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LncRNA SNHG11 aggravates cell proliferation and migration in triple‑negative breast cancer via sponging miR‑2355‑5p and targeting CBX5

  • Authors:
    • Lei Yu
    • Wei Zhang
    • Peng Wang
    • Qi Zhang
    • Aihua Cong
    • Xiuyuan Yang
    • Kai Sang
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Jiangsu Taizhou People's Hospital, Taizhou, Jiangsu 225300, P.R. China, Department of Infectious Diseases, Jiangsu Taizhou People's Hospital, Taizhou, Jiangsu 225300, P.R. China, Department of Breast Surgery, Jiangsu Taizhou People's Hospital, Taizhou, Jiangsu 225300, P.R. China
    Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 892
    |
    Published online on: June 18, 2021
       https://doi.org/10.3892/etm.2021.10324
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Abstract

Triple‑negative breast cancer (TNBC) is one of the most common malignances worldwide. Concurrently, the incidence of TNBC has continued to rise in recent years. It is reported that long non‑coding RNAs (lncRNAs) are involved in biological processes in numerous cancers including TNBC. Small nucleolar RNA host gene 11 (SNHG11) has already been studied and reported in some cancers. However, the role of SNHG11 in TNBC remains unknown. RT‑qPCR was used to measure gene expression in the current study. CCK‑8, colony formation, flow cytometry, Transwell and western blotting experiments were also performed to determine the biological function of SNHG11 in TNBC cells. Luciferase reporter and RIP assays were performed to measure relationship between genes. In the present study, the results indicated SNHG11 was highly expressed in TNBC tissues and cell lines. Moreover, SNHG11 aggravated cell proliferation and migration, and whereas it attenuated cell apoptosis in TNBC. Furthermore, SNHG11 sponged microRNA 2355‑5p (miR‑2355‑5p) in TNBC. Silencing SNHG11 increased miR‑2355‑5p expression. In addition, chromobox 5 (CBX5) was identified to be targeted by miR‑2355‑5p in TNBC. It was also suggested that CBX5 silencing suppressed cell proliferation and migration. Furthermore, overexpressed CBX5 recovered the inhibitive influence of SNHG11 silencing on proliferative and migrative abilities of TNBC cells. Overall, SNHG11 acted as a tumor promoter in TNBC and regulated TNBC cell growth by modulating the miR‑2355‑5p/CBX5 axis, which indicated that it may be used as a biomarker for TNBC treatment.
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1 

DeSantis CE, Miller KD, Goding Sauer A, Jemal A and Siegel RL: Cancer statistics for African Americans, 2019. CA Cancer J Clin. 69:211–233. 2019.PubMed/NCBI View Article : Google Scholar

2 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018.PubMed/NCBI View Article : Google Scholar

3 

Bergin ART and Loi S: Triple-negative breast cancer: Recent treatment advances. F1000Res. 8(1342)2019.PubMed/NCBI View Article : Google Scholar

4 

Lyons TG and Traina TA: Emerging novel therapeutics in triple-negative breast cancer. Adv Exp Med Biol. 1152:377–399. 2019.PubMed/NCBI View Article : Google Scholar

5 

Torre LA, Siegel RL, Ward EM and Jemal A: Global cancer incidence and mortality rates and trends-an update. Cancer Epidemiol Biomarkers Prev. 25:16–27. 2016.PubMed/NCBI View Article : Google Scholar

6 

Hombach S and Kretz M: Non-coding RNAs: Classification, biology and functioning. Adv Exp Med Biol. 937:3–17. 2016.PubMed/NCBI View Article : Google Scholar

7 

Riva P, Ratti A and Venturin M: The long non-coding RNAs in neurodegenerative diseases: Novel mechanisms of pathogenesis. Curr Alzheimer Res. 13:1219–1231. 2016.PubMed/NCBI View Article : Google Scholar

8 

Chu C, Quinn J and Chang HY: Chromatin isolation by RNA purification (ChIRP). J Vis Exp. 61(e3912)2012.PubMed/NCBI View Article : Google Scholar

9 

Mercer TR and Mattick JS: Structure and function of long noncoding RNAs in epigenetic regulation. Nat Struct Mol Biol. 20:300–307. 2013.PubMed/NCBI View Article : Google Scholar

10 

Ju C, Liu R, Zhang YW, Zhang Y, Zhou R, Sun J, Lv XB and Zhang Z: Mesenchymal stem cell-associated lncRNA in osteogenic differentiation. Biomed Pharmacother. 115(108912)2019.PubMed/NCBI View Article : Google Scholar

11 

Bhan A, Soleimani M and Mandal SS: Long noncoding RNA and cancer: A new paradigm. Cancer Res. 77:3965–3981. 2017.PubMed/NCBI View Article : Google Scholar

12 

Zheng D, Chen D, Lin F, Wang X, Lu L, Luo S, Chen J and Xu X: LncRNA NNT-AS1 promote glioma cell proliferation and metastases through miR-494-3p/PRMT1 axis. Cell Cycle. 19:1621–1631. 2020.PubMed/NCBI View Article : Google Scholar

13 

Li Y and Jiang A: ST8SIA6-AS1 promotes hepatocellular carcinoma by absorbing miR-5195-3p to regulate HOXB6. Cancer Biol Ther. 21:647–655. 2020.PubMed/NCBI View Article : Google Scholar

14 

Liu T, Wang X, Zhai J, Wang Q and Zhang B: Long noncoding RNA UCA1 facilitates endometrial cancer development by regulating KLF5 and RXFP1 gene expressions. Cancer Biother Radiopharm: May 15, 2020 (Epub ahead of print).

15 

Liu S, Yang N, Wang L, Wei B, Chen J and Gao Y: lncRNA SNHG11 promotes lung cancer cell proliferation and migration via activation of Wnt/β-catenin signaling pathway. J Cell Physiol. 235:7541–7553. 2020.PubMed/NCBI View Article : Google Scholar

16 

Bicak M, Wang X, Gao X, Xu X, Väänänen RM, Taimen P, Lilja H, Pettersson K and Klein RJ: Prostate cancer risk SNP rs10993994 is a trans-eQTL for SNHG11 mediated through MSMB. Hum Mol Genet. 29:1581–1591. 2020.PubMed/NCBI View Article : Google Scholar

17 

Huang W, Huang F, Lei Z and Luo H: LncRNA SNHG11 promotes proliferation, migration, apoptosis, and autophagy by regulating hsa-miR-184/AGO2 in HCC. Onco Targets Ther. 13:413–421. 2020.PubMed/NCBI View Article : Google Scholar

18 

Simonson B and Das S: MicroRNA therapeutics: The next magic bullet? Mini Rev Med Chem. 15:467–474. 2015.PubMed/NCBI View Article : Google Scholar

19 

Morales S, Monzo M and Navarro A: Epigenetic regulation mechanisms of microRNA expression. Biomol Concepts. 8:203–212. 2017.PubMed/NCBI View Article : Google Scholar

20 

Jámbor I, Szabó K, Zeher M and Papp G: The importance of microRNAs in the development of systemic autoimmune disorders. Orv Hetil. 160:563–572. 2019.PubMed/NCBI View Article : Google Scholar : (In Hu).

21 

Yan K, Hou L, Liu T, Jiao W, Ma Q, Fang Z, Zhang S, Song D, Liu J, Gao X and Fan Y: lncRNA OGFRP1 functions as a ceRNA to promote the progression of prostate cancer by regulating SARM1 level via miR-124-3p. Aging (Albany NY). 12:8880–8892. 2020.PubMed/NCBI View Article : Google Scholar

22 

Li Y, Liang M, Zhang Y, Yuan B, Gao W, Shi Z and Bai J: miR-93, miR-373, and miR-17-5p negatively regulate the expression of TBP2 in lung cancer. Front Oncol. 10(526)2020.PubMed/NCBI View Article : Google Scholar

23 

Cheng C, Zhang Z, Cheng F and Shao Z: Exosomal lncRNA RAMP2-AS1 derived from chondrosarcoma cells promotes angiogenesis through miR-2355-5p/VEGFR2 axis. Onco Targets Ther. 13:3291–3301. 2020.PubMed/NCBI View Article : Google Scholar

24 

Chen D, Chen J, Gao J, Zhang Y, Ma Y, Wei W and Wei Y: LncRNA DDX11-AS1 promotes bladder cancer occurrence via protecting LAMB3 from downregulation by sponging miR-2355-5p. Cancer Biother Radiopharm. 35:319–328. 2020.PubMed/NCBI View Article : Google Scholar

25 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

26 

Soudyab M, Iranpour M and Ghafouri-Fard S: The role of long non-coding RNAs in breast cancer. Arch Iran Med. 19:508–517. 2016.PubMed/NCBI

27 

Paraskevopoulou MD and Hatzigeorgiou AG: Analyzing miRNA-lncRNA interactions. Methods Mol Biol. 1402:271–286. 2016.PubMed/NCBI View Article : Google Scholar

28 

Guil S and Esteller M: RNA-RNA interactions in gene regulation: The coding and noncoding players. Trends Biochem Sci. 40:248–256. 2015.PubMed/NCBI View Article : Google Scholar

29 

Karreth FA and Pandolfi PP: ceRNA cross-talk in cancer: When ce-bling rivalries go awry. Cancer Discov. 3:1113–1121. 2013.PubMed/NCBI View Article : Google Scholar

30 

Guo J, Zhang Z, Pan L and Zhou Y: Identification of miR-758-3p as potential modulator of CBX5 expression in gastric cancer. Technol Cancer Res Treat. 17(1533033818816061)2018.PubMed/NCBI View Article : Google Scholar

31 

Pongas G, Kim MK, Min DJ, House CD, Jordan E, Caplen N, Chakka S, Ohiri J, Kruhlak MJ and Annunziata CM: BRD4 facilitates DNA damage response and represses CBX5/Heterochromatin protein 1 (HP1). Oncotarget. 8:51402–51415. 2017.PubMed/NCBI View Article : Google Scholar

32 

Smillie CL, Sirey T and Ponting CP: Complexities of post-transcriptional regulation and the modeling of ceRNA crosstalk. Crit Rev Biochem Mol Biol. 53:231–245. 2018.PubMed/NCBI View Article : Google Scholar

33 

Romero-Barrios N, Legascue MF, Benhamed M, Ariel F and Crespi M: Splicing regulation by long noncoding RNAs. Nucleic Acids Res. 46:2169–2184. 2018.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Yu L, Zhang W, Wang P, Zhang Q, Cong A, Yang X and Sang K: LncRNA SNHG11 aggravates cell proliferation and migration in triple‑negative breast cancer via sponging miR‑2355‑5p and targeting CBX5. Exp Ther Med 22: 892, 2021.
APA
Yu, L., Zhang, W., Wang, P., Zhang, Q., Cong, A., Yang, X., & Sang, K. (2021). LncRNA SNHG11 aggravates cell proliferation and migration in triple‑negative breast cancer via sponging miR‑2355‑5p and targeting CBX5. Experimental and Therapeutic Medicine, 22, 892. https://doi.org/10.3892/etm.2021.10324
MLA
Yu, L., Zhang, W., Wang, P., Zhang, Q., Cong, A., Yang, X., Sang, K."LncRNA SNHG11 aggravates cell proliferation and migration in triple‑negative breast cancer via sponging miR‑2355‑5p and targeting CBX5". Experimental and Therapeutic Medicine 22.2 (2021): 892.
Chicago
Yu, L., Zhang, W., Wang, P., Zhang, Q., Cong, A., Yang, X., Sang, K."LncRNA SNHG11 aggravates cell proliferation and migration in triple‑negative breast cancer via sponging miR‑2355‑5p and targeting CBX5". Experimental and Therapeutic Medicine 22, no. 2 (2021): 892. https://doi.org/10.3892/etm.2021.10324
Copy and paste a formatted citation
x
Spandidos Publications style
Yu L, Zhang W, Wang P, Zhang Q, Cong A, Yang X and Sang K: LncRNA SNHG11 aggravates cell proliferation and migration in triple‑negative breast cancer via sponging miR‑2355‑5p and targeting CBX5. Exp Ther Med 22: 892, 2021.
APA
Yu, L., Zhang, W., Wang, P., Zhang, Q., Cong, A., Yang, X., & Sang, K. (2021). LncRNA SNHG11 aggravates cell proliferation and migration in triple‑negative breast cancer via sponging miR‑2355‑5p and targeting CBX5. Experimental and Therapeutic Medicine, 22, 892. https://doi.org/10.3892/etm.2021.10324
MLA
Yu, L., Zhang, W., Wang, P., Zhang, Q., Cong, A., Yang, X., Sang, K."LncRNA SNHG11 aggravates cell proliferation and migration in triple‑negative breast cancer via sponging miR‑2355‑5p and targeting CBX5". Experimental and Therapeutic Medicine 22.2 (2021): 892.
Chicago
Yu, L., Zhang, W., Wang, P., Zhang, Q., Cong, A., Yang, X., Sang, K."LncRNA SNHG11 aggravates cell proliferation and migration in triple‑negative breast cancer via sponging miR‑2355‑5p and targeting CBX5". Experimental and Therapeutic Medicine 22, no. 2 (2021): 892. https://doi.org/10.3892/etm.2021.10324
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