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Effect of fibulin‑5 on aldosterone‑induced apoptosis in human ascending aortic smooth muscle cells

  • Authors:
    • Yongji Yan
    • Xujie Liu
    • Xuanchen Li
    • Xuan Zhou
    • Chaozhi Yang
    • Jintao Tian
    • Jun Pu
    • Xiaoqun Niu
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Beijing University of Chinese Medicine Dongzhimen Hospital, Beijing 100700, P.R. China, Department of Neurosurgery, Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650101, P.R. China, Department of Pneumology, Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650101, P.R. China
    Copyright: © Yan et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].
  • Article Number: 896
    |
    Published online on: June 23, 2021
       https://doi.org/10.3892/etm.2021.10328
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Abstract

The aim of the current study was to investigate the effect of aldosterone on apoptosis in human aortic smooth muscle cells (HA‑VSMC) and to determine the role of fibulin‑5 in the aldosterone‑induced apoptosis of HA‑VSMC cells. Through the construction of a fibulin‑5 eukaryotic overexpression vector and a short hairpin RNA interference plasmid, fibulin‑5 was overexpressed and silenced, respectively. The role of fibulin‑5 in the aldosterone‑induced apoptosis of HA‑VSMC was subsequently determined. The overexpression of fibulin‑5 inhibited the apoptosis of cells, particularly at low concentrations of aldosterone; a smaller effect on apoptosis was induced by high concentrations of aldosterone. fibulin‑5 knockdown promoted the apoptosis of cells induced by high concentrations of aldosterone but had a smaller effect on the apoptosis of cells induced by low concentrations of aldosterone. Therefore, the results of the current study indicate that fibulin‑5 inhibits the aldosterone‑induced apoptosis of HA‑VSMC cells and that this effect may be altered by changing the aldosterone concentration.
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Copy and paste a formatted citation
Spandidos Publications style
Yan Y, Liu X, Li X, Zhou X, Yang C, Tian J, Pu J and Niu X: Effect of fibulin‑5 on aldosterone‑induced apoptosis in human ascending aortic smooth muscle cells. Exp Ther Med 22: 896, 2021.
APA
Yan, Y., Liu, X., Li, X., Zhou, X., Yang, C., Tian, J. ... Niu, X. (2021). Effect of fibulin‑5 on aldosterone‑induced apoptosis in human ascending aortic smooth muscle cells. Experimental and Therapeutic Medicine, 22, 896. https://doi.org/10.3892/etm.2021.10328
MLA
Yan, Y., Liu, X., Li, X., Zhou, X., Yang, C., Tian, J., Pu, J., Niu, X."Effect of fibulin‑5 on aldosterone‑induced apoptosis in human ascending aortic smooth muscle cells". Experimental and Therapeutic Medicine 22.2 (2021): 896.
Chicago
Yan, Y., Liu, X., Li, X., Zhou, X., Yang, C., Tian, J., Pu, J., Niu, X."Effect of fibulin‑5 on aldosterone‑induced apoptosis in human ascending aortic smooth muscle cells". Experimental and Therapeutic Medicine 22, no. 2 (2021): 896. https://doi.org/10.3892/etm.2021.10328
Copy and paste a formatted citation
x
Spandidos Publications style
Yan Y, Liu X, Li X, Zhou X, Yang C, Tian J, Pu J and Niu X: Effect of fibulin‑5 on aldosterone‑induced apoptosis in human ascending aortic smooth muscle cells. Exp Ther Med 22: 896, 2021.
APA
Yan, Y., Liu, X., Li, X., Zhou, X., Yang, C., Tian, J. ... Niu, X. (2021). Effect of fibulin‑5 on aldosterone‑induced apoptosis in human ascending aortic smooth muscle cells. Experimental and Therapeutic Medicine, 22, 896. https://doi.org/10.3892/etm.2021.10328
MLA
Yan, Y., Liu, X., Li, X., Zhou, X., Yang, C., Tian, J., Pu, J., Niu, X."Effect of fibulin‑5 on aldosterone‑induced apoptosis in human ascending aortic smooth muscle cells". Experimental and Therapeutic Medicine 22.2 (2021): 896.
Chicago
Yan, Y., Liu, X., Li, X., Zhou, X., Yang, C., Tian, J., Pu, J., Niu, X."Effect of fibulin‑5 on aldosterone‑induced apoptosis in human ascending aortic smooth muscle cells". Experimental and Therapeutic Medicine 22, no. 2 (2021): 896. https://doi.org/10.3892/etm.2021.10328
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