Comparison of safety and efficacy between laparoscopic myomectomy and traditional laparotomy for patients with uterine fibroids and their effect on pregnancy rate after surgery

Kan,Xueqiao; Shen,Xiaoxia; Feng,Li; Hu,Yuqing; Yu,Jiadong; Yang,Xiaoju

doi:10.3892/etm.2021.10345

Comparison of safety and efficacy between laparoscopic myomectomy and traditional laparotomy for patients with uterine fibroids and their effect on pregnancy rate after surgery

Authors:
- Xueqiao Kan
- Xiaoxia Shen
- Li Feng
- Yuqing Hu
- Jiadong Yu
- Xiaoju Yang
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Affiliations: Delivery Room, Zhangqiu District Maternal and Child Health Care Hospital, Jinan, Shandong 250200, P.R. China, Department of Nursing, Zhangqiu District Maternal and Child Health Care Hospital, Jinan, Shandong 250200, P.R. China, Department of Obstetrics, The People's Hospital of Zhangqiu Area, Jinan, Shandong 250200, P.R. China, Department of Endocrinology, The People's Hospital of Zhangqiu Area, Jinan, Shandong 250200, P.R. China, Department of Personnel, The People's Hospital of Zhangqiu Area, Jinan, Shandong 250200, P.R. China, Department of Obstetrics, East Hospital of Tongji University, Shanghai 200120, P.R. China
Published online on: June 29, 2021 https://doi.org/10.3892/etm.2021.10345
Article Number: 913

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Abstract

The aim of this retrospective study was to compare the safety and efficacy between laparoscopic myomectomy and traditional laparotomy for patients with uterine fibroids and determine their effect on the pregnancy rate after surgery. In total, 86 cases with uterine fibroids were selected among patients who were admitted in the Zhangqiu District Maternal and Child Health Care Hospital during the period of April, 2016 to April, 2017. Patients who underwent laparoscopic myomectomy were enrolled in group A (n=42), and those who underwent traditional laparotomy were placed in group B (n=44). The general linear data and the operative indicators were compared. The VAS scores, serum IFN‑γ, IL‑6, VEGF levels and clinical efficacy of the two groups were also compared one week after surgery. Postoperative pregnancy rates and complications in both groups were also compared. No significant differences were observed in general data between the two groups (P>0.05). The intra‑operative blood loss in the group A was lower than that in group B (P<0.05), the average time of operation, hospital stays (days), and anal exhaust time in group A were shorter than those in group B (P<0.05). The pain degrees at 3, 6 and 18 h after surgery for patients in the group A were significantly lower than those of the group B (P<0.05). There was no significant difference IL‑6 and VEGF levels in the serum between groups A and B before and after surgery (P>0.05); however, the level of IFN‑γ expression, one week after surgery, in group B was significantly higher than that in group A (P<0.05). The pregnancy rate in the experimental group was higher than that in the control group (P<0.05), and the incidence rate of complications in group A was significantly lower than that in group B (P<0.05). Results presented in the present study suggested that compared to traditional laparotomy, laparoscopic myomectomy is a more advantageous method in terms of safety, efficacy and pregnancy rate after surgery.

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