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Clinical relevance of donor‑specific human leukocyte antigen antibodies after pediatric liver transplantation

  • Authors:
    • Wei Liu
    • Kai Wang
    • Yan-Li Xiao
    • Chun Liu
    • Wei Gao
    • Dai-Hong Li
  • View Affiliations / Copyright

    Affiliations: Department of Blood Transfusion, Tianjin First Central Hospital, Tianjin 300192, P.R. China, Department of Transplantation Surgery, Tianjin First Central Hospital, Tianjin 300192, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 867
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    Published online on: June 13, 2021
       https://doi.org/10.3892/etm.2021.10299
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Abstract

Donor‑specific human leukocyte antigen (HLA) antibodies (DSAs) have a significant role in graft survival after pediatric liver transplantation. To understand the significance of DSAs, a retrospective cohort study of 48 pediatric liver transplant recipients with posttransplant serum samples that were analyzed for DSAs was performed. According to their test results, the recipients were divided into a DSA‑positive group and a DSA‑negative group. Postoperative liver transplantation biopsies were performed in patients with abnormal liver function. The liver condition and prognosis of the recipients were recorded, and their association was analyzed. A total of 48 recipients were followed up for 2.7±0.8 years. DSA positivity was detected in 10 cases (20.8%). One case was positive for HLA class I and HLA class II antibodies, whereas 9 cases were positive for HLA class II antibodies, and the gene loci were HLA‑DR and/or DQ. Antibody‑mediated rejection (AMR) occurred in four of 10 patients in the DSA‑positive group. Liver function was abnormal in 3 of 38 cases in the DSA‑negative group. Multivariate analysis revealed that DSA positivity was an independent risk factor for liver insufficiency and long‑term survival of recipients. In addition, Kaplan‑Meier survival analysis demonstrated that there were significant differences in the survival of graft recipients between the DSA‑positive group and the DSA‑negative group (P<0.05). The positivity of DSAs after pediatric liver transplantation was closely related to the occurrence of AMR. These results suggested that DSAs should be routinely monitored post‑operatively, and that DSA‑positive recipients should be screened as soon as possible and given appropriate treatment.
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1 

Vionnet J, Sempoux C, Pascual M, Sánchez-Fueyo A and Colmenero J: Donor-specific antibodies in liver transplantation. Gastroenterol Hepatol. 43:34–45. 2020.PubMed/NCBI View Article : Google Scholar : (In English, Spanish).

2 

Kannabhiran D, Lee J, Schwartz JE, Friedlander R, Aull M, Muthukumar T, Campbell S, Epstein D, Seshan SV, Kapur S, et al: Characteristics of circulating donor human leukocyte antigen-specific immunoglobulin G antibodies predictive of acute antibody-mediated rejection and kidney allograft failure. Transplantation. 99:1156–1164. 2015.PubMed/NCBI View Article : Google Scholar

3 

Mohan S, Palanisamy A, Tsapepas D, Tanriover B, Crew RJ, Dube G, Ratner LE, Cohen DJ and Radhakrishnan J: Donor-specific antibodies adversely affect kidney allograft outcomes. J Am Soc Nephrol. 23:2061–2071. 2012.PubMed/NCBI View Article : Google Scholar

4 

Einecke G, Sis B, Reeve J, Mengel M, Campbell PM, Hidalgo LG, Kaplan B and Halloran PF: Antibody-mediated microcirculation injury is the major cause of late kidney transplant failure. Am J Transplant. 9:2520–2531. 2009.PubMed/NCBI View Article : Google Scholar

5 

Venick RS, Farmer DG, McDiarmid SV, Duffy JP, Gordon SA, Yersiz H, Hong JC, Vargas JH, Amment ME and Busuttil RW: Predictors of survival following liver transplantation in infants: A single-center analysis of more than 200 cases. Transplantation. 89:600–605. 2010.PubMed/NCBI View Article : Google Scholar

6 

Bishara A, Brautbar C, Eid A, Scherman L, Ilan Y and Safadi R: Is presensitization relevant to liver transplantation outcome? Hum Immunol. 63:742–750. 2002.PubMed/NCBI View Article : Google Scholar

7 

Muro M, López-Álvarez MR, Campillo JA, Marin L, Moya-Quiles MR, Bolarin JM, Botella C, Salgado G, Martinez P, Sánchez-Bueno F, et al: Influence of human leukocyte antigen mismatching on rejection development and allograft survival in liver transplantation: Is the relevance of HLA-A locus matching being underestimated? Transpl Immunol. 26:88–93. 2012.PubMed/NCBI View Article : Google Scholar

8 

Kaczmarek I, Deutsch MA, Kauke T, Beiras-Fernandez A, Schmoeckel M, Vicol C, Sodian R, Reichart B, Spannagl M and Ueberfuhr P: Donor-specific HLA alloantibodies: Long-term impact on cardiac allograft vasculopathy and mortality after heart transplant. Exp Clin Transplant. 63:229–235. 2008.PubMed/NCBI

9 

Smith JD, Banner NR, Hamour IM, Ozawa M, Goh A, Robinson D, Terasaki PI and Rose ML: De novo donor HLA-specific antibodies after heart transplantation are an independent predictor of poor patient survival. Am J Transplant. 11:312–319. 2011.PubMed/NCBI View Article : Google Scholar

10 

Taner T, Gandhi MJ, Sanderson SO, Poterucha CR, De Goey SR, Stegall MD and Heimbach JK: Prevalence, course and impact of HLA donor-specific antibodies in liver transplantation in the first year. Am J Transplant. 12:1504–1510. 2012.PubMed/NCBI View Article : Google Scholar

11 

Starzl TE, Demetris AJ, Todo S, Kang Y, Tzakis A, Duquesnoy R, Makowka L, Banner B, Concepcion W and Kendrick A: Evidence for hyperacute rejection of human liver grafts: The case of the canary kidneys. Clin Transplant. 3:37–45. 1989.PubMed/NCBI

12 

Kozlowski T, Rubinas T, Nickeleit V, Woosley J, Schmitz J, Collins D, Hayashi P, Passannante A and Andreoni K: Liver allograft antibody-mediated rejection with demonstration of sinusoidal C4d staining and circulating donor-specific antibodies. Liver Transpl. 17:357–368. 2011.PubMed/NCBI View Article : Google Scholar

13 

Paterno F, Shiller M, Tillery G, O'Leary JG, Susskind B, Trotter J and Klintmalm GB: Bortezomib for acute antibody-mediated rejection in liver transplantation. Am J Transplant. 12:2526–2531. 2012.PubMed/NCBI View Article : Google Scholar

14 

Musat AI, Pigott CM, Ellis TM, Agni RM, Leverson GE, Powell AJ, Richards KR, D'Alessandro AM and Lucey MR: Pretransplant donor-specific anti-HLA antibodies as predictors of early allograft rejection in ABO-compatible liver transplantation. Liver Transpl. 19:1132–1141. 2013.PubMed/NCBI View Article : Google Scholar

15 

Musat AI, Agni RM, Wai PY, Pirsch JD, Lorentzen DF, Powell A, Leverson GE, Bellingham JM, Fernandez LA, Foley DP, et al: The significance of donor-specific HLA antibodies in rejection and ductopenia development in ABO compatible liver transplantation. Am J Transplant. 11:500–510. 2011.PubMed/NCBI View Article : Google Scholar

16 

Demetris AJ, Markus BH, Burnham J, Nalesnik M, Gordon RD, Makowka L and Starzl TE: Antibody deposition in liver allografts with chronic rejection. Transplant Proc. 19 (4 Suppl 5):S121–S125. 1987.PubMed/NCBI

17 

Del Bello A, Congy-Jolivet N, Muscari F, Lavayssière L, Esposito L, Cardeau-Desangles I, Guitard J, Dörr G, Suc B, Duffas JP, et al: Prevalence, incidence and risk factors for donor-specific anti-HLA antibodies in maintenance liver transplant patients. Am J Transplant. 14:867–875. 2014.PubMed/NCBI View Article : Google Scholar

18 

Miyagawa-Hayashino A, Yoshizawa A, Uchida Y, Egawa H, Yurugi K, Masuda S, Minamiguchi S, Maekawa T, Uemoto S and Haga H: Progressive graft fibrosis and donor-specific human leukocyte antigen antibodies in pediatric late liver allografts. Liver Transpl. 18:1333–3342. 2012.PubMed/NCBI View Article : Google Scholar

19 

Wozniak LJ, Hickey MJ, Venick RS, Vargas JH, Farmer DG, Busuttil RW, McDiarmid SV and Reed EF: Donor-specific HLA antibodies are associated with late allograft dysfunction after pediatric liver transplantation. Transplantation. 99:1416–1422. 2015.PubMed/NCBI View Article : Google Scholar

20 

Dalva K and Beksac M: HLA typing with sequence-specific oligonucleotide primed PCR (PCR-SSO) and use of the Luminex technology. Methods Mol Med. 134:61–69. 2007.PubMed/NCBI View Article : Google Scholar

21 

Yoshizawa A, Egawa H, Yurugi K, Hishida R, Tsuji H, Ashihara E, Miyagawa-Hayashino A, Teramukai S, Maekawa T, Haga H and Uemoto S: Significance of semiquantitative assessment of preformed donor-specific antibody using luminex single bead assay in living related liver transplantation. Clin Dev Immunol. 2013(972705)2013.PubMed/NCBI View Article : Google Scholar

22 

Chen ZH: Problems and significance of liver allograft as an immunologically privileged organ. Zhonghua Gan Zang Bing Za Zhi. 13(221)2005.PubMed/NCBI(In Chinese).

23 

Guo H: Brief summary of recent findings on pathology of antibody-mediated rejection in organ transplantation. Chin J Transplant (Electronic Edition). 6:138–143. 2012.

24 

Zhou J and Shao CK: Advances of cellular and molecular immunology of acute rejection in liver transplantation. Chin J Organ Transplant. 6:381–383. 2007.

25 

Valcnzucla NM, Hickey MJ and Reed EF: Antibody subclass repertoire and graft outcome following solid organ transplantation. Front Immunol. 7(433)2016.PubMed/NCBI View Article : Google Scholar

26 

Kaneku H, O'Leary JG, Bannuelos N, Jenning LW, Susskind BM, Klintmalm GB and Terasaki PI: De novo donor-specific HLA antibodies decrease patient and graft survival in liver transplant recipients. Am J Transplant. 13:1541–1548. 2013.PubMed/NCBI View Article : Google Scholar

27 

O'Leary JG and Klintmalm GB: Impact of donor-specific antibodies on results of liver transplantation. Curr Opin Organ Transplant. 18:279–284. 2013.PubMed/NCBI View Article : Google Scholar

28 

O'Leary JG, Kaneku H, Jennings LW, Banuelos N, Susskind BM, Terasaki PI and Klintmalm GB: Preformed class II donor-specific antibodies are associated with an increased risk of early rejection after liver transplantation. Liver Transpl. 19:973–980. 2013.PubMed/NCBI View Article : Google Scholar

29 

Böhming GA, Exner M, Habicht A, Schillinger M, Lang U, Kletzmayr J, Säemann MD, Hörl WH, Watschinger B and Regele H: Capillary C4d deposition in kidney allografts: A specific marker of alloantibody-dependent graft injury. J Am Soc Nephrol. 13:1091–1099. 2002.PubMed/NCBI View Article : Google Scholar

30 

Ali S, Ormsby A, Shah V, Segovia MC, Kantz KL, Skorupski S, Eisenbrey AB, Mahan M and Huang MA: Significance of complement split product C4d in ABO-compatible liver allograft: Diagnosing utility in acute antibody mediated rejection. Transpl Immunol. 26:62–69. 2012.PubMed/NCBI View Article : Google Scholar

31 

Del Bello A, Congy-Jolivet N, Danjoux M, Muscari F, Lavayssière L, Esposito L, Cardeau-Desangles I, Guitard J, Dörr G, Milongo D, et al: De novo donor-specific anti-HLA antibodies mediated rejection in liver-transplant patients. Transpl Int. 28:1371–1382. 2015.PubMed/NCBI View Article : Google Scholar

32 

Kovandova B, Slavcev A, Sekerkova Z, Honsova E and Trunecka P: Antibody-mediated rejection after liver transplantation-relevance of C1q and C3d-binding antibodies. HLA. 92 (Suppl 2):S34–S37. 2018.PubMed/NCBI View Article : Google Scholar

33 

Sutherland SM, Chen G, Sequeira FA, Lou CD, Alexander SR and Tyan DB: Complement-fixing donor-specific antibodies identified by a novel C1q assay are associated with allograft loss. Pediatr Transplant. 16:12–17. 2012.PubMed/NCBI View Article : Google Scholar

34 

Wilson CH, Agarwal K, Carter V, Burt AD, Hübscher S, Talbot D, Jaques BC and Manas DM: Late humoral rejection in a compliant ABO-compatible liver transplant recipient. Transplantation. 82:988–989. 2006.PubMed/NCBI View Article : Google Scholar

35 

Watson R, Kozlowski T, Nickeleit V, Woosley JT, Schmitz JL, Zacks SL, Fair JH, Gerber DA and Andreoni KA: Isolated donor specific alloantibody-mediated rejection after ABO compatible liver transplantation. Am J Transplant. 6:3022–3029. 2006.PubMed/NCBI View Article : Google Scholar

36 

Kamar N, Lavayssière L, Muscari F, Selves J, Guilbeau-Frugier C, Cardeau I, Esposito L, Cointault O, Nogier MB, Peron JM, et al: Early plasmapheresis and rituximab for acute humoral rejection after ABO-compatible liver transplantation. World J Gastroenterol. 15:3426–3430. 2009.PubMed/NCBI View Article : Google Scholar

37 

Couchonnal E, Rivet C, Ducreux S, Dumortier J, Bosch A, Boillot O, Collardeau-Frachon S, Dubois R, Hervieu V, André P, et al: Deleterious impact of C3d-binding donor-specific anti-HLA antibodies after pediatric liver transplantation. Transpl Immunol. 45:8–14. 2017.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Liu W, Wang K, Xiao Y, Liu C, Gao W and Li D: Clinical relevance of donor‑specific human leukocyte antigen antibodies after pediatric liver transplantation. Exp Ther Med 22: 867, 2021.
APA
Liu, W., Wang, K., Xiao, Y., Liu, C., Gao, W., & Li, D. (2021). Clinical relevance of donor‑specific human leukocyte antigen antibodies after pediatric liver transplantation. Experimental and Therapeutic Medicine, 22, 867. https://doi.org/10.3892/etm.2021.10299
MLA
Liu, W., Wang, K., Xiao, Y., Liu, C., Gao, W., Li, D."Clinical relevance of donor‑specific human leukocyte antigen antibodies after pediatric liver transplantation". Experimental and Therapeutic Medicine 22.2 (2021): 867.
Chicago
Liu, W., Wang, K., Xiao, Y., Liu, C., Gao, W., Li, D."Clinical relevance of donor‑specific human leukocyte antigen antibodies after pediatric liver transplantation". Experimental and Therapeutic Medicine 22, no. 2 (2021): 867. https://doi.org/10.3892/etm.2021.10299
Copy and paste a formatted citation
x
Spandidos Publications style
Liu W, Wang K, Xiao Y, Liu C, Gao W and Li D: Clinical relevance of donor‑specific human leukocyte antigen antibodies after pediatric liver transplantation. Exp Ther Med 22: 867, 2021.
APA
Liu, W., Wang, K., Xiao, Y., Liu, C., Gao, W., & Li, D. (2021). Clinical relevance of donor‑specific human leukocyte antigen antibodies after pediatric liver transplantation. Experimental and Therapeutic Medicine, 22, 867. https://doi.org/10.3892/etm.2021.10299
MLA
Liu, W., Wang, K., Xiao, Y., Liu, C., Gao, W., Li, D."Clinical relevance of donor‑specific human leukocyte antigen antibodies after pediatric liver transplantation". Experimental and Therapeutic Medicine 22.2 (2021): 867.
Chicago
Liu, W., Wang, K., Xiao, Y., Liu, C., Gao, W., Li, D."Clinical relevance of donor‑specific human leukocyte antigen antibodies after pediatric liver transplantation". Experimental and Therapeutic Medicine 22, no. 2 (2021): 867. https://doi.org/10.3892/etm.2021.10299
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