Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
August-2021 Volume 22 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2021 Volume 22 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Mediators of extracellular matrix degradation and inflammation: A new team of possible biomarkers for oral squamous cell carcinoma stage

  • Authors:
    • Radu Radulescu
    • Alexandra Ripszky Totan
    • Marina Melescanu Imre
    • Daniela Miricescu
    • Andreea Didilescu
    • Maria Greabu
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry, Faculty of Dental Medicine, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania, Department of Complete Denture, Faculty of Dental Medicine, ‘Carol Davila’ University of Medicine and Pharmacy, 032799 Bucharest, Romania, Department of Embryology, Faculty of Dental Medicine, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania
    Copyright: © Radulescu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 877
    |
    Published online on: June 15, 2021
       https://doi.org/10.3892/etm.2021.10309
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Oral cancer represents one of the most common types of cancer worldwide, with oral squamous cell carcinoma (OSCC) being the most frequently diagnosed. Cytokines play a crucial role in inflammation, apoptosis and metastasis. Interleukin (IL)‑8 promotes the direct migration of inflammatory cells. IL‑6 induces tumor cell proliferation, increases expression of invasiveness and angiogenetic factors or matrix metalloproteinases (MMPs), promoting metastasis. Tissue inhibitor of metalloproteinases (TIMPs) blocks the action of MMPs controlling extracellular matrix degradation and inhibiting metastasis. The aim of our study was to analyze the existence of correlations between inflammation markers (IL‑6 and IL‑8) and extracellular degradation protection markers such as TIMP‑1 in OSCC tumors. Our study included 20 patients (12 females and 8 males) diagnosed with OSCC, recruited from January to April, 2020. IL‑8, IL‑6 and TIMP‑1 levels were measured in the tumor cell lysates by ELISA technique, using relevant assay kits. Our results showed a positive and significant correlation between IL‑6 and IL‑8 (P=0.005, R=0.517) indicating that high IL‑8 levels can be associated with high IL‑6 levels. We also found a significant and high negative correlation (P<0.001, R=‑0.673) between IL‑6 and TIMP‑1 and a significant and high negative correlation (P<0.001, R=‑0.684) between IL‑8 and TIMP‑1 indicating that high levels of IL‑8 and IL‑6 are significantly associated with lower levels of TIMP‑1. In conclusion, our study confirms the available literature data on IL‑6 and IL‑8 as potential markers for oral cancers such as OSCC and affect the tumor microenvironment by decreasing TIMPs. All three biomarkers included in this study have the potential to be used as detection or prognostic factors for oral cancer.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Ghantous Y and Abu Elnaaj I: Global incidence and risk factors of oral cancer (In Hebrew). Harefuah. 156:645–649. 2017.PubMed/NCBI

2 

Rivera C: Essentials of oral cancer. Int J Clin Exp Pathol. 8:11884–11894. 2015.PubMed/NCBI

3 

Liu D, Yang F, Xiong F and Gu N: The smart drug delivery system and its clinical potential. Theranostics. 6:1306–1323. 2016.PubMed/NCBI View Article : Google Scholar

4 

Hema KN, Smitha T, Sheethal HS and Mirnalini SA: Epigenetics in oral squamous cell carcinoma. J Oral Maxillofac Pathol. 21:252–259. 2017.PubMed/NCBI View Article : Google Scholar

5 

Wong T and Wiesenfeld D: Oral cancer. Aust Dent J. 63 (Suppl 1):S91–S99. 2018.PubMed/NCBI View Article : Google Scholar

6 

Bais MV: Impact of epigenetic regulation on head and neck squamous cell carcinoma. J Dent Res. 98:268–276. 2019.PubMed/NCBI View Article : Google Scholar

7 

Scully C and Kirby J: Statement on mouth cancer diagnosis and prevention. Br Dent J. 216:37–38. 2014.PubMed/NCBI View Article : Google Scholar

8 

Kalavrezos N and Scully C: Mouth cancer for clinicians part 7: Cancer diagnosis and pre-treatment preparation. Dent Update. 43:50–54, 57-60, 63-65. 2016.PubMed/NCBI View Article : Google Scholar

9 

Sahibzada HA, Khurshid Z, Khan RS, Naseem M, Siddique KM, Mali M and Zafar MS: Salivary IL-8, IL-6 and TNF-α as potential diagnostic biomarkers for oral cancer. Diagnostics (Basel). 7(21)2017.PubMed/NCBI View Article : Google Scholar

10 

Cheng YS, Rees T and Wright J: A review of research on salivary biomarkers for oral cancer detection. Clin Transl Med. 3(3)2014.PubMed/NCBI View Article : Google Scholar

11 

Hussein AA, Forouzanfar T, Bloemena E, de Visscher J, Brakenhoff RH, Leemans CR and Helder MN: A review of the most promising biomarkers for early diagnosis and prognosis prediction of tongue squamous cell carcinoma. Br J Cancer. 119:724–736. 2018.PubMed/NCBI View Article : Google Scholar

12 

Lee S and Margolin K: Cytokines in cancer immunotherapy. Cancers (Basel). 3:3856–3893. 2011.PubMed/NCBI View Article : Google Scholar

13 

David JM, Dominguez C, Hamilton DH and Palena C: The IL-8/IL-8R axis: A double agent in tumor immune resistance. Vaccines (Basel). 4(22)2016.PubMed/NCBI View Article : Google Scholar

14 

Waugh DJ and Wilson C: The interleukin-8 pathway in cancer. Clin Cancer Res. 14:6735–6341. 2008.PubMed/NCBI View Article : Google Scholar

15 

De Larco JE, Wuertz BR and Furcht LT: The potential role of neutrophils in promoting the metastatic phenotype of tumors releasing interleukin-8. Clin Cancer Res. 10:4895–4900. 2004.PubMed/NCBI View Article : Google Scholar

16 

Long X, Ye Y, Zhang L, Liu P, Yu W, Wei F, Ren X and Yu J: IL-8, a novel messenger to cross-link inflammation and tumor EMT via autocrine and paracrine pathways (Review). Int J Oncol. 48:5–12. 2016.PubMed/NCBI View Article : Google Scholar

17 

Kumari N, Dwarakanath BS, Das A and Bhatt AN: Role of interleukin-6 in cancer progression and therapeutic resistance. Tumour Biol. 37:11553–11572. 2016.PubMed/NCBI View Article : Google Scholar

18 

Johnson DE, O'Keefe RA and Grandis JR: Targeting the IL-6/JAK/STAT3 signalling axis in cancer. Nat Rev Clin Oncol. 15:234–248. 2018.PubMed/NCBI View Article : Google Scholar

19 

Lee H, Pal SK, Reckamp K, Figlin RA and Yu H: STAT3: A target to enhance antitumor immune response. Curr Top Microbiol Immunol. 344:41–59. 2011.PubMed/NCBI View Article : Google Scholar

20 

Visse R and Nagase H: Matrix metalloproteinases and tissue inhibitors of metalloproteinases: Structure, function, and biochemistry. Circ Res. 92:827–839. 2003.PubMed/NCBI View Article : Google Scholar

21 

Cui N, Hu M and Khalil RA: Biochemical and biological attributes of matrix metalloproteinases. Prog Mol Biol Transl Sci. 147:1–73. 2017.PubMed/NCBI View Article : Google Scholar

22 

Arpino V, Brock M and Gill SE: The role of TIMPs in regulation of extracellular matrix proteolysis. Matrix Biol. 44-46:247–254. 2015.PubMed/NCBI View Article : Google Scholar

23 

Brew K and Nagase H: The tissue inhibitors of metalloproteinases (TIMPs): An ancient family with structural and functional diversity. Biochim Biophys Acta. 1803:55–71. 2010.PubMed/NCBI View Article : Google Scholar

24 

Coussens LM and Werb Z: Inflammation and cancer. Nature. 420:860–867. 2002.PubMed/NCBI View Article : Google Scholar

25 

Singh N, Baby D, Rajguru JP, Patil PB, Thakkannavar SS and Pujari VB: Inflammation and cancer. Ann Afr Med. 18:121–126. 2019.PubMed/NCBI View Article : Google Scholar

26 

Hanahan D and Weinberg RA: Hallmarks of cancer: The next generation. Cell. 144:646–674. 2011.PubMed/NCBI View Article : Google Scholar

27 

Clevers H: At the crossroads of inflammation and cancer. Cell. 118:671–674. 2004.PubMed/NCBI View Article : Google Scholar

28 

Mantovani A: Cancer: Inflammation by remote control. Nature. 435:752–753. 2005.PubMed/NCBI View Article : Google Scholar

29 

Ha H, Debnath B and Neamati N: Role of the CXCL8-CXCR1/2 axis in cancer and inflammatory diseases. Theranostics. 7:1543–1588. 2017.PubMed/NCBI View Article : Google Scholar

30 

Todorović-Raković N and Milovanović J: Interleukin-8 in breast cancer progression. J Interferon Cytokine Res. 33:563–570. 2013.PubMed/NCBI View Article : Google Scholar

31 

Brandolini L, Bertini R, Bizzarri C, Sergi R, Caselli G, Zhou D, Locati M and Sozzani S: IL-1 beta primes IL-8-activated human neutrophils for elastase release, phospholipase D activity, and calcium flux. J Leukoc Biol. 59:427–434. 1996.PubMed/NCBI View Article : Google Scholar

32 

Tappia PS, Dent MR and Dhalla NS: Oxidative stress and redox regulation of phospholipase D in myocardial disease. Free Radic Biol Med. 41:349–361. 2006.PubMed/NCBI View Article : Google Scholar

33 

Li A, Dubey S, Varney ML, Dave BJ and Singh RK: IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis. J Immunol. 170:3369–3376. 2003.PubMed/NCBI View Article : Google Scholar

34 

Khurram SA, Bingle L, McCabe BM, Farthing PM and Whawell SA: The chemokine receptors CXCR1 and CXCR2 regulate oral cancer cell behaviour. J Oral Pathol Med. 43:667–674. 2014.PubMed/NCBI View Article : Google Scholar

35 

Siesser PM and Hanks SK: The signaling and biological implications of FAK overexpression in cancer. Clin Cancer Res. 12:3233–3237. 2006.PubMed/NCBI View Article : Google Scholar

36 

Kopetz S, Shah AN and Gallick GE: Src continues aging: Current and future clinical directions. Clin Cancer Res. 13:7232–7236. 2007.PubMed/NCBI View Article : Google Scholar

37 

Bournazou E and Bromberg J: Targeting the tumor microenvironment: JAK-STAT3 signaling. JAKSTAT. 2(e23828)2013.PubMed/NCBI View Article : Google Scholar

38 

Walter M, Liang S, Ghosh S, Hornsby PJ and Li R: Interleukin 6 secreted from adipose stromal cells promotes migration and invasion of breast cancer cells. Oncogene. 28:2745–2755. 2009.PubMed/NCBI View Article : Google Scholar

39 

Kurosaka M and Machida S: Interleukin-6-induced satellite cell proliferation is regulated by induction of the JAK2/STAT3 signalling pathway through cyclin D1 targeting. Cell Prolif. 46:365–373. 2013.PubMed/NCBI View Article : Google Scholar

40 

Adachi Y, Aoki C, Yoshio-Hoshino N, Takayama K, Curiel DT and Nishimoto N: Interleukin-6 induces both cell growth and VEGF production in malignant mesotheliomas. Int J Cancer. 119:1303–1311. 2006.PubMed/NCBI View Article : Google Scholar

41 

Rokavec M, Öner MG and Hermeking H: Inflammation-induced epigenetic switches in cancer. Cell Mol Life Sci. 73:23–39. 2016.PubMed/NCBI View Article : Google Scholar

42 

Chang Q, Bournazou E, Sansone P, Berishaj M, Gao SP, Daly L, Wels J, Theilen T, Granitto S, Zhang X, et al: The IL-6/JAK/Stat3 feed-forward loop drives tumorigenesis and metastasis. Neoplasia. 15:848–862. 2013.PubMed/NCBI View Article : Google Scholar

43 

O-Charoenrat P, Rhys-Evans PH and Eccles SA: Expression of matrix metalloproteinases and their inhibitors correlates with invasion and metastasis in squamous cell carcinoma of the head and neck. Arch Otolaryngol Head Neck Surg. 127:813–820. 2001.PubMed/NCBI

44 

Patterson ML, Atkinson SJ, Knäuper V and Murphy G: Specific collagenolysis by gelatinase A, MMP-2, is determined by the hemopexin domain and not the fibronectin-like domain. FEBS Lett. 503:158–162. 2001.PubMed/NCBI View Article : Google Scholar

45 

Georgescu EF, Mogoantă SŞ, Costache A, Pârvănescu V, Totolici BD, Pătraşcu Ş and Stănescu C: The assessment of matrix metalloproteinase-9 expression and angiogenesis in colorectal cancer. Rom J Morphol Embryol. 56:1137–1144. 2015.PubMed/NCBI

46 

Maciejczyk M, Pietrzykowska A, Zalewska A, Knaś M and Daniszewska I: The significance of matrix metalloproteinases in oral diseases. Adv Clin Exp Med. 25:383–390. 2016.PubMed/NCBI View Article : Google Scholar

47 

Su CW, Lin CW, Yang WE and Yang SF: TIMP-3 as a therapeutic target for cancer. Ther Adv Med Oncol. 11(1758835919864247)2019.PubMed/NCBI View Article : Google Scholar

48 

Jiang Y, Goldberg ID and Shi YE: Complex roles of tissue inhibitors of metalloproteinases in cancer. Oncogene. 21:2245–2252. 2002.PubMed/NCBI View Article : Google Scholar

49 

Lu YC, Chang JT, Liao CT, Kang CJ, Huang SF, Chen IH, Huang CC, Huang YC, Chen WH, Tsai CY, et al: OncomiR-196 promotes an invasive phenotype in oral cancer through the NME4-JNK-TIMP1-MMP signaling pathway. Mol Cancer. 13(218)2014.PubMed/NCBI View Article : Google Scholar

50 

St John MA, Li Y, Zhou X, Denny P, Ho CM, Montemagno C, Shi W, Qi F, Wu B, Sinha U, et al: Interleukin 6 and interleukin 8 as potential biomarkers for oral cavity and oropharyngeal squamous cell carcinoma. Arch Otolaryngol Head Neck Surg. 130:929–935. 2004.PubMed/NCBI View Article : Google Scholar

51 

SahebJamee M, Eslami M, AtarbashiMoghadam F and Sarafnejad A: Salivary concentration of TNFalpha, IL1 alpha, IL6, and IL8 in oral squamous cell carcinoma. Med Oral Patol Oral Cir Bucal. 13:E292–E295. 2008.PubMed/NCBI

52 

Punyani SR and Sathawane RS: Salivary level of interleukin-8 in oral precancer and oral squamous cell carcinoma. Clin Oral Investig. 17:517–524. 2013.PubMed/NCBI View Article : Google Scholar

53 

Lotfi A, Shahidi N, Bayazian G, AbdollahiFakhim S, Estakhri R, Esfahani A and Notash R: Serum level of interleukin-6 in patients with oral tongue squamous cell carcinoma. Iran J Otorhinolaryngol. 27:207–211. 2015.PubMed/NCBI

54 

Rezaei F, Mozaffari HR, Tavasoli J, Zavattaro E, Imani MM and Sadeghi M: Evaluation of serum and salivary interleukin-6 and interleukin-8 levels in oral squamous cell carcinoma patients: Systematic review and meta-analysis. J Interferon Cytokine Res. 39:727–739. 2019.PubMed/NCBI View Article : Google Scholar

55 

Berghi NO, Dumitru M, Vrinceanu D, Ciuluvica RC, Simioniuc-Petrescu A, Caragheorgheopol R, Tucureanu C, Cornateanu RS and Giurcaneanu C: Relationship between chemokines and T lymphocytes in the context of respiratory allergies (Review). Exp Ther Med. 20:2352–2360. 2020.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Radulescu R, Totan AR, Imre MM, Miricescu D, Didilescu A and Greabu M: Mediators of extracellular matrix degradation and inflammation: A new team of possible biomarkers for oral squamous cell carcinoma stage. Exp Ther Med 22: 877, 2021.
APA
Radulescu, R., Totan, A.R., Imre, M.M., Miricescu, D., Didilescu, A., & Greabu, M. (2021). Mediators of extracellular matrix degradation and inflammation: A new team of possible biomarkers for oral squamous cell carcinoma stage. Experimental and Therapeutic Medicine, 22, 877. https://doi.org/10.3892/etm.2021.10309
MLA
Radulescu, R., Totan, A. R., Imre, M. M., Miricescu, D., Didilescu, A., Greabu, M."Mediators of extracellular matrix degradation and inflammation: A new team of possible biomarkers for oral squamous cell carcinoma stage". Experimental and Therapeutic Medicine 22.2 (2021): 877.
Chicago
Radulescu, R., Totan, A. R., Imre, M. M., Miricescu, D., Didilescu, A., Greabu, M."Mediators of extracellular matrix degradation and inflammation: A new team of possible biomarkers for oral squamous cell carcinoma stage". Experimental and Therapeutic Medicine 22, no. 2 (2021): 877. https://doi.org/10.3892/etm.2021.10309
Copy and paste a formatted citation
x
Spandidos Publications style
Radulescu R, Totan AR, Imre MM, Miricescu D, Didilescu A and Greabu M: Mediators of extracellular matrix degradation and inflammation: A new team of possible biomarkers for oral squamous cell carcinoma stage. Exp Ther Med 22: 877, 2021.
APA
Radulescu, R., Totan, A.R., Imre, M.M., Miricescu, D., Didilescu, A., & Greabu, M. (2021). Mediators of extracellular matrix degradation and inflammation: A new team of possible biomarkers for oral squamous cell carcinoma stage. Experimental and Therapeutic Medicine, 22, 877. https://doi.org/10.3892/etm.2021.10309
MLA
Radulescu, R., Totan, A. R., Imre, M. M., Miricescu, D., Didilescu, A., Greabu, M."Mediators of extracellular matrix degradation and inflammation: A new team of possible biomarkers for oral squamous cell carcinoma stage". Experimental and Therapeutic Medicine 22.2 (2021): 877.
Chicago
Radulescu, R., Totan, A. R., Imre, M. M., Miricescu, D., Didilescu, A., Greabu, M."Mediators of extracellular matrix degradation and inflammation: A new team of possible biomarkers for oral squamous cell carcinoma stage". Experimental and Therapeutic Medicine 22, no. 2 (2021): 877. https://doi.org/10.3892/etm.2021.10309
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team