low expression of B-Cell-Associated protein 31 is associated with unfavorable prognosis in human colorectal cancer. Pathol Res Pract. 214:661–666. 2018.PubMed/NCBI View Article : Google Scholar

18 

Dang E, Yang S, Song C, Jiang D, Li Z, Fan W, Sun Y, Tao L, Wang J, Liu T, et al: BAP31, a newly defined cancer/testis antigen, regulates proliferation, migration, and invasion to promote cervical cancer progression. Cell Death Dis. 9(791)2018.PubMed/NCBI View Article : Google Scholar

19 

Nieto MA, Huang RY, Jackson RA and Thiery JP: EMT: 2016. Cell. 166:21–45. 2016.PubMed/NCBI View Article : Google Scholar

20 

Thiery JP, Acloque H, Huang RY and Nieto MA: Epithelial-mesenchymal transitions in development and disease. Cell. 139:871–890. 2009.PubMed/NCBI View Article : Google Scholar

21 

Loh CY, Chai JY, Tang TF, Wong WF, Sethi G, Shanmugam MK, Chong PP and Looi CY: The E-cadherin and N-cadherin switch in epithelial-to-mesenchymal transition: Signaling, therapeutic implications, and challenges. Cells. 8(1118)2019.PubMed/NCBI View Article : Google Scholar

22 

Ling ZQ, Li P, Ge MH, Zhao X, Hu FJ, Fang XH, Dong ZM and Mao WM: Hypermethylation-modulated down-regulation of CDH1 expression contributes to the progression of esophageal cancer. Int J Mol Med. 27:625–635. 2011.PubMed/NCBI View Article : Google Scholar

23 

Umbas R, Schalken JA, Aalders TW, Carter BS, Karthaus HF, Schaafsma HE, Debruyne FM and Isaacs WB: Expression of the cellular adhesion molecule E-cadherin is reduced or absent in high-grade prostate cancer. Cancer Res. 52:5104–5109. 1992.PubMed/NCBI

24 

Petrova YI, Schecterson L and Gumbiner BM: Roles for E-cadherin cell surface regulation in cancer. Mol Biol Cell. 27:3233–3244. 2016.PubMed/NCBI View Article : Google Scholar

25 

Fransvea E, Angelotti U, Antonaci S and Giannelli G: Blocking transforming growth factor-beta up-regulates E-cadherin and reduces migration and invasion of hepatocellular carcinoma cells. Hepatology. 47:1557–1566. 2008.PubMed/NCBI View Article : Google Scholar

26 

Tang G, Du R, Tang Z and Kuang Y: MiRNALet-7a mediates prostate cancer PC-3 cell invasion, migration by inducing epithelial-mesenchymal transition through CCR7/MAPK pathway. J Cell Biochem. 119:3725–3731. 2018.PubMed/NCBI View Article : Google Scholar

27 

del Valle I, Rudloff S, Carles A, Li Y, Liszewska E, Vogt R and Kemler R: E-cadherin is required for the proper activation of the Lifr/Gp130 signaling pathway in mouse embryonic stem cells. Development. 140:1684–1692. 2013.PubMed/NCBI View Article : Google Scholar

28 

Hazan RB, Qiao R, Keren R, Badano I and Suyama K: Cadherin switch in tumor progression. Ann N Y Acad Sci. 1014:155–163. 2004.PubMed/NCBI View Article : Google Scholar

29 

Muramaki M, Miyake H, Terakawa T, Kumano M, Sakai I and Fujisawa M: Expression profile of E-cadherin and N-cadherin in non-muscle-invasive bladder cancer as a novel predictor of intravesical recurrence following transurethral resection. Urol Oncol. 30:161–166. 2012.PubMed/NCBI View Article : Google Scholar

30 

Shintani Y, Hollingsworth MA, Wheelock MJ and Johnson KR: Collagen I promotes metastasis in pancreatic cancer by activating c-Jun NH(2)-terminal kinase 1 and up-regulating N-cadherin expression. Cancer Res. 66:11745–11753. 2006.PubMed/NCBI View Article : Google Scholar

31 

Puisieux A, Brabletz T and Caramel J: Oncogenic roles of EMT-inducing transcription factors. Nat Cell Biol. 16:488–494. 2014.PubMed/NCBI View Article : Google Scholar

32 

Hamamori Y, Wu HY, Sartorelli V and Kedes L: The basic domain of myogenic basic helix-loop-helix (bHLH) proteins is the novel target for direct inhibition by another bHLH protein, Twist. Mol Cell Biol. 17:6563–6573. 1997.PubMed/NCBI View Article : Google Scholar

33 

Lee MS, Lowe GN, Strong DD, Wergedal JE and Glackin CA: TWIST, a basic helix-loop-helix transcription factor, can regulate the human osteogenic lineage. J Cell Biochem. 75:566–577. 1999.PubMed/NCBI View Article : Google Scholar

34 

Verzi MP, Anderson JP, Dodou E, Kelly KK, Greene SB, North BJ, Cripps RM and Black BL: N-twist, an evolutionarily conserved bHLH protein expressed in the developing CNS, functions as a transcriptional inhibitor. Dev Biol. 249:174–190. 2002.PubMed/NCBI View Article : Google Scholar

35 

Mironchik Y, Winnard PT Jr, Vesuna F, Kato Y, Wildes F, Pathak AP, Kominsky S, Artemov D, Bhujwalla Z, Van Diest P, et al: Twist overexpression induces in vivo angiogenesis and correlates with chromosomal instability in breast cancer. Cancer Res. 65:10801–10809. 2005.PubMed/NCBI View Article : Google Scholar

36 

Ansieau S, Bastid J, Doreau A, Morel AP, Bouchet BP, Thomas C, Fauvet F, Puisieux I, Doglioni C, Piccinin S, et al: Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence. Cancer Cell. 14:79–89. 2008.PubMed/NCBI View Article : Google Scholar

37 

Rodriguez Y, Gonzalez-Mendez RR and Cadilla CL: Evolution of the twist subfamily vertebrate proteins: Discovery of a signature motif and origin of the twist1 glycine-rich motifs in the amino-terminus disordered domain. PLoS One. 11(e0161029)2016.PubMed/NCBI View Article : Google Scholar

38 

Ansieau S, Morel AP, Hinkal G, Bastid J and Puisieux A: TWISTing an embryonic transcription factor into an oncoprotein. Oncogene. 29:3173–3184. 2010.PubMed/NCBI View Article : Google Scholar

39 

Satoh K, Hamada S, Kimura K, Kanno A, Hirota M, Umino J, Fujibuchi W, Masamune A, Tanaka N, Miura K, et al: Up-regulation of MSX2 enhances the malignant phenotype and is associated with twist 1 expression in human pancreatic cancer cells. Am J Pathol. 172:926–939. 2008.PubMed/NCBI View Article : Google Scholar

40 

Ru GQ, Wang HJ, Xu WJ and Zhao ZS: Upregulation of Twist in gastric carcinoma associated with tumor invasion and poor prognosis. Pathol Oncol Res. 17:341–347. 2011.PubMed/NCBI View Article : Google Scholar

41 

Ranganathan S, Krishnan A and Sivasithambaram ND: Significance of twist and iNOS expression in human breast carcinoma. Mol Cell Biochem. 412:41–47. 2016.PubMed/NCBI View Article : Google Scholar

42 

Khan MA, Chen HC, Zhang D and Fu J: Twist: A molecular target in cancer therapeutics. Tumour Biol. 34:2497–2506. 2013.PubMed/NCBI View Article : Google Scholar

43 

Lu Z and Chen J: Introduction of WHO classification of tumours of female reproductive organs, fourth edition. Zhonghua Bing Li Xue Za Zhi. 43:649–650. 2014.PubMed/NCBI(In Chinese).

44 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

45 

Wang L, Feng Z, Wang X, Wang X and Zhang X: DEGseq: An R package for identifying differentially expressed genes from RNA-seq data. Bioinformatics. 26:136–138. 2010.PubMed/NCBI View Article : Google Scholar

46 

Scanlon CS, Van Tubergen EA, Inglehart RC and D'Silva NJ: Biomarkers of epithelial-mesenchymal transition in squamous cell carcinoma. J Dent Res. 92:114–121. 2013.PubMed/NCBI View Article : Google Scholar

47 

Malgulwar PB, Nambirajan A, Pathak P, Rajeshwari M, Suri V, Sarkar C, Singh M and Sharma MC: Epithelial-to-mesenchymal transition-related transcription factors are up-regulated in ependymomas and correlate with a poor prognosis. Hum Pathol. 82:149–157. 2018.PubMed/NCBI View Article : Google Scholar

48 

Namba T: BAP31 regulates mitochondrial function via interaction with Tom40 within ER-mitochondria contact sites. Sci Adv. 5(eaaw1386)2019.PubMed/NCBI View Article : Google Scholar

49 

Machihara K and Namba T: BAP31 inhibits cell adaptation to ER stress conditions, negatively regulating autophagy induction by interaction with STX17. Cells. 8(1350)2019.PubMed/NCBI View Article : Google Scholar

50 

Quistgaard EM: BAP31: Physiological functions and roles in disease. Biochimie. 186:105–129. 2021.PubMed/NCBI View Article : Google Scholar

51 

Wilson JD and Barlowe C: Yet1p and Yet3p, the yeast homologs of BAP29 and BAP31, interact with the endoplasmic reticulum translocation apparatus and are required for inositol prototrophy. J Biol Chem. 285:18252–18261. 2010.PubMed/NCBI View Article : Google Scholar

52 

Fu W, Sun H, Zhao Y, Chen M, Yang X, Liu Y and Jin W: BCAP31 drives TNBC development by modulating ligand-independent EGFR trafficking and spontaneous EGFR phosphorylation. Theranostics. 9:6468–6484. 2019.PubMed/NCBI View Article : Google Scholar

53 

Xu K, Han B, Bai Y, Ma XY, Ji ZN, Xiong Y, Miao SK, Zhang YY and Zhou LM: MiR-451a suppressing BAP31 can inhibit proliferation and increase apoptosis through inducing ER stress in colorectal cancer. Cell Death Dis. 10(152)2019.PubMed/NCBI View Article : Google Scholar

54 

Thiery JP: Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer. 2:442–454. 2002.PubMed/NCBI View Article : Google Scholar

55 

Shook D and Keller R: Mechanisms, mechanics and function of epithelial-mesenchymal transitions in early development. Mech Dev. 120:1351–1383. 2003.PubMed/NCBI View Article : Google Scholar

56 

Yun SJ and Kim WJ: Role of the epithelial-mesenchymal transition in bladder cancer: From prognosis to therapeutic target. Korean J Urol. 54:645–650. 2013.PubMed/NCBI View Article : Google Scholar

57 

Franco-Chuaire ML, Magda Carolina SC and Chuaire-Noack L: Epithelial-mesenchymal transition (EMT): Principles and clinical impact in cancer therapy. Invest Clin. 54:186–205. 2013.PubMed/NCBI

58 

Rosso M, Majem B, Devis L, Lapyckyj L, Besso MJ, Llauradó M, Abascal MF, Matos ML, Lanau L, Castellví J, et al: E-cadherin: A determinant molecule associated with ovarian cancer progression, dissemination and aggressiveness. PLoS One. 12(e0184439)2017.PubMed/NCBI View Article : Google Scholar

59 

Wang M, Ren D, Guo W, Huang S, Wang Z, Li Q, Du H, Song L and Peng X: N-cadherin promotes epithelial-mesenchymal transition and cancer stem cell-like traits via ErbB signaling in prostate cancer cells. Int J Oncol. 48:595–606. 2016.PubMed/NCBI View Article : Google Scholar

60 

Hui L, Zhang S, Dong X, Tian D, Cui Z and Qiu X: Prognostic significance of twist and N-cadherin expression in NSCLC. PLoS One. 8(e62171)2013.PubMed/NCBI View Article : Google Scholar

61 

Araki K, Shimura T, Suzuki H, Tsutsumi S, Wada W, Yajima T, Kobayahi T, Kubo N and Kuwano H: E/N-cadherin switch mediates cancer progression via TGF-β-induced epithelial-to-mesenchymal transition in extrahepatic cholangiocarcinoma. Br J Cancer. 105:1885–1893. 2011.PubMed/NCBI View Article : Google Scholar

62 

Yang J, Mani SA, Donaher JL, Ramaswamy S, Itzykson RA, Come C, Savagner P, Gitelman I, Richardson A and Weinberg RA: Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell. 117:927–939. 2004.PubMed/NCBI View Article : Google Scholar

63 

Rosivatz E, Becker I, Specht K, Fricke E, Luber B, Busch R, Höfler H and Becker KF: Differential expression of the epithelial-mesenchymal transition regulators snail, SIP1, and twist in gastric cancer. Am J Pathol. 161:1881–1891. 2002.PubMed/NCBI View Article : Google Scholar

64 

Kwok WK, Ling MT, Lee TW, Lau TC, Zhou C, Zhang X, Chua CW, Chan KW, Chan FL, Glackin C, et al: Up-regulation of TWIST in prostate cancer and its implication as a therapeutic target. Cancer Res. 65:5153–5162. 2005.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liang H, Dong J, Cheng Z, Li Q, Feng D and Ling B: B‑cell receptor‑associated protein 31 promotes migration and invasion in ovarian cancer cells. Exp Ther Med 22: 858, 2021.
APA
Liang, H., Dong, J., Cheng, Z., Li, Q., Feng, D., & Ling, B. (2021). B‑cell receptor‑associated protein 31 promotes migration and invasion in ovarian cancer cells. Experimental and Therapeutic Medicine, 22, 858. https://doi.org/10.3892/etm.2021.10290
MLA
Liang, H., Dong, J., Cheng, Z., Li, Q., Feng, D., Ling, B."B‑cell receptor‑associated protein 31 promotes migration and invasion in ovarian cancer cells". Experimental and Therapeutic Medicine 22.2 (2021): 858.
Chicago
Liang, H., Dong, J., Cheng, Z., Li, Q., Feng, D., Ling, B."B‑cell receptor‑associated protein 31 promotes migration and invasion in ovarian cancer cells". Experimental and Therapeutic Medicine 22, no. 2 (2021): 858. https://doi.org/10.3892/etm.2021.10290
Copy and paste a formatted citation
x
Spandidos Publications style
Liang H, Dong J, Cheng Z, Li Q, Feng D and Ling B: B‑cell receptor‑associated protein 31 promotes migration and invasion in ovarian cancer cells. Exp Ther Med 22: 858, 2021.
APA
Liang, H., Dong, J., Cheng, Z., Li, Q., Feng, D., & Ling, B. (2021). B‑cell receptor‑associated protein 31 promotes migration and invasion in ovarian cancer cells. Experimental and Therapeutic Medicine, 22, 858. https://doi.org/10.3892/etm.2021.10290
MLA
Liang, H., Dong, J., Cheng, Z., Li, Q., Feng, D., Ling, B."B‑cell receptor‑associated protein 31 promotes migration and invasion in ovarian cancer cells". Experimental and Therapeutic Medicine 22.2 (2021): 858.
Chicago
Liang, H., Dong, J., Cheng, Z., Li, Q., Feng, D., Ling, B."B‑cell receptor‑associated protein 31 promotes migration and invasion in ovarian cancer cells". Experimental and Therapeutic Medicine 22, no. 2 (2021): 858. https://doi.org/10.3892/etm.2021.10290
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team