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Role of microRNAs in intervertebral disc degeneration (Review)

  • Authors:
    • Fengguang Yang
    • Jizu Wang
    • Zhixin Chen
    • Yuping Yang
    • Wenhui Zhang
    • Shifang Guo
    • Qingshan Yang
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Gansu Provincial Hospital, Lanzhou, Gansu 730000, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 860
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    Published online on: June 10, 2021
       https://doi.org/10.3892/etm.2021.10292
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Abstract

The incidence of lower back pain caused by intervertebral disc degeneration (IDD) is gradually increasing. IDD not only affects the quality of life of the patients, but also poses a major socioeconomic burden. There is currently no optimal method for delaying or reversing IDD, mainly due to its unknown pathogenesis. MicroRNAs (miRNAs/miRs) participate in the development of a number of diseases, including IDD. Abnormal expression of miRNAs in the intervertebral disc is implicated in various pathological processes underlying the development of IDD, including nucleus pulposus (NP) cell (NPC) proliferation, NPC apoptosis, extracellular matrix remodeling, inflammation and cartilaginous endplate changes, among others. The focus of the present review was the advances in research on the involvement of miRNAs in the mechanism underlying IDD. Further research is expected to identify markers for early diagnosis of IDD and new targets for delaying or reversing IDD.
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Copy and paste a formatted citation
Spandidos Publications style
Yang F, Wang J, Chen Z, Yang Y, Zhang W, Guo S and Yang Q: Role of microRNAs in intervertebral disc degeneration (Review). Exp Ther Med 22: 860, 2021.
APA
Yang, F., Wang, J., Chen, Z., Yang, Y., Zhang, W., Guo, S., & Yang, Q. (2021). Role of microRNAs in intervertebral disc degeneration (Review). Experimental and Therapeutic Medicine, 22, 860. https://doi.org/10.3892/etm.2021.10292
MLA
Yang, F., Wang, J., Chen, Z., Yang, Y., Zhang, W., Guo, S., Yang, Q."Role of microRNAs in intervertebral disc degeneration (Review)". Experimental and Therapeutic Medicine 22.2 (2021): 860.
Chicago
Yang, F., Wang, J., Chen, Z., Yang, Y., Zhang, W., Guo, S., Yang, Q."Role of microRNAs in intervertebral disc degeneration (Review)". Experimental and Therapeutic Medicine 22, no. 2 (2021): 860. https://doi.org/10.3892/etm.2021.10292
Copy and paste a formatted citation
x
Spandidos Publications style
Yang F, Wang J, Chen Z, Yang Y, Zhang W, Guo S and Yang Q: Role of microRNAs in intervertebral disc degeneration (Review). Exp Ther Med 22: 860, 2021.
APA
Yang, F., Wang, J., Chen, Z., Yang, Y., Zhang, W., Guo, S., & Yang, Q. (2021). Role of microRNAs in intervertebral disc degeneration (Review). Experimental and Therapeutic Medicine, 22, 860. https://doi.org/10.3892/etm.2021.10292
MLA
Yang, F., Wang, J., Chen, Z., Yang, Y., Zhang, W., Guo, S., Yang, Q."Role of microRNAs in intervertebral disc degeneration (Review)". Experimental and Therapeutic Medicine 22.2 (2021): 860.
Chicago
Yang, F., Wang, J., Chen, Z., Yang, Y., Zhang, W., Guo, S., Yang, Q."Role of microRNAs in intervertebral disc degeneration (Review)". Experimental and Therapeutic Medicine 22, no. 2 (2021): 860. https://doi.org/10.3892/etm.2021.10292
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